메뉴 건너뛰기




Volumn 4, Issue 13, 2012, Pages 1751-1761

Natural products as a rich source of tau-targeting drugs for Alzheimers disease

Author keywords

[No Author keywords available]

Indexed keywords

ABIXA; ACETYLCHOLINE; ALZHAMED; AMYLOID BETA PROTEIN; AMYLOID PROTEIN; CINNAMALDEHYDE DERIVATIVE; CINNAMON EXTRACT; CURCUMIN; DONEPEZIL; FLURBIPROFEN; GALANTAMINE; GELDANAMYCIN; GOSSYPETIN; HOMOTAURINE; ISOFLAVAN DERIVATIVE; LIGNAN DERIVATIVE; MEMANTINE; MEMOX; METHYLENE BLUE; MINOCYCLINE; MYRICANOL; MYRICETIN; MYRICETIN 3 RHAMNOSIDE; NATURAL PRODUCT; PACLITAXEL; PROCYANIDIN DERIVATIVE; REMBER; RIVASTIGMINE; TACRINE; TANSHINONE IIA; TARENFLURBIL; TAU PROTEIN; TIDEGLUSIB; TURMERIC; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 84865749287     PISSN: 17568919     EISSN: 17568927     Source Type: Journal    
DOI: 10.4155/fmc.12.124     Document Type: Review
Times cited : (93)

References (91)
  • 2
    • 84865794180 scopus 로고    scopus 로고
    • Alzheimer: The life of a physician and the career of a disease
    • Freeman WJ. Alzheimer: the life of a physician and the career of a disease. J. Am. Med. Assoc. 293, 745-746 (2005).
    • (2005) J. Am. Med. Assoc. , vol.293 , pp. 745-746
    • Freeman, W.J.1
  • 3
    • 11444269588 scopus 로고    scopus 로고
    • Alzheimer disease and down syndrome: Factors in pathogenesis
    • Lott IT, Head E. Alzheimer disease and down syndrome: factors in pathogenesis. Neurobiol. Aging 26, 383-389 (2005).
    • (2005) Neurobiol. Aging , vol.26 , pp. 383-389
    • Lott, I.T.1    Head, E.2
  • 4
    • 40849093600 scopus 로고    scopus 로고
    • Genome-wide association studies in Alzheimer disease
    • Waring SC, Rosenberg RN. Genome-wide association studies in Alzheimer disease. Arch. Neurol. 65, 329-334 (2008).
    • (2008) Arch. Neurol. , vol.65 , pp. 329-334
    • Waring, S.C.1    Rosenberg, R.N.2
  • 5
    • 33645808672 scopus 로고    scopus 로고
    • Apolipoprotein E4: A causative factor and therapeutic target in neuropathology including Alzheimer's disease
    • Mahley RW, Weisgraber KH, Huang Y. Apolipoprotein E4: a causative factor and therapeutic target in neuropathology including Alzheimer's disease. Proc. Natl Acad. Sci. USA 103, 5644-5651 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 5644-5651
    • Mahley, R.W.1    Weisgraber, K.H.2    Huang, Y.3
  • 6
    • 0022273983 scopus 로고
    • The cholinergic hypothesis: A historical overview, current perspective, and future directions
    • Bartus RT, Dean RL, Pontecorvo MJ, Flicker C. The cholinergic hypothesis: a historical overview, current perspective, and future directions. Ann. NY Acad. Sci. 444, 332-358 (1985).
    • (1985) Ann. NY Acad. Sci. , vol.444 , pp. 332-358
    • Bartus, R.T.1    Dean, R.L.2    Pontecorvo, M.J.3    Flicker, C.4
  • 7
    • 0035140975 scopus 로고    scopus 로고
    • Going new places using an old MAP: Tau, microtubules and human neurodegenerative disease
    • Garcia ML, Cleveland DW. Going new places using an old MAP: tau, microtubules and human neurodegenerative disease. Curr. Opin. Cell Biol. 13, 41-48 (2001).
    • (2001) Curr. Opin. Cell Biol. , vol.13 , pp. 41-48
    • Garcia, M.L.1    Cleveland, D.W.2
  • 8
    • 0034826896 scopus 로고    scopus 로고
    • Regulation of microtubule associated protein
    • Cassimeris L, Spittle C. Regulation of microtubule associated protein. Int. Rev. Cytol. 210, 163-226 (2001).
    • (2001) Int. Rev. Cytol. , vol.210 , pp. 163-226
    • Cassimeris, L.1    Spittle, C.2
  • 10
    • 0032543684 scopus 로고    scopus 로고
    • Association of missense and5́-splice-site mutations in tau with the inherited dementia FTDP-17
    • Hutton M, Lendon CL, Rizzu, P et al. Association of missense and5́-splice-site mutations in tau with the inherited dementia FTDP-17. Nature 393, 702-705 (1998).
    • (1998) Nature , vol.393 , pp. 702-705
    • Hutton, M.1    Lendon, C.L.2    Rizzu, P.3
  • 11
    • 33745018376 scopus 로고    scopus 로고
    • The genetics of neurodegenerative diseases
    • Hardy J, Orr H. The genetics of neurodegenerative diseases. J. Neurochem. 97, 1690-1699 (2006).
