Analysis of genes encoding penicillin-binding proteins in clinical isolates of Acinetobacter baumannii

Antimicrobial Agents and Chemotherapy

Volumn 55, Issue 12, 2011, Pages 5907-5913

  Cayô, Rodrigo ^a   Rodríguez, María Cruz ^a,f   Espinal, Paula ^b   Fernández Cuenca, Felipe ^c   Ocampo Sosa, Alain A ^a   Pascual, Álvaro ^c   Ayala, Juan A ^d   Vila, Jordi ^b   Martínez Martínez, Luis ^a,e  

^a HOSPITAL UNIVERSITARIO MARQUÉS DE VALDECILLA   (Spain)

^b UNIVERSITY OF BARCELONA   (Spain)

^c HOSPITAL UNIVERSITARIO VIRGEN MACARENA   (Spain)

^d CENTRO DE BIOLOGÍA MOLECULAR SEVERO OCHOA   (Spain)

^e UNIVERSITY OF CANTABRIA   (Spain)

^f University of Cantabria   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; BETA LACTAM; CARBAPENEM; GLYCOSYLTRANSFERASE; PENICILLIN BINDING PROTEIN; PENICILLIN BINDING PROTEIN 2A; PENICILLIN BINDING PROTEIN 2B; PENICILLIN BINDING PROTEIN 3; PENICILLIN BINDING PROTEIN 7; UNCLASSIFIED DRUG;

ACINETOBACTER BAUMANNII; ALLELE; AMINO ACID ANALYSIS; AMINO ACID SEQUENCE; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GENETICS; BACTERIUM ISOLATE; CONTROLLED STUDY; GENE IDENTIFICATION; GENE INSERTION SEQUENCE; GENE SEQUENCE; GENOME; MOLECULAR WEIGHT; MUTATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SPAIN; SPECIES IDENTIFICATION; TEACHING HOSPITAL;

ACINETOBACTER BAUMANNII; ACINETOBACTER INFECTIONS; AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; BETA-LACTAM RESISTANCE; CARBAPENEMS; HOSPITALS, TEACHING; HUMANS; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; PENICILLIN-BINDING PROTEINS; POINT MUTATION; SEQUENCE ANALYSIS, DNA; SPAIN;

EID: 81555201965     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.00459-11     Document Type: Article

References (45)

