Stem cells and aging: A chicken-or-the-egg issue?

Aging and Disease

Volumn 3, Issue 3, 2012, Pages 260-268

  Smith, Johanna A ^a   Daniel, René ^a,b,c  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

^c THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

Aging; Microenvironment; Progeroid syndromes; Stem cells

Indexed keywords

EID: 84865793345     PISSN: None     EISSN: 21525250     Source Type: Journal    
DOI: None     Document Type: Review

References (102)

1. Goyns MH (2002). Genes, telomeres and mammalian ageing. Mech Ageing Dev, 123: 791-799
2. Li H, Mitchell JR and Hasty P (2008). DNA double-strand breaks: a potential causative factor for mammalian aging? Mech Ageing Dev, 129: 416-424
3. Rodriguez-Rodero S, Fernandez-Morera JL, Fernandez AF, Menendez-Torre E and Fraga MF Epigenetic regulation of aging. Discov Med, 10: 225-233
4. Do JT and Scholer HR (2009). Regulatory circuits underlying pluripotency and reprogramming. Trends Pharmacol Sci, 30: 296-302
5. Okita K and Yamanaka S (2006). Intracellular signaling pathways regulating pluripotency of embryonic stem cells. Curr Stem Cell Res Ther, 1: 103-111
6. Woolthuis CM, de Haan G and Huls G Aging of hematopoietic stem cells: Intrinsic changes or micro-environmental effects? Curr Opin Immunol, 23: 512-517
7. Kim M, Moon HB and Spangrude GJ (2003). Major age-related changes of mouse hematopoietic stem/progenitor cells. Ann N Y Acad Sci, 996: 195-208
8. Rossi DJ, Bryder D, Zahn JM, Ahlenius H, Sonu R, Wagers AJ and Weissman IL (2005). Cell intrinsic alterations underlie hematopoietic stem cell aging. Proc Natl Acad Sci U S A, 102: 9194-9199
9. Sudo K, Ema H, Morita Y and Nakauchi H (2000). Age-associated characteristics of murine hematopoietic stem cells. J Exp Med, 192: 1273-1280
10. Beerman I, Maloney WJ, Weissmann IL and Rossi DJ Stem cells and the aging hematopoietic system. Curr Opin Immunol, 22: 500-506
11. Chambers SM, Shaw CA, Gatza C, Fisk CJ, Donehower LA and Goodell MA (2007). Aging hematopoietic stem cells decline in function and exhibit epigenetic dysregulation. PLoS Biol, 5: e201
12. Morrison SJ, Wandycz AM, Akashi K, Globerson A and Weissman IL (1996). The aging of hematopoietic stem cells. Nat Med, 2: 1011-1016
13. Taraldsrud E, Grogaard HK, Solheim S, Lunde K, Floisand Y, Arnesen H, Seljeflot I and Egeland T (2009). Age and stress related phenotypical changes in bone marrow CD34+ cells. Scand J Clin Lab Invest, 69: 79-84
14. Challen GA, Boles NC, Chambers SM and Goodell MA Distinct hematopoietic stem cell subtypes are differentially regulated by TGF-beta1. Cell Stem Cell, 6: 265-278
15. Cho RH, Sieburg HB and Muller-Sieburg CE (2008). A new mechanism for the aging of hematopoietic stem cells: aging changes the clonal composition of the stem cell compartment but not individual stem cells. Blood, 111: 5553-5561
16. Roeder I, Horn K, Sieburg HB, Cho R, Muller-Sieburg C and Loeffler M (2008). Characterization and quantification of clonal heterogeneity among hematopoietic stem cells: a model-based approach. Blood, 112: 4874-4883
17. Wang J, Geiger H and Rudolph KL Immunoaging induced by hematopoietic stem cell aging. Curr Opin Immunol, 23: 532-536
18. Deng J, Petersen BE, Steindler DA, Jorgensen ML and Laywell ED (2006). Mesenchymal stem cells spontaneously express neural proteins in culture and are neurogenic after transplantation. Stem Cells, 24: 1054-1064
19. Engler AJ, Sen S, Sweeney HL and Discher DE (2006). Matrix elasticity directs stem cell lineage specification. Cell, 126: 677-689