    • (2006) J. Neurochem. , vol.97 , pp. 1690-1699
    • Hardy, J.1    Orr, H.2
  • 12
    • 0032950744 scopus 로고    scopus 로고
    • Tau gene mutation in familial progressive subcortical gliosis
    • Goedert M, Spillantini MG, Crowther RA et al. Tau gene mutation in familial progressive subcortical gliosis. Nat. Med. 5, 454-457 (1999).
    • (1999) Nat. Med. , vol.5 , pp. 454-457
    • Goedert, M.1    Spillantini, M.G.2    Crowther, R.A.3
  • 13
    • 44049102976 scopus 로고    scopus 로고
    • Current and future therapy in Alzheimer's disease
    • Van Marum RJ. Current and future therapy in Alzheimer's disease. Fundam. Clin. Pharmacol. 22, 265-274 (2008).
    • (2008) Fundam. Clin. Pharmacol. , vol.22 , pp. 265-274
    • Van Marum, R.J.1
  • 14
    • 22344438508 scopus 로고    scopus 로고
    • Tau suppression in a neurodegenerative mouse model improves memory function
    • Santacruz K, Lewis J, Spires T et al. Tau suppression in a neurodegenerative mouse model improves memory function. Science 309, 476-448 (2005).
    • (2005) Science , vol.309 , pp. 476-448
    • Santacruz, K.1    Lewis, J.2    Spires, T.3
  • 15
    • 38549120646 scopus 로고    scopus 로고
    • In vivo imaging reveals dissociation between caspase activation and acute neuronal death in tangle-bearing neurons
    • Spires-Jones TL, de Calignon A, Matsui T et al. In vivo imaging reveals dissociation between caspase activation and acute neuronal death in tangle-bearing neurons. Neuroscience 28, 862-867(2008).
    • (2008) Neuroscience , vol.28 , pp. 862-867
    • Spires-Jones, T.L.1    De Calignon, A.2    Matsui, T.3
  • 16
    • 34548023741 scopus 로고    scopus 로고
    • Potency of a tau fibrillization inhibitor is influenced by its aggregation state
    • Congdon EE, Necula M, Blackstone RD, Kuret J. Potency of a tau fibrillization inhibitor is influenced by its aggregation state. Arch. Biochem. Biophys. 465, 127-135 (2007).
    • (2007) Arch. Biochem. Biophys. , vol.465 , pp. 127-135
    • Congdon, E.E.1    Necula, M.2    Blackstone, R.D.3    Kuret, J.4
  • 17
    • 33846015514 scopus 로고    scopus 로고
    • Reduction of soluble Ab and tau, but not Soluble Ab alone, ameliorates cognitive decline in transgenic mice with plaques and tangles
    • Oddo S, Vasilevko V, Caccamo A, Kitazawa M, Cribbs DH, La Ferla FM. Reduction of soluble Ab and tau, but not Soluble Ab alone, ameliorates cognitive decline in transgenic mice with plaques and tangles. J. Biol. Chem. 281, 39413-39423 (2006).
    • (2006) J. Biol. Chem. , vol.281 , pp. 39413-39423
    • Oddo, S.1    Vasilevko, V.2    Caccamo, A.3    Kitazawa, M.4    Cribbs, D.H.5    La Ferla, F.M.6
  • 18
    • 26444581827 scopus 로고    scopus 로고
    • Tau gene mutations and their effects
    • Goedert M. Tau gene mutations and their effects. Mov. Disord. 20, 45-52 (2005).
    • (2005) Mov. Disord. , vol.20 , pp. 45-52
    • Goedert, M.1
  • 21
    • 33847369469 scopus 로고    scopus 로고
    • The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins
    • Dickey CA, Kamal A, Lundgren K et al. The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins. J. Clin. Invest. 117, 648-658 (2007).
    • (2007) J. Clin. Invest. , vol.117 , pp. 648-658
    • Dickey, C.A.1    Kamal, A.2    Lundgren, K.3
  • 22
    • 72549105935 scopus 로고    scopus 로고
    • Effect of Tarenflurbil on cognitive decline and activities of daily living in patients with mild Alzheimer disease
    • Green RC, Schneider LS, Amato DA et al. Effect of Tarenflurbil on cognitive decline and activities of daily living in patients with mild Alzheimer disease. J. Am. Med. Assoc. 302, 2557-2564 (2009).
    • (2009) J. Am. Med. Assoc. , vol.302 , pp. 2557-2564
    • Green, R.C.1    Schneider, L.S.2    Amato, D.A.3
  • 23
    • 70349637413 scopus 로고    scopus 로고
    • Effect of Tramiprosate in Patients with Mild-to-moderate Alzheimer's disease: Exploratory analyses of the MRI sub-group of the Alphase study
    • Gauthier S, Aisen PS, Ferris SH et al. Effect of Tramiprosate in Patients with Mild-to-moderate Alzheimer's disease: exploratory analyses of the MRI sub-group of the Alphase study. J. Nutr. Health Aging 13, 550-557 (2009).
    • (2009) J. Nutr. Health Aging , vol.13 , pp. 550-557
    • Gauthier, S.1    Aisen, P.S.2    Ferris, S.H.3
  • 24
    • 34249058674 scopus 로고    scopus 로고
    • Naproxen and celecoxib do notprevent AD in early results from a randomized controlled trial
    • Lyketsos CG, Breitner JC, Green RC et al. Naproxen and celecoxib do notprevent AD in early results from a randomized controlled trial. Neurology 68, 1800-1808 (2007).
