Telomere rejuvenation during nuclear reprogramming

Current Opinion in Genetics and Development

Volumn 20, Issue 2, 2010, Pages 190-196

  Marión, Rosa M ^a   Blasco, Maria A ^a  

^a Centro Nacional de Investigaciones Oncológicas   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

DICER; DNA; DNA METHYLTRANSFERASE 1; HISTONE H3; HISTONE H4; PROTEIN P53; TELOMERASE; TELOMERIC REPEAT BINDING FACTOR 1; TELOMERIC REPEAT BINDING FACTOR 2;

AGING; CELL CYCLE ARREST; CELL DIFFERENTIATION; CELL DIVISION; CHROMATIN STRUCTURE; CHROMOSOMAL INSTABILITY; DNA DAMAGE; DNA METHYLATION; ENZYME ACTIVATION; ENZYME REGULATION; EPIGENETICS; GENE EXPRESSION; HUMAN; NONHUMAN; NUCLEAR REPROGRAMMING; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; REVIEW; SENESCENCE; TELOMERE;

ANIMALS; CELL DIFFERENTIATION; EPIGENESIS, GENETIC; HUMANS; INDUCED PLURIPOTENT STEM CELLS; MODELS, GENETIC; NUCLEAR REPROGRAMMING; TELOMERASE; TELOMERE;

IPS;

EID: 77952240404     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.gde.2010.01.005     Document Type: Review

References (70)

