Reduced surface toll-like receptor-4 expression and absent interferon-γinducible protein-10 induction in cystic fibrosis airway cells

Experimental Lung Research

Volumn 37, Issue 6, 2011, Pages 319-326

  John, Gerrit ^a,b   Chillappagari, Shashi ^a   Rubin, Bruce K ^c   Gruenert, Dieter C ^d   Henke, Markus O ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

^c VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Adaptive immunity; Airway epithelium; CFTR; IFN inducible protein (IP) 10; Inflammation; Innate immunity; Toll like receptor

Indexed keywords

CELL SURFACE PROTEIN; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; LIPOPOLYSACCHARIDE; SMALL INTERFERING RNA; TOLL LIKE RECEPTOR 4; TRANSMEMBRANE CONDUCTANCE REGULATOR;

ADAPTIVE IMMUNITY; ARTICLE; CELL LINE; CONTROLLED STUDY; CYSTIC FIBROSIS; ENDOPLASMIC RETICULUM; HUMAN; HUMAN CELL; LUNG ALVEOLUS CELL; LUNG ALVEOLUS EPITHELIUM; LUNG FIBROSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION;

CELL LINE; CHEMOKINE CXCL10; CYSTIC FIBROSIS; ENDOPLASMIC RETICULUM; EPITHELIAL CELLS; HUMANS; INTERFERON-GAMMA; INTERLEUKIN-6; INTERLEUKIN-8; LIPOPOLYSACCHARIDES; MYELOID DIFFERENTIATION FACTOR 88; RESPIRATORY MUCOSA; RESPIRATORY SYSTEM; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TOLL-LIKE RECEPTOR 4;

EID: 79960723018     PISSN: 01902148     EISSN: 15210499     Source Type: Journal    
DOI: 10.3109/01902148.2011.569968     Document Type: Article

References (41)

