Rational Design of α-Helical Antimicrobial Peptides to Target Gram-negative Pathogens, Acinetobacter baumannii and Pseudomonas aeruginosa: Utilization of Charge, 'Specificity Determinants,' Total Hydrophobicity, Hydrophobe Type and Location as Design Parameters to Improve the Therapeutic Ratio

Chemical Biology and Drug Design

Volumn 77, Issue 4, 2011, Pages 225-240

  Jiang, Ziqing ^a   Vasil, Adriana I ^b   Gera, Lajos ^a   Vasil, Michael L ^b   Hodges, Robert S ^a  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

Acinetobacter baumannii; Antimicrobial peptides; Gram negative pathogens; Pseudomonas aeruginosa; Specificity determinants

Indexed keywords

K 13; PEPTIDE D1; PEPTIDE D11; PEPTIDE D14; PEPTIDE D15; PEPTIDE D16; PEPTIDE D22; POLYPEPTIDE ANTIBIOTIC AGENT; UNCLASSIFIED DRUG;

ACINETOBACTER BAUMANNII; ANTIBIOTIC RESISTANCE; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL STRAIN; CONTROLLED STUDY; DRUG DESIGN; GRAM NEGATIVE BACTERIUM; GRAM NEGATIVE INFECTION; HEMOLYSIS; HYDROPHOBICITY; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA;

ACINETOBACTER BAUMANNII; AMINO ACID SEQUENCE; ANTI-INFECTIVE AGENTS; DRUG DESIGN; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; INHIBITORY CONCENTRATION 50; MOLECULAR SEQUENCE DATA; PEPTIDES; PSEUDOMONAS AERUGINOSA;

ACINETOBACTER BAUMANNII; ADRIANA; BACTERIA (MICROORGANISMS); NEGIBACTERIA; PSEUDOMONAS AERUGINOSA;

EID: 79952614254     PISSN: 17470277     EISSN: 17470285     Source Type: Journal    
DOI: 10.1111/j.1747-0285.2011.01086.x     Document Type: Article

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