1. Gurdon J.B., Melton D.A. Nuclear reprogramming in cells. Science 2008, 322:1811-1815.
2. Rideout W.M., Eggan K., Jaenisch R. Nuclear cloning and epigenetic reprogramming of the genome. Science 2001, 293:1093-1098.
3. Yang X., Smith S.L., Tian X.C., Lewin H.A., Renard J.P., Wakayama T. Nuclear reprogramming of cloned embryos and its implications for therapeutic cloning. Nat Genet 2007, 39:295-302.
4. Hochedlinger K., Plath K. Epigenetic reprogramming and induced pluripotency. Development 2009, 136:509-523.
5. Wilmut I., Schnieke A.E., McWhir J., Kind A.J., Campbell K.H. Viable offspring derived from fetal and adult mammalian cells. Nature 1997, 385:810-813.
6. Tada M., Takahama Y., Abe K., Nakatsuji N., Tada T. Nuclear reprogramming of somatic cells by in vitro hybridization with ES cells. Curr Biol 2001, 11:1553-1558.
7. Wakayama T., Perry A.C., Zuccotti M., Johnson K.R., Yanagimachi R. Full-term development of mice from enucleated oocytes injected with cumulus cell nuclei. Nature 1998, 394:369-374.
8. Kato Y., Tani T., Sotomaru Y., Kurokawa K., Kato J., Doguchi H., Yasue H., Tsunoda Y. Eight calves cloned from somatic cells of a single adult. Science 1998, 282:2095-2098.
9. Polejaeva I.A., Chen S.H., Vaught T.D., Page R.L., Mullins J., Ball S., Dai Y., Boone J., Walker S., Ayares D.L., Colman A., Campbell K.H. Cloned pigs produced by nuclear transfer from adult somatic cells. Nature 2000, 407:86-90.
10. Chesné P., Adenot P.G., Viglietta C., Baratte M., Boulanger L., Renard J.P. Cloned rabbits produced by nuclear transfer from adult somatic cells. Nat Biotechnol 2002, 20:366-369.
11. Shin T., Kraemer D., Pryor J., Liu L., Rugila J., Howe L., Buck S., Murphy K., Lyons L., Westhusin M. A cat cloned by nuclear transplantation. Nature 2002, 415:859.
12. Takahashi K., Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006, 126:663-676.
13. Takahashi K., Tanabe K., Ohnuki M., Narita M., Ichisaka T., Tomoda K., Yamanaka S. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007, 131:861-872.
14. Amabile G., Meissner A. Induced pluripotent stem cells: current progress and potential for regenerative medicine. Trends Mol Med 2009, 15:59-68.
15. Chan S.R., Blackburn E.H. Telomeres and telomerase. Philos Trans R Soc Lond B Biol Sci 2004, 359:109-121.
16. Palm W., de Lange T. How shelterin protects mammalian telomeres. Annu Rev Genet 2008, 42:301-334.
17. Blackburn E.H. Switching and signaling at the telomere. Cell 2001, 106:661-673.
18. de Lange T. Shelterin: the protein complex that shapes and safeguards human telomeres. Genes Dev 2005, 19:2100-2110.
19. d'Adda di Fagagna F., Reaper P.M., Clay-Farrace L., Fiegler H., Carr P., Von Zglinicki T., Saretzki G., Carter N.P., Jackson S.P. A DNA damage checkpoint response in telomere-initiated senescence. Nature 2003, 426:194-198.
20. Harley C.B., Futcher A.B., Greider C.W. Telomeres shorten during ageing of human fibroblasts. Nature 1990, 345:458-460.
21. Blasco M.A. Telomeres and human disease: ageing, cancer and beyond. Nat Rev Genet 2005, 6:611-622.
22. Chan S.W., Blackburn E.H. New ways not to make ends meet: telomerase, DNA damage proteins and heterochromatin. Oncogene 2002, 21:553-563.
23. Collins K., Mitchell J.R. Telomerase in the human organism. Oncogene 2002, 21:564-579.
24. Dunham M.A., Neumann A.A., Fasching C.L., Reddel R.R. Telomere maintenance by recombination in human cells. Nat Genet 2000, 26:447-450.
25. Schoeftner S., Blasco M.A. A 'higher order' of telomere regulation: telomere heterochromatin and telomeric RNAs. EMBO J 2009, 28:2323-2336.
26. Schoeftner S., Blasco M.A. Chromatin regulation and non-coding RNAs at mammalian telomeres. Semin Cell Dev Biol 2009, 10.1016/j.semcdb.2009.09.015.
27. García-Cao M., O'Sullivan R., Peters A.H., Jenuwein T., Blasco M.A. Epigenetic regulation of telomere length in mammalian cells by the Suv39h1 and Suv39h2 histone methyltransferases. Nat Genet 2004, 36:94-99.
