Inhibition of the class C β-lactamase from Acinetobacter spp.: Insights into effective inhibitor design

Biochemistry

Volumn 49, Issue 2, 2010, Pages 329-340

  Drawz, Sarah M ^a   Babic, Maja ^b   Bethel, Christopher R ^c   Taracila, Magda ^b   Distler, Anne M ^a,e   Ori, Claudia ^d   Caselli, Emilia ^d   Prati, Fabio ^d   Bonomo, Robert A ^a,c  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY HOSPITALS OF CLEVELAND   (United States)

^c LOUIS STOKES CLEVELAND VA MEDICAL CENTER   (United States)

^d UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^e Cuyahoga Community College   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACINETOBACTERS; ACTIVE SITE; ANTIMICROBIAL SUSCEPTIBILITY; BAUMANNII; BORONIC ACID; CARBAPENEM ANTIBIOTIC; CARBAPENEMS; CEFOPERAZONE; CEFOTAXIME; CEFTAZIDIME; CEPHALOTHIN; CONFORMATIONAL CHANGE; DRUG RESISTANCE; ELECTROSPRAY IONIZATION MASS SPECTROMETRY; GRAM-NEGATIVE PATHOGENS; INHIBITOR DESIGN; LACTAMASES; MEROPENEM; MINIMUM INHIBITORY CONCENTRATION;

ACIDS; AMIDES; CARBOXYLATION; ELECTROSPRAY IONIZATION; ENZYMES; ESCHERICHIA COLI; MASS SPECTROMETRY; MULTICARRIER MODULATION;

REACTION INTERMEDIATES;

BETA LACTAM; BETA LACTAMASE; BORONIC ACID DERIVATIVE; CARBAPENEM; CARBOXYLIC ACID; CEFALOTIN; CEFOPERAZONE; CEFOTAXIME; CEFTAZIDIME; CEPHALOSPORINASE; IMIPENEM; MEROPENEM; CARBAPENEM DERIVATIVE; PENICILLINASE;

ACINETOBACTER BAUMANNII; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL CELL; BLAADC GENE; CHEMICAL REACTION; COMPREHENSION; CONFORMATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ELECTROSPRAY MASS SPECTROMETRY; ENZYME ACTIVE SITE; ENZYME INHIBITION; ESCHERICHIA COLI; GENE; INTROSPECTION; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SYNTHESIS; ACINETOBACTER; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG DESIGN; DRUG EFFECT; ENZYMOLOGY; GRAM NEGATIVE BACTERIUM; KINETICS; METABOLISM; MICROBIOLOGICAL EXAMINATION; PROTEIN CONFORMATION; STRUCTURE ACTIVITY RELATION;

ACINETOBACTER; ACINETOBACTER BAUMANNII; ESCHERICHIA COLI; NEGIBACTERIA;

ACINETOBACTER; BETA-LACTAMASES; CARBAPENEMS; CEPHALOSPORINASE; CEPHALOTHIN; DRUG DESIGN; ESCHERICHIA COLI; GRAM-NEGATIVE BACTERIA; KINETICS; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; PENICILLINASE; PROTEIN CONFORMATION; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 75349096353     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9015988     Document Type: Article

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