In vitro antibacterial properties of pexiganan, an analog of magainin

Antimicrobial Agents and Chemotherapy

Volumn 43, Issue 4, 1999, Pages 782-788

  Ge, Yigong ^a   MacDonald, Dorothy L ^a   Holroyd, Kenneth J ^a   Thornsberry, Clyde ^b   Wexler, Hannah ^c   Zasloff, Michael ^a  

^a Genaera Corporation   (United States)

^b MRL Pharmaceutical Services   (United States)

^c Wadsworth Anaerobe Laboratory   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT; CEFAZOLIN; CEFOXITIN; CIPROFLOXACIN; CLINDAMYCIN; GENTAMICIN; IMIPENEM; MAGAININ DERIVATIVE; OFLOXACIN; OXACILLIN; PEXIGANAN; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; CROSS RESISTANCE; DRUG ISOLATION; FROG; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; TOPICAL DRUG ADMINISTRATION;

EID: 0032942727     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.43.4.782     Document Type: Article

References (27)

1. Bessalle, R., A. Kapitkovshy, A. Gorea, I. Shalit, and M. Fridkin. 1990. All D-magainin: chirality antimicrobial activity, and proteolytic resistance. FEBS Lett. 274:151-155.
2. Boman, H. G. 1995. Peptide antibiotics and their role in innate immunity. Annu. Rev. Immunol. 13:61-92.
3. Fuchs, P. C., A. L. Barry, and S. D. Brown. 1998. In vitro antimicrobial activity of MSI-78, a magainin analog. Antimicrob. Agents Chemother. 42: 1213-1216.
4. Groisman, E. A. 1994. How bacteria resist killing by host-defense peptides. Trends Microbiol. 2:444-449.
5. Groisman, E. A., and A. Aspedon. 1995. The genetic basis of microbial resistance to antimicrobial peptides. Methods Mol. Biol. 78:205-215.
6. Gunn, J. S., K. B. Lim, J. Krueger, K. Kim, M. Hackett, and S. I. Miller. 1998. PmrA-PmrB-regulated genes necessary for 4-aminoarabinose lipid A modification and polymyxin resistance. Mol. Microbiol. 27:1171-1182.
7. Hancock, R. E. W. 1997. Peptide antibiotics. Lancet 349:418-422.
8. Iwahori, A., Y. Hirota, P. Sampe, S. Miyano, N. Takahashi, M. Sasatsu, I. Kondo, and N. Numao. 1997. On the antibacterial activity of normal and reversed magainin 2 analogs against Helicobacter pylori. Biol. Pharm. Bull. 20:805-808.
9. Jacob, L., and M. Zasloff. 1994. Potential therapeutic application of magainins and other antimicrobial agents for animal origin. Ciba Found. Symp. 186:197-216.
10. Lipsky, B. A., P. A. Litka, M. Zasloff, K. Nelson, and the MSI-78-303 and 304 Study Group. 1997. Microbial eradication and clinical resolution of infected diabetic foot ulcers treated with topical MSI-78 vs. oral ofloxacin, abstr. LM-57, p. 374. In Program and abstracts of the 37th Interscience Conference on Antimicrobial Agents and Chemotherapy. American Society for Microbiology, Washington, D.C.
11. Lorian, V. 1996. Antibiotics in laboratory medicine. The Williams & Wilkins Co., Baltimore, Md.
12. Ludtke, S. J., W. Heller, T. A. Harroun, L. Yang, and H. W. Huang, 1996. Membrane pores induced by magainin. Biochemistry 35:13723-13728.
13. National Committee for Clinical Laboratory Standards. 1987. Methods for determining bactericidal activity of antimicrobial agents. Proposed guideline (M26-P). Approved standard (M11-A3). National Committee for Clinical Laboratory Standards, Wayne, Pa.
14. National Committee for Clinical Laboratory Standards. 1993. Methods for antimicrobial susceptibility testing of anaerobic bacteria, 3rd ed. Approved standard (M11-A3). National Committee for Clinical Laboratory Standards, Wayne, Pa.
15. National Committee for Clinical Laboratory Standards. 1997. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically, 4th ed. Approved standard (M7-A4). National Committee for Clinical Laboratory Standards, Wayne, Pa.
16. Nicolas, P., and A. Mor. 1995. Peptides as weapons against microorganisms in the chemical defense system of vertebrates. Annu. Rev. Microbiol. 49:277-304.
17. Nissen-Meyer, J., and I. F. Nes. 1997. Ribosomally synthesized antimicrobial peptides: their function, structure, biogenesis, and mechanism of action. Arch. Microbiol. 167:67-77.
18. Peterson, A. A., S. W. Fesik, and E. J. McGroarty. 1987. Decreased binding of antibiotics to lipopolysaccharides from polymyxin-resistant strains of Escherichia coli and Salmonella typhimurium. Antimicrob. Agents Chemother. 31:230-237.
19. Schonwetter, B. S., E. D. Stolzenberg, and M. A. Zasloff. 1995. Epithelial antibiotics induced at sites of inflammation. Science 267:1645-1648.
20. Steinberg, D. A., M. A. Hurst, C. A. Fujii, H. C. Kung, J. F. Ho, F. C. Cheng, D. J. Loury, and J. C. Fiddes. 1997. Protegrin-1: a broad-spectrum, rapidly microbicidal peptide with in vivo activity. Antimicrob. Agents Chemother. 41:1738-1742.
21. Stolzenberg, E. D., G. M. Anderson, M. R. Ackermann, R. H. Whitlock, and M. Zasloff. 1997. Epithelial antibiotic induced in states of disease. Proc. Natl. Acad. Sci. USA 94:8686-8690.
22. Tytler, E. M., G. M. Anantharamaiah, D. E. Walker, V. K. Mishra, M. N. Palgunachari, and J. P. Segrest. 1995. Molecular basis for prokaryotic specificity of magainin-induced lysis. Biochemistry 34:4393-4401.
23. Wade, D., A. Boman, B. Wahlin, C. M. Drain, D. Andreu, H. G. Boman, and R. B. Merrifield. 1990. All-D amino acid-containing channel-forming antibiotic peptides. Proc. Natl. Acad. Sci. USA 87:4761-4765.
24. Wenk, M. R., and J. Seelig. 1998. Magainin 2 amide interaction with lipid membranes: calorimetric detection of peptide binding and pore formation. Biochemistry 37:3909-3916.
25. Wright, S. Personal communication.
26. Zasloff, M. 1987. Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor. Proc. Natl. Acad. Sci. USA 84:5449-5453.
27. Zasloff, M., D. MacDonald, and Y. Ge. Unpublished data.