28. Gonzalo S., Jaco I., Fraga M.F., Chen T., Li E., Esteller M., Blasco M.A. DNA methyltransferases control telomere length and telomere recombination in mammalian cells. Nat Cell Biol 2006, 8:416-424.
29. Benetti R., Gonzalo S., Jaco I., Schotta G., Klatt P., Jenuwein T., Blasco M.A. Suv4-20h deficiency results in telomere elongation and derepression of telomere recombination. J Cell Biol 2007, 178:925-936.
30. Benetti R., Gonzalo S., Jaco I., Muñoz P., Gonzalez S., Schoeftner S., Murchison E., Andl T., Chen T., Klatt P., Li E., Serrano M., Millar S., Hannon G., Blasco M.A. A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases. Nat Struct Mol Biol 2008, 15:268-279.
31. Azzalin C.M., Reichenbach P., Khoriauli L., Giulotto E., Lingner J. Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends. Science 2007, 318:798-801.
32. Schoeftner S., Blasco M.A. Developmentally regulated transcription of mammalian telomeres by DNA-dependent RNA polymerase II. Nat Cell Biol 2008, 10:228-236.
33. van Steensel B., de Lange T. Control of telomere length by the human telomeric protein TRF1. Nature 1997, 385:740-743.
34. Muñoz P., Blanco R., Flores J.M., Blasco M.A. XPF nuclease-dependent telomere loss and increased DNA damage in mice overexpressing TRF2 result in premature aging and cancer. Nat Genet 2005, 37:1063-1071.
35. Ye J.Z., de Lange T. TIN2 is a tankyrase 1 PARP modulator in the TRF1 telomere length control complex. Nat Genet 2004, 36:618-623.
36. Smith S., de Lange T Tankyrase promotes telomere elongation in human cells. Curr Biol 2000, 10:1299-1302.
37. Blasco M.A. Telomere length, stem cells and aging. Nat Chem Biol 2007, 3:640-649.
38. Flores I., Cayuela M.L., Blasco M.A. Effects of telomerase and telomere length on epidermal stem cell behavior. Science 2005, 309:1253-1256.
39. Flores I., Benetti R., Blasco M.A. Telomerase regulation and stem cell behavior. Curr Opin Cell Biol 2006, 18:254-260.
40. Liu L., Bailey S.M., Okuka M., Muñoz P., Li C., Zhou L., Wu C., Czerwiec E., Sandler L., Seyfang A., Blasco M.A., Keefe D.L. Telomere lengthening early in development. Nat Cell Biol 2007, 9:1436-1441.
41. Flores I., Canela A., Vera E., Tejera A., Cotsarelis G., Blasco M.A. The longest telomeres: a general signature of adult stem cell compartments. Genes Dev 2008, 22:654-667.
42. Mitchell J.R., Wood E., Collins K. A telomerase component is defective in the human disease dyskeratosis congenital. Nature 1999, 402:551-555.
43. Yamaguchi H., Calado R.T., Ly H., Kajigaya S., Baerlocher G.M., Chanock S.J., Lansdorp P.M., Young N.S. Mutations in TERT, the gene for telomerase reverse transcriptase, in aplastic anemia. N Engl J Med 2005, 352:1413-1424.
44. Tsakiri K.D., Cronkhite J.T., Kuan P.J., Xing C., Raghu G., Weissler J.C., Rosenblatt R.L., Shay J.W., Garcia C.K. Adult-onset pulmonary fibrosis caused by mutations in telomerase. Proc Natl Acad Sci U S A 2007, 104:7552-7557.
45. Armanios M.Y., Chen J.J., Cogan J.D., Alder J.K., Ingersoll R.G., Markin C., Lawson W.E., Xie M., Vulto I., Phillips J.A., Lansdorp P.M., Greider C.W., Loyd J.E. Telomerase mutations in families with idiopathic pulmonary fibrosis. N Engl J Med 2007, 356:1317-1326.
46. Blasco M.A., Lee H.W., Hande M.P., Samper E., Lansdorp P.M., DePinho R.A., Greider C.W. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell 1997, 91:25-34.
47. Lee H.W., Blasco M.A., Gottlieb G.J., Horner J.W., Greider C.W., DePinho R.A. Essential role of mouse telomerase in highly proliferative organs. Nature 1998, 392:569-574.
48. Herrera E., Samper E., Martín-Caballero J., Flores J.M., Lee H.W., Blasco M.A. Disease states associated with telomerase deficiency appear earlier in mice with short telomeres. EMBO J 1999, 18:2950-2960.
49. Samper E., Fernández P., Eguía R., Martín-Rivera L., Bernad A., Blasco M.A., Aracil M. Long-term repopulating ability of telomerase-deficient murine hematopoietic stem cells. Blood 2002, 99:2767-2775.
50. Ferrón S., Mira H., Franco S., Cano-Jaimez M., Bellmunt E., Ramírez C., Fariñas I., Blasco M.A. Telomere shortening and chromosomal instability abrogates proliferation of adult but not embryonic neural stem cells. Development 2004, 131:4059-4070.