1. Baumann, P. 1968. Isolation of Acinetobacter from soil and water. J. Bacteriol. 96:39-42.
2. Bertsche, U., E. Breukink, T. Kast, and W. Vollmer. 2005. In vitro murein peptidoglycan synthesis by dimers of the bifunctional transglycosylase- transpeptidase PBP1B from Escherichia coli. J. Biol. Chem. 280:38096-38101. (Pubitemid 41642424)
3. Born, P., E. Breukink, and W. Vollmer. 2006. In vitro synthesis of cross-linked murein and its attachment to sacculi by PBP1A from Escherichia coli. J. Biol. Chem. 281:26985-26993. (Pubitemid 44401727)
4. Cabeen, M. T., and C. Jacobs-Wagner. 2005. Bacterial cell shape. Nat. Rev. Microbiol. 3:601-610. (Pubitemid 41052147)
5. OXA-23 collected from hospitals in Rio de Janeiro, Brazil. Int. J. Antimicrob. Agents 34:25-28.
6. Catalano, M., L. S. Quelle, P. E. Jeric, A. Di Martino, and S. M. Maimonet. 1999. Survival of Acinetobacter baumannii on bed rails during an outbreak and during sporadic cases. J. Hosp. Infect. 42:27-35. (Pubitemid 29240300)
7. OXA-51-like gene with an upstream ISAba1 in carbapenem-resistant Acinetobacter baumannii in Taiwan. Antimicrob. Agents Chemother. 54:4575-4581.
8. Clinical and Laboratory Standards Institute. 2009. Methods for dilution antimicrobial susceptibility test for bacteria that grow aerobically. Eighth edition: approved standard M7-A8. CLSI, Wayne, PA.
9. Clinical and Laboratory Standards Institute. 2011. Performance standards for antimicrobial susceptibility testing. Twenty-first edition. Informational supplement M100-S21. CLSI, Wayne, PA.
10. Den Blaauwen, T., M. E. Aarsman, N. O. Vischer, and N. Nanninga. 2003. Penicillin-binding protein PBP2 of Escherichia coli localizes preferentially in the lateral wall and at mid-cell in comparison with the old cell pole. Mol. Microbiol. 47:539-547. (Pubitemid 36121042)
11. Dijkshoorn, L., et al. 1996. Comparison of outbreak and nonoutbreak Acinetobacter baumannii strains by genotypic and phenotypic methods. J. Clin. Microbiol. 34:1519-1525. (Pubitemid 26161019)
12. Fernández-Cuenca, F., et al. 2003. Relationship between beta-lactamase production, outer membrane protein and penicillin-binding protein profiles on the activity of carbapenems against clinical isolates of Acinetobacter baumannii. J. Antimicrob. Chemother. 51:565-574. (Pubitemid 36336148)
13. Gehrlein, M., H. Leying, W. Cullmann, S. Wendt, and W. Opferkuch. 1991. Imipenem resistance in Acinetobacter baumannii is due to altered penicillin-binding proteins. Chemotherapy 37:405-412.
14. Ghosh, A. S., C. Chowdhury, and D. E. Nelson. 2008. Physiological functions of D-alanine carboxypeptidases in Escherichia coli. Trends Microbiol. 16:309-317.
15. Giamarellou, H., A. Antoniadou, and K. Kanellakopoulou. 2008. Acinetobacter baumannii: a universal threat to public health? Int. J. Antimicrob. Agents 32:106-119.
16. Giannouli, M., et al. 2010. Molecular epidemiology of multidrug-resistant Acinetobacter baumannii in a tertiary care hospital in Naples, Italy, shows the emergence of a novel epidemic clone. J. Clin. Microbiol. 48:1223-1230.
17. Goffin, C., and J. M. Ghuysen. 1998. Multimodular penicillin-binding proteins: an enigmatic family of orthologs and paralogs. Microbiol. Mol. Biol. Rev. 62:1079-1093. (Pubitemid 28558293)
18. Héritier, C., et al. 2005. Characterization of the naturally occurring oxacillinase of Acinetobacter baumannii. Antimicrob. Agents Chemother. 49:4174-4179. (Pubitemid 41400961)
19. Higgins, P. G., C. Dammhayn, M. Hackel, and H. Seifert. 2010. Global spread of carbapenem-resistant Acinetobacter baumannii. J. Antimicrob. Chemother. 65:233-238.
20. Huang, L., L. Sun, G. Xu, and T. Xia. 2008. Differential susceptibility to carbapenems due to the AdeABC efflux pump among nosocomial outbreak isolates of Acinetobacter baumannii in a Chinese hospital. Diagn. Microbiol. Infect. Dis. 62:326-332.
21. Jawad, A., H. Seifert, A. M. Snelling, J. Heritage, and P. M. Hawkey. 1998. Survival of Acinetobacter baumannii on dry surfaces: comparison of outbreak and sporadic isolates. J. Clin. Microbiol. 36:1938-1941. (Pubitemid 28277780)
22. Michalopoulos, A., and M. E. Falagas. 2010. Treatment of Acinetobacter infections. Expert Opin. Pharmacother. 11:779-788.