20. Petersen BE, Bowen WC, Patrene KD, Mars WM, Sullivan AK, Murase N, Boggs SS, Greenberger JS and GoffJP (1999). Bone marrow as a potential source of hepatic oval cells. Science, 284: 1168-1170.
21. Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, Moorman MA, Simonetti DW, Craig S and Marshak DR (1999). Multilineage potential of adult human mesenchymal stem cells. Science, 284: 143-147
22. Smith JR, Pochampally R, Perry A, Hsu SC and Prockop DJ (2004). Isolation of a highly clonogenic and multipotential subfraction of adult stem cells from bone marrow stroma. Stem Cells, 22: 823-831
23. Sethe S, Scutt A and Stolzing A (2006). Aging of mesenchymal stem cells. Ageing Res Rev, 5: 91-116
24. Chen TL (2004). Inhibition of growth and differentiation of osteoprogenitors in mouse bone marrow stromal cell cultures by increased donor age and glucocorticoid treatment. Bone, 35: 83-95
25. Knopp E, Troiano N, Bouxsein M, Sun BH, Lostritto K, Gundberg C, Dziura J and Insogna K (2005). The effect of aging on the skeletal response to intermittent treatment with parathyroid hormone. Endocrinology, 146: 1983-1990
26. Sun Y, Li W, Lu Z, Chen R, Ling J, Ran Q, Jilka RL and Chen XD Rescuing replication and osteogenesis of aged mesenchymal stem cells by exposure to a young extracellular matrix. FASEB J, 25: 1474-1485
27. Hunt DP, Morris PN, Sterling J, Anderson JA, Joannides A, Jahoda C, Compston A and Chandran S (2008). A highly enriched niche of precursor cells with neuronal and glial potential within the hair follicle dermal papilla of adult skin. Stem Cells, 26: 163-172
28. Fernandes KJ, McKenzie IA, Mill P, Smith KM, Akhavan M, Barnabe-Heider F, Biernaskie J, Junek A, Kobayashi NR, Toma JG, Kaplan DR, Labosky PA, Rafuse V, Hui CC and Miller FD (2004). A dermal niche for multipotent adult skin-derived precursor cells. Nat Cell Biol, 6: 1082-1093
29. Fernandes KJ, Toma JG and Miller FD (2008). Multipotent skin-derived precursors: adult neural crest-related precursors with therapeutic potential. Philos Trans R Soc Lond B Biol Sci, 363: 185-198
30. Gago N, Perez-Lopez V, Sanz-Jaka JP, Cormenzana P, Eizaguirre I, Bernad A and Izeta A (2009). Age-dependent depletion of human skin-derived progenitor cells. Stem Cells, 27: 1164-1172
31. Racila D and Bickenbach JR (2009). Are epidermal stem cells unique with respect to aging? Aging (Albany NY), 1: 746-750
32. Heiss C, Keymel S, Niesler U, Ziemann J, Kelm M and Kalka C (2005). Impaired progenitor cell activity in age-related endothelial dysfunction. J Am Coll Cardiol, 45: 1441-1448
33. Asahara T, Murohara T, Sullivan A, Silver M, van der Zee R, Li T, Witzenbichler B, Schatteman G and Isner JM (1997). Isolation of putative progenitor endothelial cells for angiogenesis. Science, 275: 964-967
34. Reyes M, Dudek A, Jahagirdar B, Koodie L, Marker PH and Verfaillie CM (2002). Origin of endothelial progenitors in human postnatal bone marrow. J Clin Invest, 109: 337-346
35. Brack AS and Rando TA (2007). Intrinsic changes and extrinsic influences of myogenic stem cell function during aging. Stem Cell Rev, 3: 226-237
36. Jones DL and Rando TA Emerging models and paradigms for stem cell ageing. Nat Cell Biol, 13: 506-512
37. Brack AS, Conboy MJ, Roy S, Lee M, Kuo CJ, Keller C and Rando TA (2007). Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis. Science, 317: 807-810
38. Conboy IM, Conboy MJ, Smythe GM and Rando TA (2003). Notch-mediated restoration of regenerative potential to aged muscle. Science, 302: 1575-1577
