Clinical trials in head injury

Journal of Neurotrauma

Volumn 19, Issue 5, 2002, Pages 503-557

  Narayan, Raj K ^a   Michel, Mary Ellen ^b   Ansell, Beth ^c   Baethman, Alex ^d   Biegon, Anat ^e   Bracken, Michael B ^f   Bullock, M Ross ^g   Choi, Sung C ^g   Clifton, Guy L ^h   Contant, Charles F ⁱ   Coplin, William M ^j   Dietrich, W Dalton ^k   Ghajar, Jamshid ^l   Grady, Sean M ^m   Grossman, Robert G ⁱ   Hall, Edward D ⁿ   Heetderks, William ^o   Hovda, David A ^p   Jallo, Jack ^q   Katz, Russell L ^r   Knoller, Nachshon ^s   Kochanek, Patrick M ^t   Maas, )Andrew I ^u   Majde, Jeannine ^v   Marion, Donald W ^t   Marmarou, Anthony ^g   Marshall, Lawrence F ^w   McIntosh, Tracy K ^m   Miller, Emmy ^h   Mohberg, Noel ⁿ   Muizelaar, J Paul ^x   Pitts, Lawrence H ^y   Quinn, Peter ^l   Riesenfeld, Gad ^z   Robertson, Claudia S ⁱ   Strauss, Kenneth I ^q   Teasdale, Graham ^aa   Temkin, Nancy ^ab   Tuma, Ronald ^z   Wade, Charles ^z   Walker, Michael D ^o   Weinrich, Michael ^c   Whyte, John ^p   Wilberger, Jack ^ac   Young, A Byron ^ad   Yurkewicz, Lorraine ⁿ   more..

^a TEMPLE UNIVERSITY HOSPITAL   (United States)

^b National Institute of Neurological Disorders and Stroke   (Canada)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

^d UNIVERSITY OF MUNICH   (Germany)

^e LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^f YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^h UNIVERSITY OF TEXAS   (United States)

ⁱ BAYLOR COLLEGE OF MEDICINE   (United States)

^j WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^k UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^l Brain Trauma Foundation   (United States)

^m HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

ⁿ PFIZER INC   (United States)

^o NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^p UNIVERSITY OF CALIFORNIA   (United States)

^q TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^r CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^s SHEBA MEDICAL CENTER   (Israel)

^t UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^u ERASMUS MEDICAL CENTER   (Netherlands)

^v OFFICE OF NAVAL RESEARCH   (United States)

^w UNIVERSITY OF CALIFORNIA   (United States)

^x UNIVERSITY OF CALIFORNIA   (United States)

^y UNIVERSITY OF CALIFORNIA   (United States)

^z University of Washington ^*  (United States)

^aa SOUTHERN GENERAL HOSPITAL   (United Kingdom)

^ab UNIVERSITY OF WASHINGTON   (United States)

^ac ALLEGHENY GENERAL HOSPITAL   (United States)

^ad UNIVERSITY OF KENTUCKY   (United States)

more..

Author keywords

Clinical trials; Head injury; Intracranial pressure; Outcome measures; Traumatic brain injury; Trial design; Uniformed consent

Indexed keywords

4 PHOSPHONOMETHYLPIPECOLIC ACID; ANTICONVULSIVE AGENT; APTIGANEL; DELTIBANT; DEXANABINOL; NIMODIPINE; OMEGA CONOTOXIN MVIIA; STEROID; TIRILAZAD; TRAXOPRODIL;

ADULT; AGED; ARTICLE; BRAIN PERFUSION; CLINICAL TRIAL; CONSERVATIVE TREATMENT; FEMALE; HEAD INJURY; HUMAN; INFORMED CONSENT; INTRACRANIAL PRESSURE; MAJOR CLINICAL STUDY; MALE; OUTCOMES RESEARCH; PENETRATING TRAUMA; PHYSICAL DISABILITY; TREATMENT FAILURE; TREATMENT PLANNING;

BRAIN INJURIES; CLINICAL TRIALS; HUMANS;

EID: 0036260647     PISSN: 08977151     EISSN: None     Source Type: Journal    
DOI: 10.1089/089771502753754037     Document Type: Article

