메뉴 건너뛰기




Volumn 10, Issue 12, 2003, Pages 1255-1266

GSK-3-Selective Inhibitors Derived from Tyrian Purple Indirubins

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA; GASTROPODA; INDIGOFERA; MOLLUSCA; TYRIA;

EID: 0346875916     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2003.11.010     Document Type: Article
Times cited : (731)

References (69)
  • 2
    • 0034859101 scopus 로고    scopus 로고
    • The multifaceted roles of glycogen synthase kinase 3 in cellular signaling
    • Grimes C.A., Jope R.S. The multifaceted roles of glycogen synthase kinase 3 in cellular signaling. Prog. Neurobiol. 65:2001;391-426.
    • (2001) Prog. Neurobiol. , vol.65 , pp. 391-426
    • Grimes, C.A.1    Jope, R.S.2
  • 3
    • 0036090823 scopus 로고    scopus 로고
    • Glycogen synthase kinase 3: An emerging therapeutic target
    • Eldar-Finkelman H. Glycogen synthase kinase 3. an emerging therapeutic target Trends Mol. Med. 8:2002;126-132.
    • (2002) Trends Mol. Med. , vol.8 , pp. 126-132
    • Eldar-Finkelman, H.1
  • 4
    • 0036606693 scopus 로고    scopus 로고
    • The GSK3β signaling cascade and neurodegenerative disease
    • Kaytor M.D., Orr H.T. The GSK3β signaling cascade and neurodegenerative disease. Curr. Opin. Neurobiol. 12:2002;275-278.
    • (2002) Curr. Opin. Neurobiol. , vol.12 , pp. 275-278
    • Kaytor, M.D.1    Orr, H.T.2
  • 5
    • 0037383322 scopus 로고    scopus 로고
    • GSK-3: Tricks of the trade for a multi-tasking kinase
    • Doble B.W., Woodgett J.R. GSK-3. tricks of the trade for a multi-tasking kinase J. Cell Sci. 116:2003;1175-1186.
    • (2003) J. Cell Sci. , vol.116 , pp. 1175-1186
    • Doble, B.W.1    Woodgett, J.R.2
  • 6
    • 0036629249 scopus 로고    scopus 로고
    • Wnt signal transduction: Kinase cogs in a nano-machine
    • Ding Y., Dale T. Wnt signal transduction. kinase cogs in a nano-machine Trends Biochem. Sci. 27:2002;327-329.
    • (2002) Trends Biochem. Sci. , vol.27 , pp. 327-329
    • Ding, Y.1    Dale, T.2
  • 7
    • 0036103182 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3beta, mood stabilizers, and neuroprotection
    • Li X., Bijur G.N., Jope R.S. Glycogen synthase kinase-3beta, mood stabilizers, and neuroprotection. Bipolar Disord. 4:2002;137-144.
    • (2002) Bipolar Disord. , vol.4 , pp. 137-144
    • Li, X.1    Bijur, G.N.2    Jope, R.S.3
  • 8
    • 0035813212 scopus 로고    scopus 로고
    • Proapoptotic stimuli induce nuclear accumulation of glycogen synthase kinase-3 beta
    • Bijur G.N., Jope R.S. Proapoptotic stimuli induce nuclear accumulation of glycogen synthase kinase-3 beta. J. Biol. Chem. 276:2001;37436-37442.
    • (2001) J. Biol. Chem. , vol.276 , pp. 37436-37442
    • Bijur, G.N.1    Jope, R.S.2
  • 9
    • 0034602179 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3 beta activity is critical for neuronal death caused by inhibiting phosphatidylinositol 3-kinase or Akt but not for death caused by nerve growth factor withdrawal
    • Crowder R.J., Freeman R.S. Glycogen synthase kinase-3 beta activity is critical for neuronal death caused by inhibiting phosphatidylinositol 3-kinase or Akt but not for death caused by nerve growth factor withdrawal. J. Biol. Chem. 275:2000;34266-34271.
    • (2000) J. Biol. Chem. , vol.275 , pp. 34266-34271
    • Crowder, R.J.1    Freeman, R.S.2
  • 10
    • 0035798069 scopus 로고    scopus 로고
    • GSK-3 inhibition by adenoviral FRAT1 overexpression is neuroprotective and induces Tau dephosphorylation and beta-catenin stabilisation without elevation of glycogen synthase activity
    • Culbert A.A., Brown M.J., Frame S., Hagen T., Cross D.A., Bax B., Reith A.D. GSK-3 inhibition by adenoviral FRAT1 overexpression is neuroprotective and induces Tau dephosphorylation and beta-catenin stabilisation without elevation of glycogen synthase activity. FEBS Lett. 507:2001;288-294.