39. Olovnikov AM (1973). A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon. J Theor Biol, 41: 181-190
40. de Lange T (2005). Shelterin: the protein complex that shapes and safeguards human telomeres. Genes Dev, 19: 2100-2110
41. Donate LE and Blasco MA Telomeres in cancer and ageing. Philos Trans R Soc Lond B Biol Sci, 366: 76-84
42. Vaziri H and Benchimol S (1996). From telomere loss to p53 induction and activation of a DNA-damage pathway at senescence: the telomere loss/DNA damage model of cell aging. Exp Gerontol, 31: 295-301
43. Zimmermann S and Martens UM (2005). Telomere dynamics in hematopoietic stem cells. Curr Mol Med, 5: 179-185
44. Blasco MA, Funk W, Villeponteau B and Greider CW (1995). Functional characterization and developmental regulation of mouse telomerase RNA. Science, 269: 1267-1270
45. Blasco MA, Lee HW, Hande MP, Samper E, Lansdorp PM, DePinho RA and Greider CW (1997). Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell, 91: 25-34
46. Herrera E, Samper E, Martin-Caballero J, Flores JM, Lee HW and Blasco MA (1999). Disease states associated with telomerase deficiency appear earlier in mice with short telomeres. EMBO J, 18: 2950-2960
47. Lee HW, Blasco MA, Gottlieb GJ, Horner JW, 2nd, Greider CW and DePinho RA (1998). Essential role of mouse telomerase in highly proliferative organs. Nature, 392: 569-574
48. Siegl-Cachedenier I, Flores I, Klatt P and Blasco MA (2007). Telomerase reverses epidermal hair follicle stem cell defects and loss of long-term survival associated with critically short telomeres. J Cell Biol, 179: 277-290
49. Flores I, Cayuela ML and Blasco MA (2005). Effects of telomerase and telomere length on epidermal stem cell behavior. Science, 309: 1253-1256
50. Freitas AA and de Magalhaes JP A review and appraisal of the DNA damage theory of ageing. Mutat Res, 728: 12-22
51. Kenyon J and Gerson SL (2007). The role of DNA damage repair in aging of adult stem cells. Nucleic Acids Res, 35: 7557-7565
52. Liu J, Cao L and Finkel T (2011). Oxidants, metabolism, and stem cell biology. Free radical biology & medicine, 51: 2158-2162
53. Lee JW, Harrigan J, Opresko PL and Bohr VA (2005). Pathways and functions of the Werner syndrome protein. Mech Ageing Dev, 126: 79-86
54. Hasty P, Campisi J, Hoeijmakers J, van Steeg H and Vijg J (2003). Aging and genome maintenance: lessons from the mouse? Science, 299: 1355-1359
55. Rotman G and Shiloh Y (1997). Ataxia-telangiectasia: is ATM a sensor of oxidative damage and stress? Bioessays, 19: 911-917
56. Nijnik A, Woodbine L, Marchetti C, Dawson S, Lambe T, Liu C, Rodrigues NP, Crockford TL, Cabuy E, Vindigni A, Enver T, Bell JI, Slijepcevic P, Goodnow CC, Jeggo PA and Cornall RJ (2007). DNA repair is limiting for haematopoietic stem cells during ageing. Nature, 447: 686-690
57. Qing Y, Lin Y and Gerson SL (2011). An intrinsic BM hematopoietic niche occupancy defect of HSC in scid mice facilitates exogenous HSC engraftment. Blood
58. Bender CF, Sikes ML, Sullivan R, Huye LE, Le Beau MM, Roth DB, Mirzoeva OK, Oltz EM and Petrini JH (2002). Cancer predisposition and hematopoietic failure in Rad50(S/S) mice. Genes Dev, 16: 2237-2251
59. Ito K, Hirao A, Arai F, Matsuoka S, Takubo K, Hamaguchi I, Nomiyama K, Hosokawa K, Sakurada K, Nakagata N, Ikeda Y, Mak TW and Suda T (2004). Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells. Nature, 431: 997-1002
60. Rossi DJ, Bryder D, Seita J, Nussenzweig A, Hoeijmakers J and Weissman IL (2007). Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age. Nature, 447: 725-729
