Quorum-sensing in Gram-negative bacteria

FEMS Microbiology Reviews

Volumn 25, Issue 4, 2001, Pages 365-404

  Whitehead, Neil A ^a   Barnard, Anne M L ^a   Slater, Holly ^a   Simpson, Natalie J L ^a   Salmond, George P C ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Acyl homoserine lactone; Bacterial signalling; LuxI; LuxR; Pheromone; Quorum sensing

Indexed keywords

BACTERIAL PROTEIN; LACTONE; N (3 HYDROXY 7 TETRADECENOYL)HOMOSERINE LACTONE; N (3 HYDROXYBUTANOYL)HOMOSERINE LACTONE; N (3 OXODODECANOYL)HOMOSERINE LACTONE; N (3 OXOHEXANOYL)HOMOSERINE LACTONE; N (3 OXOOCTANOYL)HOMOSERINE LACTONE; N ACYLHOMOSERINE LACTONE DERIVATIVE; N BUTANOYLHOMOSERINE LACTONE; N HEXANOYLHOMOSERINE LACTONE; N OCTANOYLHOMOSERINE LACTONE; PIPERAZINEDIONE; PROTEIN LUXI; REGULATOR PROTEIN; SYNTHETASE; TRANSCRIPTION FACTOR LUXR; UNCLASSIFIED DRUG;

BIOFILM; BIOLUMINESCENCE; CELL INTERACTION; DNA BINDING; ENZYME SYNTHESIS; GRAM NEGATIVE BACTERIUM; MOLECULAR INTERACTION; NONHUMAN; PECTOBACTERIUM CAROTOVORUM; PROTEIN FAMILY; PSEUDOMONAS AERUGINOSA; RALSTONIA SOLANACEARUM; REGULATORY MECHANISM; REVIEW; RHIZOBIUM; RHIZOBIUM RADIOBACTER; SERRATIA LIQUEFACIENS; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; VIBRIO FISCHERI; VIBRIO HARVEYI; XANTHOMONAS CAMPESTRIS; YERSINIA;

4-BUTYROLACTONE; AMINO ACID SEQUENCE; BACTERIAL PROTEINS; COLONY COUNT, MICROBIAL; GRAM-NEGATIVE BACTERIA; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

EID: 0034886912     PISSN: 01686445     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-6445(01)00059-6     Document Type: Review

References (357)

1. Two-component signal transduction
2. Eubacterial sigma-factors
3. H-NS: A modulator of environmentally regulated gene expression
4. Clues and consequences of DNA bending in transcription
5. Quorum sensing in bacteria: The LuxR-LuxI family of cell density-responsive transcriptional regulators
6. Quorum sensing by peptide pheromones and two-component signal-transduction systems in Gram-positive bacteria
7. The ins and outs of peptide signaling
8. Thinking about bacterial populations as multicellular organisms
9. The Euprymna scolopes-Vibrio fischeri symbiosis: A biomedical model for the study of bacterial colonization of animal tissue
10. An exclusive contract: Specificity in the Vibrio fischeri-Euprymna scolopes partnership
11. Host-derived amino acids support the proliferation of symbiotic bacteria
12. Bacterial symbionts induce host organ morphogenesis during early postembryonic development of the squid Euprymna scolopes
13. Induction of a gradual, reversible morphogenesis of its host's epithelial brush border by Vibrio fischeri
14. Alterations in the proteome of the Euprymna scolopes light organ in response to symbiotic Vibrio fischeri
15. Vibrio fischeri lux genes play an important role in colonization and development of the host light organ
16. Bacterial bioluminescence: Isolation and genetic analysis of functions from Vibrio fischeri
17. A new Vibrio fischeri lux gene precedes a bidirectional termination site for the lux operon
18. Identification of genes and gene products necessary for bacterial bioluminescence
19. Conversion of aldehyde to acid in the bacterial bioluminescent reaction
20. Bacterial bioluminescence
21. Bacterial bioluminescence: An overview
22. Functional identification of the fatty acid reductase components encoded in the luminescence operon of Vibrio fischeri
23. Lux C, D and E genes of the Vibrio fischeri luminescence operon code for the reductase, transferase, and synthetase enzymes involved in aldehyde biosynthesis
24. Identification of the genes encoding NAD(P)H-flavin oxidoreductases that are similar in sequence to Escherichia coli Fre in four species of luminous bacteria: Photorhabdus luminescens, Vibrio fischeri, Vibrio harveyi, and Vibrio orientalis
25. Early observations defining quorum-dependent gene expression
26. Quorum sensing: The explanation of a curious phenomenon reveals a common characteristic of bacteria
27. Cellular control of the synthesis and activity of the bacterial luminescent system
28. Inhibition and activation of bacterial luciferase synthesis
29. Autoinduction of bacterial luciferase
30. Structural identification of autoinducer of Photobacterium fischeri luciferase
31. Diffusion of autoinducer is involved in regulation of the Vibrio fischeri luminescence system
32. Nucleotide sequence of the luxR and luxI genes and structure of the primary regulatory region of the lux regulon of Vibrio fischeri ATCC 7744
33. Identification of the operator of the lux regulon from the Vibrio fischeri strain ATCC7744
34. Quorum sensing in Vibrio fischeri: Elements of the luxI promoter
35. Detection and quantification of Vibrio fischeri autoinducer from symbiotic squid light organs
36. The Vibrio fischeri LuxR protein is capable of bidirectional stimulation of transcription and both positive and negative regulation of the luxR gene
37. Positive autoregulation of the Vibrio fischeri luxR gene
38. Requirement for autoinducer in transcriptional negative autoregulation of the Vibrio fischeri luxR gene in Escherichia coli
