Improved proteolytic stability of chicken cathelicidin-2 derived peptides by d-amino acid substitutions and cyclization

Peptides

Volumn 32, Issue 5, 2011, Pages 875-880

  Molhoek, E Margo ^a,b   Van Dijk, Albert ^b   Veldhuizen, Edwin J A ^b   Haagsman, Henk P ^b   Bikker, Floris J ^c  

^a TNO   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

^c UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

Chicken cathelicidin 2; Cyclization; d Amino acid substitution; Host defense peptide; Stability

Indexed keywords

BACTERIAL PROTEIN; BACTERIUM LIPOPOLYSACCHARIDE; CATHELICIDIN; CATHELICIDIN 2; PHENYLALANINE; PROTEINASE; TRYPTOPHAN; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERICIDAL ACTIVITY; CONTROLLED STUDY; CYCLIZATION; CYTOTOXICITY; HUMAN; HUMAN CELL; NONHUMAN; PEPTIDE SYNTHESIS; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN ENGINEERING; PROTEIN MODIFICATION; PROTEIN STABILITY; PROTEIN VARIANT;

ANIMALS; ANTI-BACTERIAL AGENTS; ANTIMICROBIAL CATIONIC PEPTIDES; CELLS, CULTURED; CHICKENS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYCLIZATION; DRUG STABILITY; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MICROBIAL SENSITIVITY TESTS; PEPTIDES; STAPHYLOCOCCUS AUREUS;

BACTERIA (MICROORGANISMS);

EID: 79955470808     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.peptides.2011.02.017     Document Type: Article

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