The 222- to 234-kilodalton latent nuclear protein (LNA) of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) is encoded by orf73 and is a component of the latency-associated nuclear antigen

Journal of Virology

Volumn 71, Issue 8, 1997, Pages 5915-5921

  Rainbow, Lucille ^a   Platt, Georgina M ^a   Simpson, Guy R ^a   Sarid, Ronit ^b   Gao, Shou Jiang ^b,c   Stoiber, Heribert ^a   Herrington, C Simon ^a   Moore, Patrick S ^b   Schulz, Thomas F ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b Columbia University ^*  (United States)

^c UNIVERSITY OF TEXAS AT SAN ANTONIO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS ANTIGEN;

ANTIBODY AFFINITY; ARTICLE; CARBOXY TERMINAL SEQUENCE; DNA LIBRARY; DNA SEQUENCE; GENE EXPRESSION; HERPES VIRUS; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; KAPOSI SARCOMA; LYMPHOMA; OPEN READING FRAME; PRIORITY JOURNAL; PROTEIN PROCESSING; RNA SEQUENCE; SPINDLE CELL; VIRUS GENE;

EID: 0030834122     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.71.8.5915-5921.1997     Document Type: Article

References (45)

1. Albrecht, J.-C., J. Nicholas, D. Biller, K. R. Cameron, B. Biesinger, C. Newman, S. Wittmann, M. A. Craxton, H. Coleman, B. Fleckenstein, and R. W. Honess. 1992. Primary structure of the herpesvirus saimiri genome. J. Virol. 66:5047-5058.
2. Ambroziak, J. A., D. J. Blackbourn, B. G. Herndier, R. G. Glogau, J. H. Gullett, A. R. McDonald, E. T. Lennette, and J. A. Levy. 1995. Herpes-like sequences in HIV-infected and uninfected Kaposi's sarcoma patients. Science 268:582-583.
3. Baer, R., A. T. Bankier, M. D. Biggin, P. L. Deiniger, P. J. Farrell, T. J. Gibson, G. Hatfull, G. S. Hudson, S. C. Satchwell, C. Séguin, P. S. Tuffnell, and B. G. Barrell. 1984. DNA sequence and expression of the B95-8 Epstein-Barr virus genome. Nature 310:207-211.
4. Beral, V., T. A. Peterman, R. L. Berkelman, and H. W. Jaffe. 1990. Kaposi's sarcoma among persons with AIDS: a sexually transmitted infection? Lancet 335:123-128.
5. Boshoff, C., D. Whitby, T. Hatzioannou, C. Fisher, J. van der Walt, A. Hatzakis, R. A. Weiss, and T. F. Schulz. 1995. Kaposi's sarcoma associated herpesvirus in HIV-negative Kaposi sarcoma. Lancet 345:1043-1044.
6. Boshoff, C., T. F. Schulz, M. M. Kennedy, A. K. Graham, C. Fisher, A. Thomas, J. O. McGee, R. A. Weiss, and J. J. O'Leary. 1995. Kaposi's sarcoma associated herpesvirus infects endothelial and spindle cells. Nat. Med. 1:1274-1278.
7. Cesarman, E., Y. Chang, P. S. Moore, J. W. Said, and D. M. Knowles. 1995. Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas. N. Engl. J. Med. 332:1186-1191.
8. Cesarman, E., P. S. Moore, P. H. Rao, G. Inghirami, D. M. Knowles, and Y. Chang. 1995. In vitro establishment and characterization of two acquired immunodeficiency syndrome-related lymphoma cell lines (BC-1 and BC-2) containing Kaposi's sarcoma-associated herpesvirus-like (KSHV) DNA sequences. Blood 86:2708-2714.
9. Cesarman, E., R. G. Nador, F. Bai, R. A. Bohenzky, J. J. Russo, P. S. Moore, Y. Chang, and D. M. Knowles. 1996. Kaposi's sarcoma-associated herpesvirus contains G protein-coupled receptor and cyclin D homologs which are expressed in Kaposi's sarcoma and malignant lymphoma. J. Virol. 70:8218-8223.
10. Chang, Y., E. Cesarman, M. S. Pessin, F. Lee, J. Culpepper, D. M. Knowles, and P. S. Moore. 1994. Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science 266:1865-1869.
11. Chang, Y., J. Ziegler, H. Wabinga, E. Katangole-Mbidde, C. Boshoff, T. F. Schulz, D. Whitby, D. Maddalena, H. W. Jaffe, R. A. Weiss, and P. S. Moore. 1996. Kaposi's sarcoma-associated herpesvirus and Kaposi's sarcoma in Africa. Arch. Intern. Med. 156:202-204.
