Maintaining mammalian iron and oxygen homeostasis: Sensors, regulation, and cross-talk

Annals of the New York Academy of Sciences

Volumn 1177, Issue , 2009, Pages 30-38

  Salahudeen, Ameen A ^a   Bruick, Richard K ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

FBXL5; Hemerythrin; Hypoxia; Hypoxia inducible factor (HIF); Iron; Iron regulatory protein (IRP); Iron and 2 oxoglutarate dependent dioxygenase; Oxygen

Indexed keywords

IRON; IRON REGULATORY FACTOR; MESSENGER RNA; OXYGEN;

CONFERENCE PAPER; GENE TARGETING; HOMEOSTASIS; NONHUMAN; REGULATORY MECHANISM; RNA STABILITY; TRANSLATION REGULATION;

MAMMALIA;

EID: 70350357467     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2009.05038.x     Document Type: Conference Paper

References (44)

1. Ozer, A. & R.K. Bruick. 2007. Non-heme dioxygenases: cellular sensors and regulators jelly rolled into one? Nat. Chem. Biol. 3: 144-153.
2. Rouault, T.A. 2006. The role of iron regulatory proteins in mammalian iron homeostasis and disease. Nat. Chem. Biol. 2: 406-414.
3. Wallander, M.L., E.A. Leibold & R.S. Eisenstein. 2006. Molecular control of vertebrate iron homeostasis by iron regulatory proteins. Biochim. Biophys. Acta 1763: 668-689.
4. Galaris, D. & K. Pantopoulos. 2008. Oxidative stress and iron homeostasis: mechanistic and health aspects. Crit. Rev. Clin. Lab. Sci. 45: 1-23.
5. Hentze, M.W., M.U. Muckenthaler & N.C. Andrews. 2004. Balancing acts: molecular control of mammalian iron metabolism. Cell 117: 285-297.
6. Semenza, G.L. 2007. Hypoxia-inducible factor 1 (HIF-1) pathway. Sci. STKE 2007: cm8.
7. Ivan, M., K. Kondo, H. Yang, et al. 2001. HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications forO2 sensing. Science 292: 464-468.
8. Jaakkola, P., D.R. Mole, Y.M. Tian, et al. 2001. Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science 292: 468-472.
9. Bruick, R.K. & S.L. McKnight. 2001. A conserved family of prolyl-4-hydroxylases that modify HIF. Science 294: 1337-1340.
10. Epstein, A.C., J.M. Gleadle, L.A.McNeill, et al. 2001. C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell 107: 43-54.
11. Ivan, M., T. Haberberger, D.C. Gervasi, et al. 2002. Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor. Proc. Natl. Acad. Sci. USA 99: 13459-13464.
12. Lando,D.,D.J. Peet, J.J. Gorman, et al. 2002. FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor. Genes Dev. 16: 1466-1471.
13. Peyssonnaux, C., V. Nizet & R.S. Johnson. 2008. Role of the hypoxia inducible factors HIF in iron metabolism. Cell Cycle 7: 28-32.
14. Muckenthaler,M.U., B. Galy &M.W. Hentze. 2008. Systemic iron homeostasis and the iron-responsive element/iron-regulatory protein (IRE/IRP) regulatory network. Annu. Rev. Nutr. 28: 197-213.
15. Pantopoulos, K. 2004. Iron metabolism and the IRE/IRP regulatory system: an update. Ann. N. Y. Acad. Sci. 1012: 1-13.
16. Wrighting, D.M. & N.C. Andrews. 2008. Iron homeostasis and erythropoiesis. Curr. Top. Dev. Biol. 82: 141-167.
17. Nemeth, E., M.S. Tuttle, J. Powelson, et al. 2004. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 306: 2090-2093.
18. Piccinelli, P. & T. Samuelsson. 2007. Evolution of the iron-responsive element. RNA 13: 952-966.
19. Koeller,D.M., J.L. Casey,M.W.Hentze, et al. 1989.A cytosolic protein binds to structural elements within the iron regulatory region of the transferrin receptor mRNA. Proc. Natl. Acad. Sci. USA 86: 3574-3578.
20. Meyron-Holtz, E.G., M.C. Ghosh, K. Iwai, et al. 2004. Genetic ablations of iron regulatory proteins 1 and 2 reveal why iron regulatory protein 2 dominates iron homeostasis. EMBO J. 23: 386-395.
21. LaVaute, T., S. Smith, S. Cooperman, et al. 2001. Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice. Nat. Genet. 27: 209-214.
