Apurinic/apyrimidinic endonuclease APE1 is required for PACAP-induced neuroprotection against global cerebral ischemia

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 7, 2010, Pages 3204-3209

  Stetler, R Anne ^a,b   Gao, Yanqin ^b   Zukin, R Suzanne ^c   Vosler, Peter S ^a   Zhang, Lili ^a   Zhang, Feng ^a   Cao, Guodong ^a,b   Bennett, Michael V L ^c   Chen, Jun ^a,b  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b FUDAN UNIVERSITY   (China)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Activating transcription factor 2; cAMP response element binding; Delayed neurodegeneration; DNA repair; Oxidative stress

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 2; APURINIC APYRIMIDINIC ENDONUCLEASE 1; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DNA (APURINIC OR APYRIMIDINIC SITE) LYASE; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE; MITOGEN ACTIVATED PROTEIN KINASE P38; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN ISCHEMIA; CELL DEATH; DNA REPAIR; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVITY; MALE; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; UPREGULATION;

ACTIVATING TRANSCRIPTION FACTOR 2; ANALYSIS OF VARIANCE; ANIMALS; APOPTOSIS; BRAIN ISCHEMIA; CHROMATIN IMMUNOPRECIPITATION; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DNA REPAIR; DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION; HIPPOCAMPUS; HUMANS; LUCIFERASES; OXIDATIVE STRESS; PHOSPHORYLATION; PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION;

EID: 77649251477     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1000030107     Document Type: Article

References (29)