12. Chang, Y., P. S. Moore, S. J. Talbot, C. Boshoff, T. Zarkowska, D. Godden-Kent, H. Paterson, R. A. Weiss, and S. Mittnacht. 1996. Cyclin encoded by KS herpesvirus. Nature 382:410.
13. Collandre, H., S. Ferris, O. Grau, L. Montagnier, and A. Blanchard. 1995. Kaposi's sarcoma and new herpesvirus. Lancet 345:1043.
14. Cook, P. Unpublished data.
15. Decker, L. L., P. Shankar, and G. Khan. 1996. The Kaposi sarcoma-associated herpesvirus (KSHV) is present as an intact latent genome in KS tissue but replicates in the peripheral blood mononuclear cells of KS patients. J. Exp. Med. 184:283-288.
16. Gaidano, G., K. Cechova, Y. Chang, P. S. Moore, D. M. Knowles, and R. Dalla-Favera. 1996. Establishment of AIDS-related lymphoma cell lines from lymphomatous effusions. Leukemia 10:1237-1240.
17. Gao, S. J., L. Kingsley, D. R. Hoover, T. J. Spira, C. R. Rinaldo, A. Saah, J. Phair, R. Detels, P. Parry, Y. Chang, and P. S. Moore. 1996. Seroconversion to antibodies against Kaposi's sarcoma-associated herpesvirus-related latent nuclear antigens before the development of Kaposi's sarcoma. N. Engl. J. Med. 335:233-241.
18. Gao, S. J., L. Kingsley, M. Li, W. Zheng, C. Parravicini, J. Ziegler, R. Newton, C. R. Rinaldo, A. Saah, J. Phair, R. Detels, Y. Chang, and P. S. Moore. 1996. KSHV antibodies among North Americans, Italians, and Ugandans with and without Kaposi's sarcoma. Nat. Med. 2:925-928.
19. Jung, J. U., and R. C. Desrosiers. 1991. Identification and characterization of the herpesvirus saimiri oncoprotein STP-C488. J. Virol. 65:6953-6960.
20. Kedes, D. H., E. Operskalski, M. Busch, R. Kohn, J. Flood, and D. Ganem. 1996. The seroepidemiology of human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus): distribution of infection in Kaposi's sarcoma risk groups and evidence for sexual transmission. Nat. Med. 2:918-924.
21. Kieff, E. 1996. Epstein-Barr virus and its replication, p. 1109-1166. In B. N. Fields, D. M. Knipe, P. M. Howley, et al. (ed.), Fundamental virology, 3rd ed. Lippincott-Raven, Philadelphia, Pa.
22. Lebbé, C., P. de Crémoux, M. Rybojad, C. Costa da Cunha, P. Morel, and F. Calvo. 1995. Kaposi's sarcoma and new herpesvirus. Lancet 345:1180.
23. Lennette, E. T., D. J. Blackbourn, and J. A. Levy. 1996. Antibodies to human herpesvirus type 8 in the general population and in Kaposi's sarcoma patients. Lancet 348:858-861.
24. Lomonte, P., M. Bublot, V. van Santen, G. M. Keil, P.-P. Pastoret, and E. Thiry. 1995. Analysis of bovine herpesvirus 4 genomic regions located outside the conserved gammaherpesvirus gene blocks. J. Gen. Virol. 76:1835-1841.
25. Melbye, M., P. M. Cook, H. Hjalgrim, K. Begtrup, G. R. Simpson, R. J. Biggar, P. Ebbesen, and T. F. Schulz. Risk factors for HHV-8 seropositivity in a cohort of homosexual men, 1981-1996. Submitted for publication.
26. Miller, G., M. O. Rigsby, L. Heston, E. Grogan, R. Sun, C. Metroka, J. A. Levy, S.-J. Gao, Y. Chang, and P. S. Moore. 1996. Antibodies to butyrate-inducible antigens of Kaposi's sarcoma-associated herpesvirus in patients with HIV-1 infection. N. Engl. J. Med. 334:1292-1297.
27. Miller G., L. Heston, E. Grogan, L. Gradoville, M. Rigsby, R. Sun, D. Shedd, V. M. Kushnaryov, S. Grossberg, and Y. Chang. 1997. Selective switch between latency and lytic replication of Kaposi's sarcoma herpesvirus and Epstein-Barr virus in dually infected body cavity lymphoma cells. J. Virol. 71:114-324.