    • (2001) FEBS Lett. , vol.507 , pp. 288-294
    • Culbert, A.A.1    Brown, M.J.2    Frame, S.3    Hagen, T.4    Cross, D.A.5    Bax, B.6    Reith, A.D.7
  • 11
    • 0034718421 scopus 로고    scopus 로고
    • Regulation and localization of tyrosine216 phosphorylation of glycogen synthase kinase-3beta in cellular and animal models of neuronal degeneration
    • Bhat R.V., Shanley J., Correll M.P., Fieles W.E., Keith R.A., Scott C.W., Lee C.M. Regulation and localization of tyrosine216 phosphorylation of glycogen synthase kinase-3beta in cellular and animal models of neuronal degeneration. Proc. Natl. Acad. Sci. USA. 97:2000;11074-11079.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 11074-11079
    • Bhat, R.V.1    Shanley, J.2    Correll, M.P.3    Fieles, W.E.4    Keith, R.A.5    Scott, C.W.6    Lee, C.M.7
  • 12
    • 0035087123 scopus 로고    scopus 로고
    • Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurones from death
    • Cross D.A., Culbert A.A., Chalmers K.A., Facci L., Skaper S.D., Reith A.D. Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurones from death. J. Neurochem. 77:2001;94-102.
    • (2001) J. Neurochem. , vol.77 , pp. 94-102
    • Cross, D.A.1    Culbert, A.A.2    Chalmers, K.A.3    Facci, L.4    Skaper, S.D.5    Reith, A.D.6
  • 13
    • 0034677804 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3beta facilitates staurosporine- and heat shock-induced apoptosis. Protection by lithium
    • Bijur G.N., De Sarno P., Jope R.S. Glycogen synthase kinase-3beta facilitates staurosporine- and heat shock-induced apoptosis. Protection by lithium. J. Biol. Chem. 275:2000;7583-7590.
    • (2000) J. Biol. Chem. , vol.275 , pp. 7583-7590
    • Bijur, G.N.1    De Sarno, P.2    Jope, R.S.3
  • 14
    • 0037160134 scopus 로고    scopus 로고
    • Central role of glycogen synthase kinase-3beta in endoplasmic reticulum stress-induced caspase-3 activation
    • Song L., De Sarno P., Jope R.S. Central role of glycogen synthase kinase-3beta in endoplasmic reticulum stress-induced caspase-3 activation. J. Biol. Chem. 277:2002;44701-44708.
    • (2002) J. Biol. Chem. , vol.277 , pp. 44701-44708
    • Song, L.1    De Sarno, P.2    Jope, R.S.3
  • 15
    • 0037072807 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3beta inhibitors prevent cellular polyglutamine toxicity caused by the Huntington's disease mutation
    • Carmichael J., Sugars K.L., Bao Y.P., Rubinsztein D.C. Glycogen synthase kinase-3beta inhibitors prevent cellular polyglutamine toxicity caused by the Huntington's disease mutation. J. Biol. Chem. 277:2002;33791-33798.
    • (2002) J. Biol. Chem. , vol.277 , pp. 33791-33798
    • Carmichael, J.1    Sugars, K.L.2    Bao, Y.P.3    Rubinsztein, D.C.4
  • 17
    • 0037031934 scopus 로고    scopus 로고
    • Fibroblast growth factor 1 regulates signaling via the glycogen synthase kinase-3beta pathway. Implications for neuroprotection
    • Hashimoto M., Sagara Y., Langford D., Everall I.P., Mallory M., Everson A., Digicaylioglu M., Masliah E. Fibroblast growth factor 1 regulates signaling via the glycogen synthase kinase-3beta pathway. Implications for neuroprotection. J. Biol. Chem. 277:2002;32985-32991.
    • (2002) J. Biol. Chem. , vol.277 , pp. 32985-32991
    • Hashimoto, M.1    Sagara, Y.2    Langford, D.3    Everall, I.P.4    Mallory, M.5    Everson, A.6    Digicaylioglu, M.7    Masliah, E.8
  • 18
  • 19
    • 0035863188 scopus 로고    scopus 로고
    • Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice
    • Lucas J.J., Hernandez F., Gomez-Ramos P., Moran M.A., Hen R., Avila J. Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice. EMBO J. 20:2001;27-39.
