메뉴 건너뛰기




Volumn 60, Issue 4, 2011, Pages 1210-1222

Δ40 isoform of p53 controls β-cell proliferation and glucose homeostasis in mice

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN D1; CYCLIN D2; GLUCAGON; GLUCOSE; INSULIN; PROTEIN P21; PROTEIN P53; TRANSCRIPTION FACTOR PDX 1;

EID: 79953198598     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db09-1379     Document Type: Article
Times cited : (49)

References (50)
  • 1
    • 33749428116 scopus 로고    scopus 로고
    • Increased islet beta cell replication adjacent to intrapancreatic gastrinomas in humans
    • DOI 10.1007/s00125-006-0410-5
    • Meier JJ, Butler AE, Galasso R, Rizza RA, Butler PC. Increased islet beta cell replication adjacent to intrapancreatic gastrinomas in humans. Diabetologia 2006;49:2689-2696 (Pubitemid 44510793)
    • (2006) Diabetologia , vol.49 , Issue.11 , pp. 2689-2696
    • Meier, J.J.1    Butler, A.E.2    Galasso, R.3    Rizza, R.A.4    Butler, P.C.5
  • 2
    • 2342510386 scopus 로고    scopus 로고
    • Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation
    • DOI 10.1038/nature02520
    • Dor Y, Brown J, Martinez OI, Melton DA. Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature 2004;429:41-46 (Pubitemid 38620543)
    • (2004) Nature , vol.429 , Issue.6987 , pp. 41-46
    • Dor, Y.1    Brown, J.2    Martinez, O.I.3    Melton, D.A.4
  • 3
    • 9644268967 scopus 로고    scopus 로고
    • PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance
    • DOI 10.1172/JCI200421845
    • Kulkarni RN, Jhala US, Winnay JN, Krajewski S, Montminy M, Kahn CR. PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance. J Clin Invest 2004;114:828-836 (Pubitemid 39578742)
    • (2004) Journal of Clinical Investigation , vol.114 , Issue.6 , pp. 828-836
    • Kulkarni, R.N.1    Jhala, U.S.2    Winnay, J.N.3    Krajewski, S.4    Montminy, M.5    Kahn, C.R.6
  • 5
    • 9644266753 scopus 로고    scopus 로고
    • Beta cell replication is the primary mechanism for maintaining postnatal beta cell mass
    • DOI 10.1172/JCI200422098
    • Georgia S, Bhushan A. Beta cell replication is the primary mechanism for maintaining postnatal beta cell mass. J Clin Invest 2004;114:963-968 (Pubitemid 39578724)
    • (2004) Journal of Clinical Investigation , vol.114 , Issue.7 , pp. 963-968
    • Georgia, S.1    Bhushan, A.2
  • 6
    • 34247644369 scopus 로고    scopus 로고
    • Growth and Regeneration of Adult beta Cells Does Not Involve Specialized Progenitors
    • DOI 10.1016/j.devcel.2007.04.011, PII S153458070700158X
    • Teta M, Rankin MM, Long SY, Stein GM, Kushner JA. Growth and regeneration of adult beta cells does not involve specialized progenitors. Dev Cell 2007;12:817-826 (Pubitemid 46667754)
    • (2007) Developmental Cell , vol.12 , Issue.5 , pp. 817-826
    • Teta, M.1    Rankin, M.M.2    Long, S.Y.3    Stein, G.M.4    Kushner, J.A.5
  • 7
    • 58149378342 scopus 로고    scopus 로고
    • Carbonic anhydrase II-positive pancreatic cells are progenitors for both endocrine and exocrine pancreas after birth
    • Inada A, Nienaber C, Katsuta H, et al. Carbonic anhydrase II-positive pancreatic cells are progenitors for both endocrine and exocrine pancreas after birth. Proc Natl Acad Sci U S A 2008;105:19915-19919
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 19915-19919
