Multicopy blaOXA-58 gene as a source of high-level resistance to carbapenems in Acinetobacter baumannii

Antimicrobial Agents and Chemotherapy

Volumn 51, Issue 7, 2007, Pages 2324-2328

  Bertini, Alessia ^a   Poirel, Laurent ^b   Bernabeu, Sandrine ^b   Fortini, Daniela ^a   Villa, Laura ^a   Nordmann, Patrice ^b   Carattoli, Alessandra ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^b BICÊTRE HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CARBAPENEM DERIVATIVE; CEFTAZIDIME; IMIPENEM; MEROPENEM; ANTIINFECTIVE AGENT; BACTERIAL DNA; BETA LACTAMASE; OXACILLINASE; UNCLASSIFIED DRUG;

ACINETOBACTER BAUMANNII; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; BACTERIAL GENETICS; BACTERIUM ISOLATE; BLA OXA 58 GENE; GENE SEQUENCE; GENETIC VARIABILITY; ITALY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASMID; PRIORITY JOURNAL; UNIVERSITY HOSPITAL; BIOSYNTHESIS; DNA SEQUENCE; DRUG EFFECT; ENZYMOLOGY; GENE DOSAGE; GENETICS; HUMAN; ISOLATION AND PURIFICATION; MICROBIOLOGICAL EXAMINATION; MOLECULAR CLONING; NUCLEIC ACID AMPLIFICATION; POLYMERASE CHAIN REACTION;

ACINETOBACTER BAUMANNII; ANTI-BACTERIAL AGENTS; BASE SEQUENCE; BETA-LACTAM RESISTANCE; BETA-LACTAMASES; CARBAPENEMS; CLONING, MOLECULAR; DNA, BACTERIAL; GENE DOSAGE; GENES, BACTERIAL; HUMANS; MICROBIAL SENSITIVITY TESTS; NUCLEIC ACID AMPLIFICATION TECHNIQUES; PLASMIDS; POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS, DNA; VARIATION (GENETICS);

EID: 34447263268     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.01502-06     Document Type: Article

References (34)

