Soybean isoflavone alleviates β-amyloid 1-42 induced inflammatory response to improve learning and memory ability by down regulation of Toll-like receptor 4 expression and nuclear factor-κB activity in rats

International Journal of Developmental Neuroscience

Volumn 29, Issue 5, 2011, Pages 537-542

  Ding, B J ^a   Ma, W W ^a   He, L L ^a   Zhou, X ^a   Yuan, L H ^a   Yu, H L ^a   Feng, J F ^a   Xiao, R ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

A ; Inflammation; Morris water maze; Neuroprotection; NF B; Soybean isoflavone; TLR4

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; INTERLEUKIN 1BETA; ISOFLAVONE DERIVATIVE; MESSENGER RNA; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BRAIN TISSUE; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; INFLAMMATION; LEARNING DISORDER; MALE; MAZE TEST; MEMORY DISORDER; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RAT; SOYBEAN; UPREGULATION;

AMYLOID BETA-PEPTIDES; ANIMALS; BRAIN; INFLAMMATION; INTERLEUKIN-1BETA; ISOFLAVONES; MALE; MAZE LEARNING; MEMORY; PEPTIDE FRAGMENTS; RANDOM ALLOCATION; RATS; RATS, WISTAR; SOYBEANS; TOLL-LIKE RECEPTOR 4; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR-ALPHA;

GLYCINE MAX; RATTUS;

EID: 79958718238     PISSN: 07365748     EISSN: 1873474X     Source Type: Journal    
DOI: 10.1016/j.ijdevneu.2011.04.002     Document Type: Article

References (33)