    • Inada, A.1    Nienaber, C.2    Katsuta, H.3
  • 8
    • 64649104150 scopus 로고    scopus 로고
    • Survey of the human pancreatic beta-cell G1/S proteome reveals a potential therapeutic role for cdk-6 and cyclin D1 in enhancing human beta-cell replication and function in vivo
    • Fiaschi-Taesch N, Bigatel TA, Sicari B, et al. Survey of the human pancreatic beta-cell G1/S proteome reveals a potential therapeutic role for cdk-6 and cyclin D1 in enhancing human beta-cell replication and function in vivo. Diabetes 2009;58:882-893
    • (2009) Diabetes , vol.58 , pp. 882-893
    • Fiaschi-Taesch, N.1    Bigatel, T.A.2    Sicari, B.3
  • 9
    • 0032937751 scopus 로고    scopus 로고
    • Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia
    • Rane SG, Dubus P, Mettus RV, et al. Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia. Nat Genet 1999;22:44-52
    • (1999) Nat Genet , vol.22 , pp. 44-52
    • Rane, S.G.1    Dubus, P.2    Mettus, R.V.3
  • 12
    • 77951152217 scopus 로고    scopus 로고
    • Cyclin D2 is essential for the compensatory beta-cell hyperplastic response to insulin resistance in rodents
    • Georgia S, Hinault C, Kawamori D, et al. Cyclin D2 is essential for the compensatory beta-cell hyperplastic response to insulin resistance in rodents. Diabetes 2010;59:987-996
    • (2010) Diabetes , vol.59 , pp. 987-996
    • Georgia, S.1    Hinault, C.2    Kawamori, D.3
  • 13
    • 33644754585 scopus 로고    scopus 로고
    • Akt induces beta-cell proliferation by regulating cyclin D1, cyclin D2, and p21 levels and cyclin-dependent kinase-4 activity
    • DOI 10.2337/diabetes.55.02.06.db05-0757
    • Fatrai S, Elghazi L, Balcazar N, et al. Akt induces beta-cell proliferation by regulating cyclin D1, cyclin D2, and p21 levels and cyclin-dependent kinase-4 activity. Diabetes 2006;55:318-325 (Pubitemid 43343259)
    • (2006) Diabetes , vol.55 , Issue.2 , pp. 318-325
    • Fatrai, S.1    Elghazi, L.2    Balcazar, N.3    Cras-Meneur, C.4    Krits, I.5    Kiyokawa, H.6    Bernal-Mizrachi, E.7
  • 15
    • 0035210374 scopus 로고    scopus 로고
    • Islet beta cell expression of constitutively active Akt1/PKBalpha induces striking hypertrophy, hyperplasia, and hyperinsulinemia
    • DOI 10.1172/JCI200113785
    • Bernal-Mizrachi E, Wen W, Stahlhut S, Welling CM, Permutt MA. Islet beta cell expression of constitutively active Akt1/PKB alpha induces striking hypertrophy, hyperplasia, and hyperinsulinemia. J Clin Invest 2001;108: 1631-1638 (Pubitemid 33144873)
    • (2001) Journal of Clinical Investigation , vol.108 , Issue.11 , pp. 1631-1638
    • Bernal-Mizrachi, E.1    Wen, W.2    Stahlhut, S.3    Welling, C.M.4    Permutt, M.A.5
  • 17
    • 59149104922 scopus 로고    scopus 로고
    • Growth factor control of pancreatic islet regeneration and function
    • Assmann A, Hinault C, Kulkarni RN. Growth factor control of pancreatic islet regeneration and function. Pediatr Diabetes 2009;10:14-32
    • (2009) Pediatr Diabetes , vol.10 , pp. 14-32
    • Assmann, A.1    Hinault, C.2    Kulkarni, R.N.3
  • 19
    • 18344377030 scopus 로고    scopus 로고
    • The p53 pathway: Positive and negative feedback loops
    • DOI 10.1038/sj.onc.1208615
    • Harris SL, Levine AJ. The p53 pathway: positive and negative feedback loops. Oncogene 2005;24:2899-2908 (Pubitemid 40638098)