28. Moore, P. S., and Y. Chang. 1995. Detection of herpesvirus-like DNA sequences in Kaposi's sarcoma in patients with and without HIV infection. N. Engl. J. Med. 332:1181-1185.
29. Moore, P. S., L. A. Kingsley, S. D. Holmberg, T. Spira, P. Gupta, D. R. Hoover, J. P. Parry, L. Conley, H. W. Jaffe, and Y. Chang. 1996. KSHV infection prior to onset of Kaposi's sarcoma. AIDS 10:175-180.
30. Moore, P. S., S. J. Gao, G. Dominguez, E. Cesarman, O. Lungu, D. M. Knowles, R. Garber, P. E. Pellett, D. J. McGeoch, and Y. Chang. 1996. Primary characterization of a herpesvirus agent associated with Kaposi's sarcoma. J. Virol. 70:549-558.
31. Moore, P. S., C. Boshoff, R. A. Weiss, and Y. Chang. 1996. Molecular mimicry of human cytokine and cytokine response pathway genes by KSHV. Science 274:1739-1744.
32. Peterman, T. A., H. W. Jaffe, and V. Beral. 1993. Epidemiological clues to the etiology of Kaposi's sarcoma. AIDS 7:605-611.
33. Renne, R., W. Zhong, B. Herndier, M. McGrath, N. Abbey, D. Kedes, and D. Ganem. 1996. Lytic growth of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in culture. Nat. Med. 2:342-346.
34. Russo, J. J., R. A. Bohenzky, M.-C. Chien, J. Chen, M. Yan, D. Maddalena, J. P. Parry, D. Peruzzi, I. S. Edelman, Y. Chang, and P. S. Moore. 1996. Nucleotide sequence of Kaposi's sarcoma-associated herpesvirus (HHV 8). Proc. Natl. Acad. Sci. USA 93:14862-14868.
35. Sarid, R., and Y. Chang. Unpublished observations.
36. Schalling, M., M. Ekman, E. E. Kaaya, A. Linde, and P. Biberfeld. 1995. A role for a new herpesvirus (KSHV) in different forms of Kaposi's sarcoma. Nat. Med. 1:707-708.
37. Schulz, T. F. Unpublished observations.
38. Simpson, G. R., T. F. Schulz, D. Whitby, P. M. Cook, C. Boshoff, L. Rainbow, M. R. Howard, S.-J. Gao, R. A. Bohenzky, P. Simmonds, C. Lee, A. de Ruiter, A. Hatzakis, R. S. Tedder, I. V. D. Weller, R. A. Weiss, and P. S. Moore. 1996. Prevalence of Kaposi's sarcoma-associated herpesvirus infection measured by antibodies to recombinant capsid protein and latent immunofluorescence antigen. Lancet 348:1133-1138.
39. Soulier, J., L. Grollet, E. Oksenhendler, P. Cacoub, D. Cazals-Hatem, P. Babinet, M. F. d'Agay, J. P. Clauvel, M. Raphael, L. Degos, and F. Sigaux. 1995. Kaposi's sarcoma-associated herpesvirus-like DNA sequences in multicentric Castleman's disease. Blood 86:1276-1280.
40. Staskus, K. A., W. Zhong, K. Gebhard, B. Herndier, H. Wang, R. Renne, J. Beneke, J. Pudney, D. J. Anderson, D. Ganem, and A. T. Haase. 1997. Kaposi's sarcoma-associated herpesvirus gene expression in endothelial (spindle) tumor cells. J. Virol. 71:715-719.
41. Stürzl, M. Personal communication.
42. Tetford, E. A. R., M. S. Watson, H. C. Aird, J. Perry, and A. J. Davison. 1995. The DNA sequence of equine herpesvirus 2. J. Mol. Biol. 249:520-528.
43. Thome, M., P. Schneider, K. Hofmann, H. Fickenscher, E. Meinl, F. Neipel, C. Mattmann, K. Burns, J.-L. Bodmer, M. Schröter, C. Scaffidi, P. H. Krammer, M. E. Peter, and J. Tschopp. 1997. Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors. Nature 386:517-521.
44. Whitby, D., M. R. Howard, M. Tenant-Flowers, N. S. Brink, A. Copas, C. Boshoff, T. Hatzioannou, F. E. Suggett, D. M. Aldam, A. S. Denton, R. F. Miller, I. V. D. Weller, R. A. Weiss, R. S. Tedder, and T. F. Schulz. 1995. Detection of Kaposi sarcoma-associated herpesvirus (KSHV) in peripheral blood of HIV-infected individuals and progression to Kaposi's sarcoma. Lancet 346:799-802.
45. Zhong, Y., H. Wang, B. Herndier, and D. Ganem. 1996. Restricted expression of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) genes in Kaposi's sarcoma. Proc. Natl. Acad. Sci. USA 93:6641-6646.