The Acinetobacter baumannii oxymoron: Commensal hospital dweller turned pan-drug-resistant menace

Frontiers in Microbiology

Volumn 3, Issue APR, 2012, Pages

  Roca, Ignasi ^a   Espinal, Paula ^a   Vila Fanés, Xavier ^a   Vila, Jordi ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

Author keywords

Acinetobacter baumannii; Antimicrobial peptides; Antimicrobial resistance; Biofilm; Pathogenesis

Indexed keywords

EID: 84864768392     PISSN: None     EISSN: 1664302X     Source Type: Journal    
DOI: 10.3389/fmicb.2012.00148     Document Type: Article

References (356)

1. Acosta, J., Merino, M., Viedma, E., Poza, M., Sanz, E, Otero, J. R., Chaves, E, and Bou, G. (2011). Multidrug-resistant Acinetobacter baumannii Harboring OXA-24 carbapenemase, Spain. Emerging Infect. Dis. 17, 1064-1067.
2. Adams, M. D., Chan, E. R., Molyneaux, N. D., and Bonomo, R. A. (2010). Genomewide analysis of divergence of antibiotic resistance determinants in closely related isolates of Acinetobacter baumannii. Antimicrob. Agents Chemother. 54, 3569-3577.
3. Adams, M. D., Goglin, K., Molyneaux, N., Hujer, K. M., Lavender, H., Jamison, J. J., MacDonald, I. J., Martin, K. M., Russo, T., Campagnari, A. A., Hujer, A. M., Bonomo, R. A., and Gill, S. R. (2008). Comparative genome sequence analysis of multidrug-resistant Acinetobacter baumannii. J. Bacteriol. 190, 8053-8064.
4. Adams, M. D., Nickel, G. C, Bajak-souzian, S., Lavender, H., Murthy, A. R., Jacobs, M. R., and Bonomo, R. A. (2009). Resistance to colistin in Acinetobacter baumannii associated with mutations in the PmrAB two-component system. Antimicrob. Agents Chemother. 53, 3628-3634.
5. Adams-Haduch, J. M., Onuoha, E. O., Bogdanovich, T., Tian, G. B., Marschall, J., Urban, C. M., Spellberg, B. J., Rhee, D., Halstead, D. C, Pasculle, A. W., and Doi, Y. (2011). Molecular epidemiology of carbapenem-non-susceptible Acinetobacter baumannii in the United States. J. Clin. Microbiol 49, 3849-3854.
6. Adams-Haduch, J. M., Paterson, D. L., Sidjabat, H. E., Pasculle, A. W., Potoski, B. A., Muto, C. A., Harrison, L. H., and Doi, Y. (2008). Genetic basis of multi drug resistance in Acinetobacter baumannii clinical isolates at a tertiary medical center in Pennsylvania. Antimicrob. Agents Chemother. 52, 3837-3843.
7. Afzal-Shah, M., Woodford, N., and Livermore, D. M. (2001). Characterization of OXA-25, OXA-26, and OXA-27, molecular class D (3-lactamases associated with carbapenem resistance in clinical isolates of Acinetobacter baumannii. Antimicrob. Agents Chemother. 45, 583-588.
8. Al-Sweih, N. A., Al-Hubail, M. A., and Rotimi, V. O. (2011). Emergence of tigecycline and colistin resistance in Acinetobacter species isolated from patients in Kuwait hospitals. J. Chemother. 23, 13-16.
9. Ambler, R. P. (1980). The structure of 3-lactamases. Philos. Trans. R. Soc. Lond. B. Biol Sci. 289, 321-331.
10. Andreu, D., Ubach, J., Boman, A., Wahlin, B., Wade, D., Merrifield, R. B., and Boman, H. G. (1992). Shortened cecropin A-melittin hybrids. Significant size reduction retains potent antibiotic activity. FEBS Lett. 296, 190-194.
11. Andriamanantena, T. S., Ratsima, E., Rakotonirina, H. C, Randrianirina, F., Ramparany, L., Carod, J. E, Richard, V., and Talarmin, A. (2010). Dissemination of multidrug resistant Acinetobacter baumannii in various hospitals of Antananarivo Madagascar. Ann. Clin. Microbiol. Antimicrob. 9, 17.
12. Antunes, L. C, Imperi, E, Carattoli, A., and Visca, P. (2011a). Deciphering the multifactorial nature of Acinetobacter baumannii pathogenicity. PLoS ONE 6, e22674. doi:10.1371/journal.pone.0022674.g003
13. Antunes, L. C, Imperi, E, Towner, K. J., and Visca, P. (2011b). Genome-assisted identification of putative iron-utilization genes in Acinetobacter baumannii and their distribution among a genotypically diverse collection of clinical isolates. Res. Microbiol. 162,279-284.
14. Arroyo, L. A., Herrera, C. M., Fernandez, L, Hankins, J. V., Trent, M. S., and Hancock, R. E. (2011). The pmr-CAB operon mediates polymyxin resistance in Acinetobacter baumannii ATCC 17978 and clinical isolates through phosphoethanolamine modification of lipid A. Antimicrob. Agents Chemother. 55, 3743-3751.
15. Bassetti, M., Repetto, E., Righi, E., Boni, S., Diverio, M., Molinari, M. P., Mussap, M., Artioli, S., Ansaldi, E, Durando, P., Orengo, G., Bobbio Pallavicini, E, and Viscoli, C. (2008). Colistin and rifampicin in the treatment of multidrug-resistant Acinetobacter baumannii infections. J. Antimicrob. Chemother. 61, 417-420.
16. Beceiro, A., Llobet, E., Aranda, J., Bengoechea, J. A., Doumith, M., Hornsey, M., Dhanji, H., Chart, H., Bou, G., Livermore, D. M., and Woodford, N. (2011). Phosphoethanolamine modification of lipid A in colistin-resistant variants of Acinetobacter baumannii mediated by the pmrAB two-component regulatory system. Antimicrob. Agents Chemother. 55, 3370-3379.
17. Bernards, A. T., van der Toorn, J., van Boven, C. P., and Dijkshoorn, L. (1996). Evaluation of the ability of a commercial system to identify Acinetobacter genomic species. Eur. J. Clin. Microbiol. Infect. Dis. 15, 303-308.
18. Bertini, A., Poirel, L., Bernabeu, S., Fortini, D., Villa, L., Nordmann, P., and Carattoli, A. (2007). Multicopy blaOXA-58 gene as a source of high-level resistance to carbapenems in Acinetobacter baumannii. Antimicrob. Agents Chemother. 51, 2324-2328.
19. Bertini, A., Poirel, L., Mugnier, P. D., Villa, L., Nordmann, P., and Carattoli, A. (2010). Characterization and PCR-based replicon typing of resistance plasmids in Acinetobacter baumannii. Antimicrob. Agents Chemother. 54, 4168-4177.
20. Bhargava, N., Sharma, P., and Capalash, N. (2010). Quorum sensing in Acinetobacter: an emerging pathogen. Crit. Rev. Microbiol. 36, 349-360.
21. Bogaerts, P., Naas, T., El Garch, E, Cuzon, G., Deplano, A., Delaire, T., Huang, T. D., Lissoir, B., Nordmann, P., and Glupczynski, Y. (2010). GES extended-spectrum 3-lactamases in Acinetobacter baumannii isolates in Belgium. Antimicrob. Agents Chemother. 54, 4872-4878.
22. Bonnet, R., Marchandin, H., Chanal, C, Sirot, D., Labia, R., De Champs, C, Jumas-Bilak, E., and Sirot, J. (2002). Chromosome-encoded class D p-lactamase OXA-23 in Proteus mirabilis. Antimicrob. Agents Chemother. 46, 2004-2006.
23. Bonnin, R. A., Nordmann, P., Potron, A., Lecuyer, H., Zahar, J. R., and Poirel, L. (2011a). Carbapenem-hydrolyzing GES-type extended-spectrum (3-lactamase in Acinetobacter baumannii. Antimicrob. Agents Chemother. 55, 349-354.
24. Bonnin, R. A., Potron, A., Poirel, L., Lecuyer, H., Neri, R., and Nordmann, P. (2011b). PER-7, an extended-spectrum beta-lactamase with increased activity toward broad-spectrum cephalosporins in Acinetobacter baumannii. Antimicrob. Agents Chemother. 55, 2424-2427.
25. Bonnin, R. A., Poirel, L., and Nordmann, P. (2012). AbaR-type transposon structures in Acinetobacter baumannii. J. Antimicrob. Chemother. 67, 234-236.
26. Bou, G., Cervero, G., Dominguez, M. A., Quereda, C, and Martinez-Beltran, J. (2000a). Characterization of a nosocomial outbreak caused by a multiresistant Acinetobacter baumannii strain with a carbapenem-hydrolyzing enzyme: high-level carbapenem resistance in A. baumannii is not due solely to the presence of 3-lactamases. J. Clin. Microbiol. 38, 3299-3305.
27. Bou, G., and Martinez-Beltran, J. (2000b). Cloning, nucleotide sequencing, and analysis of the gene encoding an AmpC (3-lactamase in Acinetobacter baumannii. Antimicrob. Agents Chemother. 44, 428-432.
28. Bou, G., Oliver, A., and Martinez-Beltran, J. (2000c). OXA-24, a novel class D 3-lactamase with car-bapenemase activity in an Acinetobacter baumannii clinical strain. Antimicrob. Agents Chemother. 44, 1556-1561.
29. Braunstein, A., Papo, N., and Shai, Y. (2004). In vitro activity and potency of an intravenously injected antimicrobial peptide and its DL amino acid analog in mice infected with bacteria. Antimicrob. Agents Chemother. 48, 3127-3129.
30. Bresser, P., van Alphen, L., Habets, E J., Hart, A. A., Dankert, J., Jansen, H. M., and Lutter, R. (1997). Persisting Haemophilus influenzae strains induce lower levels of interleukin-6 and interleukin-8 in H292 lung epithelial cells than nonpersisting strains. Eur. Respir. J. 10,2319-2326.
31. Brown, S., Young, H. K., and Amyes, S. G. (2005). Characterisation of OXA-51, a novel class D carbapenemase found in genetically unrelated clinical strains of Acinetobacter baumannii from Argentina. Clin. Microbiol. Infect. 11, 15-23.
32. Bush, K., and Jacoby, G. A. (2010). Updated functional classification of (3-lactamases. Antimicrob. Agents Chemother. 54, 969-976.
33. Camarena, L., Bruno, V., Euskirchen, G., Poggio, S., and Snyder, M. (2010). Molecular mechanisms of ethanol-induced pathogenesis revealed by RNA-sequencing. PLoS Pathog. 6, el000834. doi:10.1371/journal.ppat.1000834.t001
34. Canton, R., and Coque, T. M. (2006). The CTX-M 3-lactamase pandemic. Curr. Opin. Microbiol. 9,466-475.
35. Cayo, R., Rodriguez, M. C, Espinal, P., Fernandez-Cuenca, F., Ocampo-Sosa, A. A., Pascual, A., Ayala, J. A., Vila, J., and Martinez-Martinez, L. (2011). Analysis of genes encoding for penicillin-binding proteins in clinical isolates of Acinetobacter baumannii. Antimicrob. Agents Chemother. 55,5907-5913.
36. Celenza, G., Pellegrini, C, Caccamo, M., Segatore, B., Amicosante, G., and Perilli, M. (2006). Spread of blaCTX-M-type and blaPER-2 3-lactamase genes in clinical isolates from Bolivian hospitals. J. Antimicrob. Chemother. 57, 975-978.
37. Cerqueira, G. M., and Peleg,A. Y. (2011). Insights into Acinetobacter baumannii pathogenicity. IUBMB Life 63, 1055-1060.
38. Chan, K. G., Atkinson, S., Mathee, K., Sam, C. K., Chhabra, S. R., Camara, M., Koh, C. L., and Williams, P. (2011). Characterization of N-acylhomoserine lactone-degrading bacteria associated with the Zingiber offtcinale (ginger) rhizosphere: co-existence of quorum quenching and quorum sensing in Acinetobacter and Burk-holderia. BMC Microbiol. 11, 51. doi:10.1186/1471-2180-11-51
39. Chen, Y., Vasil, A. I., Rehaume, L., Mant, C. T., Burns, J. L., Vasil, M. L, Hancock, R. E., and Hodges, R. S. (2006). Comparison of biophysical and biologic properties of alpha-helical enantiomeric antimicrobial peptides. Chem. Biol. Drug Des. 67, 162-173.
40. Chen, Y, Zhou, Z., Jiang, Y, and Yu, Y (2011). Emergence of NDM-1-producing Acinetobacter baumannii in China. J. Antimicrob. Chemother. 66, 1255-1259.
41. Cho, Y J., Moon, D. C, Jin, J. S., Choi, C. H., Lee, Y. C, and Lee, J. C. (2009). Genetic basis of resistance to amino-glycosides in Acinetobacter spp. and spread of armA in Acinetobacter baumannii sequence group 1 in Korean hospitals. Diagn. Microbiol. Infect. Dis. 64, 185-190.