    • (2005) Oncogene , vol.24 , Issue.17 , pp. 2899-2908
    • Harris, S.L.1    Levine, A.J.2
  • 20
    • 0026561121 scopus 로고
    • Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
    • Donehower LA, Harvey M, Slagle BL, et al. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 1992;356:215-221
    • (1992) Nature , vol.356 , pp. 215-221
    • Donehower, L.A.1    Harvey, M.2    Slagle, B.L.3
  • 23
    • 34547577319 scopus 로고    scopus 로고
    • p53 and its isoforms in cancer
    • Bourdon JC. p53 and its isoforms in cancer. Br J Cancer 2007;97:277-282
    • (2007) Br J Cancer , vol.97 , pp. 277-282
    • Bourdon, J.C.1
  • 24
    • 58549090153 scopus 로고    scopus 로고
    • Regenerative capacity of neural precursors in the adult mammalian brain is under the control of p53
    • Medrano S, Burns-Cusato M, Atienza MB, Rahimi D, Scrable H. Regenerative capacity of neural precursors in the adult mammalian brain is under the control of p53. Neurobiol Aging 2009;30:483-497
    • (2009) Neurobiol Aging , vol.30 , pp. 483-497
    • Medrano, S.1    Burns-Cusato, M.2    Atienza, M.B.3    Rahimi, D.4    Scrable, H.5
  • 25
    • 0033964010 scopus 로고    scopus 로고
    • American Diabetes Association diabetes diagnostic criteria, advancing age, and cardiovascular disease risk profiles: Results from the Third National Health and Nutrition Examination Survey
    • Resnick HE, Harris MI, Brock DB, Harris TB. American Diabetes Association diabetes diagnostic criteria, advancing age, and cardiovascular disease risk profiles: results from the Third National Health and Nutrition Examination Survey. Diabetes Care 2000;23:176-180 (Pubitemid 30071020)
    • (2000) Diabetes Care , vol.23 , Issue.2 , pp. 176-180
    • Resnick, H.E.1    Harris, M.I.2    Brock, D.B.3    Harris, T.B.4
  • 26
    • 30844471395 scopus 로고    scopus 로고
    • Diabetes mellitus in the elderly: Insulin resistance and/or impaired insulin secretion?
    • Scheen AJ. Diabetes mellitus in the elderly: insulin resistance and/or impaired insulin secretion? Diabetes Metab 2005;31(Spec No. 2):5S27-5S34
    • (2005) Diabetes Metab , vol.31 , Issue.SPEC NO. 2
    • Scheen, A.J.1
  • 29
    • 53549085679 scopus 로고    scopus 로고
    • Differential expression of cell cycle proteins during ageing of pancreatic islet cells
    • Hinault C, Hu J, Maier BF, Mirmira RG, Kulkarni RN. Differential expression of cell cycle proteins during ageing of pancreatic islet cells. Diabetes Obes Metab 2008;10(Suppl. 4):136-146
    • (2008) Diabetes Obes Metab , vol.10 , Issue.SUPPL. 4 , pp. 136-146
    • Hinault, C.1    Hu, J.2    Maier, B.F.3    Mirmira, R.G.4    Kulkarni, R.N.5
  • 30
    • 75749108616 scopus 로고    scopus 로고
    • Regenerating pancreatic beta-cells: Plasticity of adult pancreatic cells and the feasibility of in-vivo neogenesis
    • Juhl K, Bonner-Weir S, Sharma A. Regenerating pancreatic beta-cells: plasticity of adult pancreatic cells and the feasibility of in-vivo neogenesis. Curr Opin Organ Transplant 2010;15:79-85
    • (2010) Curr Opin Organ Transplant , vol.15 , pp. 79-85
    • Juhl, K.1    Bonner-Weir, S.2    Sharma, A.3
  • 31
    • 12344323484 scopus 로고    scopus 로고
    • Type 2 diabetes - A matter of beta-cell life and death?