    • (2001) EMBO J. , vol.20 , pp. 27-39
    • Lucas, J.J.1    Hernandez, F.2    Gomez-Ramos, P.3    Moran, M.A.4    Hen, R.5    Avila, J.6
  • 20
    • 0037118247 scopus 로고    scopus 로고
    • Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila
    • Jackson G.R., Wiedau-Pazos M., Sang T.-K., Wagle N., Brown C.A., Massachi S., Geschwind D.H. Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila. Neuron. 34:2002;509-519.
    • (2002) Neuron , vol.34 , pp. 509-519
    • Jackson, G.R.1    Wiedau-Pazos, M.2    Sang, T.-K.3    Wagle, N.4    Brown, C.A.5    Massachi, S.6    Geschwind, D.H.7
  • 21
    • 0036273020 scopus 로고    scopus 로고
    • Glycogen synthase kinase 3 (GSK-3) inhibitors as new promising drugs for diabetes, neurodegeneration, cancer, and inflammation
    • Martinez A., Castro A., Dorronsoro I., Alonso M. Glycogen synthase kinase 3 (GSK-3) inhibitors as new promising drugs for diabetes, neurodegeneration, cancer, and inflammation. Med. Res. Rev. 22:2002;373-384.
    • (2002) Med. Res. Rev. , vol.22 , pp. 373-384
    • Martinez, A.1    Castro, A.2    Dorronsoro, I.3    Alonso, M.4
  • 22
    • 0034306450 scopus 로고    scopus 로고
    • Specificity and mechanism of action of some commonly used protein kinase inhibitors
    • Davies S.P., Reddy H., Caivano M., Cohen P. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem. J. 351:2000;95-105.
    • (2000) Biochem. J. , vol.351 , pp. 95-105
    • Davies, S.P.1    Reddy, H.2    Caivano, M.3    Cohen, P.4
  • 23
    • 0036305698 scopus 로고    scopus 로고
    • Crystal structure of an enzyme displaying both inositol-polyphosphate-1- phosphatase and 3′-phosphoadenosine-5′-phosphate phosphatase activities: A novel target of lithium therapy
    • Patel S., Yenush L., Rodriguez P.L., Serrano R., Blundell T.L. Crystal structure of an enzyme displaying both inositol-polyphosphate-1-phosphatase and 3′-phosphoadenosine-5′-phosphate phosphatase activities. a novel target of lithium therapy J. Mol. Biol. 315:2002;677-685.
    • (2002) J. Mol. Biol. , vol.315 , pp. 677-685
    • Patel, S.1    Yenush, L.2    Rodriguez, P.L.3    Serrano, R.4    Blundell, T.L.5
  • 24
    • 0035808457 scopus 로고    scopus 로고
    • Indirubins inhibit glycogen synthase kinase-3β and CDK5/p25, two kinases involved in abnormal tau phosphorylation in Alzheimer's disease-A property common to most CDK inhibitors?
    • Leclerc S., Garnier M., Hoessel R., Marko D., Bibb J.A., Snyder G.L., Greengard P., Biernat J., Wu Y.Z., Mandelkow E.-M.et al. Indirubins inhibit glycogen synthase kinase-3β and CDK5/p25, two kinases involved in abnormal tau phosphorylation in Alzheimer's disease-A property common to most CDK inhibitors? J. Biol. Chem. 276:2001;251-260.
    • (2001) J. Biol. Chem. , vol.276 , pp. 251-260
    • Leclerc, S.1    Garnier, M.2    Hoessel, R.3    Marko, D.4    Bibb, J.A.5    Snyder, G.L.6    Greengard, P.7    Biernat, J.8    Wu, Y.Z.9    Mandelkow, E.-M.10
  • 25
    • 0037067733 scopus 로고    scopus 로고
    • Intracellular targets of paullones: Identification by affinity chromatography using immobilized inhibitor
    • Knockaert M., Viking K., Schmitt S., Leost M., Mottram J., Kunick C., Meijer L. Intracellular targets of paullones. identification by affinity chromatography using immobilized inhibitor J. Biol. Chem. 277:2002;25493-25501.
