mTOR supports long-term self-renewal and suppresses mesoderm and endoderm activities of human embryonic stem cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 19, 2009, Pages 7840-7845

  Zhou, Jiaxi ^a,b   Su, Pei ^a,b   Wang, Lu ^a,b   Chen, Joanna ^a   Zimmermann, Maike ^c   Genbacev, Olga ^d   Afonja, Olubunmi ^e   Horne, Mary C ^c   Tanaka, Tetsuya ^b   Duan, Enkui ^f   Fisher, Susan J ^d   Liao, Jiayu ^g   Chen, Jie ^a   Wang, Fei ^a,b  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^c UNIVERSITY OF IOWA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f INSTITUTE OF ZOOLOGY   (China)

^g University of California Riverside   (United States)

Author keywords

Differentiation; Long term undifferentiated growth; OCT 4; Pluripotency

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN SERINE THREONINE KINASE;

ARTICLE; CELL ACTIVITY; CELL DIFFERENTIATION; CELL GROWTH; CELL MATURATION; CELL PROLIFERATION; CONTROLLED STUDY; DEVELOPMENTAL GENE; EMBRYONIC STEM CELL; ENDODERM; GENOME; HUMAN; HUMAN CELL; MESODERM; MOLECULAR MECHANICS; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; REGENERATION; TISSUE REPAIR;

CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; EMBRYONIC STEM CELLS; ENDODERM; GENE EXPRESSION REGULATION; GENOME, HUMAN; HUMANS; MESODERM; MODELS, BIOLOGICAL; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTEIN KINASES; REGENERATION; SIGNAL TRANSDUCTION;

MAMMALIA;

EID: 66049149059     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0901854106     Document Type: Article

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