메뉴 건너뛰기




Volumn 60, Issue 6, 2011, Pages 533-539

Oxymatrine reduces neuronal cell apoptosis by inhibiting Toll-like receptor 4/nuclear factor kappa-B-dependent inflammatory responses in traumatic rat brain injury

Author keywords

Inflammatory cytokine; Neuronal cell apoptosis; Nuclear factor kappa B; Oxymatrine; Toll like receptor 4; Traumatic brain injury

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; OXYMATRINE; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA;

EID: 79956224307     PISSN: 10233830     EISSN: 1420908X     Source Type: Journal    
DOI: 10.1007/s00011-010-0300-7     Document Type: Article
Times cited : (50)

References (22)
  • 1
    • 0347990376 scopus 로고    scopus 로고
    • The neurophysiology of brain injury
    • DOI 10.1016/S1388-2457(03)00258-X
    • M Gaetz 2004 The neurophysiology of brain injury Clin Neurophysiol 115 4 18 14706464 10.1016/S1388-2457(03)00258-X 1:CAS:528:DC%2BD2cXptlSq (Pubitemid 38045590)
    • (2004) Clinical Neurophysiology , vol.115 , Issue.1 , pp. 4-18
    • Gaetz, M.1
  • 2
    • 33747768260 scopus 로고    scopus 로고
    • Cortical expression of nuclear factor κB after human brain contusion
    • DOI 10.1016/j.brainres.2006.06.045, PII S000689930601794X
    • CH Hang G Chen JX Shi X Zhang JS Li 2006 Cortical expression of nuclear factor kappaB after human brain contusion Brain Res 1109 14 21 16857176 10.1016/j.brainres.2006.06.045 1:CAS:528:DC%2BD28XovVSht7w%3D (Pubitemid 44279581)
    • (2006) Brain Research , vol.1109 , Issue.1 , pp. 14-21
    • Hang, C.-H.1    Chen, G.2    Shi, J.-X.3    Zhang, X.4    Li, J.-S.5
  • 3
    • 40049104041 scopus 로고    scopus 로고
    • Progesterone administration modulates TLRS/NF-κB signaling pathway in rat brain after cortical contusion
    • G Chen J Shi W Jin L Wang W Xie J Sun C Hang 2008 Progesterone administration modulates TLRs/NF-kappaB signaling pathway in rat brain after cortical contusion Ann Clin Lab Sci 38 65 74 18316784 1:CAS:528: DC%2BD1cXktFakt7o%3D (Pubitemid 351323727)
    • (2008) Annals of Clinical and Laboratory Science , vol.38 , Issue.1 , pp. 65-74
    • Chen, G.1    Shi, J.2    Jin, W.3    Wang, L.4    Xie, W.5    Sun, J.6    Hang, C.7
  • 4
    • 62049083748 scopus 로고    scopus 로고
    • Simvastatin reduces secondary brain injury caused by cortical contusion in rats: Possible involvement of TLR4/NF-kappaB pathway
    • 19166837 10.1016/j.expneurol.2008.12.019 1:CAS:528:DC%2BD1MXjsVOjt7c%3D
    • G Chen S Zhang J Shi J Ai M Qi C Hang 2009 Simvastatin reduces secondary brain injury caused by cortical contusion in rats: possible involvement of TLR4/NF-kappaB pathway Exp Neurol 216 398 406 19166837 10.1016/j.expneurol.2008. 12.019 1:CAS:528:DC%2BD1MXjsVOjt7c%3D
    • (2009) Exp Neurol , vol.216 , pp. 398-406
    • Chen, G.1    Zhang, S.2    Shi, J.3    Ai, J.4    Qi, M.5    Hang, C.6
  • 5
    • 5044225699 scopus 로고    scopus 로고
    • Effect of systemic LPS injection on cortical NF-κB activity and inflammatory response following traumatic brain injury in rats
