-
1
-
-
0034829801
-
The molecular bases of Alzheimer's disease and other neurodegenerative disorders
-
DOI 10.1016/S0188-4409(01)00316-2, PII S0188440901003162
-
Maccioni RB, Munoz JP, Barbeito L (2001) The molecular bases of Alzheimer's disease and other neurodegenerative disorders. Arch Med Res 32, 367-381. (Pubitemid 32918139)
-
(2001)
Archives of Medical Research
, vol.32
, Issue.5
, pp. 367-381
-
-
Maccioni, R.B.1
Munoz, J.P.2
Barbeito, L.3
-
2
-
-
0022744803
-
Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology
-
Grundke-Iqbal I, Iqbal K, Tung YC, Quinlan M, Wisniewski HM, Binder LI (1986) Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology. Proc Natl Acad Sci USA 83, 4913-4917.
-
(1986)
Proc Natl Acad Sci USA
, vol.83
, pp. 4913-4917
-
-
Grundke-Iqbal, I.1
Iqbal, K.2
Tung, Y.C.3
Quinlan, M.4
Wisniewski, H.M.5
Binder, L.I.6
-
3
-
-
34548036227
-
Tau-mediated neurodegeneration in Alzheimer's disease and related disorders
-
DOI 10.1038/nrn2194, PII NRN2194
-
Ballatore C, Lee VM, Trojanowski JQ (2007) Tau-mediated neurodegeneration in Alzheimer's disease and related disorders. Nat Rev Neurosci 8, 663-672. (Pubitemid 47283144)
-
(2007)
Nature Reviews Neuroscience
, vol.8
, Issue.9
, pp. 663-672
-
-
Ballatore, C.1
Lee, V.M.-Y.2
Trojanowski, J.Q.3
-
4
-
-
0029078972
-
Correlations of synaptic and pathological markers with cognition of the elderly
-
discussion 298-304
-
Dickson DW, Crystal HA, Bevona C, Honer W, Vincent I, Davies P (1995) Correlations of synaptic and pathological markers with cognition of the elderly. Neurobiol Aging 16, 285-298; discussion 298-304.
-
(1995)
Neurobiol Aging
, vol.16
, pp. 285-298
-
-
Dickson, D.W.1
Crystal, H.A.2
Bevona, C.3
Honer, W.4
Vincent, I.5
Davies, P.6
-
5
-
-
0038326624
-
Neurofibrillary tangles, amyloid, and memory in aging and mild cognitive impairment
-
DOI 10.1001/archneur.60.5.729
-
Guillozet AL, Weintraub S, Mash DC, Mesulam MM (2003) Neurofibrillary tangles, amyloid, and memory in aging and mild cognitive impairment. Arch Neurol 60, 729-736. (Pubitemid 36569891)
-
(2003)
Archives of Neurology
, vol.60
, Issue.5
, pp. 729-736
-
-
Guillozet, A.L.1
Weintraub, S.2
Mash, D.C.3
Marsel Mesulam, M.4
-
6
-
-
33847194237
-
Hereditary frontotemporal dementia caused by Tau gene mutations
-
van Swieten J, Spillantini MG (2007) Hereditary frontotemporal dementia caused by Tau gene mutations. Brain Pathol 17, 63-73.
-
(2007)
Brain Pathol
, vol.17
, pp. 63-73
-
-
Van Swieten, J.1
Spillantini, M.G.2
-
7
-
-
33846015514
-
Reduction of soluble Aβ and tau, but not soluble Aβ alone, ameliorates cognitive decline in transgenic mice with plaques and tangles
-
DOI 10.1074/jbc.M608485200
-
Oddo S, Vasilevko V, Caccamo A, Kitazawa M, Cribbs DH, LaFerla FM (2006) Reduction of soluble Abeta and tau, but not soluble Abeta alone, ameliorates cognitive decline in transgenic mice with plaques and tangles. J Biol Chem 281, 39413-39423. (Pubitemid 46041901)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.51
, pp. 39413-39423
-
-
Oddo, S.1
Vasilevko, V.2
Caccamo, A.3
Kitazawa, M.4
Cribbs, D.H.5
LaFerla, F.M.6
-
8
-
-
33644851265
-
Inducible expression of tau repeat domain in cell models of tauopathy: Aggregation is toxic to cells but can be reversed by inhibitor drugs
-
Khlistunova I, Biernat J,WangY, Pickhardt M, von Bergen M, Gazova Z, Mandelkow E, Mandelkow EM (2006) Inducible expression of tau repeat domain in cell models of tauopathy: Aggregation is toxic to cells but can be reversed by inhibitor drugs. J Biol Chem 281, 1205-1214.