39. Identification of a distantly located regulatory element in the luxCD gene required for negative autoregulation of the Vibrio fischeri luxR gene
40. Regulatory circuitry controlling luminescence autoinduction in Vibrio fischeri
41. Quorum regulation of luminescence in Vibrio fischeri
42. Control of Vibrio fischeri lux gene transcription by a cyclic AMP receptor protein-LuxR protein regulatory circuit
43. Multiple N-acyl-L-homoserine lactone autoinducers of luminescence in the marine symbiotic bacterium Vibrio fischeri
44. Modulation of luminescence operon expression by N-octanoyl-L-homoserine lactone in ainS mutants of Vibrio fischeri
45. LuxR- and acyl-homoserine-lactone-controlled non-lux genes define a quorum-sensing regulon in Vibrio fischeri
46. AinS and a new family of autoinducer synthesis proteins
47. Acylhomoserine lactone synthase activity of the Vibrio fischeri AinS protein
48. Induction of luciferase synthesis in Beneckea harveyi by other marine bacteria
49. Overproduction and purification of the luxR gene product: Transcriptional activator of the Vibrio fischeri luminescence system
50. Nucleotide sequence of the luxR and luxI genes and structure of the primary regulatory region of the lux regulon of Vibrio fischeri ATCC 7744
51. Formation of the LuxR protein in the Vibrio fischeri lux system is controlled by HtpR through the GroESL proteins
52. GroESL proteins facilitate binding of externally added inducer by LuxR protein-containing E. coli cells
53. 32, is involved in transcriptional regulation of the Vibrio fischeri luminescence genes in Escherichia coli
54. The Vibrio fischeri luminescence gene activator LuxR is a membrane-associated protein
55. Use of regulated cell lysis in a lethal genetic selection in Escherichia coli: Identification of the autoinducer-binding region of the LuxR protein from Vibrio fischeri ATCC7744
56. Critical regions of the Vibrio fischeri LuxR protein defined by mutational analysis
57. Evidence that the N-terminal region of the Vibrio fischeri LuxR protein constitutes an autoinducer-binding domain
58. Autoinducer binding by the quorum-sensing regulator TraR increases affinity for target promoters in vitro and decreases TraR turnover rates in whole cells
59. Quorum-sensing signal binding results in dimerization of TraR and its release from membranes into the cytoplasm
60. N-Acyl homoserine lactone binding to the CarR receptor determines quorum-sensing specificity in Erwinia
61. Genetic evidence for multimerization of LuxR, the transcriptional activator of Vibrio fischeri luminescence
62. The quorum-sensing transcriptional regulator TraR requires its cognate signaling ligand for protein folding, protease resistance, and dimerization
63. Signal-dependent DNA binding and functional domains of the quorum-sensing activator TraR as identified by repressor activity
64. Genetic dissection of DNA binding and luminescence gene activation by the Vibrio fischeri LuxR protein
65. Quorum sensing in Vibrio fischeri: Analysis of the LuxR DNA binding region by alanine-scanning mutagenesis
66. Amino acid residues in LuxR critical for its mechanism of transcriptional activation during quorum sensing in Vibrio fischeri
67. The C-terminal region of the Vibrio fischeri LuxR protein contains an autoinducer-independent lux gene activating domain
68. Intragenic suppression of a luxR mutation: Characterization of an autoinducer-independent LuxR
69. Autoinducer-independent mutants of the LuxR transcriptional activator exhibit differential effects on the two lux promoters of Vibrio fischeri
70. Conversion of the Vibrio fischeri transcriptional activator, LuxR, to a repressor
71. Quorum sensing in Vibrio fischeri: Essential elements for activation of the luminescence genes
72. Involvement of the RNA polymerase α-subunit C-terminal domain in LuxR-dependent activation of the Vibrio fischeri luminescence genes
73. Positive activation of gene expression
74. Synergistic binding of the Vibrio fischeri LuxR transcriptional activator domain and RNA polymerase to the lux promoter region
75. Characterization of the Erwinia chrysanthemi expI-expR locus directing the synthesis of two N-acyl-homoserine lactone signal molecules
76. Integration of the quorum-sensing system in the regulatory networks controlling virulence factor synthesis in Erwinia chrysanthemi
77. Enzymatic synthesis of a quorum-sensing autoinducer through use of defined substrates
78. Generation of cell-to-cell signals in quorum sensing: Acyl homoserine lactone synthase activity of a purified Vibrio fischeri LuxI protein
79. Synthesis of the lux gene autoinducer in Vibrio fischeri is positively autoregulated
80. Quorum sensing in Vibrio fischeri: Evidence that S-adenosylmethionine is the amino acid substrate for autoinducer synthesis
81. In vitro biosynthesis of the Pseudomonas aeruginosa quorum-sensing signal molecule N-butanoyl-L-homoserine lactone
82. Construction and use of low-copy number T7 expression vectors for purification of problem proteins: Purification of Mycobacterium tuberculosis RmlD and Pseudomonas aeruginosa LasI and RhlI proteins, and functional analysis of purified RhlI