42. Choi, A. H., Slamti, L., Avci, E Y, Pier, G. B., and Maira-Litran, T. (2009). The pgaABCD locus of Acinetobacter baumannii encodes the production of poly-beta-1-6-N-acetylglucosamine, which is critical for biofirm formation. J. Bacterial. 191,5953-5963.
43. Choi, C. H., Lee, E.Y, Lee, Y.C., Park, T. I., Kim, H. J., Hyun, S. H., Kim, S. A., Lee, S. K., and Lee, J. C. (2005). Outer membrane protein 38 of Acinetobacter baumannii localizes to the mitochondria and induces apoptosis of epithelial cells. Cell. Microbiol. 7, 1127-1138.
44. Choi, C. H., Lee, J. S., Lee, Y C, Park, T. I., and Lee, J. C. (2008). Acinetobacter baumannii invades epithelial cells and outer membrane protein A mediates interactions with epithelial cells. BMC Microbiol. 8, 216. doi:10.1186/1471-2180-8-216
45. Chu, Y. W., Afzal-Shah, M., Houang, E. T., Palepou, M. I., Lyon, D. J., Woodford, N., and Livermore, D. M. (2001). IMP-4, a novel metallo-p-lactamase from nosocomial Acinetobacter spp. collected in Hong Kong between 1994 and 1998. Antimicrob. Agents Chemother. 45, 710-714.
46. Chu, Y W., Chau, S. L., and Houang, E. T. (2006). Presence of active efflux systems AdeABC, AdeDE and AdeXYZ in different Acinetobacter genomic DNA groups. J. Med. Microbiol. 55, 477-478.
47. Clemmer, K. M., Bonomo, R. A., and Rather, P. N. (2011). Genetic analysis of surface motility in Acinetobacter baumannii. Microbiology 157, 2534-2544.
48. Conlon, J. M., Ahmed, E., and Condamine, E. (2009). Antimicrobial properties of brevinin-2-related peptide and its analogs: efficacy against multidrug-resistant Acinetobacter baumannii. Chem. Biol. Drug Des. 74, 488-493.
49. Conlon, J. M., Ahmed, E., Pal, T., and Sonnevend, A. (2010). Potent and rapid bactericidal action of alyteserinlc and its [E4K] analog against multidrug-resistant strains of Acinetobacter baumannii. Peptides 31,1806-1810.
50. Cornaglia, G., Giamarellou, H., and Rossolini, G. M. (2011). Metallo-3-lactamases: a last frontier for (3-lactams? Lancet Infect. Dis. 11, 381-393.
51. Corvee, S., Poirel, L., Naas, T., Drugeon, H., and Nordmann, P. (2007). Genetics and expression of the carbapenem-hydrolyzing oxacillinase gene blaOXA-23 in Acinetobacter baumannii. Antimicrob. Agents Chemother. 51, 1530-1533.
52. Costerton, J. (1995). Overview of microbial biofilsm. J. Ind. Microbiol. 15, 137-140.
53. Coyne, S., Guigon, G., Courvalin, P., and Perichon, B. (2010a). Screening and quantification of the expression of antibiotic resistance genes in Acinetobacter baumannii with a microarray. Antimicrob. Agents Chemother. 54, 333-340.
54. Coyne, S., Rosenfeld, N., Lambert, T., Courvalin, P., and Perichon, B. (2010b). Overexpression of resistance-nodulation-cell division pump AdeFGH confers multidrug resistance in Acinetobacter baumannii. Antimicrob. Agents Chemother. 54,4389-4393.
55. Culebras, E., Gonzalez-Romo, E, Head, J., Gomez, M., Morales, G., and Picazo, J. J. (2010). Outbreak of Acinetobacter baumannii producing OXA-66 in a Spanish hospital: epidemiology and study of patient movements. Microb. Drug Resist. 16, 309-315.
56. Da Silva, G. J., Correia, M., Vital, C, Ribeiro, G., Sousa, J. C, Leitao, R., Peixe, L., and Duarte,A. (2002). Molecular characterization of blalMP-5, a new integron-borne metallof)-lactamase gene from an Acinetobacter baumannii nosocomial isolate in Portugal. FEMS Microbiol. Lett. 215, 33-39.
57. Damier-Piolle, L., Magnet, S., Bremont, S., Lambert, T., and Courvalin, P. (2008). AdelJK, a resistance-nodulation-cell division pump effluxing multiple antibiotics in Acinetobacter baumannii. Antimicrob. Agents Chemother. 52, 557-562.
58. D'Andrea, M. M., Giani, T., D'Arezzo, S., Capone, A., Petrosillo, N., Visca, P., Luzzaro, E, and Rossolini, G. M. (2009). Characterization of pABVAOl, a plasmid encoding the OXA-24 carbapenemase from Italian isolates of Acinetobacter baumannii. Antimicrob. Agents Chemother. 53, 3528-3533.
59. D'Arezzo, S., Capone, A., Petrosillo, N., Visca, P., Ballardini, M., Bartolini, S., Bordi, E., Di Stefano, A., Galie, M., Minniti, R., Meledandri, M., Pacciani, L., Parisi, G., Prignano, G., Santini, C, Valmarin, M., Venditti, M., and Ziantoni, S. (2009). Epidemic multidrug-resistant Acinetobacter baumannii related to European Clonal Types I and II in Rome (Italy). Clin. Microbiol. Infect. 15, 347-357.
60. Davies, T. A., Marie Queenan, A., Morrow, B. J., Shang, W., Amsler, K., He, W., Lynch, A. S., Pillar, C, and Flamm, R. K. (2011). Longitudinal survey of carbapenem resistance and resistance mechanisms in Enter-obacteriaceae and non-fermenters from the USA in 2007-09. J. Antimicrob. Chemother. 66, 2298-2307.
61. de Breij, A., Dijkshoorn, L., Lagendijk, E., van der Meer, J., Koster, A., Bloemberg, G., Wolterbeek, R., van den Broek, P., and Nibbering, P. (2010). Do biofirm formation and interactions with human cells explain the clinical success of Acinetobacter baumannii1. PLoS ONE 5, elO732. doi:10.1371/journal.pone.0010732
62. de Breij, A., Gaddy, J., van der Meer, J., Koning, R., Koster, A., van den Broek, P., Actis, L., Nibbering, P., and Dijkshoorn, L. (2009). CsuA/BABCDE-dependent pili are not involved in the adherence of Acinetobacter baumannii ATCC19606(T) to human airway epithelial cells and their inflammatory response. Res. Microbiol 160, 213-218.
63. De La Fuente, L., Burr, T. J., and Hoch, H. C. (2007). Mutations in type I and type IV pilus biosynthetic genes affect twitching motility rates in Xylella fastidiosa. J. Bacterial. 189, 7507-7510.
64. del Mar Tomas, M., Beceiro, A., Perez, A., Velasco, D., Moure, R., Villanueva, R., Martinez-Beltran, J., and Bou, G. (2005). Cloning and functional analysis of the gene encoding the 33-to 36-kilodalton outer membrane protein associated with carbapenem resistance in Acinetobacter baumannii. Antimicrob. Agents Chemother. 49,5172-5175.
65. Di Nocera, P. P., Rocco, E, Giannouli, M., Triassi, M., and Zarrilli, R. (2011). Genome organization of epidemic Acinetobacter baumannii strains. BMC Microbiol 11, 224. doi:10.1186/1471-2180-11-224
66. Di Popolo, A., Giannouli, M., Triassi, M., Brisse, S., and Zarrilli, R. (2011). Molecular epidemiological investigation of multidrug-resistant Acinetobacter baumannii strains in four Mediterranean countries with a multilocus sequence typing scheme. Clin. Microbiol. Infect. 17, 197-201.
67. Dijkshoorn, L., Brouwer, C. P., Bogaards, S. J., Nemec, A., van den Broek, P. J., and Nibbering, P. H. (2004). The synthetic N-terminal peptide of human lactoferrin, hLF(l-l 1), is highly effective against experimental infection caused by multidrug-resistant Acinetobacter baumannii. Antimicrob. Agents Chemother. 48, 4919-4921.
68. Dijkshoorn, L., Nemec, A., and Seifert, H. (2007). An increasing threat in hospitals: multidrug-resistant Acinetobacter baumannii. Nat. Rev. Microbiol. 5,939-951.
69. Docquier, J. D., Lamotte-Brasseur, J., Galleni, M., Amicosante, G., Frere, J. M., and Rossolini, G. M. (2003). On functional and structural heterogeneity of VIM-type metallo-(3-lactamases. J. Antimicrob. Chemother. 51,257-266.
70. Doi, Y., Adams, J. M., Yamane, K., and Paterson, D. L. (2007). Identification of 16S rRNA methylase-producing Acinetobacter baumannii clinical strains in North America. Antimicrob. Agents Chemother. 51, 4209-4210.
71. Doi, Y, and Arakawa, Y (2007). 16S ribosomal RNA methylation: emerging resistance mechanism against aminoglycosides. Clin. Infect. Dis. 45, 88-94.
72. Donlan, R. (2002). Biofilms: microbial life on surfaces. Emerging Infect. Dis. 8,881-890.
73. Donnarumma, F., Sergi, S., Indorato, C, Mastromei, G., Monnanni, R., Nicoletti, P., Pecile, P., Cecconi, D., Mannino, R., Bencini, S., Fanci, R., Bosi, A., and Casalone, E. (2010). Molecular characterization of Acinetobacter isolates collected in intensive care units of six hospitals in Florence, Italy, during a 3-year surveillance program: a population structure analysis. J. Clin. Microbiol. 48, 1297-1304.
74. Dorsey, C. W., Beglin, M. S., and Actis, L. A. (2003a). Detection and analysis of iron uptake components expressed by Acinetobacter baumannii clinical isolates. J. Clin. Microbiol. 41, 4188-4193.
75. Dorsey, C. W., Tolmasky, M. E., Crosa, J. H., and Actis, L. A. (2003b). Genetic organization of an Acinetobacter baumannii chromosomal region harbouring genes related to siderophore biosynthesis and transport. Microbiology 149, 1227-1238.
76. Drawz, S. M., Babic, M., Bethel, C. R., Taracila, M., Distler, A. M., Ori, C, Caselli, E., Prati, F., and Bonomo, R. A. (2010). Inhibition of the class C (3-lactamase from Acinetobacter spp.: insights into effective inhibitor design. Biochemistry 49, 329-340.
77. Dupont, M., Pages, J. M., Lafitte, D., SiroyA., and Bollet.C. (2005). Identification of an OprD homologue in Acinetobacter baumannii. J. Proteome Res. 4,2386-2390.
78. Eijkelkamp, B. A., Stroeher, U. H., Hassan, K. A., Papadimitrious, M. S., Paulsen, I. T., and Brown, M. H. (2011). Adherence and motility characteristics of clinical Acinetobacter baumannii isolates. FEMS Microbiol. Lett. 323, 44-51.
79. Endimiani, A., Luzzaro, E, Migliavacca, R., Mantengoli, E., Hujer, A. M., Hujer, K. M., Pagani, L., Bonomo, R. A., Rossolini, G. M., and Toniolo, A. (2007). Spread in an Italian hospital of a clonal Acinetobacter baumannii strain producing the TEM-92 extended-spectrum (3-lactamase. Antimicrob. Agents Chemother. 51, 2211-2214.
80. Erridge, C, Moncayo-Nieto, O. L., Morgan, R., Young, M., and Poxton, I. R. (2007). Acinetobacter baumannii lipopolysaccharides are potent stimulators of human monocyte activation via Tolllike receptor 4 signalling. J. Med. Microbiol. 56, 165-171.
81. Espinal, P., Fugazza, G., Lopez, Y, Kasma, M., Lerman, Y, Malhotra-Kumar, S., Goosens, H., Carmeli, Y, and Vila, J. (2011a). Dissemination of the NDM-2-producing Acinetobacter baumannii clone in an Israeli Rehabilitation Center. Antimicrob. Agents Chemother. 55, 5396-5398.
82. Espinal, P., Roca, I., and Vila, J. (2011b). Clinical impact and molecular basis of antimicrobial resistance in non-baumannii Acinetobacter. Future Microbiol. 6,495-511.
83. Espinal, P., Seifert, H., Dijkshoorn, L, Vila, J., and Roca, I. (2011c). Rapid and accurate identification of genomic species from the Acinetobacter baumannii (Ab) group by MALDI-TOF MS. Clin. Microbiol. Infect, (in press). doi: 10. Ill 1/j. 1469-0691.2011.03696.x
84. Espinal, P., Marti, S., and Vila, J. (2012). Effect of biofilm formation on the survival of Acinetobacter baumannii on dry surfaces. J. Hasp. Infect. 80, 56-60.
85. Evans, B. A., Hamouda, A., Towner, K. J., and Amyes, S. G. (2010). Novel genetic context of multiple blaOXA-58 genes in Acinetobacter genospecies 3. J. Antimicrob. Chemother. 65, 1586-1588.
86. Fabrega, A., Madurga, S., Giralt, E., and Vila, J. (2009). Mechanism of action of and resistance to quinolones. Microb. Biotechnol. 2,40-61.
87. Falagas, M. E., and Kasiakou, S. K. (2005). Colistin: the revival of polymyxins for the management of multidrug-resistant Gram-negative bacterial infections. Clin. Infect. Dis. 40,1333-1341.