    • (2007) Neurology , vol.68 , pp. 1800-1808
    • Lyketsos, C.G.1    Breitner, J.C.2    Green, R.C.3
  • 25
    • 0023762975 scopus 로고
    • Clinicopathological studies in dementia: Nondemented subjects with pathological confirmed Alzheimer's disease
    • Crystal H, Dickson D, Fuld P et al. Clinicopathological studies in dementia: nondemented subjects with pathological confirmed Alzheimer's disease. Neurology 38, 1682-1687 (1988).
    • (1988) Neurology , vol.38 , pp. 1682-1687
    • Crystal, H.1    Dickson, D.2    Fuld, P.3
  • 26
    • 0025863618 scopus 로고
    • Neuropathological stageing of Alzheimer-related changes
    • Braak H, Braak E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol. (Ber.) 82, 239-259 (1991).
    • (1991) Acta Neuropathol. (Ber.) , vol.82 , pp. 239-259
    • Braak, H.1    Braak, E.2
  • 27
    • 85027934488 scopus 로고    scopus 로고
    • List of drugs in development for neurodegenerative diseases: Update October 2011
    • Kramp VP. List of drugs in development for neurodegenerative diseases: update October 2011. Neurodegen. Dis. 9, 210-283 (2012).
    • (2012) Neurodegen. Dis. , vol.9 , pp. 210-283
    • Kramp, V.P.1
  • 28
    • 33745893779 scopus 로고    scopus 로고
    • Alzheimer disease: Progress or profit?
    • Mount C, Downton C. Alzheimer disease: progress or profit? Nat. Med. 12, 780-784 (2006).
    • (2006) Nat. Med. , vol.12 , pp. 780-784
    • Mount, C.1    Downton, C.2
  • 30
    • 78149452312 scopus 로고    scopus 로고
    • Plant sources of Galathamine: Phytochemical and biotechnological aspects
    • Brekov S, Georgieva L, Kondakova V et al. Plant sources of Galathamine: phytochemical and biotechnological aspects. Biotechnol. Biotechnol. Eq. 23, 1170-1176 (2009).
    • (2009) Biotechnol. Biotechnol. Eq. , vol.23 , pp. 1170-1176
    • Brekov, S.1    Georgieva, L.2    Kondakova, V.3
  • 31
    • 0032439162 scopus 로고    scopus 로고
    • Cholinesterase inhibitors in the treatment of Alzheimer disease: A comparison of tolerability and pharmacology
    • Nordberg A, Svensson AL. Cholinesterase inhibitors in the treatment of Alzheimer disease: a comparison of tolerability and pharmacology. Drug Saf. 19, 465-480 (1998).
    • (1998) Drug Saf , vol.19 , pp. 465-480
    • Nordberg, A.1    Svensson, A.L.2
  • 32
    • 79955477912 scopus 로고    scopus 로고
    • (+)-Arisugacin A -computational evidence of a dual binding site covalent inhibitor of acetylcholinesterase
    • Al-Rashid ZF, Hsung RP. (+)-arisugacin A - computational evidence of a dual binding site covalent inhibitor of acetylcholinesterase. Bioorg. Med. Chem. Lett. 21, 2687-2691 (2011).
    • (2011) Bioorg. Med. Chem. Lett. , vol.21 , pp. 2687-2691
    • Al-Rashid, Z.F.1    Hsung, R.P.2
  • 33
    • 69449093036 scopus 로고    scopus 로고
    • Age-dependent impairment of cognitive and synaptic function in the tau mouse model of tau pathology
    • Polydoro M, Acker CM, Duff K, Castillo PE, Davies PJ. Age-dependent impairment of cognitive and synaptic function in the tau mouse model of tau pathology. Neurosci. 29, 10741-10749 (2009).
    • (2009) Neurosci , vol.29 , pp. 10741-10749
    • Polydoro, M.1    Acker, C.M.2    Duff, K.3    Castillo, P.E.4    Davies, P.J.5
  • 34
    • 84858308226 scopus 로고    scopus 로고
    • Natural products as sources of new drugs over the 30 years from 1981 to 2010
    • Newman DJ, Cragg GM. Natural products as sources of new drugs over the 30 years from 1981 to 2010. J. Nat. Prod.75, 311-335 (2012).
    • (2012) J. Nat. Prod. , vol.75 , pp. 311-335
    • Newman, D.J.1    Cragg, G.M.2
  • 35
    • 23044439880 scopus 로고    scopus 로고
    • Cyanine dye N744 inhibits tau fibrillization by blocking filament extension: Implications for the treatment of tauopathic neurodegenerative diseases
    • Necula M, Chirita CN, Kuret J. Cyanine dye N744 inhibits tau fibrillization by blocking filament extension: implications for the treatment of tauopathic neurodegenerative diseases. Biochemistry 44, 10227-10237 (2005).
    • (2005) Biochemistry , vol.44 , pp. 10227-10237
    • Necula, M.1    Chirita, C.N.2    Kuret, J.3
  • 36
    • 77951540816 scopus 로고    scopus 로고
    • Caspase activation precedes and leads to tangles
    • de Calignon A, Fox LM, Pitstick R et al. Caspase activation precedes and leads to tangles. Nature 464, 1201-1204 (2010).