83. Acyl homoserine-lactone quorum-sensing signal generation
84. In vivo evidence that S-adenosylmethionine and fatty acid synthesis intermediates are the substrates for the LuxI family of autoinducer synthases
85. Characterization of Pseudomonas aeruginosa enoyl-acyl carrier protein reductase (FabI): A target for the antimicrobial triclosan and its role in acylated homoserine lactone synthesis
86. Mutational analysis of the Vibrio fischeri LuxI polypeptide: Critical regions of an autoinducer synthase
87. Analysis of random and site-directed mutations in rhlI, a Pseudomonas aeruginosa gene encoding an acylhomoserine lactone synthase
88. The biocontrol strain Pseudomonas fluorescens F113 produces the Rhizobium small bacteriocin, N-(3-hydroxy-7-cis-tetradecenoyl) homoserine lactone, via HdtS, a putative novel N-acylhomoserine lactone synthase
89. Quorum sensing and Chromobacterium violaceum: Exploitation of violacein production and inhibition for the detection of N-acylhomoserine lactones
90. Detecting and characterizing N-acyl-homoserine lactone signal molecules by thin-layer chromatography
91. Construction and analysis of luxCDABE-based plasmid sensors for investigating N-acyl homoserine lactone-mediated quorum sensing
92. A novel strategy for the isolation of luxI homologues: Evidence for the widespread distribution of a LuxR: LuxI superfamily in enteric bacteria
93. Extraction of violacein from Chromobacterium violaceum provides a new quantitative bioassay for N-acyl homoserine lactone autoinducers
94. A novel and sensitive method for the quantification of N-3-oxoacyl homoserine lactones using gas chromatography-mass spectrometry: Application to a model bacterial biofilm
95. gfp-based N-acyl homoserine-lactone sensor systems for detection of bacterial communication
96. Analogs of the autoinducer 3-oxooctanoyl-homoserine lactone strongly inhibit activity of the TraR protein of Agrobacterium tumefaciens
97. N-Acyl homoserine lactone-mediated gene regulation in Gram-negative bacteria
98. Active efflux and diffusion are involved in transport of Pseudomonas aeruginosa cell-to-cell signals
99. Pseudomonas aeruginosa
100. Pathogenesis of cystic fibrosis
101. Microbial pathogenesis in cystic fibrosis: Mucoid Pseudomonas aeruginosa and Burkholderia cepacia
102. The contribution of exoproducts to virulence of Pseudomonas aeruginosa
103. Cell-to-cell signaling and Pseudomonas aeruginosa infections
104. Cloning and characterization of the Pseudomonas aeruginosa lasR gene, a transcriptional activator of elastase expression
105. Expression of Pseudomonas aeruginosa virulence genes requires cell-to-cell communication
106. Structure of the autoinducer required for expression of Pseudomonas aeruginosa virulence genes
107. Pseudomonas aeruginosa LasA: A second elastase under the transcriptional control of lasR
108. LasR of Pseudomonas aeruginosa is a transcriptional activator of the alkaline protease gene (apr) and an enhancer of exotoxin A expression
109. The lux autoinducer regulates the production of exoenzyme virulence determinants in Erwinia carotovora and Pseudomonas aeruginosa
110. Purification and characterization of LasR as a DNA-binding protein
111. Activation of the Pseudomonas aeruginosa lasI gene by LasR and the Pseudomonas autoinducer PAI: An autoinduction regulatory hierarchy
112. Vfr controls quorum sensing in Pseudomonas aeruginosa
113. Regulation of las and rhl quorum sensing in Pseudomonas aeruginosa
114. A second N-acylhomoserine lactone signal produced by Pseudomonas aeruginosa
115. Multiple N-acyl-L-homoserine lactone signal molecules regulate production of virulence determinants and secondary metabolites in Pseudomonas aeruginosa
116. Isolation and characterization of a regulatory gene affecting rhamnolipid biosurfactant synthesis in Pseudomonas aeruginosa
117. Swarming of Pseudomonas aeruginosa is dependent on cell-to-cell signaling and requires flagella and pili
118. Synthesis of multiple exoproducts in Pseudomonas aeruginosa is under the control of RhlR-RhlI, another set of regulators in strain PAO1 with homology to the autoinducer-responsive LuxR-LuxI family
119. Multiple homologues of LuxR and LuxI control expression of virulence determinants and secondary metabolites through quorum sensing in Pseudomonas aeruginosa PAO1
120. Autoinducer-mediated regulation of rhamnolipid biosurfactant synthesis in Pseudomonas aeruginosa
121. Roles of Pseudomonas aeruginosa las and rhl quorum-sensing systems in control of elastase and rhamnolipid biosynthesis genes
122. The Pseudomonas aeruginosa lectins PA-IL and PA-IIL are controlled by quorum sensing and by RpoS
123. Transcriptional control of the hydrogen cyanide biosynthetic genes hcnABC by the anaerobic regulator ANR and the quorum-sensing regulators LasR and RhlR in Pseudomonas aeruginosa
124. A hierarchical quorum-sensing cascade in Pseudomonas aeruginosa links the transcriptional activators LasR and RhlR (VsmR) to expression of the stationary-phase sigma factor RpoS
125. Regulation of quorum sensing by RpoS in Pseudomonas aeruginosa