22. Smith, S.R., M.C. Ghosh, H. Ollivierre-Wilson, et al. 2006. Complete loss of iron regulatory proteins 1 and 2 prevents viability of murine zygotes beyond the blastocyst stage of embryonic development. Blood Cells Mol. Dis. 36: 283-287.
23. Galy, B., D. Ferring, B. Minana, et al. 2005. Altered body iron distribution and microcytosis in mice defi- cient in iron regulatory protein 2 (IRP2). Blood 106: 2580-2589.
24. Wingert, R.A., J.L. Galloway, B. Barut, et al. 2005. Deficiency of glutaredoxin 5 reveals Fe-S clusters are required for vertebrate haem synthesis. Nature 436: 1035-1039.
25. Pondarre, C., B.B. Antiochos, D.R. Campagna, et al. 2006. The mitochondrial ATP-binding cassette transporter Abcb7 is essential in mice and participates in cytosolic iron-sulfur cluster biogenesis. Hum. Mol. Genet. 15: 953-964.
26. Knowles, H.J., R.R. Raval, A.L. Harris, et al. 2003. Effect of ascorbate on the activity of hypoxiainducible factor in cancer cells. Cancer Res. 63: 1764-1768.
27. Sanchez, M., B. Galy, M.U. Muckenthaler, et al. 2007. Iron-regulatory proteins limit hypoxiainducible factor-2alpha expression in iron deficiency. Nat. Struct. Mol. Biol. 14: 420-426.
28. Zimmer, M., B.L. Ebert, C. Neil, et al. 2008. Smallmolecule inhibitors of HIF-2a translation link its 5 prime;UTR iron-responsive element to oxygen sensing. Mol. Cell 32: 838-848.
29. Mendel, G.A. 1961. Studies on iron absorption. I. The relationships between the rate of erythropoiesis, hypoxia and iron absorption. Blood 18: 727-736.
30. Shah, Y.M., T. Matsubara, S. Ito, et al. 2009. Intestinal hypoxia-inducible transcription factors are essential for iron absorption following iron deficiency. Cell Metab. 9: 152-164.
31. Mastrogiannaki, M., P. Matak, B. Keith, et al. 2009. HIF-2alpha, but not HIF-1alpha, promotes iron absorption in mice. J. Clin. Invest. 119: 1159-1166.
32. Peyssonnaux, C., A.S. Zinkernagel, R.A. Schuepbach, et al. 2007. Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs). J. Clin. Invest. 117: 1926-1932.
33. Nicolas, G., C. Chauvet, L. Viatte, et al. 2002. The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation. J. Clin. Invest. 110: 1037-1044.
34. Meyron-Holtz, E.G., M.C. Ghosh & T.A. Rouault. 2004. Mammalian tissue oxygen levels modulate iron-regulatory protein activities in vivo. Science 306: 2087-2090.
35. Hanson, E.S., M.L. Rawlins & E.A. Leibold. 2003. Oxygen and iron regulation of iron regulatory protein 2. J. Biol. Chem. 278: 40337-40342.
36. Salahudeen, A.A., J.T. Thompson, J.C. Ruiz, et al. Submitted. An E3 ligase possessing an iron responsive hemerythrin domain is a regulator of iron homeostasis. Science. In press.
37. Stenkamp, R.E. 1994. Dioxygen and hemerythrin. Chem. Rev. 94: 715-726.
38. French, C.E., J.M. Bell & F.B. Ward. 2008. Diversity and distribution of hemerythrin-like proteins in prokaryotes. FEMS Microbiol. Lett. 279: 131-145.
39. Hentze,M.W.&L.C.Kuhn. 1996. Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress. Proc. Natl. Acad. Sci. USA. 93: 8175-8182.
40. Taylor, C.T. 2008. Mitochondria and cellular oxygen sensing in the HIF pathway. Biochem. J. 409: 19-26.
41. Lee, D.W. & J.K. Andersen. 2006. Role of HIF-1 in iron regulation: potential therapeutic strategy for neurodegenerative disorders. Curr. Mol. Med. 6: 883-893.
42. Olivares,D., X. Huang, L. Branden, et al. 2009. Physiological and pathological role of alpha-synuclein in Parkinson disease through iron mediated oxidative stress; the role of a putative iron-responsive element. Int. J. Mol. Sci. 10: 1226-1260.
43. Manalo, D.J., A. Rowan, T. Lavoie, et al. 2005. Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1. Blood 105: 659-669.
44. Xia, X., E.M. Lemieux, W. Li, et al. 2009. Integrative analysis of HIF binding and transactivation reveals its role in maintaining histone methylation homeostasis. Proc. Natl. Acad. Sci. USA 106: 4260-4265.