-
(2006)
J Biol Chem
, vol.281
, pp. 1205-1214
-
-
Khlistunova, I.1
Biernat, J.2
Wang, Y.3
Pickhardt, M.4
Von Bergen, M.5
Gazova, Z.6
Mandelkow, E.7
Mandelkow, E.M.8
-
9
-
-
47149112621
-
42 immunisation in Alzheimer's disease: Follow-up of a randomised, placebo-controlled phase I trial
-
DOI 10.1016/S0140-6736(08)61075-2, PII S0140673608610752
-
Holmes C, Boche D,Wilkinson D, Yadegarfar G, Hopkins V, Bayer A, Jones RW, Bullock R, Love S, Neal JW, Zotova E, Nicoll JA (2008) Long-term effects of Abeta42 immunisation in Alzheimer's disease: Follow-up of a randomised, placebocontrolled phase I trial. Lancet 372, 216-223. (Pubitemid 351978111)
-
(2008)
The Lancet
, vol.372
, Issue.9634
, pp. 216-223
-
-
Holmes, C.1
Boche, D.2
Wilkinson, D.3
Yadegarfar, G.4
Hopkins, V.5
Bayer, A.6
Jones, R.W.7
Bullock, R.8
Love, S.9
Neal, J.W.10
Zotova, E.11
Nicoll, J.A.12
-
10
-
-
77949300796
-
GrundmanM11C-PiB PET assessment of change in fibrillar amyloid-beta load in patients with Alzheimer's disease treated with bapineuzumab: A phase 2, double-blind, placebo-controlled, ascending-dose study
-
Rinne JO, Brooks DJ, Rossor MN, Fox NC, Bullock R, Klunk WE, Mathis CA, Blennow K, Barakos J, Okello AA (2010) Rodriguez Martinez de Liano S, Liu E, Koller M, Gregg KM, Schenk D, Black R, GrundmanM11C-PiB PET assessment of change in fibrillar amyloid-beta load in patients with Alzheimer's disease treated with bapineuzumab: A phase 2, double-blind, placebo-controlled, ascending-dose study. Lancet Neurol 9, 363-372.
-
(2010)
Lancet Neurol
, vol.9
, pp. 363-372
-
-
Rinne, J.O.1
Brooks, D.J.2
Rossor, M.N.3
Fox, N.C.4
Bullock, R.5
Klunk, W.E.6
Mathis, C.A.7
Blennow, K.8
Barakos, J.9
Okello, A.A.10
Rodriguez Martinez De Liano, S.11
Liu, E.12
Koller, M.13
Gregg, K.M.14
Schenk, D.15
Black, R.16
-
11
-
-
77957361080
-
Alzheimer's failure raises questions about disease-modifying strategies
-
Extance A (2010) Alzheimer's failure raises questions about disease-modifying strategies. Nat Rev Drug Discov 9, 749-751.
-
(2010)
Nat Rev Drug Discov
, vol.9
, pp. 749-751
-
-
Extance, A.1
-
12
-
-
70349638299
-
Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies
-
Brunden KR, Trojanowski JQ, Lee VM (2009) Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies. Nat Rev Drug Discov 8, 783-793.
-
(2009)
Nat Rev Drug Discov
, vol.8
, pp. 783-793
-
-
Brunden, K.R.1
Trojanowski, J.Q.2
Lee, V.M.3
-
13
-
-
61349145507
-
Development of tau aggregation inhibitors for Alzheimer's disease
-
Bulic B, Pickhardt M, Schmidt B, Mandelkow EM, Waldmann H, Mandelkow E (2009) Development of tau aggregation inhibitors for Alzheimer's disease. Angew Chem Int Ed Engl 48, 1740-1752.