126. Regulation of the xcp secretion pathway by multiple quorum-sensing modulons in Pseudomonas aeruginosa
127. Protein secretion in Pseudomonas aeruginosa
128. Contribution of quorum sensing to the virulence of Pseudomonas aeruginosa in burn wound infections
129. Contribution of the regulatory gene lasR to the pathogenesis of Pseudomonas aeruginosa infection of burned mice
130. Contribution of specific Pseudomonas aeruginosa virulence factors to pathogenesis of pneumonia in a neonatal mouse model of infection
131. Pseudomonas aeruginosa cell-to-cell signaling is required for virulence in a model of acute pulmonary infection
132. Pseudomonas aeruginosa killing of Caenorhabditis elegans to identify P. aeruginosa virulence factors
133. Positive correlation between virulence of Pseudomonas aeruginosa mutants in mice and insects
134. Pseudomonas aeruginosa lasR transcription correlates with the transcription of lasA, lasB, and toxA in chronic lung infections associated with cystic fibrosis
135. migA, a quorum-responsive gene of Pseudomonas aeruginosa, is highly expressed in the cystic fibrosis lung environment and modifies low-molecular-mass lipopolysaccharide
136. Detection of N-acylhomoserine lactones in lung tissues of mice infected with Pseudomonas aeruginosa
137. Quorum-sensing and siderophore biosynthesis in Pseudomonas aeruginosa: LasR/lasI mutants exhibit reduced pyoverdine biosynthesis
138. Quorum sensing in Pseudomonas aeruginosa controls expression of catalase and superoxide dismutase genes and mediates biofilm susceptibility to hydrogen peroxide
139. Identification of genes controlled by quorum sensing in Pseudomonas aeruginosa
140. Effect of rpoS mutation on the stress response and expression of virulence factors in Pseudomonas aeruginosa
141. The global activator GacA of Pseudomonas aeruginosa PAO positively controls the production of the autoinducer N-butyryl-homoserine lactone and the formation of the virulence factors pyocyanin, cyanide, and lipase
142. RsaL, a novel repressor of virulence gene expression in Pseudomonas aeruginosa
143. Polyphosphate kinase is essential for biofilm development, quorum sensing, and virulence of Pseudomonas aeruginosa
144. Contribution of phenazine antibiotic biosynthesis to the ecological competence of fluorescent pseudomonads in soil habitats
145. Suppression of take-all of wheat by seed treatments with fluorescent pseudomonads
146. Role of a phenazine antibiotic from Pseudomonas fluorescens in biological control of Gaeumannomyces graminis var. tritici
147. The phzI gene of Pseudomonas aureofaciens 30-84 is responsible for the production of a diffusible signal required for phenazine antibiotic production
148. N-Acyl-homoserine lactone-mediated regulation of phenazine gene expression by Pseudomonas aureofaciens 30-84 in the wheat rhizosphere
149. Phenazine antibiotic biosynthesis in Pseudomonas aureofaciens 30-84 is regulated by PhzR in response to cell density
150. Two component transcriptional regulation of N-acyl-homoserine lactone production in Pseudomonas aureofaciens
151. Cloning and heterologous expression of the phenazine biosynthetic locus from Pseudomonas aureofaciens 30-84
152. Molecular analysis of genes encoding phenazine biosynthesis in the biological control bacterium Pseudomonas aureofaciens 30-84
153. A seven-gene locus for synthesis of phenazine-1-carboxylic acid by Pseudomonas fluorescens 2-79
154. Phenazine antibiotic production in Pseudomonas aureofaciens: Role in rhizosphere ecology and pathogen suppression
155. Description of the colonization of a gnotobiotic tomato rhizosphere by Pseudomonas fluorescens biocontrol strain WC5365, using scanning electron microscopy
156. Biocontrol by phenazine-1-carboxamide-producing Pseudomonas chlororaphis PCL1391 of tomato root rot caused by Fusarium oxysporum f. sp. radicis-lycopersici
157. Structural and functional organization of Pseudomonas fluorescens genes encoding enzymes of phenazine-1-carboxylic acid biosynthesis
158. Production of acyl-homoserine lactone quorum-sensing signals by Gram-negative plant-associated bacteria
159. Promotion of antibiotic production by ethanol, high NaCl concentration, or heat shock in Pseudomonas fluorescens S272
160. Genetic and physiological evidence for the production of N-acyl homoserine lactones by Pseudomonas syringae pv. syringae and other fluorescent plant pathogenic Pseudomonas species
161. Swarming by Pseudomonas syringae B728a requires gacS (lemA) and gacA but not the acyl-homoserine lactone biosynthetic gene ahlI
162. A newly identified regulator is required for virulence and toxin production in Pseudomonas syringae
163. Burkholderia cepacia: Medical, taxonomic and ecological issues
164. Quorum sensing in Burkholderia cepacia: Identification of the LuxRI homologs CepRI
165. Influence of Pseudomonas aeruginosa exoproducts on virulence factor production in Burkholderia cepacia: Evidence of interspecies communication
166. Production of N-acyl-L-homoserine lactones by P. aeruginosa isolates from chronic lung infections associated with cystic fibrosis