1. Dakin CJ, Numa AH, Wang H, Morton JR, Vertzyas CC, Henry RL: Infammation, infection, and pulmonary function in infants and young children with cystic fbrosis. Am J Respir Crit Care Med. 2002;165:904-910. (Pubitemid 34774655)
2. Burns JL, Gibson RL, McNamara S, et al.: Longitudinal assessment of Pseudomonas aeruginosa in young children with cystic fbrosis. J Infect Dis. 2001;183:444-452. (Pubitemid 32105604)
3. Khan TZ, Wagener JS, Bost T, Martinez J, Accurso FJ, Riches DW. Early pulmonary infammation in infants with cystic fbro-sis. Am J Respir Crit Care Med. 1995;151:1075-1082.
4. Greene CM, Carroll TP, Smith SG, et al.: TLR-induced infam-mation in cystic fbrosis and non-cystic fbrosis airway epithelial cells. J Immunol. 2005;174:1638-1646.
5. Muir A, Soong G, Sokol S, et al.: Toll-like receptors in normal and cystic fbrosis airway epithelial cells. Am J Respir Cell Mol Biol. 2004;30:777-783. (Pubitemid 38736900)
6. Nakamura H, Yoshimura K, McElvaney NG, Crystal RG. Neutrophil elastase in respiratory epithelial lining fuid of individuals with cystic fbrosis induces interleukin-8 gene expression in a human bronchial epithelial cell line. J Clin Invest. 1992;89:1478-1484.
7. Kube D, Sontich U, Fletcher D, Davis PB. Proinfammatory cytokine responses to Paeruginos a infection in human airway epithelial cell lines. Am J Physiol Lung Cell Mol Physiol. 2001;280:L493-L502.
8. Di Mango E, Zar HJ, Bryan R, Prince A. Diverse Pseudomonas aeruginosa gene products stimulate respiratory epithelial cells to produce interleukin-8. J Clin Invest. 1995;96:2204-2210.
9. Fitzgerald KA, Rowe DC, Barnes BJ, et al.: LPS-TLR4 signaling to IRF-3/7 and NF-kappa B involves the toll adapters TRAM and TRIF. J Exp Med. 2003;198:1043-1055. (Pubitemid 37248620)
10. Yamamoto M, Sato S, Hemmi H, et al.: Role of adaptor TRIF in the My D88-independent toll-like receptor signaling pathway. Science. 2003;301:640-643. (Pubitemid 36927946)
11. Neville LF, Mathiak G, Bagasra O. The immunobiology of interferon-gamma inducible protein 10 k D (IP-10): a novel, pleiotropic member of the C-X-C chemokine superfamily. Cy-tokine Growth Factor Rev. 1997;8:207-219. (Pubitemid 28077928)
12. Spurrell JC, Wiehler S, Zaheer RS, Sanders SP, Proud D. Human airway epithelial cells produce IP-10 (CXCL10) in vitro and in vivo upon rhinovirus infection. Am J Physiol Lung Cell Mol Physiol. 2005;289:L85-L95. (Pubitemid 40863558)
13. Soejima K, Rollins BJ. A functional IFN-gamma-inducible protein-10/CXCL10-specific receptor expressed by epithelial and endothelial cells that is neither CXCR3 nor glycosamino-glycan. J Immunol. 2001;167:6576-6582. (Pubitemid 33081594)
14. Saetta M, Mariani M, Panina-Bordignon P, et al.: Increased expression of the chemokine receptor CXCR3 and its ligand CXCL10 in peripheral airways of smokers with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2002;165:1404-1409. (Pubitemid 34522945)
15. Owen C. Chemokine receptors in airway disease: which receptors to target? Pulm Pharmacol Ther. 2001;14:193-202. (Pubitemid 32619924)
16. Ulrich M, Worlitzsch D, Viglio S, et al: Alveolar infammation in cystic fbrosis. J Cyst Fibros. 2010;9:217-227.
17. Al Alam D, Deslee G, Tournois C, et al.: Impaired interleukin-8 chemokine secretion by Staphylococcus aureus-activated epithelium and T-cell chemotaxis in cystic fbrosis. Am J Respir Cell Mol Biol. 2010;42:644-650.
18. Bastonero S, Le PY, Armand M, et al.: New microbici-dal functions of tracheal glands: defective anti-infectious response to Pseudomonas aeruginosa in cystic fbrosis. PLoS ONE. 2009;4:e5357.
19. John G, Yildirim AO, Rubin BK, Gruenert DC, Henke MO. TLR-4-mediated innate immunity is reduced in cystic fbrosis airway cells. Am J Respir Cell Mol Biol. 2010;42:424-431.
20. Bruscia E, Sangiuolo F, Sinibaldi P, Goncz KK, Novelli G, Gruenert DC. Isolation of CF cell lines corrected at Delta F508-CFTR locus by SFHR- mediated targeting. Gene Ther. 2002;9:683-685. (Pubitemid 34591465)