    • Rhodes CJ. Type 2 diabetes-a matter of beta-cell life and death? Science 2005;307:380-384
    • (2005) Science , vol.307 , pp. 380-384
    • Rhodes, C.J.1
  • 32
    • 38149028453 scopus 로고    scopus 로고
    • The tumour-suppressor p53 is not required for pancreatic beta cell death during diabetes and upon irradiation
    • Nam SY, Lee MK, Sabapathy K. The tumour-suppressor p53 is not required for pancreatic beta cell death during diabetes and upon irradiation. J Physiol 2008;586:407-417
    • (2008) J Physiol , vol.586 , pp. 407-417
    • Nam, S.Y.1    Lee, M.K.2    Sabapathy, K.3
  • 33
    • 34250326302 scopus 로고    scopus 로고
    • The emerging role of FOXO transcription factors in pancreatic beta cells
    • Glauser DA, Schlegel W. The emerging role of FOXO transcription factors in pancreatic beta cells. J Endocrinol 2007;193:195-207
    • (2007) J Endocrinol , vol.193 , pp. 195-207
    • Glauser, D.A.1    Schlegel, W.2
  • 35
    • 0034643331 scopus 로고    scopus 로고
    • AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27(kip1)
    • DOI 10.1038/35008115
    • Medema RH, Kops GJ, Bos JL, Burgering BM. AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1. Nature 2000;404:782-787 (Pubitemid 30212408)
    • (2000) Nature , vol.404 , Issue.6779 , pp. 782-787
    • Medema, R.H.1    Kops, G.J.P.L.2    Bos, J.L.3    Burgering, B.M.T.4
  • 40
    • 0037015397 scopus 로고    scopus 로고
    • DeltaN-p53, a natural isoform of p53 lacking the first transactivation domain, counteracts growth suppression by wild-type p53
    • Courtois S, Verhaegh G, North S, et al. DeltaN-p53, a natural isoform of p53 lacking the first transactivation domain, counteracts growth suppression by wild-type p53. Oncogene 2002;21:6722-6728 (Pubitemid 35221914)
    • (2002) Oncogene , vol.21 , Issue.44 , pp. 6722-6728
    • Courtois, S.1    Verhaegh, G.2    North, S.3    Luciani, M.-G.4    Lassus, P.5    Hibner, U.6    Oren, M.7    Hainaut, P.8
  • 41
    • 4444351219 scopus 로고    scopus 로고
    • Regulation of human p53 activity and cell localization by alternative splicing
    • DOI 10.1128/MCB.24.18.7987-7997.2004
    • Ghosh A, Stewart D, Matlashewski G. Regulation of human p53 activity and cell localization by alternative splicing. Mol Cell Biol 2004;24:7987-7997 (Pubitemid 39167449)
    • (2004) Molecular and Cellular Biology , vol.24 , Issue.18 , pp. 7987-7997
    • Ghosh, A.1    Stewart, D.2    Matlashewski, G.3
  • 42
    • 33644778091 scopus 로고    scopus 로고
    • IGF-1 increases laminin, cyclin D1, and p21Cip1 expression in glomerular mesangial cells: An investigation of the intracellular signaling pathway and cell-cycle progression
    • Jiang Y, Cheng DW, Levi E, Singh LP. IGF-1 increases laminin, cyclin D1, and p21Cip1 expression in glomerular mesangial cells: an investigation of the intracellular signaling pathway and cell-cycle progression. J Cell Biochem 2006;98:208-220
    • (2006) J Cell Biochem , vol.98 , pp. 208-220
    • Jiang, Y.1    Cheng, D.W.2    Levi, E.3    Singh, L.P.4
  • 43
    • 0032910989 scopus 로고    scopus 로고
    • Increased beta-cell proliferation and reduced mass before diabetes onset in the nonobese diabetic mouse
    • DOI 10.2337/diabetes.48.5.989