167. Biofilms on indwelling urethral catheters produce quorum-sensing molecules in situ and in vitro
168. Evidence of autoinducer activity in naturally occurring biofilms
169. Quorum sensing autoinducers: Do they play a role in natural microbial habitats?
170. Extracellular products as mediators of the formation and detachment of Pseudomonas fluorescens biofilms
171. The involvement of cell-to-cell signals in the development of a bacterial biofilm
172. Roles of Pseudomonas aeruginosa las and rhl quorum-sensing systems in control of twitching motility
173. Flagellar and twitching motility are necessary for Pseudomonas aeruginosa biofilm development
174. Quorum-sensing signals indicate that cystic fibrosis lungs are infected with bacterial biofilms
175. Quorum-sensing cross talk: Isolation and chemical characterization of cyclic dipeptides from Pseudomonas aeruginosa and other Gram-negative bacteria
176. Quinolone signaling in the cell-to-cell communication system of Pseudomonas aeruginosa
177. The Pseudomonas quinolone signal regulates rhl quorum sensing in Pseudomonas aeruginosa
178. Ecology of the soft rot erwinias
179. Extracellular enzymes and their role in Erwinia virulence
180. Virulence determinants in the bacterial phytopathogen Erwinia
181. Structure and regulation of the Erwinia carotovora subspecies carotovora SCC3193 cellulase gene celV1 and the role of cellulase in phytopathogenicity
182. Isolation of an extracellular protease gene of Erwinia carotovora subsp. carotovora strain SCC3193 by transposon mutagenesis and the role of protease in phytopathogenicity
183. Secretion of extracellular virulence factors by plant-pathogenic bacteria
184. SQ27850, a simple carbapenem produced by species of Serratia and Erwinia
185. Role of antibiosis in competition of Erwinia strains in potato infection courts
186. Carbapenem antibiotic production in Erwinia carotovora is regulated by CarR, a homologue of the LuxR transcriptional activator
187. Analysis of bacterial carbapenem antibiotic production genes reveals a novel β-lactam biosynthesis pathway
188. Analysis of the carbapenem gene cluster of Erwinia carotovora: Definition of the antibiotic biosynthetic genes and evidence for a novel β-lactam resistance mechanism
189. N-(3-Oxohexanoyl)-L-homoserine lactone regulates carbapenem antibiotic production in Erwinia carotovora
190. A general role for the lux autoinducer in bacterial cell signalling: Control of antibiotic biosynthesis in Erwinia
191. A small diffusible signal molecule is responsible for the global control of virulence and exoenzyme production in Erwinia carotovora
192. Inactivation of rsmA leads to overproduction of extracellular pectinases, cellulases, and proteases in Erwinia carotovora subsp. carotovora in the absence of the starvation/cell density-sensing signal, N-(3-oxohexanoyl)-L-homoserine lactone
193. Ecbl and EcbR: Homologs of LuxI and LuxR affecting antibiotic and exoenzyme production by Erwinia carotovora subsp. betavasculorum
194. Multiple genetic and physiological factors regulate carbapenem antibiotic production in Erwinia carotovora by modulating the quorum sensing mechanism
195. Cryptic carbapenem antibiotic production genes are widespread in Erwinia carotovora: Facile trans activation by the carR transcriptional regulator
196. The bacterial 'enigma': Cracking the code of cell-cell communication
197. Ecc
198. Early events in the activation of plant defence responses
199. Induction of plant defense response by exoenzymes of Erwinia carotovora subsp. carotovora
200. Identification of a global repressor gene, rsmA, of Erwinia carotovora subsp. carotovora that controls extracellular enzymes, N-(3-oxohexanoyl)-L-homoserine lactone, and pathogenicity in soft-rotting Erwinia spp.
201. Identification and molecular characterization of csrA, a pleiotropic gene from Escherichia coli that affects glycogen biosynthesis, gluconeogenesis, cell size, and surface properties
202. Pleiotropic regulation of central carbohydrate metabolism in Escherichia csrA
203. The global regulator CsrA of Escherichia coli is a specific mRNA-binding protein
204. Ecc and elicit a hypersensitive reaction-like response in tobacco leaves
205. The RNA molecule CsrB binds to the global regulatory protein CsrA and antagonizes its activity in Escherichia coli
206. Global regulation by the small RNA-binding protein CsrA and the non-coding RNA molecule CsrB
207. Regulation of the production of extracellular pectinase, cellulase, and protease in the soft rot bacterium Erwinia carotovora ssp. carotovora evidence that aepH of E. carotovora subsp. carotovora 71 activates gene expression in E. carotovora subsp. carotovora, E. carotovora subsp. atroseptica, and Escherichia coli
208. Characterization of a novel RNA regulator of Erwinia carotovora ssp. carotovora that controls production of extracellular enzymes and secondary metabolites
209. Quorum sensing as a population-density-dependent determinant of bacterial physiology
210. (Ecc) production and virulence by modulating levels of regulatory RNA (rsmB) and RNA-binding protein (RsmA)
211. The hexY genes of Erwinia carotovora subsp. carotovora and subsp. atroseptica encode novel proteins which co-ordinately regulate virulence and motility
212. The hexA gene of Erwinia carotovora encodes a LysR homologue and regulates motility and the expression of multiple virulence determinants
213. RpoS (sigma-S) controls expression of rsmA, a global regulator of secondary metabolites, harpin, and extracellular proteins in Erwinia carotovora
214. hexA of Erwinia carotovora ssp. carotovora strain Ecc71 negatively regulates production of RpoS and rsmB RNA, a global regulator of extracellular proteins, plant virulence and the quorum-sensing signal, N-(3-oxohexanoyl)-L-homoserine lactone