    • (2010) Nature , vol.464 , pp. 1201-1204
    • De Calignon, A.1    Fox, L.M.2    Pitstick, R.3
  • 37
    • 33749818217 scopus 로고    scopus 로고
    • The structural biology of protein aggregation diseases: Fundamental questions and some answers
    • Eisenberg D, Nelson R, Sawaya MR et al. The structural biology of protein aggregation diseases: fundamental questions and some answers. Acc. Chem. Res. 39, 568-575 (2006).
    • (2006) Acc. Chem. Res. , vol.39 , pp. 568-575
    • Eisenberg, D.1    Nelson, R.2    Sawaya, M.R.3
  • 38
    • 61849088424 scopus 로고    scopus 로고
    • Tau phosphorylation: The therapeutic challenge for neurodegenerative disease
    • Hanger DP, Anderton BH, Noble W. Tau phosphorylation: the therapeutic challenge for neurodegenerative disease. Trends Mol. Med. 15, 112-119 (2009).
    • (2009) Trends Mol. Med. , vol.15 , pp. 112-119
    • Hanger, D.P.1    Anderton, B.H.2    Noble, W.3
  • 39
    • 34447503455 scopus 로고    scopus 로고
    • Untangling tau hyperphosphorylation in drug design for neurodegenerative diseases
    • Mazanetz MP, Fischer PM. Untangling tau hyperphosphorylation in drug design for neurodegenerative diseases. Nat. Rev. Drug Discov. 6, 464-479 (2007).
    • (2007) Nat. Rev. Drug Discov. , vol.6 , pp. 464-479
    • Mazanetz, M.P.1    Fischer, P.M.2
  • 40
    • 55249086251 scopus 로고    scopus 로고
    • Hyperphosphorylation of microtubule-associated protein tau: A promising therapeutic target for Alzheimer disease
    • Gong CX, Iqbal K. Hyperphosphorylation of microtubule-associated protein tau: a promising therapeutic target for Alzheimer disease. Curr. Med. Chem. 15, 2321-2328 (2008).
    • (2008) Curr. Med. Chem. , vol.15 , pp. 2321-2328
    • Gong, C.X.1    Iqbal, K.2
  • 41
    • 46749128127 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3 (GSK-3) inhibitors reach the clinic
    • Medina M, Castro A. Glycogen synthase kinase-3 (GSK-3) inhibitors reach the clinic. Curr. Opin. Drug Discov. Dev. 11, 533-543 (2008).
    • (2008) Curr. Opin. Drug Discov. Dev. , vol.11 , pp. 533-543
    • Medina, M.1    Castro, A.2
  • 42
    • 36048983139 scopus 로고    scopus 로고
    • Efficacy of small-molecule glycogen synthase kinase-3 inhibitors in the post natal rat model of tau hyperphosphorylation
    • Selenica ML, Jensen HS, Larsen AK et al. Efficacy of small-molecule glycogen synthase kinase-3 inhibitors in the post natal rat model of tau hyperphosphorylation. Br. J. Pharmacol. 152, 959-979 (2007).
    • (2007) Br. J. Pharmacol. , vol.152 , pp. 959-979
    • Selenica, M.L.1    Jensen, H.S.2    Larsen, A.K.3
  • 43
    • 0033230886 scopus 로고    scopus 로고
    • Age-dependent emergence and progression of a tauopathy in transgenic mice overexpressing the shortest human tau isoform
    • Ishihara T, Hong M, Zhang B et al. Age-dependent emergence and progression of a tauopathy in transgenic mice overexpressing the shortest human tau isoform. Neuron. 24, 751-762 (1999).
    • (1999) Neuron , vol.24 , pp. 751-762
    • Ishihara, T.1    Hong, M.2    Zhang, B.3
  • 44
    • 19944429064 scopus 로고    scopus 로고
    • Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model
    • Zhang B, Maiti A, Shively S et al. Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model. Proc. Natl Acad. Sci. USA 102, 227-223 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 227-223
    • Zhang, B.1    Maiti, A.2    Shively, S.3
  • 45
    • 78650450609 scopus 로고    scopus 로고
    • Natural products as a source of Alzheimer's drug leads
    • Williams P, Sorribas A, Howes MJR. Natural products as a source of Alzheimer's drug leads. Nat. Prod. Rep. 28, 48-77 (2011).
    • (2011) Nat. Prod. Rep. , vol.28 , pp. 48-77
    • Williams, P.1    Sorribas, A.2    Howes, M.J.R.3
  • 46
    • 79551671732 scopus 로고    scopus 로고
    • The role of natural products in the discovery of new drug candidates for the treatment of neurodegenerative disorders II: Alzheimer's disease
    • Da Rocha MD, Dias Viegas FP, Campos HC et al. The role of natural products in the discovery of new drug candidates for the treatment of neurodegenerative disorders II: Alzheimer's disease. CNS Neurol. Disord. Drug Targets 10, 251-270 (2011).
    • (2011) CNS Neurol. Disord. Drug Targets , vol.10 , pp. 251-270
    • Da Rocha, M.D.1    Dias Viegas, F.P.2    Campos, H.C.3
  • 48
    • 84856505107 scopus 로고    scopus 로고
    • Ethnobotanical treatment strategies against Alzheimer's disease
    • Howes MJ, Houghton PJ. Ethnobotanical treatment strategies against Alzheimer's disease. Curr. Alzheimer Res. 9, 67-85 (2012).