1. Bertini, A., A. Giordano, P. Varesi, L. Villa, C. Mancini, and A. Carattoli. 2006. First report of the plasmid-mediated carbapenem-hydrolyzing oxacillinase OXA-58 in Acinetobacter baumannii isolates in Italy. Antimicrob. Agents Chemother. 50:2268-2269.
2. Carattoli, A., V. Miriagou, A. Bertini, A. Loli, L. Villa, J. M. Whichard, and G. M. Rossolini. 2006. Replicon typing of plasmid encoding resistance to newer β-lactams. Emerg. Infect. Dis. 12:1145-1148.
3. Clinical and Laboratory Standards Institute. January 2005. Performance standards for antimicrobial susceptibility testing; 15th supplement, vol. 24, no.1. CLSI, Wayne, PA
4. Coelho, J., N. Woodford, M. Afzal-Shah, and D. M. Livermore. 2006. Occurrence of OXA-58-like carbapenemases in Acinetobacter spp. collected over 10 years in three continents. Antimicrob. Agents Chemother. 50:756-758.
5. Corbella, X., A. Montero, M. Pujol, M. A. Domínguez, J. Ayats, M. J. Argerich, F. Garrigosa, J. Ariza, and F. Gudiol. 2000. Emergence and rapid spread of carbapenem resistance during a large and sustained hospital outbreak of multiresistant Acinetobacter baumannii. J. Clin. Microbiol. 38:4086-4095.
6. del Mar Tomas, M., M. Cartelle, S. Pertega, A. Beceiro, P. Llinares, D. Canle, F. Molina, R. Villanueva, J. M. Cisneros, and G. Bou. 2005. Hospital outbreak caused by a carbapenem-resistant strain of Acinetobacter baumannii: patient prognosis and risk-factors for colonization and infection. Clin. Microbiol. Infect. 11:540-546.
7. Doroshenko, V. G., and V. A. Livshits. 2004. Structure and mode of transposition of Tn2555 carrying sucrose utilization genes. FEMS Microbiol. Lett. 233:353-359.
8. Dorsey, C. W., A. P. Tomaras, and L. A. Actis. 2006. Sequence and organization of pMAC, an Acinetobacter baumannii plasmid harboring genes involved in organic peroxide resistance. Plasmid 56:112-123.
9. Gales, A. C., R. N. Jones, K. R. Forward, J. Linares, H. S. Sader, and J. Verhoef. 2001. Emerging importance of multidrug-resistant Acinetobacter species and Stenotrophomonas maltophilia as pathogens in seriously ill patients: geographic patterns, epidemiological features, and trends in the SENTRY Antimicrobial Surveillance Program (1997-1999). Clin. Infect. Dis. 32:S104-S113.
10. Giamarellou, H. 2006. Treatment options for multidrug-resistant bacteria. Exp. Rev. Anti-Infect. Ther. 4:601-618.
11. SHV genes in Klebsiella pneumoniae: different allele distributions are associated with different promoters within individual isolates. Antimicrob. Agents Chemother. 49:256-263.
12. Hanlon, G. W. 2005. The emergence of multidrug resistant Acinetobacter species: a major concern in the hospital setting. Lett. Appl. Microbiol. 41:375-378.
13. Héritier, C., A. Dubouix, L. Poirel, N. Marty, and P. Nordmann. 2005. A nosocomial outbreak of Acinetobacter baumannii isolates expressing the carbapenem-hydrolyzing oxacillinase OXA-58. J. Antimicrob. Chemother. 55: 115-118.
14. Héritier, C., L. Poirel, and P. Nordmann. 2006. Cephalosporinase overexpression resulting from insertion of ISAba1 in Acinetobacter baumannii. Clin. Microbiol. Infect. 12:123-130.
15. Héritier, C., L. Poirel, T. Lambert, and P. Nordmann. 2005. Contribution of acquired carbapenem-hydrolyzing oxacillinases to carbapenem resistance in Acinetobacter baumannii. Antimicrob. Agents Chemother. 49:3198-3202.
16. Jeon, B. C., S. H. Jeong, I. K. Bae, S. B. Kwon, K. Lee, D. Young, J. H. Lee, J. S. Song, and S. H. Lee. 2005. Investigation of a nosocomial outbreak of imipenem-resistant Acinetobacter baumannii producing the OXA-23 β-lactamase in Korea. J. Clin. Microbiol. 43:2241-2245.
17. V1M-1. J. Antimicrob. Chemother. 58:2741-2750.
18. Murray, C. K., and D. R. Hospenthal. 2005. Treatment of multidrug resistant Acinetobacter. Curr. Opin. Infect. Dis. 18:502-506.
19. Navon-Venezia, S., R. Ben-Ami, and Y. Carmeli. 2005. Update on Pseudomonas aeruginosa and Acinetobacter baumannii infections in the healthcare setting. Curr. Opin. Infect. Dis. 18:306-313.
20. Poirel, L., M. Guibert, D. Girlich, T. Naas, and P. Nordmann. 1999. Cloning, sequence analyses, expression, and distribution of ampC-ampR from Morganella morganii clinical isolates. Antimicrob. Agents Chemother. 43:769-776.
21. Poirel, L., and P. Nordmann. 2006. Carbapenem resistance in Acinetobacter baumannii: mechanisms and epidemiology. Clin. Microbiol. Infect. 12:826-836.
22. OXA-58 in Acinetobacter baumannii. Antimicrob. Agents Chemother. 50: 1442-1448.
23. Poirel, L., E. Lebessi, C. Heritier, A. Patsoura, M. Foustoukou, and P. Nordmann. 2006. Nosocomial spread of OXA-58-positive carbapenem-resistant Acinetobacter baumannii isolates in a pediatric hospital in Greece. Clin. Microbiol. Infect. 12:1138-1141.
24. Poirel, L., S. Marque, C. Héritier, C. Segonds, G. Chabanon, and P. Nordmann. 2005. OXA-58, a novel class D β-lactamase involved in resistance to carbapenems in Acinetobacter baumannii. Antimicrob. Agents Chemother. 49:202-208.
25. Pournaras, S., A. Ikonomidis, A. Markogiannakis, A. N. Maniatis, and A. Tsakris. 2005. Heteroresistance to carbapenems in Acinetobacter baumannii. J. Antimicrob. Chemother. 55:1055-1056.
26. Pournaras, S., A. Markogiannakis, A. Ikonomidis, L. Kondyli, K. Bethimouti, A. N. Maniatis, N. J. Legakis, and A. Tsakris. 2006. Outbreak of multiple clones of imipenem-resistant Acinetobacter baumannii isolates expressing OXA-58 carbapenemase in an intensive care unit. J. Antimicrob. Chemother. 57:557-561.
27. IMP allelic variants carried by gene cassettes of different phylogeny. Antimicrob. Agents Chemother. 44:1229-1235.
28. Thomson, J. M., and R. A. Bonomo. 2005. The threat of antibiotic resistance in Gram-negative pathogenic bacteria: beta-lactams in peril! Curr. Opin. Microbiol. 8:518-524.
29. Turton, J. F., M. E. Ward, N. Woodford, M. E. Kaufmann, R. Pike, D. M. Livermore, and T. L. Pitt. 2006. The role of ISAba1 in expression of OXA carbapenemase genes in Acinetobacter baumannii. FEMS Microbiol. Lett. 258:72-77.
30. Tysall, L., M. W. Stockdale, P. R. Chadwick, M. F. Palepou, K. J. Towner, D. M. Livermore, and N. Woodford. 2002. IMP-1 carbapenemase detected in an Acinetobacter clinical isolate from the UK. J. Antimicrob. Chemother. 49:217-218.
31. Walsh, T. R., A. Bolmström, A. Qwärnström, and A. Gales. 2002. Evaluation of a new Etest for detecting metallo-β- lactamases in routine clinical testing. J. Clin. Microbiol. 40:2755-2759.
32. Walsh, T. R., M. A. Toleman, L. Poirel, and P. Nordmann. 2005. Metalloβ-lactamases: the quiet before the storm? Clin. Microbiol. Rev. 18:306-325.
33. Walther-Rasmussen, J., and N. Høiby. 2006. OXA-type carbapenemases. J. Antimicrob. Chemother. 57:373-383.
34. Zarrilli, R., M. Crispino, M. Bagattini, E. Barretta, A. Di Popolo, M. Triassi, and P. Villari. 2004. Molecular epidemiology of sequential outbreaks of Acinetobacter baumannii in an intensive care unit shows the emergence of carbapenem resistance. J. Clin. Microbiol. 42:946-953.