215. Capsular polysaccharide biosynthesis and pathogenicity in Erwinia stewartii require induction by an N-acyl homoserine lactone autoinducer
216. A negative regulator mediates quorum-sensing control of exopolysaccharide production in Pantoea stewartii subsp. stewartii
217. The genus Serratia
218. Genetic analysis of extracellular proteins of Serratia marcescens
219. Control of exoenzyme production, motility and cell differentiation in Serratia liquefaciens
220. Cloning and expression in Escherichia coli of the gene for an extracellular phospholipase from Serratia liquefaciens
221. Bees aren't the only ones: Swarming in Gram-negative bacteria
222. Involvement of N-acyl-L-homoserine lactone autoinducers in controlling the multicellular behaviour of Serratia liquefaciens
223. N-Acyl-L-homoserine lactone autoinducers control production of an extracellular lipopeptide biosurfactant required for swarming motility of Serratia liquefaciens MG1
224. A novel extracellular cyclic lipopeptide which promotes flagellum-dependent and -independent spreading growth of Serratia marcescens
225. Two separate regulatory systems participate in control of swarming motility of Serratia liquefaciens MG1
226. A pheromone-independent CarR protein controls carbapenem antibiotic synthesis in the opportunistic human pathogen Serratia marcescens
227. Biosynthesis of carbapenem antibiotic and prodigiosin pigment in Serratia is under quorum sensing control
228. Genus VIII. Serratia
229. The pigments of Serratia
230. Immunomodulating properties of prodigiosin 25-C, an antibiotic which preferentially suppresses induction of cytotoxic T-cells
231. Selective immunosuppression of prodigiosin 25-C and FK506 in the murine immune-system
232. The Rap and Hor proteins of Erwinia, Serratia and Yersinia: A novel subgroup in a growing superfamily of proteins regulating diverse physiological processes in bacterial pathogens
233. PecS - A locus controlling pectinase, cellulase and blue pigment production in Erwinia chrysanthemi
234. Binding of purified multiple antibiotic resistance repressor protein (MarR) to mar operator sequences
235. Induction of haemolytic activity in Escherichia coli by the slyA gene product
236. A chromosomally encoded regulator is required for expression of the Yersinia enterocolitica inv gene and for virulence
237. Characterisation of the yenI/yenR locus from Yersinia enterocolitica mediating the synthesis of two N-acyl homoserine lactone signal molecules
238. A hierarchical quorum-sensing system in Yersinia pseudotuberculosis is involved in the regulation of motility and clumping
239. Quorum sensing in Aeromonas and Yersinia
240. Coordinated regulation of octopine degradation and conjugative transfer of Ti plasmids in Agrobacterium tumefaciens: Evidence for a common regulatory gene and separate operons
241. Conjugal transfer of nopaline and agropine Ti-plasmids - The role of agrocinopines
242. The bases of crown gall tumorigenesis
243. Conjugation in Rhizobiaceae
244. Transcription of the octopine catabolism operon of the Agrobacterium tumor-inducing plasmid pTiA6 is activated by a LysR-type regulatory protein
245. The A. tumefaciens transcriptional activator OccR causes a bend at a target promoter, which is partially relaxed by a plant tumor metabolite
246. A LuxR-LuxI type regulatory system activates Agrobacterium Ti plasmid conjugal transfer in the presence of a plant tumour metabolite
247. Localization of OccR-activated and TraR-activated promoters that express two ABC-type permeases and the traR gene of Ti plasmid pTiR10
248. Hierarchical gene regulatory systems arising from fortuitous gene associations: Controlling quorum sensing by the opine regulon in Agrobacterium
249. Conserved cis-acting promoter elements are required for density-dependent transcription of Agrobacterium tumefaciens conjugal transfer genes
250. Octopine-type Ti plasmids code for a mannopine-inducible dominant-negative allele of traR, the quorum-sensing activator that regulates Ti plasmid conjugal transfer
251. Activity of the quorum-sensing regulator TraR of Agrobacterium tumefaciens is inhibited by a truncated, dominant defective TraR-like protein
252. Opine catabolism and conjugal transfer of the nopaline Ti plasmid pTiC58 are coordinately regulated by a single repressor
253. Characterization of the acc operon from the nopaline-type Ti plasmid pTiC58, which encodes utilization of agrocinopines A and B and susceptibility to agrocin 84
254. Conjugation factor of Agrobacterium tumefaciens regulates Ti plasmid transfer by autoinduction
255. Agrobacterium conjugation and gene regulation by N-acyl-L-homoserine lactones
256. TraI, a LuxI homologue, is responsible for production of conjugation factor, the Ti plasmid N-acylhomoserine lactone autoinducer
257. Activity of the Agrobacterium Ti plasmid conjugal transfer regulator TraR is inhibited by the product of the traM gene
258. A new regulatory element modulates homoserine lactone-mediated autoinduction of Ti plasmid conjugal transfer
259. Modulating quorum sensing by antiactivation: TraM interacts with TraR to inhibit activation of Ti plasmid conjugal transfer genes
260. The antiactivator TraM interferes with the autoinducer-dependent binding of TraR to DNA by interfering with the C-terminal region of the quorum-sensing activator
261. Quorum sensing but not autoinduction of Ti plasmid conjugal transfer requires control by the opine regulon and the antiactivator TraM
262. The Rhizobium-plant symbiosis
263. Molecular basis of symbiotic promiscuity
264. Bacteroid formation in the Rhizobium-legume symbiosis
265. The regulatory locus cinRI in Rhizobium leguminosarum controls a network of quorum-sensing loci