1. Burcham PC (1998) Genotoxic lipid peroxidation products: their DNA damaging properties and role in formation of endogenous DNA adducts. Mutagenesis 13: 287-305.
2. Chen J, et al. (1997) Early detection of DNA strand breaks in the brain after transient focal ischemia: implications for the role of DNA damage in apoptosis and neuronal cell death. J Neurochem 69:232-245.
3. Halliwell B, Aruoma OI (1991) DNA damage by oxygen-derived species. Its mechanism and measurement in mammalian systems. FEBS Lett 281:9-19.
4. Li W, et al. (2006) Ischemic preconditioning in the rat brain enhances the repair of endogenous oxidative DNA damage by activating the base-excision repair pathway. J Cereb Blood Flow Metab 26:181-198.
5. Guillet M, Boiteux S (2002) Endogenous DNA abasic sites cause cell death in the absence of Apn1, Apn2 and Rad1/Rad10 in Saccharomyces cerevisiae. EMBO J 21: 2833-2841.
6. Lan J, et al. (2003) Inducible repair of oxidative DNA lesions in the rat brain after transient focal ischemia and reperfusion. J Cereb Blood Flow Metab 23:1324-1339.
7. Srivastava DK, et al. (1998) Mammalian abasic site base excision repair. Identification of the reaction sequence and rate-determining steps. J Biol Chem 273:21203-21209.
8. Nagayama T, et al. (2000) Activation of poly(ADP-ribose) polymerase in the rat hippocampus may contribute to cellular recovery following sublethal transient global ischemia. J Neurochem 74:1636-1645.
9. Parsons JL, Dianova II, Dianov GL (2004) APE1 is the major 3′-phosphoglycolate activity in human cell extracts. Nucleic Acids Res 32:3531-3536.
10. Kawase M, Fujimura M, Morita-Fujimura Y, Chan PH (1999) Reduction of apurinic/ apyrimidinic endonuclease expression after transient global cerebral ischemia in rats: implication of the failure of DNA repair in neuronal apoptosis. Stroke, 30:441-448 discussion 449.
11. Narasimhan P, et al. (2005) Overexpression of human copper/zinc- superoxide dismutase in transgenic animals attenuates the reduction of apurinic/apyrimidinic endonuclease expression in neurons after in vitro ischemia and after transient global cerebral ischemia. J Neurochem 93:351-358.
12. Vasko MR, Guo C, Kelley MR (2005) The multifunctional DNA repair/redox enzyme Ape1/Ref-1 promotes survival of neurons after oxidative stress. DNA Repair (Amst) 4: 367-379.
13. Miyata A, et al. (1989) Isolation of a novel 38 residue-hypothalamic polypeptide which stimulates adenylate cyclase in pituitary cells. Biochem Biophys Res Commun 164:567-574.
14. Ohtaki H, Nakamachi T, Dohi K, Shioda S (2008) Role of PACAP in ischemic neural death. J Mol Neurosci 36:16-25.
15. Uchida D, Arimura A, Somogyvári-Vigh A, Shioda S, Banks WA (1996) Prevention of ischemia-induced death of hippocampal neurons by pituitary adenylate cyclase activating polypeptide. Brain Res 736:280-286.
16. Reglodi D, Somogyvari-Vigh A, Vigh S, Kozicz T, Arimura A (2000) Delayed systemic administration of PACAP38 is neuroprotective in transient middle cerebral artery occlusion in the rat. Stroke 31:1411-1417.
17. Bhave SV, Hoffman PL (2004) Phosphatidylinositol 3′-OH kinase and protein kinase A pathways mediate the anti-apoptotic effect of pituitary adenylyl cyclase-activating polypeptide in cultured cerebellar granule neurons: modulation by ethanol. J Neurochem 88:359-369.
18. Fung H, Liu P, Demple B (2007) ATF4-dependent oxidative induction of the DNA repair enzyme Ape1 counteracts arsenite cytotoxicity and suppresses arsenitemediated mutagenesis. Mol Cell Biol 27:8834-8847.
19. Tell G, Damante G, Caldwell D, Kelley MR (2005) The intracellular localization of APE1/Ref-1: more than a passive phenomenon? Antioxid Redox Signal 7:367-384.
20. McNeill DR, Wilson DM, 3rd (2007) A dominant-negative form of the major human abasic endonuclease enhances cellular sensitivity to laboratory and clinical DNAdamaging agents. Mol Cancer Res 5:61-70.
21. Ono Y, Furuta T, Ohmoto T, Akiyama K, Seki S (1994) Stable expression in rat glioma cells of sense and antisense nucleic acids to a human multifunctional DNA repair enzyme, APEX nuclease. Mutat Res 315:55-63.
22. Fujimura M, Morita-Fujimura Y, Kawase M, Chan PH (1999) Early decrease of apurinic/ apyrimidinic endonuclease expression after transient focal cerebral ischemia in mice. J Cereb Blood Flow Metab 19:495-501.
23. Lewén A, Sugawara T, Gasche Y, Fujimura M, Chan PH (2001) Oxidative cellular damage and the reduction of APE/Ref-1 expression after experimental traumatic brain injury. Neurobiol Dis 8:380-390.
24. Fujimura M, et al. (1999) Copper-zinc superoxide dismutase prevents the early decrease of apurinic/apyrimidinic endonuclease and subsequent DNA fragmentation after transient focal cerebral ischemia in mice. Stroke 30:2408-2415.
25. Kopp M, Meissl H, Korf HW (1997) The pituitary adenylate cyclase-activating polypeptide-induced phosphorylation of the transcription factor CREB (cAMP response element binding protein) in the rat suprachiasmatic nucleus is inhibited by melatonin. Neurosci Lett 227:145-148.
26. Sumner AD, Margiotta JF (2008) Pituitary adenylate cyclase-activating polypeptide (PACAP) alters parasympathetic neuron gene expression in a time-dependent fashion. J Mol Neurosci 36:141-156.
27. Formisano L, et al. (2007) Ischemic insults promote epigenetic reprogramming of mu opioid receptor expression in hippocampal neurons. Proc Natl Acad Sci USA 104: 4170-4175.
28. Cao G, et al. (2007) Critical role of calpain I in mitochondrial release of apoptosisinducing factor in ischemic neuronal injury. J Neurosci 27:9278-9293.
29. Park YG, Nesterova M, Agrawal S, Cho-Chung YS (1999) Dual blockade of cyclic AMP response element- (CRE) and AP-1-directed transcription by CRE-transcription factor decoy oligonucleotide, gene-specific inhibition of tumor growth. J Biol Chem 274: 1573-1580.