88. Fernandez-Cuenca, E, Martinez-Martinez, L., Conejo, M. C, Ayala, J. A., Perea, E. J., and Pascual, A. (2003). Relationship between (3-lactamase production, outer membrane protein and penicillin-binding protein profiles on the activity of carbapenems against clinical isolates of Acinetobacter baumannii. J. Antimicrob. Chemother. 51,565-574.
89. Fernandez-Cuenca, E, Smani, Y, Gomez-Sanchez, M. C, Docobo-Perez, F., Caballero-Moyano, F. J., Dominguez-Herrera, J., Pascual, A., and Pachon, J. (2011). Attenuated virulence of a slow-growing pandrug-resistant Acinetobacter baumannii is associated with decreased expression of genes encoding the porins CarO and OprD-like. Int. J. Antimicrob. Agents 38, 548-549.
90. Fernandez-Reyes, M., Diaz, D., de la Torre, B. G., Cabrales-Rico, A., Valles-Miret, M., Jimenez-Barbero,J., Andreu, D., and Rivas, L. (2010). Lysine N(epsilon)-trimethylation, a tool for improving the selectivity of antimicrobial peptides. J. Med. Chem. 53,5587-5596.
91. Fernandez-Reyes, M., Rodriguez-Falcon, M., Chiva, C, Pachon, J., Andreu, D., and Rivas, L. (2009). The cost of resistance to colistin in Acinetobacter baumannii: a proteomic perspective. Proteomics 9, 1632-1645.
92. Figueiredo, S., Poirel, L., Papa, A., Koulourida, V, and Nordmann, P. (2008). First identification of VIM-4 metallo-3-lactamase in Acinetobacter spp. Clin. Microbiol. Infect. 14, 289-290.
93. Figueiredo, S., Poirel, L., Papa, A., Koulourida, V, and Nordmann, P. (2009). Overexpression of the naturally occurring blaOXA-51 gene in Acinetobacter baumannii mediated by novel insertion sequence ISAba9. Antimicrob. Agents Chemother. 53, 4045-4047.
94. Fournier, P. E., Vallenet, D., Barbe, V, Audic, S., Ogata, H., Poirel, L, Richet, H., Robert, C, Mangenot, S., Abergel, C, Nordmann, P., Weissenbach, J., Raoult, D., and Claverie, J. M. (2006). Comparative genomics of multidrug resistance in Acinetobacter baumannii. PLoS Genet. 2, e7. doi:10.1371/joumal.pgen.0020007
95. Friedman, M. (2010). Origin, microbiology, nutrition, and pharmacology of D-amino acids. Chem. Biodivers. 7,1491-1530.
96. Gaddy, J. A., and Actis, L. A. (2009). Regulation of Acinetobacter baumannii biofilm formation. Future Microbiol. 4, 273-278.
97. Gaddy, J. A., Tomaras, A. P., and Actis, L. A. (2009). The Acinetobacter baumannii 19606 OmpA protein plays a role in biofilm formation on abiotic surfaces and in the interaction of this pathogen with eukaryotic cells. Infect. Immun. 77, 3150-3160.
98. Gales, A. C, Tognim, M. C, Reis, A. O., Jones, R. N., and Sader, H. S. (2003). Emergence of an IMP-like metalloenzyme in an Acinetobacter baumannii clinical strain from a Brazilian teaching hospital. Diagn. Microbiol. Infect. Dis. 45, 77-79.
99. Garcia, A., Salgado, F., Solar, H., Gonzalez, C. L., Zemelman, R., and Onate, A. (1999). Some immunological properties of lipopolysaccharide from Acinetobacter baumannii. I Med. Microbiol. 48, 479-483.
100. Ge, Y., MacDonald, D. L, Holroyd, K. J., Thornsberry, C, Wexler, H., and Zasloff, M. (1999). In vitro antibacterial properties of pexiganan, an analog of magainin. Antimkrob. Agents Chemother. 43, 782-788.
101. Gehrlein, M., Leying, H., Cullmann, W., Wendt, S., and Opferkuch, W. (1991). Imipenem resistance in Acinetobacter baumanii is due to altered penicillin-binding proteins. Chemotherapy 37, 405-412.
102. Giacometti, A., Cirioni, O., Del Prete, M. S., Barchiesi, E, Paggi, A. M., Petrelli, E., and Scalise, G. (2000). Comparative activities of polycationic peptides and clinically used antimicrobial agents against multidrug-resistant nosocomial isolates of Acinetobacter baumannii. J. Antimicrob. Chemother. 46, 807-810.
103. Giacometti, A., Cirioni, O., Kamysz, W., D'Amato, G., Silvestri, C, Del Prete, M. S., Lukasiak, J., and Scalise, G. (2003). Comparative activities of cecropin A, melittin, and cecropin A-melittin peptide CA(1-7)M(2-9)NH2 against multidrug-resistant nosocomial isolates of Acinetobacter baumannii. Peptides 24, 1315-1318.
104. Giannouli, M., Tomasone, F., Agodi, A., Vahaboglu, H., Daoud, Z., Triassi, M., Tsakris, A., and Zarrilli, R. (2009). Molecular epidemiology of carbapenem-resistant Acine tobacter baumannii strains in intensive care units of multiple Mediterranean hospitals. J. Antimicrob. Chemother. 63,828-830.
105. Gogou, V., Poumaras, S., Giannouli, M., Voulgari, E., Piperaki, E. T., Zarrilli, R., and Tsakris, A. (2011). Evolution of multidrug-resistant Acinetobacter baumannii clonal lineages: a 10 year study in Greece (2000-09). J. Antimicrob. Chemother. 66, 2767-2772.
106. Goic-Barisic, I., Bedenic, B., Tonkic, M., Novak, A., Katie, S., Kalenic, S., Punda-Polic, V., and Towner, K. J. (2009). Occurrence of OXA-107 and ISAbal in carbapenem-resistant isolates of Acinetobacter baumannii from Croatia. J. Clin. Microbiol. 47, 3348-3349.
107. Goic-Barisic, I., Towner, K. J., Kovacic, A., Sisko-Kraljevic, K., Tonkic, M., Novak, A., and Punda-Polic, V. (2011). Outbreak in Croatia caused by a new carbapenem-resistant clone of Acinetobacter baumannii producing OXA-72 carbapenemase. J. Hasp. Infect. 77, 368-369.
108. Gonzalez, R.H.,Dijkshoorn, L., Van den Barselaar, M., and Nudel, C. (2009). Quorum sensing signal profile of Acinetobacter strains from nosocomial and environmental sources. Rev. Argent. Microbiol. 41, 73-78.
109. Gonzalez, R. H., Nusblat, A., and Nudel, B. C. (2001). Detection and characterization of quorum sensing signal molecules in Acinetobacter strains. Microbiol Res. 155,271-277.
110. Gopalakrishnan, R., and Sureshkumar, D. (2010). Changing trends in antimicrobial susceptibility and hospital acquired infections over an 8 year period in a tertiary care hospital in relation to introduction of an infection control programme. J. Assoc. Physicians India 58(Suppl.), 25-31.
111. Gordon, N. C, Png, K., and Wareham, D. W. (2010). Potent synergy and sustained bactericidal activity of a vancomycin-colistin combination versus multidrug-resistant strains of Acinetobacter baumannii. Antimicrob. Agents Chemother. 54, 5316-5322.
112. Gribun, A., Nitzan, Y., Pechatnikov, I., Hershkovits, G., and Katcoff, D. J. (2003). Molecular and structural characterization of the HMP-AB gene encoding a pore-forming protein from a clinical isolate of Acinetobacter baumannii. Curr. Microbiol. 47, 434-443.
113. Guardabassi, L., Dijkshoorn, L., Collard, J. M., Olsen, J. E., and Dalsgaard, A. (2000). Distribution and invitro transfer of tetracycline resistance determinants in clinical and aquatic Acinetobacter strains. J. Med. Microbiol. 49, 929-936.
114. Hamouda, A., and Amyes, S. G. (2004). Novel gyrA and parC point mutations in two strains of Acinetobacter baumannii resistant to ciprofloxacin. J. Antimicrob. Chemother. 54, 695-696.
115. Henrichsen, J.,andBlom. J. (1975). Correlation between twitching motility and possession of polar fimbriae in Acinetobacter calcoaceticus. Acta Pathol. Microbiol. Scand. B 83, 103-115.
116. Heritier, C, Poirel, L., Fournier, P. E., Claverie, J. M., Raoult, D., and Nordmann, P. (2005a). Characterization of the naturally occurring oxacillinase of Acinetobacter baumannii. Antimicrob. Agents Chemother. 49, 4174-4179.
117. Heritier, C, Poirel, L., Lambert, T., and Nordmann, P. (2005b). Contribution of acquired carbapenem-hydrolyzing oxacillinases to carbapenem resistance in Acinetobacter baumannii. Antimicrob. Agents Chemother. 49, 3198-3202.
118. Heritier, C, Poirel, L., and Nordmann, P. (2006). Cephalosporinase over-expression resulting from insertion of ISAbal in Acinetobacter baumannii. Clin. Microbiol. Infect. 12, 123-130.
119. Higgins, P. G., Dammhayn, C, Hackel, M., and Seifert, H. (2010). Global spread of carbapenem-resistant Acinetobacter baumannii. J. Antimicrob. Chemother. 65,233-238.
120. Higgins, P. G., Poirel, L., Lehmann, M., Nordmann, P., and Seifert, H. (2009). OXA-143, a novel carbapenem-hydrolyzing class D 3-lactamase in Acinetobacter baumannii. Antimicrob. Agents Chemother. 53,5035-5038.
121. Higgins, P. G., Wisplinghoff, H., Stefanik, D., and Seifert, H. (2004). Selection of topoisomerase mutations and overexpression of adeB mRNA transcripts during an outbreak of Acinetobacter baumannii. J. Antimicrob. Chemother. 54, 821-823.
122. Ho,P.L.,Lo,W.U.,Yeung,M.K.,Lin,C. H., Chow, K. H., Ang, I.,Tong, A. H., Bao,J.Y.,Lok,S.,andLo,J.Y. (2011). Complete sequencing of pNDM-HK encoding NDM-1 carbapenemase from a multidrug-resistant Escherichia coli strain isolated in Hong Kong. PLoS ONE 6, el7989. doi:10.1371/journal.pone.0017989
123. Houang, E. T., Chu, Y. W., Lo, W. S., Chu, K. Y, and Cheng, A. E (2003). Epidemiology of rifampin ADP-ribosyltransferase (arr-2) and metallof)-lactamase (WaIMP-4) gene cassettes in class 1 integrons in Acinetobacter strains isolated from blood cultures in 1997 to 2000. Antimicrob. Agents Chemother. 47, 1382-1390.
124. Hu, Y, Zhang, W., Liang, H., Liu, L., Peng, G., Pan, Y, Yang, X., Zheng, B., Gao, G. E, Zhu, B., and Hu, H. (2011). Whole-genome sequence of a multidrug-resistant clinical isolate of Acinetobacter Iwoffii. J. Bacterial 193,5549-5550.
125. Huang, L. Y., Chen, T. L., Lu, P. L, Tsai, C. A., Cho, W. L., Chang, E Y, Fung, C. P., and Siu, L. K. (2008). Dissemination of multidrug-resistant, class 1 integron-carrying Acinetobacter baumannii isolates in Taiwan. Clin. Microbiol. Infect. 14, 1010-1019.
126. Huang, L. Y, Lu, P. L., Chen, T. L., Chang, F. Y, Fung, C. P., and Siu, L. K. (2010). Molecular characterization of 3-lactamase genes and their genetic structures in Acinetobacter genospecies 3 isolates in Taiwan. Antimicrob. Agents Chemother. 54, 2699-2703.
127. Hujer, K. M., Hamza, N. S., Hujer, A. M., Perez, E, Helfand, M. S., Bethel, C. R., Thomson, J. M., Anderson, V. E., Barlow, M., Rice, L. B., Tenover, E C, and Bonomo, R. A. (2005). Identification of a new allelic variant of the Acinetobacter baumannii cephalosporinase, ADC-7 betalactamase: defining a unique family of class C enzymes. Antimicrob. Agents Chemother. 49, 2941-2948.
128. Huys, G., Cnockaert, M., Nemec, A., and Swings, J. (2005a). Sequence-based typing of adeB as a potential tool to identify intraspecific groups among clinical strains of multidrug-resistant Acinetobacter baumannii. J. Clin. Microbiol. 43, 5327-5331.
129. Huys, G., Cnockaert, M., Vaneechoutte, M., Woodford, N., Nemec, A., Dijkshoorn, L., and Swings, J. (2005b). Distribution of tetracycline resistance genes in genotypically related and unrelated multiresistant Acinetobacter baumannii strains from different European hospitals. Res. Microbiol. 156,348-355.
130. Iacono, M., Villa, L., Fortini, D., Bordoni, R., Imperi, F., Bonnal, R. J. P., Sicheritz-Ponten, T., De Bellis, G., Visca, P., Cassone, A., and Carattoli, A. (2008). Whole-genome pyrose-quencing of an epidemic multidrug-resistant Acinetobacter baumannii strain belonging to the European clone II group. Antimicrob. Agents Chemother. 52,2616-2625.