266. Cell-to-cell signaling in the symbiotic nitrogen-fixing bacterium Rhizobium leguminosarum: Autoinduction of a stationary phase and rhizosphere-expressed genes
267. Bacteriocin small of Rhizobium leguminosarum belongs to the class of N-acyl-L-homoserine lactone molecules, known as autoinducers and as quorum sensing co-transcription factors
268. Analysis of quorum-sensing-dependent control of rhizosphere-expressed (rhi) genes in Rhizobium leguminosarum bv. viciae
269. Molecular characterization and regulation of the rhizosphere-expressed genes rhiABCR that can influence nodulation by Rhizobium leguminosarum biovar viciae
270. Identification of a rhizosphere protein encoded by the symbiotic plasmid of Rhizobium leguminosarum
271. Molecular basis of symbiosis between Rhizobium and legumes
272. luxI- and luxR-homologous genes of Rhizobium etli CNPAF512 contribute to synthesis of autoinducer molecules and nodulation of Phaseolus vulgaris
273. Quorum sensing in Aeromonas hydrophila and Aeromonas salmonicida: Identification of the LuxRI homologs AhyRI and AsaRI and their cognate N-acylhomoserine lactone signal molecules
274. Quorum sensing-dependent regulation and blockade of exoprotease production in Aeromonas hydrophila
275. Quorum sensing in Vibrio anguillarum: Characterization of the vanI/vanR locus and identification of the autoinducer N-(3-oxodecanoyl)-L-homoserine lactone
276. A homoserine lactone autoinducer regulates virulence of an insect-pathogenic bacterium, Xenorhabdus nematophilus (Enterobacteriaceae)
277. Signalling in bacteria beyond bioluminescence
278. Chitinolytic activity in Chromobacterium violaceum: Substrate analysis and regulation by quorum sensing
279. Detection, purification, and synthesis of N-acylhomoserine lactone quorum sensing signal molecules
280. A quorum-sensing system in the free-living photosynthetic bacterium Rhodobacter sphaeroides
281. Intercellular signalling in Vibrio harveyi: Sequence and function of genes regulating expression of luminescence
282. Purification and structural identification of an autoinducer for the luminescence system of Vibrio harveyi
283. Quorum sensing in Escherichia coli, Salmonella typhimurium, and Vibrio harveyi: A new family of genes responsible for autoinducer production
284. Multiple signalling systems controlling expression of luminescence in Vibrio harveyi: Sequence and function of genes encoding a second sensory pathway
285. Sequence and function of LuxU: A two-component phosphorelay protein that regulates quorum sensing in Vibrio harveyi
286. Sequence and function of LuxO, a negative regulator of luminescence in Vibrio harveyi
287. A genetic analysis of the function of LuxO, a two-component response regulator involved in quorum sensing in Vibrio harveyi
288. A genetic analysis of the functions of LuxN: A two-component hybrid sensor kinase that regulates quorum sensing in Vibrio harveyi
289. Regulation of quorum sensing in Vibrio harveyi by LuxO and sigma-54
290. Cloning and nucleotide sequence of luxR, a regulatory gene controlling bioluminescence in Vibrio harveyi
291. The luxR gene product is a transcriptional activator of the lux promoter
292. Inhibition of luminescence and virulence in the black tiger prawn (Penaeus monodon) pathogen Vibrio harveyi by intercellular signal antagonists
293. Control of bioluminescence in Vibrio fischeri by the LuxO signal response regulator
294. Cross-species induction of luminescence in the quorum-sensing bacterium Vibrio harveyi
295. Quorum sensing in Escherichia coli and Salmonella typhimurium
296. Intercellular communication in Helicobacter pylori: LuxS is essential for the production of an extracellular signaling molecule
297. Quorum sensing controls expression of the type III secretion gene transcription and protein secretion in enterohemorrhagic and enteropathogenic Escherichia coli
298. Shigella flexneri LuxS quorum-sensing system modulates virB expression but is not essential for virulence
299. Evidence for a signalling system in Helicobacter pylori: Detection of a luxS-encoded autoinducer
300. Regulation of autoinducer production in Salmonella typhimurium
301. Escherichia coli genes regulated by cell-to-cell signalling
302. Quorum-sensing acts at initiation of chromosomal replication in Escherichia coli
303. Analogs of the autoinducer of bioluminescence in Vibrio fischeri
304. Autoregulation of carbapenem biosynthesis in Erwinia carotovora by analogues of N-(3-oxohexanoyl)-L-homoserine lactone
305. Functional analysis of the Pseudomonas aeruginosa autoinducer PAI
306. Quorum sensing in Vibrio fischeri: Probing autoinducer-LuxR interactions with autoinducer analogs
307. Interpopulation signaling via N-acyl-homoserine lactones among bacteria in the wheat rhizosphere
308. A factor that positively regulates cell division by activating transcription of the major cluster of essential cell division genes of Escherichia coli
309. Salmonella typhimurium encodes an SdiA homolog, a putative quorum sensor of the LuxR family, that regulates genes on the virulence plasmid
310. An extracellular factor regulates expression of sdiA, a transcriptional activator of cell division genes in Escherichia coli
311. Control of cell division in Escherichia coli: Regulation of transcription of ftsQA involves both rpoS and SdiA-mediated autoinduction
312. SdiA, an Escherichia coli homologue of quorum-sensing regulators, controls the expression of virulence factors in enterohaemorrhagic Escherichia coli O157:H7
313. Regulation of virulence factors of enterohemorrhagic Escherichia coli O157:H7 by self-produced extracellular factors
314. AiiA, an enzyme that inactivates the acylhomoserine lactone quorum-sensing signal and attenuates the virulence of Erwinia carotovora