    • (2002) J. Biol. Chem. , vol.277 , pp. 25493-25501
    • Knockaert, M.1    Viking, K.2    Schmitt, S.3    Leost, M.4    Mottram, J.5    Kunick, C.6    Meijer, L.7
  • 27
    • 0034988970 scopus 로고    scopus 로고
    • Inhibitor binding to active and inactive CDK2. The crystal structure of a CDK2-cyclin A/indirubin-5-sulphonate
    • Davies T.G., Tunnah P., Meijer L., Marko D., Eisenbrand G., Endicott J.A., Noble M.E.M. Inhibitor binding to active and inactive CDK2. The crystal structure of a CDK2-cyclin A/indirubin-5-sulphonate. Structure. 9:2001;389-397.
    • (2001) Structure , vol.9 , pp. 389-397
    • Davies, T.G.1    Tunnah, P.2    Meijer, L.3    Marko, D.4    Eisenbrand, G.5    Endicott, J.A.6    Noble, M.E.M.7
  • 28
    • 0004249164 scopus 로고    scopus 로고
    • London:British Museum Press
    • Balfour-Paul, J. (1998). Indigo. (London:British Museum Press).
    • (1998) Indigo
    • Balfour-Paul, J.1
  • 29
    • 0035940873 scopus 로고    scopus 로고
    • Identification of an indigo precursor from leaves of Isatis tinctoria (Woad)
    • Maugard T., Enaud E., Choisy P., Legoy M.D. Identification of an indigo precursor from leaves of Isatis tinctoria (Woad). Phytochemistry. 58:2001;897-904.
    • (2001) Phytochemistry , vol.58 , pp. 897-904
    • Maugard, T.1    Enaud, E.2    Choisy, P.3    Legoy, M.D.4
  • 32
    • 0042894451 scopus 로고    scopus 로고
    • Tyrian purple: 6,6'-dibromoindigo and related compounds
    • Cooksey C.J. Tyrian purple. 6,6'-dibromoindigo and related compounds Mol. 6:2001;736-769.
    • (2001) Mol. , vol.6 , pp. 736-769
    • Cooksey, C.J.1
  • 35
    • 0036332286 scopus 로고    scopus 로고
    • Indirubin and meisoindigo in the treatment of chronic myelogenous leukemia in China
    • Xiao Z., Hao Y., Liu B., Qian L. Indirubin and meisoindigo in the treatment of chronic myelogenous leukemia in China. Leuk. Lymphoma. 43:2002;1763-1768.
    • (2002) Leuk. Lymphoma , vol.43 , pp. 1763-1768
    • Xiao, Z.1    Hao, Y.2    Liu, B.3    Qian, L.4
  • 36
    • 25044442969 scopus 로고
    • Uber den Farbstoff des antiken Purpurs aus Murex brandaris
    • Friedländer P. Uber den Farbstoff des antiken Purpurs aus Murex brandaris. Angew. Chem. 22:1909;2492-2494.
    • (1909) Angew. Chem. , vol.22 , pp. 2492-2494
    • Friedländer, P.1
  • 37
    • 84981946673 scopus 로고
    • Biological precursors and genesis of tyrian-purple
    • Fouquet H., Bielig H.J. Biological precursors and genesis of tyrian-purple. Angew. Chem. Int. Ed. Engl. 10:1971;816-817.
    • (1971) Angew. Chem. Int. Ed. Engl. , vol.10 , pp. 816-817
    • Fouquet, H.1    Bielig, H.J.2
  • 38
    • 0035875098 scopus 로고    scopus 로고
    • Crystal structure of glycogen synthase kinase 3β: Structural basis for phosphate-primed substrate specificity and autoinhibition
    • Dajani R., Fraser E., Roe S.M., Young N., Good V., Dale T.C., Pearl L.H. Crystal structure of glycogen synthase kinase 3β structural basis for phosphate-primed substrate specificity and autoinhibition Cell. 105:2001;721-732.
    • (2001) Cell , vol.105 , pp. 721-732
    • Dajani, R.1    Fraser, E.2    Roe, S.M.3    Young, N.4    Good, V.5    Dale, T.C.6    Pearl, L.H.7
  • 42
    • 0035479835 scopus 로고    scopus 로고
    • New aspects of Wnt signaling pathways in higher vertebrates
    • Huelsken J., Birchmeier W. New aspects of Wnt signaling pathways in higher vertebrates. Curr. Opin. Genet. Dev. 11:2001;547-553.