-
(2009)
Angew Chem Int Ed Engl
, vol.48
, pp. 1740-1752
-
-
Bulic, B.1
Pickhardt, M.2
Schmidt, B.3
Mandelkow, E.M.4
Waldmann, H.5
Mandelkow, E.6
-
14
-
-
0029742937
-
Selective inhibition of Alzheimer disease-like tau aggregation by phenothiazines
-
DOI 10.1073/pnas.93.20.11213
-
Wischik CM, Edwards PC, Lai RY, Roth M, Harrington CR (1996) Selective inhibition of Alzheimer disease-like tau aggregation by phenothiazines. Proc Natl Acad Sci USA 93, 11213-11218. (Pubitemid 26333144)
-
(1996)
Proceedings of the National Academy of Sciences of the United States of America
, vol.93
, Issue.20
, pp. 11213-11218
-
-
Wischik, C.M.1
Edwards, P.C.2
Lai, R.Y.K.3
Roth, M.4
Harrington, C.R.5
-
15
-
-
14844303721
-
Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols, and porphyrins
-
DOI 10.1074/jbc.M408714200
-
Taniguchi S, Suzuki N, Masuda M, Hisanaga S, Iwatsubo T, Goedert M, Hasegawa M (2005) Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols, and porphyrins. J Biol Chem 280, 7614-7623. (Pubitemid 40349654)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.9
, pp. 7614-7623
-
-
Taniguchi, S.1
Suzuki, N.2
Masuda, M.3
Hisanaga, S.-I.4
Iwatsubo, T.5
Goedert, M.6
Hasegawa, M.7
-
16
-
-
67349200953
-
Tau aggregation inhibitor (TAI) theraphy with Rember arrests disease progression in mild and moderate Alzheimer's disease over 50 weeks
-
Wischik CM, Bentham P, Wischik DJ, Seng KM (2008) Tau aggregation inhibitor (TAI) theraphy with Rember arrests disease progression in mild and moderate Alzheimer's disease over 50 weeks. Alzheimers Dement 4 (Suppl), T167.
-
(2008)
Alzheimers Dement
, vol.4
, Issue.SUPPL.
-
-
Wischik, C.M.1
Bentham, P.2
Wischik, D.J.3
Seng, K.M.4
-
17
-
-
33745096194
-
Inhibition of amyloid fibril formation by polyphenols: Structural similarity and aromatic interactions as a common inhibition mechanism
-
DOI 10.1111/j.1747-0285.2005.00318.x
-
Porat Y, Abramowitz A, Gazit E (2006) Inhibition of amyloid fibril formation by polyphenols: Structural similarity and aromatic interactions as a common inhibition mechanism. Chem Biol Drug Des 67, 27-37. (Pubitemid 43881385)
-
(2006)
Chemical Biology and Drug Design
, vol.67
, Issue.1
, pp. 27-37
-
-
Porat, Y.1
Abramowitz, A.2
Gazit, E.3
-
18
-
-
45549095784
-
Polyphenols as potential inhibitors of amyloid aggregation and toxicity: Possible significance to Alzheimer's disease
-
Bastianetto S, Krantic S, Quirion R (2008) Polyphenols as potential inhibitors of amyloid aggregation and toxicity: Possible significance to Alzheimer's disease. Mini Rev Med Chem 8, 429-435.
-
(2008)
Mini Rev Med Chem
, vol.8
, pp. 429-435
-
-
Bastianetto, S.1
Krantic, S.2
Quirion, R.3
-
19
-
-
77349084360
-
Naturally occurring phytochemicals for the prevention of Alzheimer's disease
-
Kim J, Lee HJ, Lee KW (2010) Naturally occurring phytochemicals for the prevention of Alzheimer's disease. J Neurochem 112, 1415-1430.
-
(2010)
J Neurochem
, vol.112
, pp. 1415-1430
-
-
Kim, J.1
Lee, H.J.2
Lee, K.W.3
-
20
-
-
67849127151
-
Cinnamon extract inhibits tau aggregation associated with Alzheimer's disease in vitro
-
Peterson DW, George RC, Scaramozzino F, LaPointe NE, Anderson RA, Graves DJ, Lew J (2009) Cinnamon extract inhibits tau aggregation associated with Alzheimer's disease in vitro. J Alzheimers Dis 17, 585-597.
-
(2009)
J Alzheimers Dis
, vol.17
, pp. 585-597
-
-
Peterson, D.W.1
George, R.C.2
Scaramozzino, F.3
Lapointe, N.E.4
Anderson, R.A.5
Graves, D.J.6
Lew, J.7
-
21
-
-
77956314492
-
Development of a grape seed polyphenolic extract with anti-oligomeric activity as a novel treatment in progressive supranuclear palsy and other tauopathies
-
Pasinetti GM, Ksiezak-Reding H, Santa-Maria I,Wang J, Ho L (2010) Development of a grape seed polyphenolic extract with anti-oligomeric activity as a novel treatment in progressive supranuclear palsy and other tauopathies. J Neurochem 114, 1557-1568.
-
(2010)
J Neurochem
, vol.114
, pp. 1557-1568
-
-
Pasinetti, G.M.1
Ksiezak-Reding, H.2
Santa-Maria, I.3
Wang, J.4
Ho, L.5
-
22
-
-
77954218448
-
Progression from model structures to molecular structures of natural organic matter components
-
Leenheer JA (2007) Progression from model structures to molecular structures of natural organic matter components. Ann Environ Sci 1, 57-68.