    • DOI 10.1016/j.brainres.2004.07.090, PII S0006899304012491
    • CH Hang JX Shi J Tian JS Li W Wu HX Yin 2004 Effect of systemic LPS injection on cortical NF-kappaB activity and inflammatory response following traumatic brain injury in rats Brain Res 1026 23 32 15476694 10.1016/j.brainres.2004.07.090 1:CAS:528:DC%2BD2cXot12jtLk%3D (Pubitemid 39336413)
    • (2004) Brain Research , vol.1026 , Issue.1 , pp. 23-32
    • Hang, C.-H.1    Shi, J.-X.2    Tian, J.3    Li, J.-S.4    Wu, W.5    Yin, H.-X.6
  • 6
    • 63849136046 scopus 로고    scopus 로고
    • Systemic inflammatory response following acute traumatic brain injury
    • 19273311 10.2741/3489 1:CAS:528:DC%2BD1MXltlWktb0%3D
    • J Lu SJ Goh PY Tng YY Deng EA Ling S Moochhala 2009 Systemic inflammatory response following acute traumatic brain injury Front Biosci 14 3795 3813 19273311 10.2741/3489 1:CAS:528:DC%2BD1MXltlWktb0%3D
    • (2009) Front Biosci , vol.14 , pp. 3795-3813
    • Lu, J.1    Goh, S.J.2    Tng, P.Y.3    Deng, Y.Y.4    Ling, E.A.5    Moochhala, S.6
  • 7
    • 0035462607 scopus 로고    scopus 로고
    • Role of cerebral inflammation after traumatic brain injury: A revisited concept
    • MC Morganti-Kossmann M Rancan VI Otto PF Stahel T Kossmann 2001 Role of cerebral inflammation after traumatic brain injury: a revisited concept Shock 16 165 177 11531017 10.1097/00024382-200116030-00001 1:STN:280: DC%2BD3MvovVKjsA%3D%3D (Pubitemid 33598193)
    • (2001) Shock , vol.16 , Issue.3 , pp. 165-177
    • Morganti-Kossmann, M.C.1    Rancan, M.2    Otto, V.I.3    Stahel, P.F.4    Kossmann, T.5
  • 8
    • 34547128958 scopus 로고    scopus 로고
    • TNF alpha and Fas mediate tissue damage and functional outcome after traumatic brain injury in mice
    • DOI 10.1038/sj.jcbfm.9600487, PII 9600487
    • D Bermpohl Z You EH Lo HH Kim MJ Whalen 2007 TNF alpha and Fas mediate tissue damage and functional outcome after traumatic brain injury in mice J Cereb Blood Flow Metab 27 1806 1818 17406655 10.1038/sj.jcbfm.9600487 1:CAS:528:DC%2BD2sXhtF2rur7P (Pubitemid 47624551)
    • (2007) Journal of Cerebral Blood Flow and Metabolism , vol.27 , Issue.11 , pp. 1806-1818
    • Bermpohl, D.1    You, Z.2    Lo, E.H.3    Kim, H.-H.4    Whalen, M.J.5
  • 9
    • 2442687858 scopus 로고    scopus 로고
    • Cell death mechanisms following traumatic brain injury
    • R Raghupathi 2004 Cell death mechanisms following traumatic brain injury Brain Pathol 14 215 222 15193035 10.1111/j.1750-3639.2004.tb00056.x (Pubitemid 38656395)
    • (2004) Brain Pathology , vol.14 , Issue.2 , pp. 215-222
    • Raghupathi, R.1
  • 10
    • 0033790030 scopus 로고    scopus 로고
    • Apoptosis after traumatic brain injury
    • 11063058 10.1089/neu.2000.17.927 1:STN:280:DC%2BD3crgvFOisg%3D%3D
    • R Raghupathi DI Graham TK McIntosh 2000 Apoptosis after traumatic brain injury J Neurotrauma 17 927 938 11063058 10.1089/neu.2000.17.927 1:STN:280:DC%2BD3crgvFOisg%3D%3D