    • (2012) Curr. Alzheimer Res. , vol.9 , pp. 67-85
    • Howes, M.J.1    Houghton, P.J.2
  • 49
    • 73949140815 scopus 로고    scopus 로고
    • Optimized turmeric extracts have potent anti-amyloidogenic effects
    • Shytle RD, Bickford PC, Rezai-zadeh K et al. Optimized turmeric extracts have potent anti-amyloidogenic effects. Curr. Alzheimer Res. 6, 564-571 (2009).
    • (2009) Curr. Alzheimer Res. , vol.6 , pp. 564-571
    • Shytle, R.D.1    Bickford, P.C.2    Rezai-Zadeh, K.3
  • 50
    • 84860520945 scopus 로고    scopus 로고
    • Optimized turmeric extract reduces b-amyloid and phosphorylated tau protein burden in Alzheimer's transgenic mice
    • Shytle RD, Tan J, Bickford PC et al. Optimized turmeric extract reduces b-amyloid and phosphorylated tau protein burden in Alzheimer's transgenic mice. Curr. Alzheimer Res. 9, 500-506 (2012).
    • (2012) Curr. Alzheimer Res. , vol.9 , pp. 500-506
    • Shytle, R.D.1    Tan, J.2    Bickford, P.C.3
  • 51
    • 79951531007 scopus 로고    scopus 로고
    • The diarylheptanoid (+) - AR,11S-myricanol and two flavones from bayberry (Myricacerifera) destabilize the microtubule-associated protein tau
    • Jones J, Lebar MD, Jinwal UK et al. The diarylheptanoid (+)-aR,11S-myricanol and two flavones from bayberry (Myricacerifera) destabilize the microtubule-associated protein tau. J. Nat. Prod. 74, 38-44 (2011).
    • (2011) J. Nat. Prod. , vol.74 , pp. 38-44
    • Jones, J.1    Lebar, M.D.2    Jinwal, U.K.3
  • 52
    • 34548797916 scopus 로고    scopus 로고
    • Antibacterial activity of gossypetin isolated from hibiscus sabdariffa
    • Mounnissamy VM, Kavimani S, Gunasegaran R. Antibacterial activity of gossypetin isolated from hibiscus sabdariffa. Antiseptic 99, 81-82 (2009).
    • (2009) Antiseptic , vol.99 , pp. 81-82
    • Mounnissamy, V.M.1    Kavimani, S.2    Gunasegaran, R.3
  • 53
    • 0033387218 scopus 로고    scopus 로고
    • Marked reduction in the minimum inhibitory concentration (MIC) of beta-lactams in methicillin-resistant Staphylococcus aureus produced by epicatechingallate, an ingredient of green tea (Camellia sinensis)
    • Shiota S, Shimizu M, Mizushima T. Marked reduction in the minimum inhibitory concentration (MIC) of beta-lactams in methicillin-resistant Staphylococcus aureus produced by epicatechingallate, an ingredient of green tea (Camellia sinensis). Biol. Pharm. Bull. 22, 1388-1390 (1999).
    • (1999) Biol. Pharm. Bull. , vol.22 , pp. 1388-1390
    • Shiota, S.1    Shimizu, M.2    Mizushima, T.3
  • 54
    • 14844303721 scopus 로고    scopus 로고
    • Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols, and porphyrins
    • Taniguchi S, Suzuki N, Masuda M. Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols, and porphyrins. J. Biol. Chem. 280, 7614-7623 (2005).
    • (2005) J. Biol. Chem. , vol.280 , pp. 7614-7623
    • Taniguchi, S.1    Suzuki, N.2    Masuda, M.3
  • 56
    • 77956314492 scopus 로고    scopus 로고
    • Development of a grape seed polyphenolic extract with antioligomeric activity as a novel treatment in progressive supranuclear palsy and other tauopathies
    • Pasinetti GM, Ksiezak-Reding H, Santa- Maria I, Wang J, Ho L. Development of a grape seed polyphenolic extract with antioligomeric activity as a novel treatment in progressive supranuclear palsy and other tauopathies. J. Neurochem. 114, 1557-1568 (2010).
    • (2010) J. Neurochem. , vol.114 , pp. 1557-1568
    • Pasinetti, G.M.1    Ksiezak-Reding, H.2    Santa- Maria, I.3    Wang, J.4    Ho, L.5
  • 57
    • 33646772566 scopus 로고    scopus 로고
    • The spice sage and its active ingredient rosmarinicacid protect PC12 cells from amyloid-b peptide-induced neurotoxicity
    • Luvone T, De Filippis D, Esposito G, D'Amico A, Izzo AA. The spice sage and its active ingredient rosmarinicacid protect PC12 cells from amyloid-b peptide-induced neurotoxicity. J. Pharmacol. Exp. Ther. 317, 1143-1149 (2006).
    • (2006) J. Pharmacol. Exp. Ther. , vol.317 , pp. 1143-1149
    • Luvone, T.1    De Filippis, D.2    Esposito, G.3    D'Amico, A.4    Izzo, A.A.5
  • 58
    • 84863424370 scopus 로고    scopus 로고
    • The protective effects of tanshinone IIA on neurotoxicity induced by b-amyloid protein through calpain and the p35/Cdk5 pathway in primary cortical neurons
    • Shi LL, Yang WN, Chen XL et al. The protective effects of tanshinone IIA on neurotoxicity induced by b-amyloid protein through calpain and the p35/Cdk5 pathway in primary cortical neurons. Neurochem. Int. 61(2), 227-235 (2012).