    • (2001) Curr. Opin. Genet. Dev. , vol.11 , pp. 547-553
    • Huelsken, J.1    Birchmeier, W.2
  • 43
    • 0035985190 scopus 로고    scopus 로고
    • Recruitment of dioxin receptor to active transcription sites
    • Elbi C., Misteli T., Hager G.L. Recruitment of dioxin receptor to active transcription sites. Mol. Biol. Cell. 13:2002;2001-2015.
    • (2002) Mol. Biol. Cell , vol.13 , pp. 2001-2015
    • Elbi, C.1    Misteli, T.2    Hager, G.L.3
  • 44
    • 0027475421 scopus 로고
    • Modulation of the glycogen synthase kinase-3 family by tyrosine phosphorylation
    • Hughes K., Nikolakaki E., Plyte S.E., Totty N.F., Woodgett J.R. Modulation of the glycogen synthase kinase-3 family by tyrosine phosphorylation. EMBO J. 12:1993;803-808.
    • (1993) EMBO J. , vol.12 , pp. 803-808
    • Hughes, K.1    Nikolakaki, E.2    Plyte, S.E.3    Totty, N.F.4    Woodgett, J.R.5
  • 45
    • 0037415737 scopus 로고    scopus 로고
    • Structural basis for recruitment of glycogen synthase kinase 3beta to the axin-APC scaffold complex
    • Dajani R., Fraser E., Roe S.M., Yeo M., Good V.M., Thompson V., Dale T.C., Pearl L.H. Structural basis for recruitment of glycogen synthase kinase 3beta to the axin-APC scaffold complex. EMBO J. 22:2003;494-501.
    • (2003) EMBO J. , vol.22 , pp. 494-501
    • Dajani, R.1    Fraser, E.2    Roe, S.M.3    Yeo, M.4    Good, V.M.5    Thompson, V.6    Dale, T.C.7    Pearl, L.H.8
  • 46
    • 0030712317 scopus 로고    scopus 로고
    • Further evidence that the inhibition of glycogen synthase kinase-3beta by IGF-1 is mediated by PDK1/PKB-induced phosphorylation of Ser-9 and not by dephosphorylation of Tyr-216
    • Shaw M., Cohen P., Alessi D.R. Further evidence that the inhibition of glycogen synthase kinase-3beta by IGF-1 is mediated by PDK1/PKB-induced phosphorylation of Ser-9 and not by dephosphorylation of Tyr-216. FEBS Lett. 416:1997;307-311.
    • (1997) FEBS Lett. , vol.416 , pp. 307-311
    • Shaw, M.1    Cohen, P.2    Alessi, D.R.3
  • 47
    • 0030866798 scopus 로고    scopus 로고
    • Head induction by simultaneous repression of Bmp and Wnt signalling in Xenopus
    • Glinka A., Wu W., Onichtchouk D., Blumenstock C., Niehrs C. Head induction by simultaneous repression of Bmp and Wnt signalling in Xenopus. Nature. 389:1997;517-519.
    • (1997) Nature , vol.389 , pp. 517-519
    • Glinka, A.1    Wu, W.2    Onichtchouk, D.3    Blumenstock, C.4    Niehrs, C.5
  • 48
    • 0029832381 scopus 로고    scopus 로고
    • The homeobox gene Siamois is a target of the Wnt dorsalisation pathway and triggers organiser activity in the absence of mesoderm
    • Carnac G., Kodjabachian L., Gurdon J.B., Lemaire P. The homeobox gene Siamois is a target of the Wnt dorsalisation pathway and triggers organiser activity in the absence of mesoderm. Development. 122:1996;3055-3065.
    • (1996) Development , vol.122 , pp. 3055-3065
    • Carnac, G.1    Kodjabachian, L.2    Gurdon, J.B.3    Lemaire, P.4
  • 49
    • 0030657868 scopus 로고    scopus 로고
    • Siamois is required for formation of Spemann's organizer
    • Kessler D.S. Siamois is required for formation of Spemann's organizer. Proc. Natl. Acad. Sci. USA. 94:1997;13017-13022.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 13017-13022
    • Kessler, D.S.1
  • 51
    • 0033397682 scopus 로고    scopus 로고
    • Wnt signaling in Xenopus embryos inhibits bmp4 expression and activates neural development
    • Baker J.C., Beddington R.S., Harland R.M. Wnt signaling in Xenopus embryos inhibits bmp4 expression and activates neural development. Genes Dev. 13:1999;3149-3159.