    • (2000) J Neurotrauma , vol.17 , pp. 927-938
    • Raghupathi, R.1    Graham, D.I.2    McIntosh, T.K.3
  • 11
    • 24944466380 scopus 로고    scopus 로고
    • Apoptosis and traumatic brain injury
    • DOI 10.1385/NCC:3:2:177
    • J Wong NW Hoe F Zhiwei I Ng 2005 Apoptosis and traumatic brain injury Neurocrit Care 3 177 182 16174891 10.1385/NCC:3:2:177 1:CAS:528: DC%2BD2MXhtF2ju7fM (Pubitemid 41325119)
    • (2005) Neurocritical Care , vol.3 , Issue.2 , pp. 177-182
    • Wong, J.1    Ng, W.H.2    Zhiwei, F.3    Ng, I.4
  • 12
    • 0036106182 scopus 로고    scopus 로고
    • Effect of oxymatrine on murine fulminant hepatitis and hepatocyte apoptosis
    • X Xiang G Wang X Cai Y Li 2002 Effect of oxymatrine on murine fulminant hepatitis and hepatocyte apoptosis Chin Med J 115 593 596 12133306 1:CAS:528:DC%2BD38XksFart7Y%3D (Pubitemid 34538109)
    • (2002) Chinese Medical Journal , vol.115 , Issue.4 , pp. 593-596
    • Xiang, X.1    Wang, G.2    Cai, X.3    Li, Y.4
  • 13
    • 0344046309 scopus 로고    scopus 로고
    • Basic and clinical study of oxymatrine on HBV infection
    • Z Zeng GJ Wang CW Si 1999 Basic and clinical study of oxymatrine on HBV infection J Gastroenterol Hepatol 14 S295 S297
    • (1999) J Gastroenterol Hepatol , vol.14
    • Zeng, Z.1    Wang, G.J.2    Si, C.W.3
  • 14
    • 64149117795 scopus 로고    scopus 로고
    • Oxymatrine protects rat brains against permanent focal ischemia and downregulates NF-kappaB expression
    • 19285049 10.1016/j.brainres.2009.02.069 1:CAS:528:DC%2BD1MXksVansrs%3D
    • Y Liu XJ Zhang CH Yang HG Fan 2009 Oxymatrine protects rat brains against permanent focal ischemia and downregulates NF-kappaB expression Brain Res 1268 174 180 19285049 10.1016/j.brainres.2009.02.069 1:CAS:528:DC%2BD1MXksVansrs%3D
    • (2009) Brain Res , vol.1268 , pp. 174-180
    • Liu, Y.1    Zhang, X.J.2    Yang, C.H.3    Fan, H.G.4
  • 15
    • 79955093970 scopus 로고    scopus 로고
    • Neuroprotection and underlying mechanisms of oxymatrine in cerebral ischemia of rats
    • doi: 10.1179/016164110X12759951866876
    • Cui L, Zhang X, Yang R, Wang L, Liu L, Li M, Du W. Neuroprotection and underlying mechanisms of oxymatrine in cerebral ischemia of rats. Neurol Res. 2010; doi: 10.1179/016164110X12759951866876.
    • (2010) Neurol Res.
    • Cui, L.1    Zhang, X.2    Yang, R.3    Wang, L.4    Liu, L.5    Li, M.6    Du, W.7
  • 16
    • 77949293053 scopus 로고    scopus 로고
    • Oxymatrine downregulates TLR4, TLR2, MyD88, and NF-kappaB and protects rat brains against focal ischemia
    • doi: 10.1155/2009/704706
    • Fan H, Li L, Zhang X, Liu Y, Yang C, Yang Y, Yin J. Oxymatrine downregulates TLR4, TLR2, MyD88, and NF-kappaB and protects rat brains against focal ischemia. Mediators Inflamm. 2009; doi: 10.1155/2009/704706.
    • (2009) Mediators Inflamm.
    • Fan, H.1    Li, L.2    Zhang, X.3    Liu, Y.4    Yang, C.5    Yang, Y.6    Yin, J.7
  • 17
    • 0019421846 scopus 로고
    • Responses to cortical injury: I. Methodology and local effects of contusions in the rat