131. Irie, Y., and Parsek, M. R. (2008). Quorum sensing and microbial biofilms. Curr. Top. Microbiol. Immunol. 322, 67-84.
132. Jacobs, A. C, Hood, I., Boyd, K. L, Olson, P. D., Morrison, J. M., Carson, S., Sayood, K., Iwen, P. C, Skaar, E. P., and Dunman, P. M. (2010). Inactivation of phospholipase D diminishes Acinetobacter baumannii pathogenesis. Infect. Immun. 78, 1952-1962.
133. Jarrell, K. E, and McBride, M. J. (2008). The surprisingly diverse ways that prokaryotes move. Nat. Rev. Microbiol. 6, 466-476.
134. Jawad, A., Heritage, J., Snelling, A. M., Gascoyne-Binzi, D. M., and Hawkey, P. M. (1996). Influence of relative humidity and suspending menstrua on survival of Acinetobacter spp. on dry surfaces. J. Clin. Microbiol. 34, 2881-2887.
135. Jawad, A., Seifert, H., Snelling, A., Heritage, J., and Hawkey, P. (1998). Survival of Acinetobacter baumannii on dry surfaces: comparison of outbreak and sporadic isolates. J. Clin. Microbiol. 36, 1938-1941.
136. Jiang, Z., Vasil, A. I., Gera, L, Vasil, M. L., and Hodges, R. S. (2011). Rational design of alpha-helical antimicrobial peptides to target Gram-negative pathogens, Acinetobacter baumannii and Pseudomonas aeruginosa: utilization of charge, 'specificity determinants,' total hydrophobicity, hydrophobe type and location as design parameters to improve the therapeutic ratio. Chem. Biol. Drug Des. 77, 225-240.
137. Jin, J. S., Kwon, S. O., Moon, D. C, Gurung, M., Lee, J. H., Kim, S. I., and Lee, J. C. (2011). Acinetobacter baumannii secretes cytotoxic outer membrane protein A via outer membrane vesicles. PLoS ONE 6, el7027. doi:10.1371/journal.pone.0017027.g001
138. Jones, R. N. (2010). Microbial etiologies of hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia. Clin. Infect. Dis. 51(Suppl. 1), S81-S87.
139. Kaase, M., Nordmann, P.,Wichelhaus, T. A., Gatermann, S. G., Bonnin, R. A., and Poirel, L. (2011). NDM-2 carbapenemase in Acinetobacter baumannii from Egypt. J. Antimicrob. Chemother. 66, 1260-1262.
140. Kang, Y. S., and Park, W. (2010a). Contribution of quorum-sensing system to hexadecane degradation and biofilm formation in Acinetobacter sp. strain DR1. J. Appl. Microbiol. 109, 1650-1659.
141. Kang, Y.S., and Park, W. (2010b). Tradeoff between antibiotic resistance and biological fitness in Acinetobacter sp. strain DR1. Environ. Microbiol. 12, 1304-1318.
142. Karthikeyan, K., Thirunarayan, M. A., and Krishnan, P. (2010). Coexistence of blaOXA-23 with blaNDM-1 and armA in clinical isolates of Acinetobacter baumannii from India. J. Antimicrob. Chemother. 65, 2253-2254.
143. Karunasagar, A., Maiti, B., Shekar, M., Shenoy, M. S., and Karunasagar, I. (2011). Prevalence of OXA-type carbapenemase genes and genetic heterogeneity in clinical isolates of Acinetobacter spp. from Mangalore, India. Microbiol. Immunol. 55, 239-246.
144. Kim, J. W., Heo, S. T., Jin, J. S., Choi, C. H., Lee, Y. C, Jeong, Y. G., Kim, S. J., and Lee, J. C. (2008). Characterization of Acinetobacter baumannii carrying blaOXA-23, blaPER-1 and armA in a Korean hospital. Clin. Microbiol. Infect. 14, 716-718.
145. Kim, S. W., Choi, C. H., Moon, D. C, Jin, J. S., Lee, J. H., Shin, J. H., Kim, J. M., Lee, Y. C, Seol, S. Y, Cho, D. T., and Lee, J. C. (2009). Serum resistance of Acinetobacter baumannii through the binding of factor H to outer membrane proteins. FEMS Microbiol. Lett. 301, 224-231.
146. Kitchel, B., Rasheed, J. K., Endimiani, A., Hujer, A. M., Anderson, K. E, Bonomo, R. A., and Patel, J. B. (2010). Genetic factors associated with elevated carbapenem resistance in KPC-producing Klebsiella pneumoniae. Antimicrob. Agents Chemother. 54,4201-4207.
147. Klieve, A. V., Yokoyama, M. T., Forster, R. J., Ouwerkerk, D., Bain, P. A., and Mawhinney, E. L. (2005). Naturally occurring DNA transfer system associated with membrane vesicles in cellulolytic Ruminococcus spp. of ruminal origin. Appl. Environ. Microbiol. 71,4248-4253.
148. Koh, T. H., Sng, L. H., Wang, G. C, Hsu, L. Y, and Zhao, Y (2007a). Carbapenemase and efflux pump genes in Acinetobacter calcoaceticus-Acinetobacter baumannii complex strains from Singapore. J. Antimicrob. Chemother. 60, 1173-1174.
149. Koh, T. H., Sng, L. H., Wang, G. C, Hsu, L. Y, and Zhao, Y (2007b). IMP-4 and OXA 3-lactamases in Acinetobacter baumannii from Singapore. J. Antimicrob. Chemother. 59,627-632.
150. Koo, S. H., Kwon, K. C, Cho, H. H., and Sung, J. Y (2010). Genetic basis of multidrug-resistant Acinetobacter baumannii clinical isolates from three university hospitals in Chungcheong Province, Korea. Korean}. Lab. Med. 30, 498-506.
151. Krizova, L., Dijkshoorn, L., and Nemec, A. (2011). Diversity and evolution of AbaR genomic resistance islands in Acinetobacter baumannii strains of European clone I. Antimicrob. Agents Chemother. 55,3201-3206.
152. Krizova, L., and Nemec, A. (2010). A 63 kb genomic resistance island found in a multidrug-resistant Acinetobacter baumannii isolate of European clone I from 1977. J. Antimicrob. Chemother. 65,1915-1918.
153. Kropec, A., Maira-Litran, T., Jefferson, K. K., Grout, M., Cramton, S. E., Gotz, E, Goldmann, D. A., and Pier, G. B. (2005). Poly-N-acetylglucosamine production in Staphylococcus aureus is essential for virulence in murine models of systemic infection. Infect. Immun. 73, 6868-6876.
154. Kusradze, I., Diene, S. M., Goderdzishvili, M., and Rolain, J. M. (2011). Molecular detection of OXA carbapenemase genes in multidrug-resistant Acinetobacter baumannii isolates from Iraq and Georgia. Int. J. Antimicrob. Agents 38, 164-168.
155. Kwon, S. O., Gho, Y. S., Lee, J. C, and Kim, S. I. (2009). Proteome analysis of outer membrane vesicles from a clinical Acinetobacter baumannii isolate. FEMS Microbiol. Lett. 297, 150-156.
156. Lam, C, Hildebrandt, J., Schutze, E., and Wenzel, A. E (1986). Membrane-disorganizing property of polymyxin B nonapeptide. Antimicrob. Chemother. 18, 9-15.
157. Lauretti, L., Riccio, M. L., Mazzariol, A., Cornaglia, G., Amicosante, G., Fontana, R., and Rossolini, G. M. (1999). Cloning and characterization of blaVIM, a new integron-borne metallo-3-lactamase gene from a Pseudomonas aeruginosa clinical isolate. Antimicrob. Agents Chemother. 43, 1584-1590.
158. Lee, H., Yong, D., Yum, J. H., Roh, K. H., Lee, K., Yamane, K., Arakawa, Y, and Chong, Y. (2006a). Dissemination of 16S rRNA methylase-mediated highly amikacin-resistant isolates of Klebsiella pneumoniae and Acinetobacter baumannii in Korea. Diagn. Microbiol. Infect. Dis. 56, 305-312.
159. Lee, J. C, Koerten, H., van den Broek, P., Beekhuizen, H., Wolterbeek, R., van den Barselaar, M., van der Reijden, T., van der Meer, J., van de Gevel, J., and Dijkshoorn, L. (2006b). Adherence of Acinetobacter baumannii strains to human bronchial epithelial cells. Res. Microbiol. 157,360-366.
160. Lee, J. C, Oh, J. Y, Kim, K. S., Jeong, Y W, Park, J. C, and Cho, J. W (2001). Apoptotic cell death induced by Acinetobacter baumannii in epithelial cells through caspase-3 activation. APMIS 109, 679-684.
161. Lee, K., Kim, M. N., Choi, T. Y, Cho, S. E., Lee, S., Whang, D. H., Yong, D., Chong, Y, Woodford, N., and Livermore, D. M. (2009a). Wide dissemination of OXA-type carbapenemases in clinical Acinetobacter spp. isolates from South Korea. Int. J. Antimicrob. Agents 33, 520-524.
162. Lee, Y T., Huang, L. Y, Chen, T. L., Siu, L. K., Fung, C. P., Cho, W. L., Yu, K. W, and Liu, C. Y. (2009b). Gene cassette arrays, antibiotic susceptibilities, and clinical characteristics of Acinetobacter baumannii bacteremic strains harboring class 1 integrons. J. Microbiol. Immunol. Infect. 42, 210-219.
163. Lee, K., Kim, M. N., Kim, J. S., Hong, H. L., Kang, J. O., Shin, J. H., Park, Y. J., Yong, D., Jeong, S. H., and Chong, Y (2011a). Further Increases in carbapenem-, amikacin-, and fluoroquinolone-resistant isolates of Acinetobacter spp. and P. aeruginosa in Korea: KONSAR study 2009. Yonsei Med.]. 52, 793-802.
164. Lee, Y, Kim, C. K., Lee, H., Jeong, S. H., Yong, D., and Lee, K. (2011b). A novel insertion sequence, ISAbalO, inserted into ISAbal adjacent to the blaOXA-23 gene and disrupting the outer membrane protein gene carO in Acinetobacter baumannii. Antimicrob. Agents Chemother. 55,361-363.
165. Lee, K., Lee, W. G., Uh, Y., Ha, G. Y, Cho, J., and Chong, Y (2003). VIM-and IMP-type metallo-3-lactamase-producing Pseudomonas spp. and Acinetobacter spp. in Korean hospitals. Emerging Infect. Dis. 9, 868-871.
166. Lee, K., Yum, J. H., Yong, D., Lee, H. M., Kim, H. D., Docquier, J. D., Rossolini, G. M., and Chong, Y (2005). Novel acquired metallo-(3-lactamase gene, blaSIM-1, in a class 1 integron from Acinetobacter baumannii clinical isolates from Korea. Antimicrob. Agents Chemother. 49, 4485-4491.
167. Lee, M. E, Peng, C. E, Hsu, H. J., and Chen, Y H. (2008). Molecular characterisation of the metallo-(3-lactamase genes in imipenem-resistant Gram-negative bacteria from a university hospital in southern Taiwan. Int. J. Antimicrob. Agents 32, 475-480.
168. Levin, A. S., Levy, C. E., Manrique, A. E., Medeiros, E. A., and Costa, S. E (2003). Severe nosocomial infections with imipenem-resistant Acinetobacter baumannii treated with ampicillin/sulbactam. Int. J. Antimicrob. Agents 21, 58-62.
169. Li, S. M., and Heide, L. (2005). New aminocoumarin antibiotics from genetically engineered Strep tomyces strains. Curr. Med. Chem. 12, 419-427.
170. Li, X. Z., and Nikaido, H. (2009). Efflux-mediated drug resistance in bacteria: an update. Drugs 69, 1555-1623.
171. Liang, W, Liu, X. E, Huang, J., Zhu, D. M., Li, J., and Zhang, J. (2011). Activities of colistin-and minocycline-based combinations against extensive drug resistant Acinetobacterbau-mannii isolates from intensive care unit patients. BMC Infect. Dis. 11, 109. doi:10.1186/1471-2334-11-109
172. Limansky, A. S., Mussi, M. A., and Viale, A. M. (2002). Loss of a 29-kilodalton outer membrane protein in Acinetobacter baumannii is associated with imipenem resistance. J. Clin. Microbiol. 40,4776-4778.
173. Lin, L., Ling, B. D., and Li, X. Z. (2009). Distribution of the multidrug efflux pump genes, adeABC, adeDE and adelJK, and class 1 integron genes in multiple-antimicrobial-resistant clinical isolates of Acinetobacter baumannii-Acinetobacter calcoaceticus complex. Int. J. Antimicrob. Agents 33, 27-32.
174. Lin,Y C.,Hsia, K. C, Chen,Y C.,Sheng, W. H., Chang, S. C, Liao, M. H., and Li, S. Y. (2010). Genetic basis of multidrug resistance in Acinetobacter clinical isolates in Taiwan. Antimicrob. Agents Chemother. 54, 2078-2084.
175. Livermore, D. M., Hope, R., Brick, G., Lillie, M., and Reynolds, R. (2008). Non-susceptibility trends among Pseudomonas aeruginosci and other non-fermentative Gram-negative bacteria from bacteraemias in the UK and Ireland, 2001-06. J. Antimicrob. Chemother. 62(Suppl. 2), 1155-1163.