-
(2007)
Ann Environ Sci
, vol.1
, pp. 57-68
-
-
Leenheer, J.A.1
-
23
-
-
0027400551
-
Effects of shilajit and its active constituents on learning and memory in rats
-
DOI 10.1002/ptr.2650070109
-
Ghosal S, Lal J, Jaiswal AK, Bhattacharya SK (1993) Effects of shilajit and its active constituents on learning and memory in rats. Phytother Res 7, 29-34. (Pubitemid 23044563)
-
(1993)
Phytotherapy Research
, vol.7
, Issue.1
, pp. 29-34
-
-
Ghosal, S.1
Lal, J.2
Jaiswal, A.K.3
Bhattacharya, S.K.4
-
24
-
-
0030163168
-
Interaction between fulvic acids of different origins and active oxygen radicals
-
Wang C, Wang Z, Peng A, Hou J, Xin W (1996) Interaction between fulvic acids of different origins and active oxygen radicals. Sci China C Life Sci 39, 267-275. (Pubitemid 126468000)
-
(1996)
Science in China, Series C: Life Sciences
, vol.39
, Issue.3
, pp. 267-275
-
-
Wang, C.1
Wang, Z.2
Peng, A.3
Hou, J.4
Xin, W.5
-
25
-
-
77953710064
-
The interaction of humic substances with the human prion protein fragment 90-231 affects its protease K resistance and cell internalization
-
Corsaro A, Anselmi C, Polano M, Aceto A, Florio T, De Nobili M (2010) The interaction of humic substances with the human prion protein fragment 90-231 affects its protease K resistance and cell internalization. J Biol Regul Homeost Agents 24, 27-39.
-
(2010)
J Biol Regul Homeost Agents
, vol.24
, pp. 27-39
-
-
Corsaro, A.1
Anselmi, C.2
Polano, M.3
Aceto, A.4
Florio, T.5
De Nobili, M.6
-
26
-
-
13544251748
-
Anthraquinones inhibit tau aggregation and dissolve Alzheimer's paired helical filaments in vitro and in cells
-
DOI 10.1074/jbc.M410984200
-
Pickhardt M, Gazova Z, von Bergen M, Khlistunova I, Wang Y, Hascher A, Mandelkow EM, Biernat J, Mandelkow E (2005) Anthraquinones inhibit tau aggregation and dissolve Alzheimer's paired helical filaments in vitro and in cells. J Biol Chem 280, 3628-3635. (Pubitemid 40223830)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.5
, pp. 3628-3635
-
-
Pickhardt, M.1
Gazova, Z.2
Von Bergen, M.3
Khlistunova, I.4
Wang, Y.5
Hascher, A.6
Mandelkow, E.-M.7
Biernat, J.8
Mandelkow, E.9
-
27
-
-
34248142548
-
High throughput screening for small molecule inhibitors of heparin-induced tau fibril formation
-
DOI 10.1016/j.bbrc.2007.03.056, PII S0006291X07005372
-
Crowe A, Ballatore C, Hyde E, Trojanowski JQ, Lee VM (2007) High throughput screening for small molecule inhibitors of heparin-induced tau fibril formation. Biochem Biophys Res Commun 358, 1-6. (Pubitemid 46719073)
-
(2007)
Biochemical and Biophysical Research Communications
, vol.358
, Issue.1
, pp. 1-6
-
-
Crowe, A.1
Ballatore, C.2
Hyde, E.3
Trojanowski, J.Q.4
Lee, V.M.-Y.5
-
28
-
-
77956242962
-
Human Tau isoforms assemble into ribbon-like fibrils that display polymorphic structure and stability
-
Wegmann S, Jung YJ, Chinnathambi S, Mandelkow EM, MandelkowE, Muller DJ (2010) Human Tau isoforms assemble into ribbon-like fibrils that display polymorphic structure and stability. J Biol Chem 285, 27302-27313.
-
(2010)
J Biol Chem
, vol.285
, pp. 27302-27313
-
-
Wegmann, S.1
Jung, Y.J.2
Chinnathambi, S.3
Mandelkow, E.M.4
Mandelkowe Muller, D.J.5
-
29
-
-
0026595567
-
Assembly and aggregation properties of synthetic Alzheimer's A4/beta amyloid peptide analogs
-
Burdick D, Soreghan B, Kwon M, Kosmoski J, Knauer M, Henschen A, Yates J, Cotman C, Glabe C (1992) Assembly and aggregation properties of synthetic Alzheimer's A4/beta amyloid peptide analogs. J Biol Chem 267, 546-554.