51. Shiels P.G., Kind A.J., Campbell K.H., Waddington D., Wilmut I., Colman A., Schnieke A.E. Analysis of telomere lengths in cloned sheep. Nature 1999, 399:316-317.
52. Wakayama T., Shinkai Y., Tamashiro K.L., Niida H., Blanchard D.C., Blanchard R.J., Ogura A., Tanemura Tachibana K.M., Perry A.C., Colgan D.F., Mombaerts P., Yanagimachi R. Cloning of mice to six generations. Nature 2000, 407:318-319.
53. Lanza R.P., Cibelli J.B., Blackwell C., Cristofalo V.J., Francis M.K., Baerlocher G.M., Mak J., Schertzer M., Chavez E.A., Sawyer N., Lansdorp P.M., West M.D. Extension of cell life-span and telomere length in animals cloned from senescent somatic cells. Science 2000, 288:665-669.
54. Tian X.C., Xu J., Yang X. Normal telomere lengths found in cloned cattle. Nat Genet 2000, 26:272-273.
55. Betts D., Bordignon V., Hill J., Winger Q., Westhusin M., Smith L., King W. Reprogramming of telomerase activity and rebuilding of telomere length in cloned cattle. Proc Natl Acad Sci USA 2001, 98:1077-1082.
56. Clark A.J., Ferrier P., Aslam S., Burl S., Denning C., Wylie D., Ross A., de Sousa P., Wilmut I., Cui W. Proliferative lifespan is conserved after nuclear transfer. Nat Cell Biol 2003, 5:535-538.
57. Miyashita N., Shiga K., Yonai M., Kaneyama K., Kobayashi S., Kojima T., Goto Y., Kishi M., Aso H., Suzuki T., Sakaguchi M., Nagai T. Remarkable differences in telomere lengths among cloned cattle derived from different cell types. Biol Reprod 2002, 66:1649-1655.
58. Schaetzlein S., Lucas-Hahn A., Lemme E., Kues W.A., Dorsch M., Manns M.P., Niemann H., Rudolph K.L. Telomere length is reset during early mammalian embryogenesis. Proc Natl Acad Sci USA 2004, 101:8034-8038.
59. Xu J., Yang X. Telomerase activity in early bovine embryos derived from parthenogenetic activation and nuclear transfer. Biol Reprod 2001, 64:770-774.
60. Thomson J.A., Itskovitz-Eldor J., Shapiro S.S., Waknitz M.A., Swiergiel J.J., Marshall V.S., Jones J.M. Embryonic stem cell lines derived from human blastocysts. Science 1998, 282:1145-1147.
61. Stadtfeld M., Maherali N., Breault D.T., Hochedlinger K. Defining molecular cornerstones during fibroblast to iPS cell reprogramming in mouse. Cell Stem Cell 2008, 2:230-240.
62. Zhu J., Wang H., Bishop J.M., Blackburn E.H. Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening. Proc Natl Acad Sci U S A 1999, 96:3723-3728.
63. Marion R.M., Strati K., Li H., Tejera A., Schoeftner S., Ortega S., Serrano M., Blasco M.A. Telomeres acquire embryonic stem cell characteristics in induced pluripotent stem cells. Cell Stem Cell 2009, 4:141-154.
64. Meshorer E., Yellajoshula D., George E., Scambler P.J., Brown D.T., Misteli T. Hyperdynamic plasticity of chromatin proteins in pluripotent embryonic stem cells. Dev Cell 2006, 10:105-116.
65. Marión R.M., Strati K., Li H., Murga M., Blanco R., Ortega S., Fernandez-Capetillo O., Serrano M., Blasco M.A. A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity. Nature 2009, 460:1149-1153.
66. Li H., Collado M., Villasante A., Strati K., Ortega S., Cañamero M., Blasco M.A., Serrano M. The Ink4/Arf locus is a barrier for iPS cell reprogramming. Nature 2009, 460:1136-1139.
67. Hong H., Takahashi K., Ichisaka T., Aoi T., Kanagawa O., Nakagawa M., Okita K., Yamanaka S. Suppression of induced pluripotent stem cell generation by the p53-p21 pathway. Nature 2009, 460:1132-1135.
68. Kawamura T., Suzuki J., Wang Y.V., Menendez S., Morera L.B., Raya A., Wahl G.M., Belmonte J.C. Linking the p53 tumour suppressor pathway to somatic cell reprogramming. Nature 2009, 460:1140-1144.
69. Utikal J., Polo J.M., Stadtfeld M., Maherali N., Kulalert W., Walsh R.M., Khalil A., Rheinwald J.G., Hochedlinger K. Immortalization eliminates a roadblock during cellular reprogramming into iPS cells. Nature 2009, 460:1145-1148.
70. Wang J., Xie L.Y., Allan S., Beach D., Hannon G.J. Myc activates telomerase. Genes Dev 1998, 12:1769-1774.