176. Loehfelm, T., Luke, N., and Campagnari, A. (2008). Identification and char acterization of an Acinetobacter bau-mannii biofilm-associated protein. J. Bacteriol 190, 1036-1044.
177. Lolans, K., Rice, T. W., Munoz-Price, L. S., and Quinn, J. P. (2006). Multicity outbreak of carbapenem-resistant Acinetobacter baumannii isolates producing the carbapenemase OXA-40. Antimicrob. Agents Chemother. 50, 2941-2945.
178. Lopes, B. S., Evans, B. A., and Amyes, S. G. (2012). Disruption of the blaOXA-51-like gene by ISAbal6 and activation of the blaOXA-58 gene leading to carbapenem resistance in Acinetobacter baumannii Ab244. J. Antimicrob. Chemother. 67, 59-63.
179. Lopez-Rojas, R., Docobo-Perez, E, Pachon-Ibanez, M. E., de la Torre, B. G., Fernandez-Reyes, M., March, C. Bengoechea, J. A., Andreu, D., Rivas, L., and Pachon, J. (2011a). Efficacy of cecropin A-melittin peptides on a sepsis model of infection by pan-resistant Acinetobacter bau mannii. Eur. J. Clin. Microbiol. Infect. Dis. 30, 1391-1398.
180. Lopez-Rojas, R., Dominguez-Herrera, J., McConnell, M. J., Docobo-Perez, F., Smani, Y., Fernandez-Reyes, M., Rivas, L, and Pachon, J. (2011b). Impaired virulence and in vivo fitness of colistin-resistant Acinetobacter baumannii. J. Infect. Dis. 203, 545-548.
181. Lopez-Rojas, R., Jimenez-Mejias, M. E., Lepe, J. A., and Pachon, J. (2011c). Acinetobacter baumannii resistant to colistin alters its antibiotic resistance profile: a case report from Spain. J. Infect. Dis. 204, 1147-1148.
182. Lu, P. L., Doumith, M., Livermore, D. M., Chen, T. P., and Woodford, N. (2009). Diversity of carbapenem resistance mechanisms in Acineto bacter baumannii from a Taiwan hospital: spread of plasmid-borne OXA-72 carbapenemase. J. Antimi crob. Chemother. 63, 641-647.
183. Magiorakos, A. P., Srinivasan, A., Carey, R. B., Carmeli, Y., Falagas, M. E., Giske, C. G., Harbarth, S., Hindler, J. E. Kahlmeter, G., Olsson-Liljequist, B., Paterson, D. L., Rice, L. B., Stelling, J., Struelens, M. J., Vatopoulos, A., Weber, J. T., and Monnet, D. L. (2012). Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance. Clin. Microbiol Infect. 18, 268-281.
184. Magnet, S., Courvalin, P., and Lambert, T. (2001). Resistance-nodulation-cell division-type efflux pump involved in aminoglycoside resistance in Acinetobacter baumannii strain BM4454. Antimicrob. Agents Chemother. 45, 3375-3380.
185. Maisetta, G., Batoni, G., Esin, S., Florio, W., Bottai, D., Favilli, E, and Campa, M. (2006). In vitro bactericidal activity of human beta-defensin 3 against multidrug-resistant nosocomial strains. Antimicrob. Agents Chemother. 50, 806-809.
186. Mak, J. K., Kim, M. J., Pham, J., Tapsall, J., and White, P. A. (2009). Antibiotic resistance determinants in nosocomial strains of multidrug-resistant Acinetobacter baumannii. J. Antimicrob. Chemother. 63, 47-54.
187. Mammeri, H., Poirel, L., Mangeney, N., and Nordmann, P. (2003). Chromosomal integration of a cephalosporinase gene from Acinetobacter baumannii into Oligella urethralis as a source of acquired resistance to (3-lactams. Antimicrob. Agents Chemother. 47,1536-1542.
188. Mangoni, M. L., Maisetta, G., Di Luca, M., Gaddi, L. M., Esin, S., Florio, W, Brancatisano, E L., Barra, D., Campa, M., and Batoni, G. (2008). Comparative analysis of the bactericidal activities of amphibian peptide analogues against multidrug-resistant nosocomial bacterial strains. Antimicrob. Agents Chemother. 52, 85-91.
189. Marchand, I., Damier-Piolle, L., Courvalin, P., and Lambert, T. (2004). Expression of the RND-type efflux pump AdeABC in Acinetobacter baumannii is regulated by the AdeRS two-component system. Antimicrob. Agents Chemother. 48, 3298-3304.
190. Marque, S., Poirel, L., Heritier, C, Brisse, S., Blasco, M. D., Filip, R., Coman, G., Naas, T., and Nordmann, P. (2005). Regional occurrence of plasmid-mediated carbapenem-hydrolyzing oxacillinase OXA-58 in Acinetobacter spp. in Europe. J. Clin. Microbiol. 43,4885-4888.
191. Marr, A. K., Gooderham, W J., and Hancock, R. E. (2006). Antibacterial peptides for therapeutic use: obstacles and realistic outlook. Curr. Opin. Pharmacol. 6,468-472.
192. Marti, S., Fernandez-Cuenca, E, Pascual, A., Ribera, A., Rodriguez-Bano, J., Bou, G., Miguel Cisneros, J., Pachon, J., Martinez-Martinez, L., and Vila, J. (2006). Prevalence of the tetA and tetB genes as mechanisms of resistance to tetracycline and minocycline in Acinetobacter baumannii clinical isolates. Enferm. Infecc. Microbiol. Clin. 24, 77-80.
193. Marti, S., Sanchez-Cespedes, J., Blasco, M. D., Espinal, P., Ruiz, M., Alba, V.,andVila,J. (2008a). Characterization of the carbapenem-hydrolyzing oxacillinase OXA-58 in an Acinetobacter phenon 6/ctl3TU clinical isolate. Diagn. Microbiol. Infect. Dis. 61, 468-470.
194. Marti, S., Sanchez-Cespedes, J., Blasco, M. D., Ruiz, M., Espinal, P., Alba, V., Fernandez-Cuenca, F., Pascual, A., and Vila, J. (2008b). Characterization of the carbapenem-hydrolyzing oxacillinase OXA-58 in an Acinetobacter genospecies 3 clinical isolate. Antimicrob. Agents Chemother. 52, 2955-2958.
195. Mattick, J. S. (2002). Type IV pili and twitching motility. Annu. Rev. Microbiol. 56, 289-314.
196. Mazel, D. (2006). Integrons: agents of bacterial evolution. Nat. Rev. Microbiol. 4, 608-620.
197. McBride, M. J. (2010). Shining a light on an opportunistic pathogen. J. Bacteriol. 192, 6325-6326.
198. McConnell, M. J., Dominguez-Herrera, J., Smani, Y, Lopez-Rojas, R., Docobo-Perez, F., and Pachon, J. (2011a). Vaccination with outer membrane complexes elicits rapid protective immunity to multidrug-resistant Acinetobacter baumannii. Infect. Immun. 79, 518-526.
199. McConnell, M. J., Rumbo, C, Bou, G., and Pachon, J. (201 lb). Outer membrane vesicles as an acellular vaccine against Acinetobacter baumannii. Vaccine 29, 5705-5710.
200. McKean, S. C, Davies, J. K., and Moore, R. J. (2007). Expression of phospholipase D, the major virulence factor of Corynebacterium pseudotuberculosis, is regulated by multiple environmental factors and plays a role in macrophage death. Microbiology 153,2203-2211.
201. Meng, H., and Kumar, K. (2007). Antimicrobial activity and protease stability of peptides containing flu-orinated amino acids. J. Am. Chem. Soc. 129, 15615-15622.
202. Merino, M., Acosta, J., Poza, M., Sanz, E, Beceiro, A., Chaves, F., and Bou, G. (2010). OXA-24 carbapenemase gene flanked by XerC/XerD-like recombination sites in different plasmids from different Acinetobacter species isolated during a nosocomial outbreak. Antimicrob. Agents Chemother. 54, 2724-2727.
203. Mihara, K., Tanabe, T., Yamakawa, Y., Funahashi, T., Nakao, H., Narimatsu, S., and Yamamoto, S. (2004). Identification and transcriptional organization of a gene cluster involved in biosynthesis and transport of acinetobactin, a siderophore produced by Acinetobacter baumannii ATCC 19606T. Microbiology 150, 2587-2597.
204. Moffatt, J. H., Harper, M., Adler, B., Nation, R. L., Li, J., and Boyce, J. D. (2011). Insertion sequence ISAbal 1 is involved in colistin resistance and loss of lipopolysaccharide in Acinetobacter baumannii. Antimicrob. Agents Chemother. 55, 3022-3024.
205. Moffatt, J. H., Harper, M., Harrison, P., Hale, J. D., Vinogradov, E., Seemann, T., Henry, R., Crane, B., St Michael, E, Cox, A. D., Adler, B., Nation, R. L., Li, J., and Boyce, J. D. (2010). Colistin resistance in Acinetobacter baumannii is mediated by complete loss of lipopolysaccharide production. Antimicrob. Agents Chemother. 54,4971-4977.
206. Molhoek, E. M., van Dijk, A., Veldhuizen, E. J., Haagsman, H. P., and Bikker, E J. (2011). Improved proteolytic stability of chicken cathelicidin-2 derived peptides by damino acid substitutions and cyclization. Peptides 32, 875-880.
207. Morgan, D. J., Weisenberg, S. A., Augen-braun, M. H., Calfee, D. P., Currie, B. P., Furuya, E. Y, Holzman, R., Montecalvo, M. C, Phillips, M., Polsky, B., and Sepkowitz, K. A. (2009). Multidrug-resistant Acinetobacter baumannii in New York City-10 years into the epidemic. Infect. Control Hosp. Epidemiol. 30, 196-197.
208. Motsch, S., Schmitt, R., Avila, P., de la Cruz, F., Ward, E., and Grinsted, J. (1985). Junction sequences generated by'one-ended transposition.' Nucleic Acids Res. 13, 3335-3342.
209. Moubareck, C, Bremont, S., Conroy, M. C, Courvalin, P., and Lambert, T. (2009). GES-11, a novel integron-associated GES variant in Acinetobacter baumannii. Antimicrob. Agents Chemother. 53, 3579-3581.
210. Mussi, M. A., Limansky, A. S., and Viale, A. M. (2005). Acquisition of resistance to carbapenems in multidrug-resistant clinical strains of Acinetobacter baumannii: natural insertional inactivation of a gene encoding a member of a novel family of 3-barrel outer membrane proteins. Antimicrob. Agents Chemother. 49, 1432-1440.
211. Naas, T., Bogaerts, P., Bauraing, C, Degheldre, Y, Glupczynski, Y, and Nordmann, P. (2006a). Emergence of PER and VEB extended-spectrum 3-lactamases in Acinetobacter baumannii in Belgium. J. Antimicrob. Chemother. 58, 178-182.
212. Naas, T., Coignard, B., Carbonne, A., Blanckaert, K., Bajolet, O., Bernet, C, Verdeil, X., Astagneau, P., Desenclos, J. C, and Nordmann, P. (2006b). VEB-1 extended-spectrum 3-lactamase-producing Acinetobacter baumannii, France. Emerging Infect. Dis. 12, 1214-1222.
213. Naas, T., Namdari, F., Reglier-Poupet, H., Poyart, C, and Nordmann, P. (2007). Panresistant extended-spectrum 3-lactamase SHV-5-producing Acinetobacter baumannii from New York City. J. Antimicrob. Chemother. 60, 1174-1176.
214. Naas, T., Poirel, L., and Nordmann, P. (2008). Minor extended-spectrum 3-lactamases. Clin. Microbiol. Infect. 14(Suppl. 1), 42-52.
215. Nagano, N., Nagano, Y., Cordevant, C, Shibata, N., and Arakawa, Y. (2004). Nosocomial transmission of CTX-M-2 3-lactamase-producing Acinetobacter baumannii in a neuro-surgery ward. J. Clin. Microbiol. 42, 3978-3984.
216. Naiemi, N. A., Duim, B., Savelkoul, P. H., Spanjaard, L., de Jonge, E., Bart, A., Vandenbroucke-Grauls, C. M., and de Jong, M. D. (2005). Widespread transfer of resistance genes between bacterial species in an intensive care unit: implications for hospital epidemiology. J. Clin. Microbiol. 43, 4862-4864.
217. Navia, M. M., Ruiz, J., and Vila, J. (2002). Characterization of an integron carrying a new class D (3-lactamase (OXA-37) in Acinetobacter baumannii. Microb. Drug Resist. 8, 261-265.
218. Nemec, A., Dolzani, L., Brisse, S., van den Broek, P., and Dijkshoorn, L. (2004). Diversity of aminoglycoside-resistance genes and their association with class 1 integrons among strains of pan-European Acinetobacter baumannii clones. J. Med. Microbiol. 53,1233-1240.
