Exogenous administration of PACAP alleviates traumatic brain injury in rats through a mechanism involving the TLR4/MyD88/NF-κB pathway

Journal of Neurotrauma

Volumn 29, Issue 10, 2012, Pages 1941-1959

  Mao, Shan Shan ^a   Hua, Rong ^b   Zhao, Xiao Ping ^a   Qin, Xia ^a   Sun, Zhen Quan ^a   Zhang, Yang ^a   Wu, Yu Qing ^a   Jia, Meng Xing ^a   Cao, Jun Li ^a   Zhang, Yong Mei ^a  

^a XUZHOU MEDICAL UNIVERSITY   (China)

^b 97th Hospital of PLA   (China)

Author keywords

inflammatory cytokines; MyD88; PACAP; toll like receptor 4; traumatic brain injury

Indexed keywords

HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; MYELOID DIFFERENTIATION FACTOR 88; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR AGONIST; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN CORTEX; BRAIN EDEMA; COGNITIVE DEFECT; CONTROLLED STUDY; HIPPOCAMPUS; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; MALE; MICROGLIA; MOTOR DYSFUNCTION; NERVE CELL; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; TRAUMATIC BRAIN INJURY; UPREGULATION;

ANIMALS; AXONS; BRAIN INJURIES; DISEASE MODELS, ANIMAL; MALE; MYELOID DIFFERENTIATION FACTOR 88; NEUROPROTECTIVE AGENTS; NEUROTRANSMITTER AGENTS; NF-KAPPA B; PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4;

EID: 84863798933     PISSN: 08977151     EISSN: 15579042     Source Type: Journal    
DOI: 10.1089/neu.2011.2244     Document Type: Article

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