    • (1999) Genes Dev. , vol.13 , pp. 3149-3159
    • Baker, J.C.1    Beddington, R.S.2    Harland, R.M.3
  • 52
    • 0037392942 scopus 로고    scopus 로고
    • The specificities of protein kinase inhibitors: An update
    • Bain J., McLauchlan H., Elliott M., Cohen P. The specificities of protein kinase inhibitors. an update Biochem. J. 371:2003;199-204.
    • (2003) Biochem. J. , vol.371 , pp. 199-204
    • Bain, J.1    McLauchlan, H.2    Elliott, M.3    Cohen, P.4
  • 53
    • 0036791512 scopus 로고    scopus 로고
    • Latest developments in crystallography and structure-based design of protein kinase inhibitors as drug candidates
    • Williams D.H., Mitchell T. Latest developments in crystallography and structure-based design of protein kinase inhibitors as drug candidates. Curr. Opin. Pharmacol. 2:2002;567-573.
    • (2002) Curr. Opin. Pharmacol. , vol.2 , pp. 567-573
    • Williams, D.H.1    Mitchell, T.2
  • 55
    • 0036799220 scopus 로고    scopus 로고
    • Inhibitors of glycogen synthase kinase-3: Future therapy for unmet medical needs?
    • Dorronsoro I., Castrob A., Martinez A. Inhibitors of glycogen synthase kinase-3. future therapy for unmet medical needs? Expert Opin. Ther. Patents. 12:2002;1-10.
    • (2002) Expert Opin. Ther. Patents , vol.12 , pp. 1-10
    • Dorronsoro, I.1    Castrob, A.2    Martinez, A.3
  • 56
    • 0036769733 scopus 로고    scopus 로고
    • GSK3beta signalling: Casting a wide net in Alzheimer's disease
    • Bhat R.V., Budd S.L. GSK3beta signalling. casting a wide net in Alzheimer's disease Neurosignals. 11:2002;251-261.
    • (2002) Neurosignals , vol.11 , pp. 251-261
    • Bhat, R.V.1    Budd, S.L.2
  • 57
    • 0036928604 scopus 로고    scopus 로고
    • Tau as a drug target in Alzheimer's disease
    • Gozes I. Tau as a drug target in Alzheimer's disease. J. Mol. Neurosci. 19:2002;337-338.
    • (2002) J. Mol. Neurosci. , vol.19 , pp. 337-338
    • Gozes, I.1
  • 58
    • 0037975676 scopus 로고    scopus 로고
    • Spherical aggregates of beta-amyloid (amylospheroid) show high neurotoxicity and activate tau protein kinase I/glycogen synthase kinase-3beta
    • Hoshi M., Sato M., Matsumoto S., Noguchi A., Yasutake K., Yoshida N., Sato K. Spherical aggregates of beta-amyloid (amylospheroid) show high neurotoxicity and activate tau protein kinase I/glycogen synthase kinase-3beta. Proc. Natl. Acad. Sci. USA. 100:2003;6370-6375.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 6370-6375
    • Hoshi, M.1    Sato, M.2    Matsumoto, S.3    Noguchi, A.4    Yasutake, K.5    Yoshida, N.6    Sato, K.7
  • 61
    • 0038187674 scopus 로고    scopus 로고
    • GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides
    • Phiel C.J., Wilson C.A., Lee V.M., Klein P.S. GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides. Nature. 423:2003;435-439.
    • (2003) Nature , vol.423 , pp. 435-439
    • Phiel, C.J.1    Wilson, C.A.2    Lee, V.M.3    Klein, P.S.4
  • 62
    • 0036481246 scopus 로고    scopus 로고
    • Alzheimer's disease: Targets for drug development
    • Larner A.J. Alzheimer's disease. targets for drug development Mini Rev. Med. Chem. 2:2002;1-9.
    • (2002) Mini Rev. Med. Chem. , vol.2 , pp. 1-9
    • Larner, A.J.1
  • 65
    • 0028922586 scopus 로고
    • Ligplot: A program to generate schematic diagrams of protein-ligand interactions
    • Wallace A.C., Laskowski R.A., Thornton J.M. Ligplot. a program to generate schematic diagrams of protein-ligand interactions Protein Eng. 8:1995;127-134.
    • (1995) Protein Eng. , vol.8 , pp. 127-134
    • Wallace, A.C.1    Laskowski, R.A.2    Thornton, J.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.