    • (2012) Neurochem. Int. , vol.61 , Issue.2 , pp. 227-235
    • Shi, L.L.1    Yang, W.N.2    Chen, X.L.3
  • 59
    • 84857843682 scopus 로고    scopus 로고
    • Biochemical characterization of novel lignansisolated from the wood of Taxus yunnanensis as effective stimulators for glycogen synthase kinase-3b and the phosphorylation of basic brain proteins by the kinase in vitro
    • Ohtsuki K, Miyai S, Yamaguchi A, Morikawa K, Okano T. Biochemical characterization of novel lignansisolated from the wood of Taxus yunnanensis as effective stimulators for glycogen synthase kinase-3b and the phosphorylation of basic brain proteins by the kinase in vitro. Biol. Pharm. Bull. 35, 385-393 (2012).
    • (2012) Biol. Pharm. Bull. , vol.35 , pp. 385-393
    • Ohtsuki, K.1    Miyai, S.2    Yamaguchi, A.3    Morikawa, K.4    Okano, T.5
  • 60
    • 67651160771 scopus 로고    scopus 로고
    • Inhibition of tau fibrillation by oleocanthal via the reaction of the amino group of tau
    • Li W, Sperry JB, Crowe A et al. Inhibition of tau fibrillation by oleocanthal via the reaction of the amino group of tau. J. Neurochem. 110, 1339-1351 (2009).
    • (2009) J. Neurochem. , vol.110 , pp. 1339-1351
    • Li, W.1    Sperry, J.B.2    Crowe, A.3
  • 61
    • 13544251748 scopus 로고    scopus 로고
    • Anthraquinones inhibit tau aggregation and dissolve Alzheimer's paired helical filaments in vitro and in cells
    • Pickhardt M, Gazova Z, von Bergen M et al. Anthraquinones inhibit tau aggregation and dissolve Alzheimer's paired helical filaments in vitro and in cells. J. Biol. Chem. 280, 3628-3635 (2005).
    • (2005) J. Biol. Chem. , vol.280 , pp. 3628-3635
    • Pickhardt, M.1    Gazova, Z.2    Von Bergen, M.3
  • 62
    • 79953137074 scopus 로고    scopus 로고
    • Young coconut juice, a potential therapeutic agent that could significantly reduce some pathologies associated with Alzheimer's disease: Novel findings
    • Radenahmad N, Saleh S, Sawangjaroen K et al. Young coconut juice, a potential therapeutic agent that could significantly reduce some pathologies associated with Alzheimer's disease: novel findings. Br. J. Nutr. 105, 738-746 (2011).
    • (2011) Br. J. Nutr. , vol.105 , pp. 738-746
    • Radenahmad, N.1    Saleh, S.2    Sawangjaroen, K.3
  • 63
    • 80255132715 scopus 로고    scopus 로고
    • Protective effects of ginsenoside Rd against okadaic acid-induced neurotoxicity in vivo and in vitro
    • Li L, Liu J, Yan X et al. Protective effects of ginsenoside Rd against okadaic acid-induced neurotoxicity in vivo and in vitro. J. Ethnopharmacol. 138, 135-141 (2011).
    • (2011) J. Ethnopharmacol. , vol.138 , pp. 135-141
    • Li, L.1    Liu, J.2    Yan, X.3
  • 64
    • 33750606278 scopus 로고    scopus 로고
    • Effect of aged garlic extract on APP processing and tau phosphorylationin Alzheimer's transgenic model Tg2576
    • Chaudan NB. Effect of aged garlic extract on APP processing and tau phosphorylationin Alzheimer's transgenic model Tg2576. J. Ethnopharm. 108, 385-394 (2006).
    • (2006) J. Ethnopharm. , vol.108 , pp. 385-394
    • Chaudan, N.B.1
  • 65
    • 73349120224 scopus 로고    scopus 로고
    • Antimicrobial, antiproliferative, cytotoxic, and tau inhibitory activity of rubellins and caeruleoramularin produced by the phytopathogenic fungusrcollo-cygni
    • Miethbauer S, Gaube F, Möllmann U et al. Antimicrobial, antiproliferative, cytotoxic, and tau inhibitory activity of rubellins and caeruleoramularin produced by the phytopathogenic fungusrcollo-cygni. Planta Med. 75, 1523-1525 (2009).
    • (2009) Planta Med. , vol.75 , pp. 1523-1525
    • Miethbauer, S.1    Gaube, F.2    Möllmann, U.3
  • 66
    • 1642419553 scopus 로고    scopus 로고
    • Geldanamycin, an inhibitor of the chaperone activity of HSP90, induces MAPK-independent cell cycle arrest
    • Bedin M, Gaben AM, Saucier C, Mester J. Geldanamycin, an inhibitor of the chaperone activity of HSP90, induces MAPK-independent cell cycle arrest. Int. J. Cancer 109, 643-652 (2004).
