ISAba825, a functional insertion sequence modulating genomic plasticity and bla OXA-58 expression in Acinetobacter baumannii

Antimicrobial Agents and Chemotherapy

Volumn 55, Issue 2, 2011, Pages 917-920

  Ravasi, Pablo ^a   Limansky, Adriana S ^a   Rodriguez, Ramiro E ^a   Viale, Alejandro M ^a   Mussi, María A ^a  

^a UNIVERSIDAD NACIONAL DE ROSARIO   (Argentina)

Author keywords

[No Author keywords available]

Indexed keywords

CARBAPENEM; KANAMYCIN;

ACINETOBACTER BAUMANNII; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; GENE DUPLICATION; GENE FUNCTION; GENE INSERTION SEQUENCE; GENE SEQUENCE; GENE TARGETING; GENETIC ASSOCIATION; GENOMICS; ISABA825 GENE; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASMID; PLASMID BORNE BLA OXA 58 GENE; PLASTICITY; PRIORITY JOURNAL; PROMOTER REGION;

ACINETOBACTER BAUMANNII; ACINETOBACTER INFECTIONS; ANTI-BACTERIAL AGENTS; BASE SEQUENCE; BETA-LACTAM RESISTANCE; BETA-LACTAMASES; CARBAPENEMS; DNA TRANSPOSABLE ELEMENTS; DNA, BACTERIAL; GENE EXPRESSION REGULATION, BACTERIAL; GENOME, BACTERIAL; HUMANS; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; PLASMIDS; POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS, DNA;

EID: 78751695143     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.00491-10     Document Type: Article

References (27)

1. Alexeyev, M. F. 1999. The pKNOCK series of broad-host-range mobilizable suicide vectors for gene knockout and targeted DNA insertion into the chromosome of gram-negative bacteria. Biotechniques 26:824-826, 828.
2. Aubert, D., T. Naas, C. Heritier, L. Poirel, and P. Nordmann. 2006. Functional characterization of IS1999, an IS4 family element involved in mobilization and expression of β-lactam resistance genes. J. Bacteriol. 188:6506-6514. (Pubitemid 44412060)
3. Chen, T., R. Wu, M. Shaio, C. Fung, and W. Cho. 2008. Acquisition of a plasmid-borne blaOXA-58 gene with an upstream IS1008 insertion conferring a high level of carbapenem resistance to Acinetobacter baumannii. Antimicrob. Agents Chemother. 52:2573-2580.
4. Coelho, J. M., et al. 2006. Occurrence of carbapenem-resistant Acinetobacter baumannii clones at multiple hospitals in London and southeast England. J. Clin. Microbiol. 44:3623-3627.
5. del Mar Tomás, M., et al. 2005. Cloning and functional analysis of the gene encoding the 33- to 36-kilodalton outer membrane protein associated with carbapenem resistance in Acinetobacter baumannii. Antimicrob. Agents Chemother. 49:5172-5175.
6. Gordon, N. C., and D. W. Wareham. 2010. Multidrug-resistant Acinetobacter baumannii: mechanisms of virulence and resistance. Int. J. Antimicrob. Agents 35:219-226.
7. Héritier, C., A. Dubouix, L. Poirel, N. Marty, and P. Nordmann. 2005. A nosocomial outbreak of Acinetobacter baumannii isolates expressing the carbapenem-hydrolysing oxacillinase OXA-58. J. Antimicrob. Chemother. 55: 115-118.
8. Hunger, M., R. Schmucker, V. Kishan, and W. Hillen. 1990. Analysis and nucleotide sequence of an origin of DNA replication in Acinetobacter calcoaceticus and its use for Escherichia coli shuttle plasmids. Gene 87:45-51.
9. Kato, N., K. Yamazoe, C. G. Han, and E. Ohtsubo. 2003. New insertion sequence elements in the upstream region of cfiA in imipenem-resistant Bacteroides fragilis strains. Antimicrob. Agents Chemother. 47:979-985.
10. Kovach, M. E., et al. 1995. Four new derivatives of the broad-host-range cloning vector pBBR1MCS, carrying different antibiotic-resistance cassettes. Gene 166:175-176.
11. Lin, H., T.-Y. Li, M.-H. Xie, and Y. Zhang. 2007. Characterization of the variants, flanking genes, and promoter activity of the Leifsonia xyli subsp. cynodontis insertion sequence IS1237. J. Bacteriol. 189:3217-3227.
12. -ΔΔCT method. Methods 25:402-408.
13. Mahillon, J., and M. Chandler. 1998. Insertion sequences. Microbiol. Mol. Biol. Rev. 62:725-774.
14. Marchiaro, P., et al. 2008. A convenient microbiological assay employing cell-free extracts for the rapid characterization of Gram-negative carbapenemase producers. J. Antimicrob. Chemother. 62:336-344.
15. Marqué, S., et al. 2005. Regional occurrence of plasmid mediated carbapenem-hydrolyzing oxacillinase OXA-58 in Acinetobacter spp. in Europe. J. Clin. Microbiol. 43:4885-4888.
16. OXA-58 in Acinetobacter baumannii from Argentina. J. Infect. Dev. Ctries. 2:235-240.
17. Mugnier, P., L. Poirel, and P. Nordmann. 2009. Functional analysis of insertion sequence ISAba1, responsible for genomic plasticity of Acinetobacter baumannii. J. Bacteriol. 191:2414-2418.
18. Mussi, M. A., A. S. Limansky, and A. M. Viale. 2005. Acquisition of resistance to carbapenems in multidrug-resistant clinical strains of Acinetobacter baumannii: natural insertional inactivation of a gene encoding a member of a novel family of beta-barrel outer membrane proteins. Antimicrob. Agents Chemother. 49:1432-1440.
19. Nagai, T., L. S. Phan Tran, Y. Inatsu, and Y. Itoh. 2000. A new IS4 family insertion sequence, IS4Bsu1, responsible for genetic instability of poly-γ-glutamic acid production in Bacillus subtilis. J. Bacteriol. 182:2387-2392.
20. Pasterán, F., et al. 2006. Emergence of PER-2 and VEB-1a in Acinetobacter baumannii strains in the Americas. Antimicrob. Agents Chemother. 50: 3222-3224.
21. Perez, F., et al. 2007. Global challenge of multidrug-resistant Acinetobacter baumannii. Antimicrob. Agents Chemother. 51:3471-3484.
22. Perez, F., A. Endimiani, and R. A. Bonomo. 2008. Why are we afraid of Acinetobacter baumannii? Expert Rev. Anti Infect. Ther. 6:269-271.
23. CTX-M- lactamase gene. Antimicrob. Agents Chemother. 47:2938-2945.
24. Poirel, L., et al. 2005. OXA-58, a novel class D β-lactamase involved in resistance to carbapenems in Acinetobacter baumannii. Antimicrob. Agents Chemother. 49:202-208.
25. OXA-58 in Acinetobacter baumannii. Antimicrob. Agents Chemother. 50: 1442-1448.
26. Poirel, L., and P. Nordmann. 2006. Carbapenem resistance in Acinetobacter baumannii: mechanisms and epidemiology. Clin. Microbiol. Infect. 12:826-836.
27. Smith, M., et al. 2007. New insights into Acinetobacter baumannii pathogenesis revealed by high-density pyrosequencing and transposon mutagenesis. Genes Dev. 21:601-614.