61. Sasaki T, Maier B, Bartke A and Scrable H (2006). Progressive loss of SIRT1 with cell cycle withdrawal. Aging Cell, 5: 413-422
62. Sommer M, Poliak N, Upadhyay S, Ratovitski E, Nelkin BD, Donehower LA and Sidransky D (2006). DeltaNp63alpha overexpression induces downregulation of Sirt1 and an accelerated aging phenotype in the mouse. Cell Cycle, 5: 2005-2011
63. Haigis MC and Guarente LP (2006). Mammalian sirtuins--emerging roles in physiology, aging, and calorie restriction. Genes Dev, 20: 2913-2921
64. Kennedy BK, Austriaco NR, Jr., Zhang J and Guarente L (1995). Mutation in the silencing gene SIR4 can delay aging in S. cerevisiae. Cell, 80: 485-496
65. Longo VD and Kennedy BK (2006). Sirtuins in aging and age-related disease. Cell, 126: 257-268
66. Calvanese V, Lara E, Kahn A and Fraga MF (2009). The role of epigenetics in aging and age-related diseases. Ageing Res Rev, 8: 268-276
67. Sedivy JM, Banumathy G and Adams PD (2008). Aging by epigenetics--a consequence of chromatin damage? Exp Cell Res, 314: 1909-1917
68. Bracken AP, Kleine-Kohlbrecher D, Dietrich N, Pasini D, Gargiulo G, Beekman C, Theilgaard-Monch K, Minucci S, Porse BT, Marine JC, Hansen KH and Helin K (2007). The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells. Genes Dev, 21: 525-530
69. Sarg B, Koutzamani E, Helliger W, Rundquist I and Lindner HH (2002). Postsynthetic trimethylation of histone H4 at lysine 20 in mammalian tissues is associated with aging. J Biol Chem, 277: 39195-39201
70. Narita M, Nunez S, Heard E, Lin AW, Hearn SA, Spector DL, Hannon GJ and Lowe SW (2003). Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell, 113: 703-716
71. Berdyshev GD, Korotaev GK, Boiarskikh GV and Vaniushin BF (1967). [Nucleotide composition of DNA and RNA from somatic tissues of humpback and its changes during spawning]. Biokhimiia, 32: 988-993
72. Esteller M (2007). Cancer epigenomics: DNA methylomes and histone-modification maps. Nat Rev Genet, 8: 286-298
73. Esteller M (2008). Epigenetics in cancer. N Engl J Med, 358: 1148-1159
74. Maegawa S, Hinkal G, Kim HS, Shen L, Zhang L, Zhang J, Zhang N, Liang S, Donehower LA and Issa JP Widespread and tissue specific age-related DNA methylation changes in mice. Genome Res, 20: 332-340
75. Swan M Steady advance of stem cell therapies: report from the 2011 World Stem Cell Summit, Pasadena, California, October 3-5. Rejuvenation Res, 14: 699-704
76. Trowbridge JJ, Snow JW, Kim J and Orkin SH (2009). DNA methyltransferase 1 is essential for and uniquely regulates hematopoietic stem and progenitor cells. Cell Stem Cell, 5: 442-449
77. Li Z, Liu C, Xie Z, Song P, Zhao RC, Guo L, Liu Z and Wu Y Epigenetic dysregulation in mesenchymal stem cell aging and spontaneous differentiation. PLoS One, 6: e20526
78. Kirkwood TB (1977). Evolution of ageing. Nature, 270: 301-304
79. Rando TA (2006). Stem cells, ageing and the quest for immortality. Nature, 441: 1080-1086
80. Marion RM and Blasco MA (2010). Telomere rejuvenation during nuclear reprogramming. Curr Opin Genet Dev, 20: 190-196
81. Mauch P, Botnick LE, Hannon EC, Obbagy J and Hellman S (1982). Decline in bone marrow proliferative capacity as a function of age. Blood, 60: 245-252
82. Mayack SR, Shadrach JL, Kim FS and Wagers AJ Systemic signals regulate ageing and rejuvenation of blood stem cell niches. Nature, 463: 495-500
83. DeBusk FL (1972). The Hutchinson-Gilford progeria syndrome. Report of 4 cases and review of the literature. J Pediatr, 80: 697-724