    • (2004) Int. J. Cancer , vol.109 , pp. 643-652
    • Bedin, M.1    Gaben, A.M.2    Saucier, C.3    Mester, J.4
  • 67
    • 0035808264 scopus 로고    scopus 로고
    • Anti-amyloidogenic activity of tetracyclines: Studies in vitro
    • Forloni G, Colombo L, Girola, Tagliavini F, Salmona M. Anti-amyloidogenic activity of tetracyclines: studies in vitro. FEBS Lett. 487, 404-407 (2007).
    • (2007) FEBS Lett. , vol.487 , pp. 404-407
    • Forloni, G.1    Colombo, L.2    Girola Tagliavini, F.3    Salmona, M.4
  • 68
    • 35348819417 scopus 로고    scopus 로고
    • Minocycline attenuates neuronal cell death and improves cognitive impairment in Alzheimer's disease models
    • Choi Y, Kim H, Shin KY et al. Minocycline attenuates neuronal cell death and improves cognitive impairment in Alzheimer's disease models. Neuropsychopharmacology 32, 2393-2404 (2007).
    • (2007) Neuropsychopharmacology , vol.32 , pp. 2393-2404
    • Choi, Y.1    Kim, H.2    Shin, K.Y.3
  • 69
    • 32344450850 scopus 로고    scopus 로고
    • Inhibitory effect of minocycline on amyloid beta fibril formation and human microglial activation
    • FamilianA, Boshuizen RS, Eikelenboom P, Veerhuis R. Inhibitory effect of minocycline on amyloid beta fibril formation and human microglial activation. Glia 53, 233-240 (2006).
    • (2006) Glia , vol.53 , pp. 233-240
    • Familian, A.1    Boshuizen, R.S.2    Eikelenboom, P.3    Veerhuis, R.4
  • 70
    • 61449177863 scopus 로고    scopus 로고
    • Minocycline reduces the development of abnormal tau species in models of Alzheimer's disease
    • Noble W, Garwood C, Stephenson J, Kinsey AM, Hanger DP, Anderton BH. Minocycline reduces the development of abnormal tau species in models of Alzheimer's disease. FASEB J. 23, 739-750 (2009).
    • (2009) FASEB J , vol.23 , pp. 739-750
    • Noble, W.1    Garwood, C.2    Stephenson, J.3    Kinsey, A.M.4    Hanger, D.P.5    Anderton, B.H.6
  • 71
    • 84863230105 scopus 로고    scopus 로고
    • The microtubule-stabilizing agent, epothilone D, reduces axonal dysfunction, neurotoxicity, cognitive deficits, and Alzheimer-like pathology in an interventional study with aged tau transgenic mice
    • Zhang B, Carroll J, Trojanowski JQ et al. The microtubule-stabilizing agent, epothilone D, reduces axonal dysfunction, neurotoxicity, cognitive deficits, and Alzheimer-like pathology in an interventional study with aged tau transgenic mice. J. Neurosci. 32, 3601-3611(2012).
    • (2012) J. Neurosci. , vol.32 , pp. 3601-3611
    • Zhang, B.1    Carroll, J.2    Trojanowski, J.Q.3
  • 74
    • 84861906161 scopus 로고    scopus 로고
    • Microtubule stabilization by peloruside A and paclitaxel rescues degenerating neurons from okadaic acid-induced tau phosphorylation
    • Das V, Miller JH. Microtubule stabilization by peloruside A and paclitaxel rescues degenerating neurons from okadaic acid-induced tau phosphorylation. Eur. J. Neurosci. 35, 1705-1717 (2012).
    • (2012) Eur. J. Neurosci. , vol.35 , pp. 1705-1717
    • Das, V.1    Miller, J.H.2
  • 75
    • 0018719792 scopus 로고
    • Palinurin, a new linear sesterterpene from a marine sponge
    • Alfano G, Cimino G, De Stefano S. Palinurin, a new linear sesterterpene from a marine sponge. Experientia 35, 1136-1137 (1979).
    • (1979) Experientia , vol.35 , pp. 1136-1137
    • Alfano, G.1    Cimino, G.2    De Stefano, S.3
  • 77
    • 0001006448 scopus 로고
    • Isolation and x-ray crystal structure of a novel bromo-compound from two marine sponges
    • CiminoG, de Rosa S, de Stefano S, Mazzarella L, Puliti R, Sodano G. Isolation and x-ray crystal structure of a novel bromo-compound from two marine sponges. Tetra. Lett. 23, 767-768 (1982).
    • (1982) Tetra. Lett. , vol.23 , pp. 767-768
    • Ciminog De Rosa, S.1    De Stefano, S.2    Mazzarella, L.3    Puliti, R.4    Sodano, G.5
  • 78
    • 35348906081 scopus 로고    scopus 로고
    • Glycogen synthasekinase-3 (GSK-3) inhibitory activity and structure-activity relationship (SAR) studies of themanzamine alkaloids. Potential for Alzheimer's disease
    • Hamann M. Alonso A, Martin-Aparicio E et al. Glycogen synthasekinase-3 (GSK-3) inhibitory activity and structure-activity relationship (SAR) studies of themanzamine alkaloids. Potential for Alzheimer's disease. J. Nat. Prod. 70, 1397-1405 (2007).