    • Sreenan S, Pick AJ, Levisetti M, Baldwin AC, Pugh W, Polonsky KS. Increased beta-cell proliferation and reduced mass before diabetes onset in the nonobese diabetic mouse. Diabetes 1999;48:989-996 (Pubitemid 29226344)
    • (1999) Diabetes , vol.48 , Issue.5 , pp. 989-996
    • Sreenan, S.1    Pick, A.J.2    Levisetti, M.3    Baldwin, A.C.4    Pugh, W.5    Polonsky, K.S.6
  • 44
    • 77449137837 scopus 로고    scopus 로고
    • Absence of p53-dependent apoptosis combined with nonhomologous end-joining deficiency leads to a severe diabetic phenotype in mice
    • Tavana O, Puebla-Osorio N, Sang M, Zhu C. Absence of p53-dependent apoptosis combined with nonhomologous end-joining deficiency leads to a severe diabetic phenotype in mice. Diabetes 2010;59:135-142
    • (2010) Diabetes , vol.59 , pp. 135-142
    • Tavana, O.1    Puebla-Osorio, N.2    Sang, M.3    Zhu, C.4
  • 45
    • 33744979065 scopus 로고    scopus 로고
    • Relationship between beta-cell mass and fasting blood glucose concentration in humans
    • Ritzel RA, Butler AE, Rizza RA, Veldhuis JD, Butler PC. Relationship between beta-cell mass and fasting blood glucose concentration in humans. Diabetes Care 2006;29:717-718 (Pubitemid 44115384)
    • (2006) Diabetes Care , vol.29 , Issue.3 , pp. 717-718
    • Ritzel, R.A.1    Butler, A.E.2    Rizza, R.A.3    Veldhuis, J.D.4    Butler, P.C.5
  • 46
    • 69949150673 scopus 로고    scopus 로고
    • A crucial role for adipose tissue p53 in the regulation of insulin resistance
    • Minamino T, Orimo M, Shimizu I, et al. A crucial role for adipose tissue p53 in the regulation of insulin resistance. Nat Med 2009;15:1082-1087
    • (2009) Nat Med , vol.15 , pp. 1082-1087
    • Minamino, T.1    Orimo, M.2    Shimizu, I.3
  • 47
    • 3042698404 scopus 로고    scopus 로고
    • Lilly lecture 2003: The struggle for mastery in insulin action: from triumvirate to republic
    • Accili D. Lilly lecture 2003: the struggle for mastery in insulin action: from triumvirate to republic. Diabetes 2004;53:1633-1642
    • (2004) Diabetes , vol.53 , pp. 1633-1642
    • Accili, D.1
  • 48
    • 27844497945 scopus 로고    scopus 로고
    • FOXO transcription factors at the interface between longevity and tumor suppression
    • DOI 10.1038/sj.onc.1209086, PII 1209086
    • Greer EL, Brunet A. FOXO transcription factors at the interface between longevity and tumor suppression. Oncogene 2005;24:7410-7425 (Pubitemid 41637981)
    • (2005) Oncogene , vol.24 , Issue.50 , pp. 7410-7425
    • Greer, E.L.1    Brunet, A.2
  • 49
    • 65249093055 scopus 로고    scopus 로고
    • Polycomb protein Ezh2 regulates pancreatic beta-cell Ink4a/Arf expression and regeneration in diabetes mellitus
    • Chen H, Gu X, Su IH, et al. Polycomb protein Ezh2 regulates pancreatic beta-cell Ink4a/Arf expression and regeneration in diabetes mellitus. Genes Dev 2009;23:975-985
    • (2009) Genes Dev , vol.23 , pp. 975-985
    • Chen, H.1    Gu, X.2    Su, I.H.3
  • 50
    • 70350435713 scopus 로고    scopus 로고
    • An Osteoblast-dependent mechanism contributes to the leptin regulation of insulin secretion
    • Hinoi E, Gao N, Jung DY, et al. An Osteoblast-dependent mechanism contributes to the leptin regulation of insulin secretion. Ann N Y Acad Sci 2009;1173(Suppl. 1):E20-E30
    • (2009) Ann N Y Acad Sci , vol.1173 , Issue.SUPPL. 1
    • Hinoi, E.1    Gao, N.2    Jung, D.Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.