Elevated cyclin G2 expression intersects with DNA damage checkpoint signaling and is required for a potent G2/M checkpoint arrest response to doxorubicin

Journal of Biological Chemistry

Volumn 287, Issue 27, 2012, Pages 22838-22853

  Zimmermann, Maike ^a,b   Arachchige Don, Aruni S ^b,c   Donaldson, Michaela S ^a   Dallapiazza, Robert F ^b,d   Cowan, Colleen E ^b,e   Horne, Mary C ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF IOWA   (United States)

^c RUTGERS CANCER INSTITUTE OF NEW JERSEY   (United States)

^d UNIVERSITY OF VIRGINIA   (United States)

^e RUSH UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-PROLIFERATIVE; ATAXIA-TELANGIECTASIA MUTATED; ATM AND RAD3-RELATED; CELL CYCLE; CELL LINES; CELL-CYCLE ARREST; CELLULAR REPLICATION; DNA DAMAGES; DNA REPAIR; DOXORUBICIN; GROWTH INHIBITION; MITOGENS; MULTIPLE CELLS; OVER-EXPRESSION; PHARMACOLOGICAL INHIBITORS; PROTEIN KINASE; SIGNALING PATHWAYS; STABLE CLONES; UP-REGULATION;

AMINO ACIDS; CELL CULTURE; DNA; INTERNET PROTOCOLS; PHOSPHORYLATION; PROTEINS; SIGNALING;

CLONE CELLS;

2 MORPHOLINO 6 (1 THIANTHRENYL) 4 PYRANONE; ATM PROTEIN; ATR PROTEIN; CAFFEINE; CHECKPOINT KINASE 2; CYCLIN B1; CYCLIN G2; DOXORUBICIN; ETOPOSIDE; GENOMIC DNA; MITOGENIC AGENT; THREONINE;

ANIMAL CELL; ARTICLE; CELL CLONE; CELL CYCLE ARREST; CELL DIVISION; CELL FUNCTION; CELL LINE; CELL STRAIN HCT116; CONTROLLED STUDY; DNA DAMAGE CHECKPOINT; DNA DAMAGE RESPONSE; DNA REPAIR; DNA STRAND BREAKAGE; DRUG RESPONSE; ENZYME PHOSPHORYLATION; G1 PHASE CELL CYCLE CHECKPOINT; G2 PHASE CELL CYCLE CHECKPOINT; GROWTH INHIBITION; HUMAN; HUMAN CELL; M PHASE CELL CYCLE CHECKPOINT; NONHUMAN; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN MODIFICATION; RNA INTERFERENCE; S PHASE CELL CYCLE CHECKPOINT; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; CELL CYCLE PROTEINS; CELL DIVISION; CYCLIN B; CYCLIN B1; CYCLIN G2; DNA DAMAGE; DNA-BINDING PROTEINS; DOXORUBICIN; G2 PHASE; GENES, CDC; HCT116 CELLS; HUMANS; MICE; NEOPLASMS; NIH 3T3 CELLS; ONCOGENE PROTEIN P21(RAS); PROTEIN-SERINE-THREONINE KINASES; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS;

ATAXIA TELANGIECTASIA;

EID: 84863305100     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.376855     Document Type: Article

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