References (50)

1. Corticosteroids in acute traumatic brain injury: Systematic review of randomized controlled trials
2. Development of HU-211 as a neuroprotectant for ischemic brain damage
3. Megadose steroids in severe head injury
4. Primary endpoints in phase III clinical trials of severe head trauma: DRS versus GOS
5. Design and statistical issues in multicenter trials of severe head injury
6. Relationship between Glasgow Outcome Scale and neuropsychological measures after brain injury
7. Lack of effect of hypothermia in acute brain injury
8. Dexamethasone and severe head injury. A prospective double-blind study
9. Neurosurgical complication after apparently minor head injury: Assessment of risk in a series of 610 patients
10. Effect of high-dose dexamethasone on outcome from severe head injury
11. Size and quality of randomized controlled trials in head injury: A review of published studies
12. Clinical neuro-protection trials in severe traumatic brain injury: Lessons from previous studies
13. Double-blind study on the effects of steroids on severe closed head injury
14. The Will Rogers phenomenon. Stage migration and new diagnostic techniques as a source of misleading statistics for survival in cancer
15. Ultrahigh dexamethasone in acute brain injury. Results from a prospective randomized double-blind multicenter trial (GUDHIS)
16. Traumatic brain injury review
17. High-dose glucocorticoids in the management of severe head injury
18. Treatment of acute cerebral edema with high dose of dexamethasone
19. Safety and tolerability of the glutamate antagonist CGS 19755 (Selfotel) in patients with acute ischemic stroke. Results of a phase IIa randomized trial
20. Failure of high-dose steroid therapy to influence intracranial pressure in patients with severe head injury
21. Management and prognosis of severe traumatic brain injury
22. Free radicals in CNS injury
23. The international stroke trial (IST): A randomized trial of aspirin, subcutaneous heparin, both or neither among 19, 435 patients with acute ischaemic stroke
24. Free oxygen radicals in cerebral vascular responses
25. George E. Brown memorial lecture. Oxygen radicals in cerebral vascular injury
26. Dexanabinol (HU-211) improves long-term outcome in rats subjected to transient focal brain ischemia
27. Neuroprotective agents in traumatic brain injury
28. Treatment of traumatic brain injury with moderate hypothermia
29. Effects of the bradykinin antagonist Bradycor (deltibant, CP-1027) in severe traumatic brain injury: Results of a multi-center, randomized, placebo-controlled trial
30. Head injury: Recent past, present, and future
31. A multicenter trial on the efficacy of using Tirilazad mesylate in cases of head injury
32. Failure of the competitive N-methyl-D-aspartate antagonist Selfotel (CGS 19755) in the treatment of severe head injury: Results of two phase III clinical trials
33. Improving the outcome of severe head injury with the oxygen scavenger polyethylene glycol-conjugated superoxide dismutase: A phase II trial
34. The European Brain Injury Consortium survey of head injuries
35. Trials: The next 50 years. Large scale randomized evidence of moderate benefits
36. Increased levels of plasma cholesteryl-ester hydroperoxides in patients with subarachnoid hemorrhage
37. Increased plasma levels of lipid hydroperoxides in patients with ischemic stroke
38. Steroids in severe head injury. A prospective randomized clinical trial
39. Differential acute and chronic responses of tumor necrosis factor-deficient mice to experimental brain injury
40. Long-term effect of HU-211, a novel non-competitive NMDA antagonist, on motor and memory functions after closed head injury in the rat
41. Cytokine production in the brain following closed head injury: Dexanabinol (HU0211) is a novel TNF-alpha inhibitor and an effective neuroprotectant
42. Optimal two-stage designs for phase II clinical trials
43. The simple model versus the super model: Translating experimental traumatic brain injury research to the bedside
44. Analyzing outcome of treatment of severe head injury: A review and update on advancing the use of the Glasgow Outcome Scale
45. Assessing medical rehabilitation practices: Distinctive methodological challenges
46. Rehabilitation of the patient with traumatic brain injury
47. Structured interviews for the Glasgow Outcome Scale and the extended Glasgow Outcome Scale: Guidelines for their use
48. The emotional and cognitive consequences of head injury in relation to the Glasgow Outcome Scale