84. Merideth MA, Gordon LB, Clauss S, Sachdev V, Smith AC, Perry MB, Brewer CC, Zalewski C, Kim HJ, Solomon B, Brooks BP, Gerber LH, Turner ML, Domingo DL, Hart TC, Graf J, Reynolds JC, Gropman A, Yanovski JA, Gerhard-Herman M, Collins FS, Nabel EG, Cannon RO, 3rd, Gahl WA and Introne WJ (2008). Phenotype and course of Hutchinson-Gilford progeria syndrome. N Engl J Med, 358: 592-604
85. Broers JL, Ramaekers FC, Bonne G, Yaou RB and Hutchison CJ (2006). Nuclear lamins: laminopathies and their role in premature ageing. Physiol Rev, 86: 967-1008
86. De Sandre-Giovannoli A, Bernard R, Cau P, Navarro C, Amiel J, Boccaccio I, Lyonnet S, Stewart CL, Munnich A, Le Merrer M and Levy N (2003). Lamin a truncation in Hutchinson-Gilford progeria. Science, 300: 2055
87. Eriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW and Collins FS (2003). Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome. Nature, 423: 293-298
88. Scaffidi P and Misteli T (2008). Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing. Nat Cell Biol, 10: 452-459
89. Sagelius H, Rosengardten Y, Hanif M, Erdos MR, Rozell B, Collins FS and Eriksson M (2008). Targeted transgenic expression of the mutation causing Hutchinson-Gilford progeria syndrome leads to proliferative and degenerative epidermal disease. J Cell Sci, 121: 969-978
90. Rosengardten Y, McKenna T, Grochova D and Eriksson M Stem cell depletion in Hutchinson-Gilford progeria syndrome. Aging Cell, 10: 1011-1020
91. Orren DK (2006). Werner syndrome: molecular insights into the relationships between defective DNA metabolism, genomic instability, cancer and aging. Front Biosci, 11: 2657-2671
92. Gray MD, Shen JC, Kamath-Loeb AS, Blank A, Sopher BL, Martin GM, Oshima J and Loeb LA (1997). The Werner syndrome protein is a DNA helicase. Nat Genet, 17: 100-103
93. Hickson ID (2003). RecQ helicases: caretakers of the genome. Nat Rev Cancer, 3: 169-178
94. Chang S, Multani AS, Cabrera NG, Naylor ML, Laud P, Lombard D, Pathak S, Guarente L and DePinho RA (2004). Essential role of limiting telomeres in the pathogenesis of Werner syndrome. Nat Genet, 36: 877-882
95. Bohr VA (2008). Rising from the RecQ-age: the role of human RecQ helicases in genome maintenance. Trends Biochem Sci, 33: 609-620
96. Turaga RV, Massip L, Chavez A, Johnson FB and Lebel M (2007). Werner syndrome protein prevents DNA breaks upon chromatin structure alteration. Aging Cell, 6: 471-481
97. Damjanov I, Horvat B and Gibas Z (1993). Retinoic acid-induced differentiation of the developmentally pluripotent human germ cell tumor-derived cell line, NCCIT. Lab Invest, 68: 220-232
98. Dahl JA and Collas P (2007). A quick and quantitative chromatin immunoprecipitation assay for small cell samples. Front Biosci, 12: 4925-4931
99. Feldman N, Gerson A, Fang J, Li E, Zhang Y, Shinkai Y, Cedar H and Bergman Y (2006). G9a-mediated irreversible epigenetic inactivation of Oct-3/4 during early embryogenesis. Nat Cell Biol, 8: 188-194
100. Schotta G, Lachner M, Sarma K, Ebert A, Sengupta R, Reuter G, Reinberg D and Jenuwein T (2004). A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin. Genes Dev, 18: 1251-1262
101. Michishita E, McCord RA, Berber E, Kioi M, Padilla-Nash H, Damian M, Cheung P, Kusumoto R, Kawahara TL, Barrett JC, Chang HY, Bohr VA, Ried T, Gozani O and Chua KF (2008). SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin. Nature, 452: 492-496
102. Hinault C, Kawamori D, Liew CW, Maier B, Hu J, Keller SR, Mirmira RG, Scrable H and Kulkarni RN (2011). Delta40 Isoform of p53 controls beta-cell proliferation and glucose homeostasis in mice. Diabetes, 60: 1210-1222