-
(1992)
J Biol Chem
, vol.267
, pp. 546-554
-
-
Burdick, D.1
Soreghan, B.2
Kwon, M.3
Kosmoski, J.4
Knauer, M.5
Henschen, A.6
Yates, J.7
Cotman, C.8
Glabe, C.9
-
30
-
-
58149268892
-
Retinoic acid attenuates Beta-amyloid deposition and rescues memory deficit in an Alzheimeŕs disease transgenic mouse model
-
Ding Y, Qiao A, Wang Z, Goodwin S, Lee ES, Block M, Allsbrook M, McDonald M, Fan GH (2008) Retinoic acid attenuates Beta-amyloid deposition and rescues memory deficit in an Alzheimeŕs disease transgenic mouse model. J Neurosci 28, 11622-11634.
-
(2008)
J Neurosci
, vol.28
, pp. 11622-11634
-
-
Ding, Y.1
Qiao, A.2
Wang, Z.3
Goodwin, S.4
Lee, E.S.5
Block, M.6
Allsbrook, M.7
McDonald, M.8
Fan, G.H.9
-
31
-
-
70849097441
-
All-trans retinoic acid as a novel therapeutic strategy for Alzheimer's disease
-
Lee HP, Casadesus G, Zhu X, Lee HG, Perry G, Smith MA, Gustaw-Rothenberg K, Lerner A (2009) All-trans retinoic acid as a novel therapeutic strategy for Alzheimer's disease. Expert Rev Neurother 9, 1615-1621.
-
(2009)
Expert Rev Neurother
, vol.9
, pp. 1615-1621
-
-
Lee, H.P.1
Casadesus, G.2
Zhu, X.3
Lee, H.G.4
Perry, G.5
Smith, M.A.6
Gustaw-Rothenberg, K.7
Lerner, A.8
-
32
-
-
0035943436
-
Formation of neurofibrillary tangles in P301L tau transgenic mice induced by Aβ42 fibrils
-
DOI 10.1126/science.1062097
-
Gotz J, Chen F, van Dorpe J, Nitsch RM (2001) Formation of neurofibrillary tangles in P301L tau transgenic mice induced by Abeta 42 fibrils. Science 293, 1491-1495. (Pubitemid 32807681)
-
(2001)
Science
, vol.293
, Issue.5534
, pp. 1491-1495
-
-
Gotz, J.1
Chen, F.2
Van Dorpe, J.3
Nitsch, R.M.4
-
33
-
-
34248181511
-
Reducing endogenous tau ameliorates amyloid β-induced deficits in an Alzheimer's disease mouse model
-
DOI 10.1126/science.1141736
-
Roberson ED, Scearce-Levie K, Palop JJ, Yan F, Cheng IH, Wu T, Gerstein H, Yu GQ, Mucke L (2007) Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model. Science 316, 750-754. (Pubitemid 46717684)
-
(2007)
Science
, vol.316
, Issue.5825
, pp. 750-754
-
-
Roberson, E.D.1
Scearce-Levie, K.2
Palop, J.J.3
Yan, F.4
Cheng, I.H.5
Wu, T.6
Gerstein, H.7
Yu, G.-Q.8
Mucke, L.9
-
34
-
-
60349096854
-
Grape seed polyphenolic extract as a potential novel therapeutic agent in tauopathies
-
Ho L, Yemul S, Wang J, Pasinetti GM (2009) Grape seed polyphenolic extract as a potential novel therapeutic agent in tauopathies. J Alzheimers Dis 16, 433-439.
-
(2009)
J Alzheimers Dis
, vol.16
, pp. 433-439
-
-
Ho, L.1
Yemul, S.2
Wang, J.3
Pasinetti, G.M.4
-
35
-
-
44849087785
-
EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers
-
DOI 10.1038/nsmb.1437, PII NSMB1437
-
Ehrnhoefer DE, Bieschke J, Boeddrich A, Herbst M, Masino L, Lurz R, Engemann S, Pastore A,Wanker EE (2008) EGCG redirects amyloidogenic polypeptides into unstructured, offpathway oligomers. Nat Struct Mol Biol 15, 558-566. (Pubitemid 351799141)
-
(2008)
Nature Structural and Molecular Biology
, vol.15
, Issue.6
, pp. 558-566
-
-
Ehrnhoefer, D.E.1
Bieschke, J.2
Boeddrich, A.3
Herbst, M.4
Masino, L.5
Lurz, R.6
Engemann, S.7
Pastore, A.8
Wanker, E.E.9
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