    • (2007) J. Nat. Prod. , vol.70 , pp. 1397-1405
    • Hamann, M.1    Alonso, A.2    Martin-Aparicio, E.3
  • 79
    • 0034010742 scopus 로고    scopus 로고
    • Inhibition of cyclin-dependent kinases, GSK-3b and CK1 by hymenialdisine, a marine sponge constituent
    • Meijer L, Thunnissen A, White AW et al. Inhibition of cyclin-dependent kinases, GSK-3b and CK1 by hymenialdisine, a marine sponge constituent. Chem. Biol. 7, 51-63 (2000).
    • (2000) Chem. Biol. , vol.7 , pp. 51-63
    • Meijer, L.1    Thunnissen, A.2    White, A.W.3
  • 80
    • 0346875916 scopus 로고    scopus 로고
    • GSK-3-selective inhibitors derived from tyrianpurple indirubins
    • Meijer L, Skaltsounis AL, Magiatis P et al. GSK-3-selective inhibitors derived from tyrianpurple indirubins. Chem. Biol. 10, 1255-1266 (2003).
    • (2003) Chem. Biol. , vol.10 , pp. 1255-1266
    • Meijer, L.1    Skaltsounis, A.L.2    Magiatis, P.3
  • 81
    • 3042547187 scopus 로고    scopus 로고
    • The flavonoid baicalein inhibits fibrillation of alpha-synuclein and disaggregates existing fibrils
    • Zhu M, Rajamani S, Kaylor J, Han S, Zhou F, Fink AL. The flavonoid baicalein inhibits fibrillation of alpha-synuclein and disaggregates existing fibrils. J. Biol. Chem. 279, 26846-26857 (2004).
    • (2004) J. Biol. Chem. , vol.279 , pp. 26846-26857
    • Zhu, M.1    Rajamani, S.2    Kaylor, J.3    Han, S.4    Zhou, F.5    Fink, A.L.6
  • 82
    • 0141632823 scopus 로고    scopus 로고
    • Drugs and natural products protein formation in a library of 2,000 new inhibitors of scrapie-associated prion
    • Kocisko DA, Baron GS, Rubenstein R, Chen J, Kuizon S, Caughey B. Drugs and natural products protein formation in a library of 2,000 new inhibitors of scrapie-associated prion. J. Virol. 77, 10288-10294 (2003).
    • (2003) J. Virol. , vol.77 , pp. 10288-10294
    • Kocisko, D.A.1    Baron, G.S.2    Rubenstein, R.3    Chen, J.4    Kuizon, S.5    Caughey, B.6
  • 83
    • 79961003604 scopus 로고    scopus 로고
    • New insights on the interaction mechanism between tau protein and oleocanthal, an extra-virgin olive-oil bioactive component
    • Monti MC, Margarucci L, Tosco A, Riccio R, Casapullo A. New insights on the interaction mechanism between tau protein and oleocanthal, an extra-virgin olive-oil bioactive component. Food Funct. 2, 423-428 (2011).
    • (2011) Food Funct , vol.2 , pp. 423-428
    • Monti, M.C.1    Margarucci, L.2    Tosco, A.3    Riccio, R.4    Casapullo, A.5
  • 84
    • 77953912416 scopus 로고    scopus 로고
    • Strategy for effective brain drug delivery
    • Alam MI, Beg S, Samad A et al. Strategy for effective brain drug delivery. Eur. J. Pharm. Sci. 40, 385-403 (2010).
    • (2010) Eur. J. Pharm. Sci. , vol.40 , pp. 385-403
    • Alam, M.I.1    Beg, S.2    Samad, A.3
  • 85
    • 20044370990 scopus 로고    scopus 로고
    • Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo
    • Yang F, Lim GP, Begum AN. Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo. J. Biol. Chem. 280, 5892-5901 (2005).
    • (2005) J. Biol. Chem. , vol.280 , pp. 5892-5901
    • Yang, F.1    Lim, G.P.2    Begum, A.N.3
  • 86
    • 84872647968 scopus 로고    scopus 로고
    • Kinetics and tissue distribution on 14C-labeled grape polyphenol fractions
    • Janle EM, Lila MA, Wood L et al. Kinetics and tissue distribution on 14C-labeled grape polyphenol fractions. FASEB J. 21, 837 (2007).
    • (2007) FASEB J. , vol.21 , pp. 837
    • Janle, E.M.1    Lila, M.A.2    Wood, L.3
  • 87
    • 79952155950 scopus 로고    scopus 로고
    • Flavonoids and the CNS
    • Jager AK, Saaby L. Flavonoids and the CNS. Molecules 16, 1471-1485(2011).
    • (2011) Molecules , vol.16 , pp. 1471-1485
    • Jager, A.K.1    Saaby, L.2
  • 88
    • 79953873279 scopus 로고    scopus 로고
    • Preparation of blood-brain barrier-permeable paclitaxel-carrier conjugate and its chemotherapeutic activity in the mouse glioblastoma model
    • Jin J, Lee WS, Joo KM et al. Preparation of blood-brain barrier-permeable paclitaxel-carrier conjugate and its chemotherapeutic activity in the mouse glioblastoma model. Med. Chem. Commun. 2, 270-273 (2011).
    • (2011) Med. Chem. Commun. , vol.2 , pp. 270-273
    • Jin, J.1    Lee, W.S.2    Joo, K.M.3
  • 91
    • 84872672692 scopus 로고    scopus 로고
    • ClinicalTrials.gov.
    • ClinicalTrials.gov. http://clinicaltrials.gov


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.