Cognitive evaluation of traumatically brain-injured rats using serial testing in the Morris water maze

Restorative Neurology and Neuroscience

Volumn 24, Issue 2, 2006, Pages 109-114

  Thompson, Hilaire J ^a,b,e   LeBold, David G ^a   Marklund, Niklas ^a,c,d   Morales, Diego M ^a,c   Hagner, Andrew P ^c   McIntosh, Tracy K ^a,c  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^e Biobehavioral Nursing and Health Systems   (United States)

Author keywords

Head injury; Multiple time points; Reversal learning; Shift learning; Water maze

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN INJURY; COGNITIVE DEFECT; CONTROLLED STUDY; HEAD INJURY; INJURY SEVERITY; LEARNING DISORDER; MALE; MAZE TEST; MEMORY CONSOLIDATION; MEMORY DISORDER; MORRIS WATER MAZE; NONHUMAN; PRIORITY JOURNAL; RAT; SWIMMING;

ANIMALS; BEHAVIOR, ANIMAL; BRAIN INJURIES; COGNITION; DISEASE MODELS, ANIMAL; MALE; MAZE LEARNING; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS;

EID: 33646699333     PISSN: 09226028     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. F.M. Bareyre, K.E. Saatman, M.A. Helfaer, G. Sinson, J.D. Weisser, A.L. Brown and T.K. McIntosh, Alterations in ionized and total blood magnesium after experimental traumatic brain injury: relationship to neurobehavioral outcome and neuroprotective efficacy of magnesium chloride, J. Neurochemistry 73 (1999), 271-280.
2. A. Blokland, J. deVente, J. Prickaerts, W. Honig, M. Markerink-van Ittersum and H. Steinbusch, Local inhibition of hippocampal nitric oxide synthase does not impair place learning in the Morris water escape task in rats, Eur. J of Neurosci. 11 (1999), 223-232.
3. D.L. Brody and D.M. Holtzman, Morris water maze search strategy analysis in PDAPP mice before and after experimental traumatic brain injury, Exp. Neurol. 197 (2006), 330-340.
4. M.R. Bullock, B.G. Lyeth and J.P. Muizelaar, Current status of neuroprotection trials for traumatic brain injury: lessons from animal models and clinical studies, Neurosurgery 45 (1999), 207-217.
5. J.A. Cheney, J.D. Weisser, F.M. Bareyre, H.L. Laurer, K.E. Saatman, R. Raghupathi, V. Gribkoff, J.E. Starrett and T.K. McIntosh, The maxi-K channel opener BMS-204352 attenuates regional cerebral edema and neurologic motor impairment after experimental brain injury, J Cereb. Blood Flow Metab. 21 (2001), 396-403.
6. F. Cirulli, A. Berry and E. Alleva, Intracerebroventricular administration of brain derived neurotrophic factor in adult rats affects analgesia and spontaneous behaviour but not memory retention in a Morris Water Maze task, Neuroscience Letters 287 (2000), 207-210.
7. F. Cirulli, A. Berry, F. Chiarotti and E. Alleva, Intrahippocampal administration of BDNF in adult rats affects short-term behavioral plasticity in the Morris water maze and performance in the elevated plus-maze, Hippocampus 14 (2004), 802-807.
8. L.B. Day and T. Schallert, Anticholinergic effects on acquisition of place learning in the Morris water task: spatial mapping deficit or inability to inhibit nonplace strategies, Behavioral Neurosci. 110 (1996), 998-1005.
9. L.B. Day, M. Weisend, R.J. Sutherland and T. Schallert, The hippocampus is not necessary for place response but may be necessary for pliancy, Behavioral Neurosci. 113 (1999), 914-924.
10. D. D'Hoog and P.P. DeDeyn, Applications of the Morris water maze in the study of learning and memory, Brain Research Reviews 36 (2001), 60-90.
11. S.T. Fujimoto, L. Longhi, K.E. Saatman and T.K. McIntosh, Motor and cognitive function evaluation following experimental traumatic brain injury, Neurosci. Biobehav. Rev. 28 (2004), 365-378.
12. M. Gallagher, R. Burwell and M. Burchinal, Severity of spatial learning impairment in aging: development of learning index for performance in the Morris water maze, Behavioral Neurosci. 107 (1993), 618-626.
13. A. Graziano, L. Petrosini and A. Bartoletti, Automatic recognition of explorative strategies in the Morris water maze, J. Neuroscience Methods 130 (2003), 33-44.
14. C.C. Giza, C.S. Griesbach and D.A. Hovda, Experience-dependent plasticity is disturbed following traumatic injury to the immature brain, Beh. Brain Res 157 (2005), 11-22.
15. T.K. McIntosh, R. Vink, L. Noble, I. Yamakami, S. Fernyak, H. Soares and A.L. Faden, Traumatic brain injury in the rat: characterization of a lateral fluid-percussion model, Neuroscience 28 (1989), 233-244.
16. R. Morris, Development of a water-maze procedure for studying spatial learning in the rat, J. Neuroscience Methods 11 (1984), 47-60.
17. National Institutes of Neurological Diseases and Stroke, Traumatic Brain Injury: Hope Through Research. (last updated Oct. 10, 2002.) http://www.ninds.nih.gov/health_and_medical /pubs/TBI.htm, Accessed November 2, 2004.
18. L.F. Pettenuzzo, A.T.S. Wyse, M.D. Clovis, C.S. Dutra-Filho, C.A. Netto and M. Wajner, Evaluation of the effect of chronic administration of drugs on rat behavior in the water maze task, Brain Research Protocols 12 (2003), 109-115.
19. J.E. Pierce, D.H. Smith, M.S. Eison and T.K. McIntosh, The nootropic compound BMY-21502 improves spatial learning ability in brain injured rats, Brain Research 624 (1993), 199-208.
20. M.L. Prins and D.A. Hovda, Mapping cerebral glucose metabolism during spatial learning: interactions of development and traumatic brain injury, J. Neurotrauma 18 (2001), 31-46.
21. K.E. Saatman, H. Murai, R.T. Bartus, D.H. Smith, N.J. Hayward, B.R. Perri and T.K. McIntosh, Calpain inhibitor AK295 attenuates motor and cognitive deficits following experimental brain injury in the rat, Proc Nat. Acad. Sci. USA 93 (1996), 3428-3433.
22. K.E. Saatman, F.M. Bareyre, M.S. Grady and T.K. McIntosh, Acute cytoskeletal alterations and cell death induced by experimental brain injury are attenuated by magnesium treatment and exacerbated by magnesium deficiency, J. Neuropathol Exp. Neurol. 60 (2001), 183-194.
23. D. Smith, K. Okiyama, M.J. Thomas, B. Claussen and T.K. McIntosh, Evaluation of memory dysfunction following experimental brain injury using the MWM, J. Neurotrauma 8 (1991), 259-269.
24. H.J. Thompson, J. Lifshitz, N. Marklund, M.S. Grady, D.I. Graham, D.A. Hovda and T.K. McIntosh, Lateral fluid percussion: A 15 year review and evaluation, J. Neurotrauma 22 (2005), 42-75.