219. Nemec, A., Krizova, L., Maixnerova, M., van der Reijden, T. J., Deschaght, P., Passet, V., Vaneechoutte, M., Brisse, S., and Dijkshoorn, L. (2011). Genotypic and phenotypic characterization of the Acinetobacter calcoaceticus-Acinetobacter baumannii complex with the proposal of Acinetobacter pittii sp. nov. (formerly Acinetobacter genomic species 3) and Acinetobacter nosocomialis sp. nov. (formerly Acinetobacter genomic species 13TU). Res. Microbiol. 162,393-404.
220. Nemec, A., Maixnerova, M., van der Reijden, T. J., van den Broek, P. J., and Dijkshoorn, L. (2007). Relationship between the AdeABC efflux system gene content, netilmicin susceptibility and multidrug resistance in a genotypically diverse collection of Acinetobacter baumannii strains. J. Antimicrob. Chemother. 60,483-489.
221. Nigro, S. J., Post, V., and Hall, R. M. (2011a). Aminoglycoside resistance in multiply antibiotic-resistant Acinetobacter baumannii belonging to global clone 2 from Australian hospitals. J. Antimicrob. Chemother. 66, 1504-1509.
222. Nigro, S. J., Post, V., and Hall, R. M. (2011b). The multiresistant Acinetobacter baumannii European clone I type strain RUH875 (A297) carries a genomic antibiotic resistance island AbaR21, plasmid pRAY and a cluster containing ISAbal-sul2-CR2-strB-strA. J. Antimicrob. Chemother. 66, 1928-1930.
223. Niu, C, Clemmer, K. M., Bonomo, R. A., and Rather, P. N. (2008). Isolation and characterization of an autoinducer synthase from Acinetobacter baumannii. J. Bacterial. 190, 3386-3392.
224. Nordmann, P., Couard, J. P., Sansot, D., and Poirel, L. (2012). Emergence of an autochthonous and community-acquired NDM-1-producing Kleb-siella pneumoniae in Europe. Clin. Infect. Dis. 54, 150-151.
225. Nordmann, P., Poirel, L., Toleman, M. A., and Walsh, T. R. (2011). Does broad-spectrum (3-lactam resistance due to NDM-1 herald the end of the antibiotic era for treatment of infections caused by Gram-negative bacteria? J. Antimicrob. Chemother. 66, 689-692.
226. Ostorhazi, E., Holub, M. C, Rozgonyi, E, Harmos, E, Cassone, M., Wade, J. D., and Otvos, L. Jr. (2011). Broad-spectrum antimicrobial efficacy of peptide A3-APO in mouse models of multidrug-resistant wound and lung infections cannot be explained by in vitro activity against the pathogens involved. Int. J. Antimicrob. Agents 37, 480-484.
227. Ostorhazi, E., Rozgonyi, F., Sztodola, A., Harmos, E, Kovalszky, I., Szabo, D., Knappe, D., Hoffmann, R., Cassone, M., Wade, J. D., Bonomo, R. A., and Otvos, L. Jr. (2010). Preclinical advantages of intramuscularly administered peptide A3-APO over existing therapies in Acinetobacter baumannii wound infections. J. Antimicrob. Chemother. 65,2416-2422.
228. Ozbek, B., and Senturk, A. (2010). Postantibiotic effects of tigecycline, colistin sulfate, and levofloxacin alone or tigecycline-colistin sulfate and tigecycline-levofloxacin combinations against Acinetobacter baumannii. Chemotherapy 56, 466-471.
229. Pachon-Ibanez, M. E., Docobo-Perez, E, Lopez-Rojas, R., Dominguez-Herrera, J., Jimenez-Mejias, M. E., Garcia-Curiel, A., Pichardo, C, Jimenez, L, and Pachon, J. (2010). Efficacy of rifampin and its combinations with imipenem, sulbactam, and colistin in experimental models of infection caused by imipenem-resistant Acinetobacter baumannii. Antimicrob. Agents Chemother. 54, 1165-1172.
230. Pachon-Ibanez, M. E., Fernandez-Cuenca, E, Docobo-Perez, E, Pachon, J., and Pascual, A. (2006). Prevention of rifampicin resistance in Acinetobacter baumannii in an experimental pneumonia murine model, using rifampicin associated with imipenem or sulbactam. J. Antimicrob. Chemother. 58,689-692.
231. Pantophlet, R., Brade, L., Dijkshoorn, L., and Brade, H. (1998). Specificity of rabbit antisera against lipopolysaccharide of Acinetobacter. J. Clin. Microbiol. 36, 1245-1250.
232. Papa, A., Koulourida, V., and Souliou, E. (2009). Molecular epidemiology of carbapenem-resistant Acine tobacter baumannii in a newly established Greek hospital. Microb. Drug Resist. 15,257-260.
233. Park, Y. K., Jung, S. I., Park, K. H., Cheong, H. S., Peck, K. R., Song, J. H., and Ko, K. S. (2009). Independent emergence of colistin-resistant Acinetobacter spp. isolates from Korea. Diagn. Microbiol. Infect. Dis. 64,43-51.
234. Pasteran, F., Rapoport, M., Petroni, A., Faccone, D., Corso, A., Galas, M., Vazquez, M., Procopio, A., Tokumoto, M., and Cagnoni, V (2006). Emergence of PER-2 and VEB-la in Acinetobacter baumannii strains in the Americas. Antimicrob. Agents Chemother. 50, 3222-3224.
235. Paton, R., Miles, R. S., Hood, J., Amyes, S. G., Miles, R. S., and Amyes, S. G. (1993). ARI 1: plactamase-mediated imipenem resistance in Acinetobacter baumannii. Int. J. Antimicrob. Agents 2, 81-87.
236. Payne, D. J., Gwynn, M. N., Holmes, D. J., and Pompliano, D. L. (2007). Drugs for bad bugs: confronting the challenges of antibacterial discovery. Nat. Rev. Drug Discov. 6, 29-40.
237. Peleg, A. Y, Franklin, C, Walters, L. J., Bell, J. M., and Spelman, D. W (2006). OXA-58 and IMP-4 carbapenem-hydrolyzing 3-lactamases in an Acinetobacter junii blood culture isolate from Australia. Antimicrob. Agents Chemother. 50, 399-400.
238. Peleg, A. Y, Seifert, H., and Paterson, D. L. (2008). Acinetobacter baumannii: emergence of a successful pathogen. Clin. Microbiol. Rev. 21, 538-582.
239. Perez, E, Ponce-Terashima, R., Adams, M. D., and Bonomo, R. A. (2011). Are we closing in on an "elusive enemy?" The current status of our battle with Acinetobacter baumannii. Virulence 2, 86-90.
240. Pfeifer, Y, Wilharm, G., Zander, E., Wichelhaus, T. A., Gottig, S., Hunfeld, K. P., Seifert, H., Witte, W, andHiggins, P. G. (2011). Molecular characterization of blaNDM-1 in an Acinetobacter baumannii strain isolated in Germany in 2007. J. Antimicrob. Chemother. 66, 1998-2001.
241. Piddock, L. J. (2006). Clinically relevant chromosomally encoded multidrug resistance efflux pumps in bacteria. Clin. Microbiol. Rev. 19, 382-402.
242. Pitart, C, Sole, M., Roca, I., Fabrega, A., Vila, J., and Marco, F. (2011). First outbreak of a plasmid-mediated carbapenem-hydrolyzing OXA-48 (3-lactamase in Klebsiella pneumoniae in Spain. Antimicrob. Agents Chemother. 55,4398-4401.
243. Poirel, L., Cabanne, L., Vahaboglu, H., and Nordmann, P. (2005a). Genetic environment and expression of the extended-spectrum (3-lactamase blaPER-1 gene in Gram-negative bacteria. Antimicrob. Agents Chemother. 49, 1708-1713.
244. Poirel, L., Marque, S., Heritier, C, Segonds, C, Chabanon, G., and Nordmann, P. (2005b). OXA-58, a novel class D (3-lactamase involved in resistance to carbapenems in Acinetobacter baumannii. Antimicrob. Agents Chemother. 49, 202-208.
245. Poirel, L., Corvee, S., Rapoport, M., Mugnier, P., Petroni, A., Pasteran, E, Faccone, D., Galas, M., Drugeon, H., Cattoir, V, and Nordmann, P. (2007). Identification of the novel narrow-spectrum 3-lactamase SCO-1 in Acinetobacter spp. from Argentina. Antimicrob. Agents Chemother. 51,2179-2184.
246. Poirel, L., Dortet, L., Bernabeu, S., and Nordmann, P. (2011a). Genetic features of blaNDM-1-positive Enterobacteriaceae. Antimicrob. Agents Chemother. 44, 5403-5407.
247. Poirel, L., Schrenzel, J., Cherkaoui, A., Bernabeu, S., Renzi, G., and Nordmann,P. (2011b). Molecular analysis of NDM-1-producing enterobacterial isolates from Geneva, Switzerland. J. Antimicrob. Chemother. 66, 1730-1733.
248. Poirel, L., Figueiredo, S., Cattoir, V., Carattoli, A., and Nordmann, P. (2008a). Acinetobacter radioresistens as a silent source of carbapenem resistance for Acinetobacter spp. Antimicrob. Agents Chemother. 52, 1252-1256.
249. Poirel, L., Mansour, W., Bouallegue, O., and Nordmann, P. (2008b). Carbapenem-resistant Acinetobacter baumannii isolates from Tunisia producing the OXA-58-like carbapenem-hydrolyzing oxacillinase OXA-97. Antimicrob. Agents Chemother. 52, 1613-1617.
250. Poirel, L., Lagrutta, E., Taylor, P., Pham, J., and Nordmann, P. (2010). Emergence of metallo-(3-lactamase NDM-1-producing multidrug-resistant Escherichia coli in Australia. Antimicrob. Agents Chemother. 54, 4914-4916.
251. Poirel, L., Lebessi, E., Heritier, C, Patsoura, A., Foustoukou, M., and Nordmann, P. (2006). Nosocomial spread of OXA-58-positive carbapenem-resistant Acinetobacter baumannii isolates in a paediatric hospital in Greece. Clin. Microbiol. Infect. 12, 1138-1141.
252. Poirel, L., Menuteau, O., Agoli, N., Cattoen, C, and Nordmann, P. (2003). Outbreak of extended-spectrum (3-lactamase VEB-1-producing isolates of Acinetobacter baumannii in a French hospital. J. Clin. Microbiol. 41,3542-3547.
253. Poirel, L., Mugnier, P. D., Toleman, M. A., Walsh, T. R., Rapoport, M. J., Petroni, A., and Nordmann, P. (2009). ISCR2, another vehicle for blaVEB gene acquisition. Antimicrob. Agents Chemother. 53, 4940-4943.
254. Poirel, L, and Nordmann, P. (2006a). Carbapenem resistance in Acinetobacter baumannii: mechanisms and epidemiology. Clin. Microbiol. Infect. 12,826-836.
255. Poirel, L., and Nordmann, P. (2006b). Genetic structures at the origin of acquisition and expression of the carbapenem-hydrolyzing oxacillinase gene blaOXA-58 in Acinetobacter baumannii. Antimicrob. Agents Chemother. 50, 1442-1448.
256. Post, V., and Hall, R. M. (2009). AbaR5, a large multiple-antibiotic resistance region found in Acinetobacter baumannii. Antimicrob. Agents Chemother. 53, 2667-2671.
257. Post, V., White, P. A., and Hall, R. M. (2010). Evolution of AbaR-type genomic resistance islands in multiply antibiotic-resistant Acinetobacter baumannii. J. Antimicrob. Chemother. 65, 1162-1170.
258. Potron, A., Munoz-Price, L. S., Nordmann, P., Cleary, T., and Poirel, L. (2011). Genetic features of CTX-M-15-producing Acinetobacter baumannii from Haiti. Antimicrob. Agents Chemother. 55, 5946-5948.
259. Potron, A., Poirel, L., Croize, J., Chanteperdrix, V., and Nordmann, P. (2009). Genetic and biochemical characterization of the first extended-spectrum CARB-type (3-lactamase, RTG-4, from Acinetobacter baumannii. Antimicrob. Agents Chemother. 53,3010-3016.
260. Pournaras, S., Markogiannakis, A., Ikonomidis, A., Kondyli, L., Bethimouti, K., Maniatis, A. N., Legakis, N. J., and Tsakris, A. (2006). Outbreak of multiple clones of imipenem-resistant Acinetobacter baumannii isolates expressing OXA-58 carbapenemase in an intensive care unit. J. Antimicrob. Chemother. 57,557-561.
261. Principe, L., D'Arezzo, S., Capone, A., Petrosillo, N., and Visca, P. (2009). In vitro activity of tigecycline in combination with various antimicrobials against multidrug resistant Acinetobacter baumannii. Ann. Clin. Microbiol. Antimicrob. 21, 8-18.
262. Qi, C, Malczynski, M., Parker, M., and Scheetz, M. H. (2008). Characterization of genetic diversity of carbapenem-resistant Acinetobacter baumannii clinical strains collected from 2004 to 2007. J. Clin. Microbiol. 46, 1106-1109.
263. Quale, J., Bratu, S., Landman, D., and Heddurshetti, R. (2003). Molecular epidemiology and mechanisms of carbapenem resistance in Acinetobacter baumannii endemic in New York City. Clin. Infect. Dis. 37, 214-220.