23. Monterrubio-Villar, J., et al. 2009. Outbreak of multiresistant Acinetobacter baumannii in a polyvalent intensive care unit: clinical, epidemiological analysis and PFGE-printing evolution. Eur. J. Clin. Microbiol. Infect. Dis. 28: 1281-1284.
24. Moya, B., et al. 2009. Beta-lactam resistance response triggered by inactivation of a nonessential penicillin-binding protein. PLoS Pathog. 5:e1000353.
25. Mussi, M. A., A. S. Limansky, and A. M. Viale. 2005. Acquisition of resistance to carbapenems in multidrug-resistant clinical strains of Acinetobacter baumannii: natural insertional inactivation of a gene encoding a member of a novel family of β-barrel outer membrane proteins. Antimicrob. Agents Chemother. 49:1432-1440. (Pubitemid 40463373)
26. Obara, M., and T. Nakae. 1991. Mechanisms of resistance to β-lactam antibiotics in Acinetobacter calcoaceticus. J. Antimicrob. Chemother. 28:791-800.
27. Orsi, G. B., et al. 2008. Multidrug-resistant Acinetobacter baumannii outbreak in an intensive care unit. J. Chemother. 20:219-224. (Pubitemid 351797063)
28. Pachón, J., and J. Vila. 2009. Treatment of multiresistant Acinetobacter baumannii infections. Curr. Opin. Investig. Drugs 10:150-156.
29. Piette, A., et al. 2004. Structural determinants required to target penicillin-binding protein 3 to the septum of Escherichia coli. J. Bacteriol. 186:6110-6117. (Pubitemid 39186999)
30. Poirel, L., and P. Nordmann. 2006. Carbapenem resistance in Acinetobacter baumannii: mechanisms and epidemiology. Clin. Microbiol. Infect. 12:826-836. (Pubitemid 44151282)
31. Poirel, L., T. Naas, and P. Nordmann. 2010. Diversity, epidemiology, and genetics of class D beta-lactamases. Antimicrob. Agents Chemother. 54:24-38.
32. Robledo, I. E., et al. 2010. Detection of KPC in Acinetobacter spp. in Puerto Rico. Antimicrob. Agents Chemother. 54:1354-1357.
33. Sauvage, E., F. Kerff, M. Terrak, J. A. Ayala, and P. Charlier. 2008. The penicillin-binding proteins: structure and role in peptidoglycan biosynthesis. FEMS Microbiol. Rev. 32:234-258. (Pubitemid 351257821)
34. Seifert, H., et al. 2005. Standardization and interlaboratory reproducibility assessment of pulsed-field gel electrophoresis-generated fingerprints of Acinetobacter baumannii. J. Clin. Microbiol. 43:4328-4335. (Pubitemid 41298209)
35. Spratt, B. G., J. Zhou, M. Taylor, and M. J. Merrick. 1996. Monofunctional biosynthetic peptidoglycan transglycosylases. Mol. Microbiol. 19:639-640.
36. Tayler, A. E., et al. 2010. Induction of beta-lactamase production in Aeromonas hydrophila is responsive to beta-lactam-mediated changes in peptidoglycan composition. Microbiology 156:2327-2335.
37. Tenover, F. C., et al. 1995. Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis: criteria for bacterial strain typing. J. Clin. Microbiol. 33:2233-2239.
38. Urban, C., E. Go, N. Mariano, and J. J. Rahal. 1995. Interaction of sulbactam, clavulanic acid and tazobactam with penicillin-binding proteins of imipenem- resistant and -susceptible Acinetobacter baumannii. FEMS Microbiol. Lett. 125:193-197.
39. Vaneechoutte, M., et al. 1995. Identification of Acinetobacter genomic species by amplified ribosomal DNA restriction analysis. J. Clin. Microbiol. 33:11-15. (Pubitemid 24382389)
40. Wang, H., et al. 2007. Molecular epidemiology of clinical isolates of carbapenem- resistant Acinetobacter spp. from Chinese hospitals. Antimicrob. Agents Chemother. 51:4022-4028. (Pubitemid 350057801)
41. Wendt, C., B. Dietze, E. Dietz, and H. Rüden. 1997. Survival of Acinetobacter baumannii on dry surfaces. J. Clin. Microbiol. 35:1394-1397. (Pubitemid 27216802)
42. Wilke, M. S., A. L. Lovering, and N. C. Strynadka. 2005. Beta-lactam antibiotic resistance: a current structural perspective. Curr. Opin. Microbiol. 8:525-533. (Pubitemid 41355032)
43. Yun, S. H., et al. 2011. Quantitative proteomic analysis of cell wall and plasma membrane fractions from multidrug-resistant Acinetobacter baumannii. J. Proteome Res. 10:459-469.
44. Zamorano, L., B. Moyá, C. Juan, and A. Oliver. 2010. Differential beta-lactam resistance response driven by ampD or dacB (PBP4) inactivation in genetically diverse Pseudomonas aeruginosa strains. J. Antimicrob. Chemother. 65:1540-1542.
45. Zapun, A., C. Contreras-Martel, and T. Vernet. 2008. Penicillin-binding proteins and β-lactam resistance. FEMS Microbiol. Rev. 32:361-385.