1. Barton G.M. Viral recognition by Toll-like receptors. Semin. Immunol. 2007, 19:33-40.
2. Blay M., Espinel A.E., Delgado M.A., Baiges I., Bladé C., Arola L., Salvadó J. Isoflavone effect on gene expression profile and biomarkers of inflammation. J. Pharm. Biomed. Anal. 2010, 51:382-390.
3. Barnes S., Sfakianos J., Coward L., Kirk M. Soy isoflavonoids and cancer prevention. Underlying biochemical and pharmacological issues. Adv. Exp. Med. Biol. 1996, 401:87-100.
4. Chen G., Zhang S., Shi J., Ai J., Qi M., Hang C. Simvastatin reduces secondary brain injury caused by cortical contusion in rats: possible involvement of TLR4/NF-kappaB pathway. Exp. Neurol. 2009, 216:398-406.
5. Doyle S.L., O'Neill L.A. Toll-like receptors: from the discovery of NFkappaB to new insights into transcriptional regulations in innate immunity. Biochem. Pharmacol. 2006, 72:1102-1113.
6. Durairajan S.S., Yuan Q., Xie L., Chan W.S., Kum W.F., Koo I., Liu C., Song Y., Huang J.D., Klein W.L., Li M. Salvianolic acid B inhibits Abeta fibril formation and disaggregates preformed fibrils and protects against Abeta-induced cytotoxicty. Neurochem. Int. 2008, 52:741-750.
7. Frank S., Copanaki E., Burbach G.J., Müller U.C., Deller T. Differential regulation of toll-like receptor mRNAs in amyloid plaque-associated brain tissue of aged APP23 transgenic mice. Neurosci. Lett. 2009, 453:41-44.
8. Fassbender K.E.A. The LPS receptor (CD14) links innate immunity with Alzheimer's disease. FASEB J. 2004, 18:203-205.
9. Gong Q.H., Wu Q., Huang X.N., Sun A.S., Shi J.S. Protective effects of Ginkgobiloba leaf extract on aluminum-induced brain dysfunction in rats. Life Sci. 2005, 77:140-148.
10. Hsu A., Bruno R.S., Löhr C.V., Taylor A.W., Dashwood R.H., Bray T.M., Ho E. Dietary soy and tea mitigate chronic inflammation and prostate cancer via NFkappaB pathway in the Noble rat model. J. Nutr. Biochem. 2010, 27.. (Epub ahead of print).
11. Hashimoto M., Hossain S., Tanabe Y., Kawashima A., Harada T., Yano T., Mizuguchi K., Shido O. The protective effect of dietary eicosapentaenoic acid against impairment of spatial cognition learning ability in rats infused with amyloid β(1-40). J. Nutr. Biochem. 2009, 20:965-973.
12. Kim H.S., Lim J.Y., Sul D., Hwang B.Y., Won T.J., Hwang K.W., Park S.Y. Neuroprotective effects of the new diterpene CBNU06 against beta-amyloid-induced toxicity through the inhibition of NF-kappaB signaling pathway in PC12 cells. Eur. J. Pharmacol. 2009, 622:25-31.
13. Kigerl K.A., Lai W., Rivest S., Hart R.P., Satoskar A.R., Popovich P.G. Toll-likereceptor (TLR)-2 and TLR-4 regulate inflammation, gliosis, and myelin sparing after spinal cord injury. J. Neurochem. 2007, 102:37-50.
14. Lee M.S., Kim Y.J. Signaling pathways downstream of pattern-recognition receptors and their cross talk. Annu. Rev. Biochem. 2007, 76:447-480.
15. Letiembre M., Liu Y., Walter S., Hao W., Pfander T., Wrede A., Schulz-Schaeffer W., Fassbender K. Screening of innate immune receptors in neurodegenerative diseases: a similar pattern. Neurobiol. Aging 2009, 30:759-768.
16. McGeer P.L., Rogers J., McGeer E.G. Inflammation, anti-inflammatory agents and Alzheimer disease: the last 12 years. J. Alzheimers Dis. 2006, 9:271-276.
17. Miyake K. Innate immune sensing of pathogens and danger signals by cell surface Toll-like receptors. Semin. Immunol. 2007, 19:3-10.
18. Ma W.W., Xiang L., Yu H.L., Yuan L.H., Guo A.M., Xiao Y.X., Li L., Xiao R. Neuroprotection of soyabean isoflavone co-administration with folic acid against beta-amyloid 1-40-induced neurotoxicity in rats. Br. J. Nutr. 2009, 102:502-505.
19. Morris R. Developments of a water-maze procedure for studying spatial learning in the rat. J. Neurosci. Methods 1984, 11:47-60.
20. Napoli I., Neumann H. Microglial clearance function in health and disease. Neuroscience 2009, 158:1030-1038.
21. Oberg F., Haseeb A., Ahnfelt M., Pontén F., Westermark B., El-Obeid A. Herbal melanin activates TLR4/NF-kappaB signaling pathway. Phytomedicine 2009, 16:477-484.
22. Reed-Geaghan E.G., Savage J.C., Hise A.G., Landreth G.E. CD14 and toll-like receptors 2 and 4 are required for fibrillar A{beta}-stimulated microglial activation. J. Neurosci. 2009, 29(38):11982-11992.
23. Schwab C., McGeer P.L. Inflammatory aspects of Alzheimer disease and other neurodegenerative disorders. J. Alzheimers Dis. 2008, 13:359-369.
24. Snihur A.W., Hampson E., Cain D.P. Estradiol and corticosterone independently impair spatial navigation in the Morris water maze in adult female rats. Behav. Brain Res. 2008, 187:56-66.
25. Salminen A., Huuskonen J., Ojala J., Kauppinen A., Kaarniranta K., Suuronen T. Activation of innate immunity system during aging: NF-kB signaling is the molecular culprit of inflamm-aging. Ageing Res. Rev. 2008, 7:83-105.
26. Tanaka S., Ide M., Shibutani T., Ohtaki H., Numazawa S., Shioda S., Yoshida T. Lipopolysaccharide-induced microglial activation induces learning and memory deficits without neuronal cell death in rats. J. Neurosci. Res. 2006, 83:557-566.
27. Trinchieri G., Sher A. Cooperation of Toll-like receptor signals in innate immune defence. Nat. Rev. Immunol. 2007, 7:179-190.
28. Taku K., Melby M.K., Takebayashi J., Mizuno S., Ishimi Y., Omori T., Watanabe S. Effect of soy isoflavone extract supplements on bone mineral density in menopausal women: meta-analysis of randomized controlled trials. Asia Pac. J. Clin. Nutr. 2010, 19:33-42.
29. Taku K., Umegaki K., Sato Y., Taki Y., Endoh K., Watanabe S. Soy isoflavones lower serum total and LDL cholesterol in humans: a meta-analysis of 11 randomized controlled trials. Am. J. Clin. Nutr. 2007, 85:1148-1156.
30. Velasquez M.T., Bhathena S.J. Dietary phytoestrogens: a possible role in renal disease protection. Am. J. Kidney Dis. 2001, 37(5):1056-1068.
31. Walter S., Letiembre M., Liu Y., Heine H., Penke B., Hao W., Bode B., Manietta N., Walter J., Schulz-Schuffer W., Fassbender K. Role of the toll-like receptor 4 in neuroinflammation in Alzheimer's disease. Cell Physiol. Biochem. 2007, 20:947-956.
32. Yirmiya R., Goshen I. Immune modulation of learning, memory, neural plasticity and neurogenesis. Brain Behav. Immun. 2010, (Epub ahead of print).
33. Youn H.S., Saitoh S.I., Miyake K., Hwang D.H. Inhibition of homodimerization of Toll-like receptor 4 by curcumin. Biochem. Pharmacol. 2006, 72:62-69.