264. Queenan, A. M., and Bush, K. (2007). Carbapenemases: the versatile (3-lactamases. Clin. Microbiol. Rev. 20, 440-458.
265. Quinteira, S., Grosso, E, Ramos, H., and Peixe, L. (2007). Molecular epidemiology of imipenem-resistant Acinetobacter haemolyticus and Acinetobacter baumannii isolates carrying plasmid-mediated OXA-40 from a Portuguese hospital. Antimicrob. Agents Chemother. 51, 3465-3466.
266. Rajamohan, G., Srinivasan, V. B., and Gebreyes, W A. (2010). Molecular and functional characterization of a novel efflux pump, AmvA, mediating antimicrobial and disinfectant resistance in Acinetobacter baumannii. J. Antimicrob. Chemother. 65, 1919-1925.
267. Ramirez, M. S., Bello, H., Gonzalez Rocha, G., Marquez, C, and Centron, D. (2010a). Tn7::In2-8 dispersion in multidrug resistant isolates of Acinetobacter baumannii from Chile. Rev. Argent. Microbiol. 42,138-140.
268. Ramirez, M. S., Pineiro, S., and Centron, D. (2010b). Novel insights about class 2 integrons from experimental and genomic epidemiology. Antimicrob. Agents Chemother. 54,699-706.
269. Rasko, D. A., and Sperandio, V. (2010). Antivirulence strategies to combat bacteria-mediated disease. Nat. Rev. DrugDiscov.9, 117-128.
270. Ravasi, P., Limansky, A. S., Rodriguez, R. E., Viale, A. M., and Mussi, M. A. (2011). ISAba825,afunctional insertion sequence modulating genomic plasticity and blaOXA-58 expression in Acinetobacter baumannii. Antimicrob. Agents Chemother. 55, 917-920.
271. Ribera, A., Roca, I., Ruiz, J., Gibert, I., and Vila, J. (2003a). Partial characterization of a transposon containing the tet(A) determinant in a clinical isolate of Acinetobacter baumannii. J. Antimicrob. Chemother. 52, 477-480.
272. Ribera, A., Ruiz, J., and Vila, J. (2003b). Presence of the Tet M determinant in a clinical isolate of Acinetobacter baumannii. Antimicrob. Agents Chemother. 47, 2310-2312.
273. Riccio, M. L., Franceschini, N., Boschi, L., Caravelli, B., Cornaglia, G., Fontana, R., Amicosante, G., and Rossolini, G. M. (2000). Characterization of the metallo-3-lactamase determinant of Acinetobacter baumannii AC-54/97 reveals the existence of blaIMP allelic variants carried by gene cassettes of different phylogeny. Antimicrob. Agents Chemother. 44, 1229-1235.
274. Roberts, A. P., Chandler, M., Courvalin, P., Guedon, G., Mullany, P., Pembroke, T., Rood, J. I., Smith, C. J., Summers, A. O., Tsuda, M., and Berg, D. E. (2008). Revised nomenclature for transposable genetic elements. Plasmid 60,167-173.
275. Robledo,I. E., Aquino, E. E., Sante, M. I., Santana, J. L., Otero, D. M., Leon, C. E, and Vazquez, G. J. (2010). Detec tion of KPC in Acinetobacter spp. in Puerto Rico. Antimicrob. Agents Chemother. 54, 1354-1357.
276. Roca, I., Espinal, P., Marti, S., and Vila, J. (2011). First identification and characterization of an AdeABC-like efflux pump in Acinetobacter genomospecies 13TU. Antimicrob. Agents Chemother. 55, 1285-1286.
277. Roca, I., Marti, S., Espinal, P., Martinez, P., Gibert, I., and Vila, J. (2009). CraA, a major facilitator superfamily efflux pump associated with chloramphenicol resistance in Acinetobacter baumannii. Antimicrob. Agents Chemother. 53,4013-4014.
278. Rodriguez-Bano, J., Marti, S., Soto, S., Fernandez-Cuenca, E, Miguel Cisneros, J., Pachon, J., Pascual, A., Martinez-Martinez, L., McQueary, C, Actis, L., Vila, J., and Spanish Group for the Study of Nosocomial Infections (GEIH). (2008). Biofilm formation in Acinetobacter baumannii: associated features and clinical implications. Clin. Microbiol. Infect. 14, 276-278.
279. Rodriguez-Hernandez, M. J., Cuberos, L., Pichardo, C, Caballero, F. J., Moreno, I., Jimenez-Mejias, M. E., Garcia-Curiel, A., and Pachon, J. (2001). Sulbactam efficacy in experimental models caused by susceptible and intermediate Acinetobacter baumannii strains. J. Antimicrob. Chemother. 47, 479-482.
280. Rodriguez-Hernandez, M. J., Saugar, J., Docobo-Perez, E, de la Torre, B. G., Pachon-Ibanez, M. E., Garcia-Curiel, A., Fernandez-Cuenca, F., Andreu, D., Rivas, L., and Pachon, J. (2006). Studies on the antimicrobial activity of cecropin A-melittin hybrid peptides in colistin-resistant clinical isolates of Acinetobacter baumannii. J. Antimicrob. Chemother. 58,95-100.
281. Rolain, J. M., Roch, A., Castanier, M., Papazian, L, and Raoult, D. (2011). Acinetobacter baumannii resistant to colistin with impaired virulence: a case report from France. J. Infect. Dis. 204, 1146-1147.
282. Rose, A. (2010).TnAbaRl:anovelTn7-related transposon in Acinetobacter baumannii that contributes to the accumulation and dissemination of large repertoires of resistance genes. Biosci. Horizons 3, 40-48.
283. Rossolini, G. M., and Mantengoli, E. (2008). Antimicrobial resistance in Europe and its potential impact on empirical therapy. Clin. Microbiol. Infect. 14(Suppl. 6), 2-8.
284. Ruiz, M., Marti, S., Fernandez-Cuenca, E, Pascual, A., and Vila, J. (2007). High prevalence of carbapenem-hydrolysing oxacillinases in epidemiologically related and unrelated Acinetobacter baumannii clinical isolates in Spain. Clin. Microbiol. Infect. 13, 1192-1198.
285. Rumbo, C, Fernandez-Moreira, E., Merino, M., Poza, M., Mendez, J. A., Soares, N. C, Mosquera, A., Chaves, E, and Bou, G. (2011). Horizontal transfer of the OXA-24 carbapenemase gene via outer membrane vesicles: a new mechanism of dissemination of carbapenem resistance genes in Acinetobacter baumannii. Antitnicrob. Agents Chetnother. 55, 3084-3090.
286. Russo, T. A., Luke, N. R., Beanan, J. M., Olson, R., Sauberan, S. L., MacDonald, U., Schultz, L. W., Umland, T. C, and Campagnari, A. A. (2010). The Kl capsular polysaccharide of Acinetobacter baumannii strain 307-0294 is a major virulence factor. Infect. Immun. 78, 3993-4000.
287. Russo, T. A., MacDonald, U., Beanan, J. M., Olson, R., MacDonald, I. J., Sauberan, S. L., Luke, N. R., Schultz, L. W., and Umland, T. C. (2009). Penicillin-binding protein 7/8 contributes to the survival of Acinetobacter baumannii in vitro and in vivo. J. Infect. Dis. 199, 513-521.
288. Russo, T. A., Page, M. G., Beanan, J. M., Olson, R., Hujer, A. M., Hujer, K. M., Jacobs, M., Bajaksouzian, S., Endimiani, A., and Bonomo, R. A. (2011). In vivo and in vitro activity of the siderophore mono-sulfactam BAL30072 against Acinetobacter baumannii. J. Antimicrob. Chemother. 66, 867-873.
289. Ruzin, A., Keeney, D., and Bradford, P. A. (2007). AdeABC multidrug efflux pump is associated with decreased susceptibility to tigecycline in Acinetobacter calcoaceticus-Acinetobacter baumannii complex. J. Antimicrob. Chemother. 59, 1001-1004.
290. Sarkar, S., and Chakraborty, R. (2008). Quorum sensing in metal tolerance of Acinetobacter junii BBlA is associated with biofilm production. FEMS Microbiol. Lett. 282, 160-165.
291. Sauer, F. G., Mulvey, M. A., Schilling, J. D., Martinez, J. J., and Hultgren, S. J. (2000). Bacterial pili: molecular mechanisms of pathogenesis. Curr. Opin. Microbiol 3, 65-72.
292. Saugar, J. M., Alarcon, T., Lopez-Hernandez, S., Lopez-Brea, M., Andreu, D., and Rivas, L. (2002). Activities of polymyxin B and cecropin A-,melittin peptide CA(1-8)M(1-18) against a multiresistant strain of Acinetobacter baumannii. Antimicrob. Agents Chemother. 46, 875-878.
293. Sauvage, E., Kerff, E, Terrak, M., Ayala, J. A., and Charlier, P. (2008). The penicillin-binding proteins: structure and role in peptidoglycan biosynthesis. FEMS Microbiol. Rev. 32,234-258.
294. Schild, S., Nelson, E. J., and Camilli, A. (2008). Immunization with Vibrio cholerae outer membrane vesicles induces protective immunity in mice. Infect. Immun. 76,4554-4563.
295. Seward, R. J., and Towner, K. J. (1998). Molecular epidemiology of quinolone resistance in Acinetobacter spp. Clin. Microbiol. Infect. 4,248-254.
296. Shaikh, E, Spence, R. P., Levi, K., Ou, H. Y., Deng, Z., Towner, K. J., and Rajakumar, K. (2009). ATPase genes of diverse multidrug-resistant Acinetobacter baumannii isolates frequently harbour integrated DNA. J. Antimicrob. Chemother. 63,260-264.
297. Shakil, S., and Khan, A. U. (2010). Detection of CTX-M-15-producing and carbapenem-resistant Acinetobacter baumannii strains from urine from an Indian hospital. J. Chemother. 22, 324-327.
298. Siguier, P., Perochon, J., Lestrade, L., Mahillon, J., and Chandler, M. (2006). ISfinder: the reference centre for bacterial insertion sequences. Nucleic Acids Res. 34, D32-D36.
299. Siroy, A., Cosette, P., Seyer, D., Lemaitre-Guillier, C, Vallenet, D., Van Dorsselaer, A., Boyer-Mariotte, S., Jouenne, T., and De, E. (2006). Global comparison of the membrane sub-proteomes between a multidrug-resistant Acinetobacter baumannii strain and a reference strain. J. Proteome Res. 5,3385-3398.
300. Siroy, A., Molle, V., Lemaitre-Guillier, C, Vallenet, D., Pestel-Caron, M., Cozzone, A. J., Jouenne, T., and De, E. (2005). Channel formation by CarO, the carbapenem resistance-associated outer membrane protein of Acinetobacter baumannii. Antimicrob. Agents Chemother. 49, 4876-4883.
301. Smith, C. A., and Baker, E. N. (2002). Aminoglycoside antibiotic resistance by enzymatic deactivation. Curr. Drug Targets Infect. Disord. 2,143-160.
302. Smith, M. G., Des Etages, S. G., and Snyder, M. (2004). Microbial synergy via an ethanoltriggered pathway. Mol. Cell. Biol. 24, 3874-3884.
303. Smith, M. G., Gianoulis, T. A., Pukatzki, S., Mekalanos, J. J., Ornston, L. N., Gerstein, M., and Snyder, M. (2007). New insights into Acinetobacter baumannii pathogenesis revealed by high-density pyrosequencing and transposon mutagenesis. Genes Dev. 21,601-614.
304. Snitkin, E. S., Zelazny, A. M., Montero, C. I., Stock, E, Mijares, L., Program, N. C. S., Murray, P. R., and Segre, J. A. (2011). Genome-wide recombination drives diversification of epidemic strains of Acinetobacter baumannii. Proc. Natl. Acad. Sci. U.S.A. 108,13758-13763.
305. Sole, M., Pitart, C, Roca, I., Fabrega, A., Salvador, P., Mufioz, L., Oliveira, I., Gascon, J., Marco, F., and Vila, J. (2011). First description of an Escherichia coli strain producing NDM-1 carbapenemase in Spain. Antimicrob. Agents Chemother. 55, 4402-4404.
306. Spence, R. P., and Towner, K. J. (2003). Frequencies and mechanisms of resistance to moxifloxacin in nosocomial isolates of Acinetobacter baumannii. J. Antimicrob. Chemother. 52, 687-690.
307. Srinivasan, V B., Rajamohan, G., and Gebreyes, W. A. (2009a). Role of AbeS, a novel efflux pump of the SMR family of transporters, in resistance to antimicrobial agents in Acinetobacter baumannii. Antimicrob. Agents Chemother. 53,5312-5316.
308. Srinivasan, V B., Rajamohan, G., Pancholi, P., Stevenson, K., Tadesse, D., Patchanee, P., Marcon, M., and Gebreyes, W. A. (2009b). Genetic relatedness and molecular characterization of multidrug resistant Acinetobacter baumannii isolated in central Ohio, USA. Ann. Clin. Microbiol. Antimicrob. 8,21.
309. Stanley, N., and Lazazzera, B. A. (2004). Environmental signals and regulatory pathways that influence biofilm formation. Mol. Microbiol. 52,917-924.
