Active immunization with amyloid-β 1-42 impairs memory performance through TLR2/4-dependent activation of the innate immune system

Journal of Immunology

Volumn 185, Issue 10, 2010, Pages 6338-6347

  Vollmar, Patrick ^a   Kullmann, Jennifer S ^b   Thilo, Barbara ^c   Claussen, Malte C ^a   Rothhammer, Veit ^a   Jacobi, Hortenzia ^a   Sellner, Johann ^a,d   Nessler, Stefan ^a   Korn, Thomas ^a   Hemmer, Bernhard ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY HOSPITAL ESSEN   (Germany)

^c UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^d UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; GAMMA INTERFERON; INTERLEUKIN 1BETA; INTERLEUKIN 6; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR;

ACTIVE IMMUNIZATION; AGED; ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTOSIS; CELL INFILTRATION; CENTRAL NERVOUS SYSTEM; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; CYTOKINE RELEASE; FEMALE; INNATE IMMUNITY; KNOCKOUT MOUSE; LEARNING; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ADJUVANTS, IMMUNOLOGIC; ALZHEIMER VACCINES; AMYLOID BETA-PEPTIDES; ANIMALS; BEHAVIOR, ANIMAL; BRAIN; CELL SEPARATION; CYTOKINES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; FREUND'S ADJUVANT; HUMANS; IMMUNITY, INNATE; MACROPHAGES; MEMORY DISORDERS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MONOCYTES; PEPTIDE FRAGMENTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4; VACCINATION;

EID: 78650693417     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1001765     Document Type: Article

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