DNA Methyltransferase 1 Is Essential for and Uniquely Regulates Hematopoietic Stem and Progenitor Cells

Cell Stem Cell

Volumn 5, Issue 4, 2009, Pages 442-449

  Trowbridge, Jennifer J ^a   Snow, Jonathan W ^a   Kim, Jonghwan ^a,b   Orkin, Stuart H ^a,b  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

STEMCELL

Indexed keywords

DNA METHYLTRANSFERASE 1;

ANIMAL CELL; ARTICLE; CELL COMPARTMENTALIZATION; CELL CYCLE REGULATION; CELL DIFFERENTIATION; CELL POPULATION; CELL RENEWAL; CONTROLLED STUDY; DNA METHYLATION; FEMALE; GENE EXPRESSION; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC SYSTEM; MOUSE; MULTIGENE FAMILY; MULTIPOTENT STEM CELL; MYELOID PROGENITOR CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN FUNCTION;

ANIMALS; BLOTTING, WESTERN; BONE MARROW TRANSPLANTATION; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; FEMALE; FLOW CYTOMETRY; HEMATOPOIETIC STEM CELLS; MICE; POLYMERASE CHAIN REACTION;

EID: 70349469788     PISSN: 19345909     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.stem.2009.08.016     Document Type: Article

References (16)

1. Dennis Jr. G., Sherman B.T., Hosack D.A., Yang J., Gao W., Lane H.C., and Lempicki R.A. DAVID: Database for Annotation, Visualization, and Integrated Discovery. Genome Biol. 4 (2003) P3
2. Fan G., Beard C., Chen R.Z., Csankovszki G., Sun Y., Siniaia M., Biniszkiewicz D., Bates B., Lee P.P., Kuhn R., et al. DNA hypomethylation perturbs the function and survival of CNS neurons in postnatal animals. J. Neurosci. 21 (2001) 788-797
3. Gaudet F., Rideout III W.M., Meissner A., Dausman J., Leonhardt H., and Jaenisch R. Dnmt1 expression in pre- and postimplantation embryogenesis and the maintenance of IAP silencing. Mol. Cell. Biol. 24 (2004) 1640-1648
4. Hock H., Meade E., Medeiros S., Schindler J.W., Valk P.J., Fujiwara Y., and Orkin S.H. Tel/Etv6 is an essential and selective regulator of adult hematopoietic stem cell survival. Genes Dev. 18 (2004) 2336-2341
5. Jackson-Grusby L., Beard C., Possemato R., Tudor M., Fambrough D., Csankovszki G., Dausman J., Lee P., Wilson C., Lander E., et al. Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation. Nat. Genet. 27 (2001) 31-39
6. Jaenisch R. DNA methylation and imprinting: Why bother?. Trends Genet. 13 (1997) 323-329
7. Jasinski M., Keller P., Fujiwara Y., Orkin S.H., and Bessler M. GATA1-Cre mediates Piga gene inactivation in the erythroid/megakaryocytic lineage and leads to circulating red cells with a partial deficiency in glycosyl phosphatidylinositol-linked proteins (paroxysmal nocturnal hemoglobinuria type II cells). Blood 98 (2001) 2248-2255
8. Kuhn R., Schwenk F., Aguet M., and Rajewsky K. Inducible gene targeting in mice. Science 269 (1995) 1427-1429
9. Lei H., Oh S.P., Okano M., Juttermann R., Goss K.A., Jaenisch R., and Li E. De novo DNA cytosine methyltransferase activities in mouse embryonic stem cells. Development 122 (1996) 3195-3205
10. Li E., Bestor T.H., and Jaenisch R. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell 69 (1992) 915-926
11. Okano M., Bell D.W., Haber D.A., and Li E. DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 99 (1999) 247-257
12. Schadt E.E., Li C., Ellis B., and Wong W.H. Feature extraction and normalization algorithms for high-density oligonucleotide gene expression array data. J. Cell Biochem. Suppl. Suppl 37 (2001) 120-125
13. Tadokoro Y., Ema H., Okano M., Li E., and Nakauchi H. De novo DNA methyltransferase is essential for self-renewal, but not for differentiation, in hematopoietic stem cells. J. Exp. Med. 204 (2007) 715-722
14. Tsumura A., Hayakawa T., Kumaki Y., Takebayashi S., Sakaue M., Matsuoka C., Shimotohno K., Ishikawa F., Li E., Ueda H.R., et al. Maintenance of self-renewal ability of mouse embryonic stem cells in the absence of DNA methyltransferases Dnmt1, Dnmt3a and Dnmt3b. Genes Cells 11 (2006) 805-814
15. Villeval J.L., Testa U., Vinci G., Tonthat H., Bettaieb A., Titeux M., Cramer P., Edelman L., Rochant H., Breton-Gorius J., et al. Carbonic anhydrase I is an early specific marker of normal human erythroid differentiation. Blood 66 (1985) 1162-1170
16. Walkley C.R., Shea J.M., Sims N.A., Purton L.E., and Orkin S.H. Rb regulates interactions between hematopoietic stem cells and their bone marrow microenvironment. Cell 129 (2007) 1081-1095