310. Su, X. Z., Chen, J., Mizushima, T., Kuroda, T., and Tsuchiya, T. (2005). AbeM, an H+-coupled Acinetobacter baumannii multidrug efflux pump belonging to the MATE family of transporters. Antimicrob. Agents Chemother. 49, 4362-4364.
311. Sutherland, I. (2001). Biofilm exopolysaccharides: a strong and sticky framework. Microbiology 147, 3-9.
312. Taneja, N., Singh, G., Singh, M., and Sharma, M. (2011). Emergence of tigecycline & colistin resistant Acinetobacter baumanii in patients with complicated urinary tract infections in north India. Indian J. Med. Res. 133,681-684.
313. Tian, G. B., Adams-Haduch, J. M., Bogdanovich, T., Pasculle, A. W., Quinn, J.P.,Wang,H.N.,andDoi,Y. (2011). Identification of diverse OXA-40 group carbapenemases, including a novel variant, OXA-160, from Acinetobacter baumannii in Pennsylvania. Antimicrob. Agents Chemother. 55, 429-432.
314. Toleman, M. A., Bennett, P. M., and Walsh, T. R. (2006). ISCR elements: novel gene-capturing systems of the 21st century? Microbiol. Mol. Biol. Rev. 70,296-316.
315. Tomaras, A., Dorsey, C, Edelmann, R., and Actis, L. (2003). Attachment to and biofilm formation on abiotic surfaces by Acinetobacter baumannii: involvement of a novel chaperone-usher pili assembly system. Microbiology 149, 3473-3484.
316. Towner, K. J. (2009). Acinetobacter: an old friend, but a new enemy. J. Hasp. Infect. 73, 355-363.
317. Towner, K. J., Gee, T., and Boswell, T. (2002). An unwanted import to the UK: a carbapenem-resistant clinical isolate of Acinetobacter baumannii producing metallo-3-lactamase. J. Antimicrob. Chemother. 50,1092-1093.
318. Tsakris, A., Ikonomidis, A., Poulou, A., Spanakis, N., Vrizas, D., Diomidous, M., Pournaras, S., and Markou, F. (2008). Clusters of imipenem-resistant Acinetobacter baumannii clones producing different carbapenemases in an intensive care unit. Clin. Microbiol. Infect. 14, 588-594.
319. Tsakris, A., Ikonomidis, A., Pournaras, S., Tzouvelekis, L. S., Sofianou, D., Legakis, N. J., and Maniatis, A. N. (2006). VIM-1 metallo-p-lactamase in Acinetobacter baumannii. Emerginglnfect. Dis. 12,981-983.
320. Turton, J. E, Ward, M. E., Wood-ford, N., Kaufmann, M. E., Pike, R., Livermore, D. M., and Pitt, T. L. (2006). The role of ISAbal in expression of OXA carbapenemase genes in Acinetobacter baumannii. FEMS Microbiol. Lett. 258, 72-77.
321. Urban, C, Go, E., Mariano, N., and Rahal, J. J. (1995). Interaction of sulbactam, clavulanic acid and tazobactam with penicillin-binding proteins of imipenem-resistant and-susceptible Acinetobacter baumannii. FEMS Microbiol. Lett. 125, 193-197.
322. Vahaboglu, H., Ozturk, R., Aygun, G., Coskunkan, F., Yaman, A., Kaygusuz, A., Leblebicioglu, H., Balik, I., Aydin, K., and Otkun, M. (1997). Widespread detection of PER-1-type extended-spectrum (3-lactamases among nosocomial Acinetobacter and Pseudomonas aeruginosa isolates in Turkey: a nationwide multicenter study. Antimicrob. Agents Chemother. 41, 2265-2269.
323. Valentine, S. C, Contreras, D., Tan, S., Real, L. J., Chu, S., and Xu, H. H. (2008). Phenotypic and molecular characterization of Acinetobacter baumannii clinical isolates from nosocomial outbreaks in Los Angeles County, California. J. Clin. Microbiol. 46, 2499-2507.
324. Vallenet, D., Nordmann, P., Barbe, V, Poirel, L., Mangenot, S., Bataille, E., Dossat, C, Gas, S., Kreimeyer, A., Lenoble, P., Oztas, S., Poulain, J., Segurens, B., Robert, C, Abergel, C, Claverie, J. M., Raoult, D., Medigue, C, Weissenbach, J., and Cruveiller, S. (2008). Comparative analysis of Acinetobacters: three genomes for three lifestyles. PLoS ONE 3, el805. doi:10.1371/journal.pone.0001805
325. Vidal, R., Dominguez, M., Urrutia, H., Bello, H., Gonzalez, G., Garcia, A., and Zemelman, R. (1996). Biofilm formation by Acinetobacter baumannii. Microbios 86, 49-58.
326. Vila, J., Marti, S., and Sanchez-Cespedes, J. (2007). Porins, efflux pumps and multidrug resistance in Acinetobacter baumannii. J. Antimicrob. Chemother. 59, 1210-1215.
327. Vila, J., Navia, M., Ruiz, J., and Casals, C. (1997a). Cloning and nucleotide sequence analysis of a gene encoding an OXA-derived 3-lactamase in Acinetobacter baumannii. Antimicrob. Agents Chemother. 41,2757-2759.
328. Vila, J., Ruiz, J., Goni, P., and Jimenez de Anta, T. (1997b). Quinolone-resistance mutations in the topoisomerase IV parC gene of Acinetobacter baumannii. J. Antimicrob. Chemother. 39, 757-762.
329. Vila, J., Ruiz, J., Goni, P., Marcos, A., and Jimenez de Anta, T. (1995). Mutation in the gyrA gene of quinolone-resistant clinical isolates of Acinetobacter baumannii. Antimicrob. Agents Chemother. 39, 1201-1203.
330. Vila, J., Sanchez-Cespedes, J., Sierra, J. M., Piqueras,M., Nicolas, E., Freixas, J., and Giralt, E. (2006). Antibacterial evaluation of a collection of nor-floxacin and ciprofloxacin derivatives against multiresistant bacteria. Int. J. Antimicrob. Agents 28, 19-24.
331. Vila-Farres, X., Garcia de la Maria, C, Lopez-Rojas, R., Pachon, J., Giralt, E. and Vila, J. (2012). In vitro activity of several antimicrobial peptides against colistin-susceptible and colistin-resistant Acinetobacter baumannii. Clin. Microbiol. Infect. 18, 383-387.
332. Vincent, J. L, Rello, J., Marshall, J., Silva, E., Anzueto, A., Martin, C. D., Moreno, R., Lipman, J., Gomersall, C, Sakr, Y., and Reinhart, K. (2009). International study of the prevalence and outcomes of infection in intensive care units. JAMA 302,2323-2329.
333. Visca, P., Seifert, H., and Towner, K. J. (2011). Acinetobacter infection-an emerging threat to human health. IUBMB Life 63,1048-1054.
334. Wang, H., Guo, P., Sun, H., Wang, H., Yang, Q., Chen, M., Xu, Y, and Zhu, Y (2007). Molecular epidemiology of clinical isolates of carbapenem-resistant Acinetobacter spp. from Chinese hospitals. Antimicrob. Agents Chemother. 51, 4022-4028.
335. Wareham, D. W, Gordon, N. C, and Hornsey, M. (2011). In vitro activity of teicoplanin combined with colistin versus multidrug-resistant strains of Acinetobacter baumannii. J. Antimicrob. Chemother. 66, 1047-1051.
336. Watanabe, M., Iyobe, S., Inoue, M., and Mitsuhashi, S. (1991). Transferable imipenem resistance in Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 35,147-151.
337. Wendt, C, Dietze, B., Dietz, E., and Ruden, H. (1997). Survival of Acinetobacter baumannii on dry surfaces. J. Clin. Microbiol. 35,1394-1397.
338. Whitehead, N. A., Barnard, A. M., Slater, H., Simpson, N. J., and Salmond, G. P. (2001). Quorum-sensing in Gram-negative bacteria. FEMS Microbiol. Rev. 25, 365-404.
339. Wisplinghoff, H., Bischoff, T., Tallent, S. M., Seifert, H., Wenzel, R. P., and Edmond, M. B. (2004). Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study. Clin. Infect. Dis. 39, 309-317.
340. Wisplinghoff, H., Decker, M., Haefs, C, Krut, O., Plum, G., and Seifert, H. (2003). Mutations in gyrA and parC associated with resistance to fluoroquinolones in epidemiologically denned clinical strains of Acinetobacter baumannii. J. Antimicrob. Chemother. 51,177-180.
341. Wong, E. W, Yusof, M. Y., Mansor, M. B., Anbazhagan, D., Ong, S. Y, and Sekaran, S. D. (2009). Disruption of adeB gene has a greater effect on resistance to meropenems than adeA gene in Acinetobacter spp. isolated from University Malaya Medical Centre. Singapore Med. J. 50, 822-826.
342. Wroblewska, M., Sawicka-Grzelak, A., Luczak, M., and Sivan, A. (2008). Biofilm production by clinical strains of Acinetobacter baumannii isolated from patients hospitalized in two tertiary care hospitals. FEMS Immunol. Med. Microbiol. 53, 140-144.
343. Wroblewska, M. M., Towner, K. J., Marchel, H., and Luczak, M. (2007). Emergence and spread of carbapenem-resistant strains of Acinetobacter baumannii in a tertiary-care hospital in Poland. Clin. Microbiol. Infect. 13, 490-496.
344. Yamamoto, M., Nagao, M., Matsumura, Y., Matsushima, A., Ito, Y, Takakura, S., and Ichiyama, S. (2011). Inter-species dissemination of a novel class 1 integron carrying blalMP-19 among Acinetobacter species in Japan. J. Antimicrob. Chemother. 66, 2480-2483.
345. Yamamoto, S., Okujo, N., and Sakakibara, Y. (1994). Isolation and structure elucidation of acinetobactin, a novel siderophore from Acinetobacter baumannii. Arch. Microbiol. 162, 249-254.
346. Yamane, K., Wachino, J., Doi, Y, Kurokawa, H., and Arakawa, Y (2005). Global spread of multiple aminoglycoside resistance genes. Emerging Infect. Dis. 11, 951-953.
347. Yin, X. L, Hou, T. W, Xu, S. B., Ma, C. Q., Yao, Z. Y, Li, W, and Wei, L. (2008). Detection of drug resistance-associated genes of multidrug-resistant Acinetobacter baumannii. Microb. Drug Resist. 14, 145-150.
348. Yong, D., Toleman, M. A., Giske, C. G., Cho, H. S., Sundman, K., Lee, K., and Walsh, T. R. (2009). Characterization of a new metallo-(3-lactamase gene, blaNDM-1, and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India. Antimicrob. Agents Chemother. 53, 5046-5054.
349. Yu, Y S., Zhou, H., Yang, Q., Chen, Y. G., and Li, L. J. (2007). Widespread occurrence of aminoglycoside resistance due to ArmA methylase in imipenem-resistant Acinetobacter baumannii isolates in China. J. Antimicrob. Chemother. 60,454-455.
350. Yum, J. H., Yi, K., Lee, H., Yong, D., Lee, K., Kim, J. M., Rossolini, G. M., and Chong, Y (2002). Molecular characterization of metallo-(3-lactamase-producing Acinetobacter baumannii and Acinetobacter genomospecies 3 from Korea: identification of two new integrons carrying the blaVIM-2 gene cassettes. J. Antimicrob. Chemother. 49, 837-840.
351. Yun,S.H.,Choi,C.W,Kwon,S.O.,Park, G. W., Cho, K., Kwon, K. H., Kim, J. Y.,Yoo, J.S., Lee, J.C., Choi, J.S., Kim, S., and Kim, S. I. (2011). Quantitative proteomic analysis of cell wall and plasma membrane fractions from multidrug-resistant Acinetobacter baumannii. J. Proteome Res. 10, 459-469.
352. Zarrilli, R., Crispino, M., Bagattini, M., Barretta, E., Di Popolo, A., Triassi, M., and Villari, P. (2004). Molecular epidemiology of sequential outbreaks of Acinetobacter baumannii in an intensive care unit shows the emergence of carbapenem resistance. J. Clin. Microbiol. 42, 946-953.
353. Zhao, W H., and Hu, Z. Q. (2011). IMP-type metallo-(3-lactamases in Gram-negative bacilli: distribution, phylogeny, and association with integrons. Crit. Rev. Microbiol. 37, 214-226.
354. Zhao, W H., and Hu, Z. Q. (2012). Acinetobacter: a potential reservoir and dispenser for (3-lactamases. Crit. Rev. Microbiol. 38, 30-51.
355. Zhou, H., Zhang, T., Yu, D., Pi, B., Yang, Q., Zhou, J., Hu, S., and Yu, Y (2011). Genomic analysis of the multidrug-resistant Acinetobacter baumannii strain MDR-ZJ06 widely spread in China. Antimicrob. Agents Chemother. 55, 4506-4512.
356. Zimbler, D. L., Penwell, W. E, Gaddy, J. A., Menke, S. M., Tomaras, A. P., Connerly, P. L., and Actis, L. A. (2009). Iron acquisition functions expressed by the human pathogen Acinetobacter baumannii. Biometals 22,23-32.