Molecular characterization of blaNDM-1 in an Acinetobacter baumannii strain isolated in Germany in 2007

Journal of Antimicrobial Chemotherapy

Volumn 66, Issue 9, 2011, Pages 1998-2001

  Pfeifer, Yvonne ^a   Wilharm, Gottfried ^a   Zander, Esther ^b   Wichelhaus, Thomas A ^c   Göttig, Stefan ^c   Hunfeld, Klaus Peter ^d   Seifert, Harald ^b   Witte, Wolfgang ^a   Higgins, Paul G ^b  

^a ROBERT KOCH INSTITUTE   (Germany)

^b UNIVERSITY OF COLOGNE   (Germany)

^c UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^d Nordwest Medical Center Frankfurt   (Germany)

Author keywords

Carbapenemases; Diversilab; Metallo lactamases; Multidrug resistance; Transposons

Indexed keywords

BETA LACTAMASE NDM 1; BETA LACTAMASE OXA 64; CARBAPENEM; CARRIER PROTEIN; GENOMIC DNA; METALLO BETA LACTAMASE; PLASMID DNA; PROTEIN MAJOR FACILITATOR SUPERFAMILY; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; BACTERIAL DNA; BETA LACTAMASE; BETA-LACTAMASE NDM-1; CARBAPENEM DERIVATIVE;

ACINETOBACTER BAUMANNII; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIUM CONJUGATION; BACTERIUM IDENTIFICATION; BACTERIUM ISOLATION; BACTERIUM TRANSFORMATION; DNA HYBRIDIZATION; GENE AMPLIFICATION; GENE INSERTION SEQUENCE; GENE SEQUENCE; GERMANY; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; TRANSPOSON; ACINETOBACTER INFECTION; ANTIBIOTIC RESISTANCE; CHEMISTRY; CROSS INFECTION; DRUG EFFECT; ENZYMOLOGY; ESCHERICHIA COLI; GENETICS; MICROBIOLOGICAL EXAMINATION; MICROBIOLOGY; MOLECULAR GENETICS; MULTILOCUS SEQUENCE TYPING; PLASMID; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ACINETOBACTER BAUMANNII; ACINETOBACTER INFECTIONS; ANTI-BACTERIAL AGENTS; BETA-LACTAMASES; CARBAPENEMS; CROSS INFECTION; DNA TRANSPOSABLE ELEMENTS; DNA, BACTERIAL; DRUG RESISTANCE, BACTERIAL; ESCHERICHIA COLI; GERMANY; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; MULTILOCUS SEQUENCE TYPING; PLASMIDS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 80051678537     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dkr256     Document Type: Article

References (21)

1. Bonomo RA. New Delhi metallo-b-lactamase and multidrug resistance: a global SOS? Clin Infect Dis 2011; 52: 485-7.
2. Nordmann P, Poirel L, Toleman MA et al. Does broad-spectrum β-lactam resistance due to NDM-1 herald the end of the antibiotic era for treatment of infections caused by Gram-negative bacteria? J Antimicrob Chemother 2011; 66: 689-92.
3. NDM-1, and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India. Antimicrob Agents Chemother 2009; 53: 5046-54.
4. Kumarasamy KK, Toleman MA, Walsh TR et al. Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study. Lancet Infect Dis 2010; 10: 597-602.
5. NDM-1 and armA in clinical isolates of Acinetobacter baumannii from India. J Antimicrob Chemother 2010; 65: 2253-4.
6. Goöttig S, Pfeifer Y, Wichelhaus TA et al. Global spread of New Delhi metallo-b-lactamase 1. Lancet Infect Dis 2010; 10: 828-9.
7. Chen Y, Zhou Z, Jiang Y et al. Emergence of NDM-1-producing Acinetobacter baumannii in China. J Antimicrob Chemother 2011; 66: 1255-9.
8. Kaase M, Nordmann P, Wichelhaus TA et al. NDM-2 carbapenemase in Acinetobacter baumannii from Egypt. J Antimicrob Chemother 2011; 66: 1260-2.
9. Higgins PG, Dammhayn C, Hackel M et al. Global spread of carbapenem-resistant Acinetobacter baumannii. J Antimicrob Chemother 2010; 65: 233-8.
10. Clinical and Laboratory Standards Institute. Performance Standards for Antimicrobial Susceptibility Testing: Twenty-first Informational Supplement M100-S21. CLSI, Wayne, PA, USA, 2011.
11. Woodford N, Ellington MJ, Coelho JM et al. Multiplex PCR for genes encoding prevalent OXA carbapenemases in Acinetobacter spp. Int J Antimicrob Agents 2006; 27: 351-3.
12. Turton JF, Ward ME, Woodford N et al. The role of ISAba1 in expression of OXA carbapenemase genes in Acinetobacter baumannii. FEMS Microbiol Lett 2006; 258: 72-7.
13. Turton JF, Gabriel SN, Valderrey C et al. Use of sequence-based typing and multiplex PCR to identify clonal lineages of outbreak strains of Acinetobacter baumannii. Clin Microbiol Infect 2007; 13: 807-15.
14. Choi KH, Kumar A, Schweizer HP. A 10-min method for preparation of highly electrocompetent Pseudomonas aeruginosa cells: application for DNA fragment transfer between chromosomes and plasmid transformation. J Microbiol Methods 2006; 64: 391-7.
15. Barton BM, Harding GP, Zuccarelli AJ. A general-method for detecting and sizing large plasmids. Anal Biochem 1995; 226: 235-40.
16. Kovach ME, Phillips RW, Elzer PH et al. pBBR1MCS: a broad-host-range cloning vector. Biotechniques 1994; 16: 800-2.
17. OXA-51 variant and DiversiLab worldwide clonal lineages in Acinetobacter baumannii. In: Abstracts of the Twenty-first European Congress of Clinical Microbiology and Infectious Diseases/Twenty-seventh International Congress of Chemotherapy, Milan, Italy, 2011. Abstract P1731. European Society of Clinical Microbiology and Infectious Diseases, Basel, Switzerland.
18. Mussi MA, Limansky AS, Viale AM. Acquisition of resistance to carbapenems in multidrug-resistant clinical strains of Acinetobacter baumannii: natural insertional inactivation of a gene encoding a member of a novel family of β-barrel outer membrane proteins. Antimicrob Agents Chemother 2005; 49: 1432-40.
19. OXA-58 genes in Acinetobacter genospecies 3. J Antimicrob Chemother 2010; 65: 1586-8.
20. Meric M, Kasap M, Gacar G et al. Emergence and spread of carbapenem-resistant Acinetobacter baumannii in a tertiary care hospital in Turkey. FEMS Microbiol Lett 2008; 282: 214-8.
21. OXA-18, encoding a clavulanic acid-inhibited extendedspectrum oxacillinase. Antimicrob Agents Chemother 2008; 52: 3898-904.