    • DOI 10.1016/0006-8993(81)90067-6
    • DM Feeney MG Boyeson RT Linn HM Murray WG Dail 1981 Responses to cortical injury: I. Methodology and local effects of contusions in the rat Brain Res 211 67 77 7225844 10.1016/0006-8993(81)90067-6 1:CAS:528:DyaL3MXhslahtbc%3D (Pubitemid 11147211)
    • (1981) Brain Research , vol.211 , Issue.1 , pp. 67-77
    • Feeney, D.M.1    Boyeson, M.G.2    Linn, R.T.3
  • 18
    • 0034680145 scopus 로고    scopus 로고
    • Toll-like receptors in the induction of the innate immune response
    • 10963608 10.1038/35021228 1:STN:280:DC%2BD3cvjtVOhuw%3D%3D
    • A Aderem RJ Ulevitch 2000 Toll-like receptors in the induction of the innate immune response Nature 406 782 787 10963608 10.1038/35021228 1:STN:280:DC%2BD3cvjtVOhuw%3D%3D
    • (2000) Nature , vol.406 , pp. 782-787
    • Aderem, A.1    Ulevitch, R.J.2
  • 19
    • 0034886143 scopus 로고    scopus 로고
    • Toll-like receptors: Critical proteins linking innate and acquired immunity
    • DOI 10.1038/90609
    • S Akira K Takeda T Kaisho 2001 Toll-like receptors: critical proteins linking innate and acquired immunity Nat Immunol 2 675 680 11477402 10.1038/90609 1:CAS:528:DC%2BD3MXlslGjtLs%3D (Pubitemid 32747155)
    • (2001) Nature Immunology , vol.2 , Issue.8 , pp. 675-680
    • Akira, S.1    Takeda, K.2    Kaisho, T.3
  • 20
    • 0033966411 scopus 로고    scopus 로고
    • Toll signaling pathways in the innate immune response
    • DOI 10.1016/S0952-7915(99)00045-X
    • KV Anderson 2000 Toll signaling pathways in the innate immune response Curr Opin Immunol 12 13 19 10679407 10.1016/S0952-7915(99)00045-X 1:CAS:528:DC%2BD3cXhsVOktbg%3D (Pubitemid 30093445)
    • (2000) Current Opinion in Immunology , vol.12 , Issue.1 , pp. 13-19
    • Anderson, K.V.1
  • 21
    • 48749105482 scopus 로고    scopus 로고
    • Cardioprotective effects and underlying mechanisms of oxymatrine against ischemic myocardial injuries of rats
    • 18389484 10.1002/ptr.2452
    • S Hong-Li L Lei S Lei Z Dan D De-Li Q Guo-Fen L Yan C Wen-Feng Y Bao-Feng 2008 Cardioprotective effects and underlying mechanisms of oxymatrine against ischemic myocardial injuries of rats Phytother Res 22 985 989 18389484 10.1002/ptr.2452
    • (2008) Phytother Res , vol.22 , pp. 985-989
    • Hong-Li, S.1    Lei, L.2    Lei, S.3    Dan, Z.4    De-Li, D.5    Guo-Fen, Q.6    Yan, L.7    Wen-Feng, C.8    Bao-Feng, Y.9
  • 22
    • 52949129442 scopus 로고    scopus 로고
    • Oxymatrine attenuates intestinal ischemia/reperfusion injury in rats
    • 18820869 10.1007/s00595-008-3785-8
    • J Zhao S Yu L Tong F Zhang X Jiang S Pan H Jiang X Sun 2008 Oxymatrine attenuates intestinal ischemia/reperfusion injury in rats Surg Today 38 931 937 18820869 10.1007/s00595-008-3785-8
    • (2008) Surg Today , vol.38 , pp. 931-937
    • Zhao, J.1    Yu, S.2    Tong, L.3    Zhang, F.4    Jiang, X.5    Pan, S.6    Jiang, H.7    Sun, X.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.