Lysine N ε-trimethylation, a tool for improving the selectivity of antimicrobial peptides

Journal of Medicinal Chemistry

Volumn 53, Issue 15, 2010, Pages 5587-5596

  Fernández Reyes, María ^a   Díaz, Dolores ^a   De La Torre, Beatriz G ^b   Cabrales Rico, Ania ^b,c   Vallès Miret, Mariona ^b,d   Jiménez Barbero, Jesús ^a   Andreu, David ^b   Rivas, Luis ^a  

^a CENTRO DE INVESTIGACIONES BIOLÓGICAS   (Spain)

^b UNIVERSITAT POMPEU FABRA   (Spain)

^c CENTER FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Cuba)

^d UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CECROPIN A; LYSINE; MELITTIN; POLYPEPTIDE ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT; ANTIMICROBIAL CATIONIC PEPTIDE; ANTITRYPANOSOMAL AGENT; CECROPIN A(1 7)MELITTIN(2 9); CECROPIN A(1-7)MELITTIN(2-9);

ACINETOBACTER BAUMANNII; ANIMAL CELL; ANTIMICROBIAL ACTIVITY; ANTIPROTOZOAL ACTIVITY; ARTICLE; BACTERICIDAL ACTIVITY; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG SELECTIVITY; DRUG STABILITY; ELECTRON MICROSCOPY; HEMOLYSIS; LEISHMANIA; METHYLATION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; AMINO ACID SEQUENCE; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; DRUG EFFECT; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; MOLECULAR GENETICS; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; ANTI-INFECTIVE AGENTS; ANTIMICROBIAL CATIONIC PEPTIDES; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; HEMOLYSIS; LEISHMANIA; LYSINE; METHYLATION; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR SEQUENCE DATA; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPANOCIDAL AGENTS;

EID: 77955372104     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm100261r     Document Type: Article

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