315. Metabolism of acyl-homoserine lactone quorum-sensing signals by Variovorax paradoxus
316. Eukaryotic interference with homoserine lactone-mediated prokaryotic signalling
317. Do marine natural products interfere with prokaryotic AHL regulatory systems?
318. How Delisea pulchra furanones affect quorum sensing and swarming motility in Serratia liquefaciens MG1
319. Evidence that halogenated furanones from Delisea pulchra inhibit acylated homoserine lactone (AHL)-mediated gene expression by displacing the AHL signal from its receptor protein
320. Plants secrete substances that mimic bacterial N-acyl homoserine lactone signal activities and affect population density-dependent behaviors in associated bacteria
321. The Pseudomonas aeruginosa quorum-sensing signal molecule N-(3-oxododecanoyl)-L-homoserine lactone has immunomodulatory activity
322. Pseudomonas aeruginosa quorum-sensing signal molecule N-(3-oxododecanoyl)-L-homoserine lactone inhibits expression of P2Y receptors in cystic fibrosis tracheal gland cells
323. The Pseudomonas aeruginosa quorum-sensing signal molecule, N-(3-oxododecanoyl)-L-homoserine lactone, inhibits porcine arterial smooth muscle contraction
324. Bacterial N-acyl-homoserine-lactone-dependent signalling and its potential biotechnological applications
325. Quorum sensing: A novel target for anti-infective therapy
326. Quorum sensing: Potential means of treating gram-negative infections?
327. Novel synthetic analogs of the Pseudomonas autoinducer
328. Plants genetically modified to produce N-acylhomoserine lactones communicate with bacteria
329. To be or not to be: How Pseudomonas solanacearum decides whether or not to express virulence genes
330. Differential expression of virulence genes and motility in Ralstonia (Pseudomonas) solanacearum during exponential growth
331. Phenotype conversion in Pseudomonas solanacearum due to spontaneous inactivation of PhcA, a putative LysR transcriptional regulator
332. A two-component system in Ralstonia (Pseudomonas) solanacearum modulates production of phcA-regulated virulence factors in response to 3-hydroxypalmitic acid methyl ester
333. Identification of 3-hydroxypalmitic acid methyl ester as a novel autoregulator controlling virulence in Ralstonia solanacearum
334. Hierarchical autoinduction in Ralstonia solanacearum: Control of acyl-homoserine lactone production by a novel autoregulatory system responsive to 3-hydroxypalmitic acid methyl ester
335. Evidence that Ralstonia eutropha (Alcaligenes eutrophus) contains a functional homologue of the Ralstonia solanacearum Phc cell density sensing system
336. A rpoS (sigmaS) homologue regulates acylhomoserine lactone-dependent autoinduction in Ralstonia solanacearum
337. Control of virulence and pathogenicity genes of Ralstonia solanacearum by an elaborate sensory network
338. Black rot of crucifers
339. Pathogenicity determinants and global regulation of pathogenicity of Xanthomonas campestris pv. campestris
340. A novel regulatory system required for pathogenicity of Xanthomonas campestris is mediated by a small diffusible signal molecule
341. Novel genes involved in the regulation of pathogenicity factor production within the rpf gene cluster of Xanthomonas campestris
342. Genetic and molecular analysis of a cluster of rpf genes involved in positive regulation of synthesis of extracellular enzymes and polysaccharide in Xanthomonas campestris pathovar campestris
343. The rpfA gene of Xanthomonas campestris pathovar campestris, which is involved in the regulation of pathogenicity factor production, encodes an aconitase
344. A two-component system involving an HD-GYP domain protein links cell-cell signalling to pathogenicity gene expression in Xanthomonas campestris
345. A novel device of bacterial signal transducers
346. A specialized version of the HD hydrolase domain implicated in signal transduction
347. Central role of the BvgS receiver as a phosphorylated intermediate in a complex two-component phosphorelay
348. Integration of multiple domains in a two-component sensor protein: The Bordetella pertussis BvgAS phosphorelay
349. pigB determines a diffusible factor needed for extracellular polysaccharide slime and xanthomonadin production in Xanthomonas campestris pv. campestris
350. Xanthomonas campestris pv. campestris requires a functional pigB for epiphytic survival and host infection
351. Purification, characterization and biological role of a pheromone produced by Xanthomonas campestris pv. campestris
352. Synthesis of extracellular polysaccharide, extracellular enzymes, and xanthomonadin in Xanthomonas campestris: Evidence for the involvement of two intercellular regulatory signals
353. Xylella genomics and bacterial pathogenicity to plants