21. Illek B, Maurisse R, Wahler L, Kunzelmann K, Fischer H, Gruenert DC. Cl transport in complemented CF bronchial epithelial cells correlates with CFTR m RNA expression levels. Cell Physiol Biochem. 2008;22:57-68.
22. Kumar A, Zhang J, Yu FS. Toll-like receptor 3 agonist poly(I:C)-induced antiviral response in human corneal epithelial cells. Immunology. 2006;117:11-21.
23. Kessler BM, Tortorella D, Altun M, et al: Extended peptide-based inhibitors effciently target the proteasome and reveal overlapping specificities of the catalytic beta-subunits. Chem Biol. 2001;8:913-929. (Pubitemid 32863208)
24. Shimada T, Hiramatsu N, Hayakawa K, et al.: Dual suppression of adipogenesis by cigarette smoke through activation of the aryl hydrocarbon receptor and induction of endoplasmic reticulum stress. Am J Physiol Endocrinol Metab. 2009;296:E721-E730.
25. Smith JJ, Travis SM, Greenberg EP, Welsh MJ. Cystic fbrosis airway epithelia fail to kill bacteria because of abnormal airway surface fuid [published erratum appears in Cell. 1996;87:fol-lowing 355]. Cell. 1996;85:229-236. (Pubitemid 26118164)
26. Shuto T, Furuta T, Oba M, et al.: Promoter hypomethylation of Toll-like receptor-2 gene is associated with increased proin-fammatory response toward bacterial peptidoglycan in cystic fbrosis bronchial epithelial cells. FASEB J. 2006;20:782-784. (Pubitemid 46671214)
27. Hauber HP, Tulic MK, Tsicopoulos A, et al.: Toll-like receptors 4 and 2 expression in the bronchial mucosa of patients with cystic fbrosis. Can Respir J. 2005;12:13-18. (Pubitemid 40468246)
28. Carpenter S, O'Neill LA. How important are Toll-like receptors for antimicrobial responses? Cell Microbiol. 2007;9:1891-1901. (Pubitemid 47087081)
29. Siegmann N, Griesenbach U, Gulbins E, Doering G. Accumulation of NKT cells in tissues of cystic fbrosis mice. J Cyst Fi-bros. 2009;8(Suppl 2):S54.
30. Keane MP, Belperio JA, Arenberg DA, et al.: IFN-gamma-inducible protein-10 attenuates bleomycin-induced pulmonary fbrosis via inhibition of angiogenesis. J Immunol. 1999;163:5686-5692.
31. Moss RB, Hsu YP, Olds L. Cytokine dysregulation in activated cystic fbrosis (CF) peripheral lymphocytes. Clin Exp Immunol. 2000;120:518-525. (Pubitemid 30365559)
32. Koller DY, Nething I, Otto J, Urbanek R, Eichler I. Cytokine concentrations in sputum from patients with cystic fbrosis and their relation to eosinophil activity. Am J Respir Crit Care Med. 1997;155:1050-1054. (Pubitemid 27133422)
33. Becker MN, Sauer MS, Muhlebach MS, et al: Cytokine secretion by cystic fbrosis airway epithelial cells. Am J Respir Crit Care Med. 2004;169:645-653. (Pubitemid 38270902)
34. Tabary O, Muselet C, Escotte S, et al.: Interleukin-10 inhibits elevated chemokine interleukin-8 and regulated on activation normal T cell expressed and secreted production in cystic f-brosis bronchial epithelial cells by targeting the I(κ)B kinase alpha/beta complex. Am J Pathol. 2003;162:293-302. (Pubitemid 36042011)
35. Barasch J, Kiss B, Prince A, Saiman L, Gruenert D, Al Awqati Q. Defective acidification of intracellular organelles in cystic f-brosis. Nature. 1991;352:70-73. (Pubitemid 21896700)
36. Cheng PW, Boat TF, Cranfll K, Yankaskas JR, Boucher RC. Increased sulfation of glycoconjugates by cultured nasal epithelial cells from patients with cystic fbrosis. J Clin Invest. 1989;84:68-72. (Pubitemid 19170096)
37. Jensen TJ, Loo MA, Pind S, Williams DB, Goldberg AL, Rior-dan JR. Multiple proteolytic systems, including the proteasome, contribute to CFTR processing. Cell. 1995;83:129-135.
38. Howell GJ, Holloway ZG, Cobbold C, Monaco AP, Ponnam-balam S. Cell biology of membrane traffcking in human disease. Int Rev Cytol. 2006;252:1-69. (Pubitemid 44376837)
39. Jarosch E, Lenk U, Sommer T. Endoplasmic reticulum-associated protein degradation. Int Rev Cytol. 2003;223:39-81. (Pubitemid 36278511)
40. Armstrong DS, Grimwood K, Carlin JB, et al.: Lower airway infammation in infants and young children with cystic f-brosis. Am J Respir Crit Care Med. 1997;156(4 Pt 1):1197-1204.
41. Bonfeld TL, Panuska JR, Konstan MW, et al.: Infammatory cytokines in cystic fbrosis lungs. Am J Respir Crit Care Med. 1995;152:2111-2118.