Topoisomerase poisons differentially activate DNA damage checkpoints through ataxia-telangiectasia mutated-dependent and -independent mechanisms

Molecular Cancer Therapeutics

Volumn 3, Issue 5, 2004, Pages 621-632

  Siu, Wai Yi ^a   Lau, Anita ^a   Arooz, Talha ^a   Chow, Jeremy P H ^a   Ho, Horace T B ^a   Poon, Randy Y C ^a  

^a HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; BROXURIDINE; CAFFEINE; CAMPTOTHECIN; CYCLIN B1; DNA TOPOISOMERASE; DNA TOPOISOMERASE (ATP HYDROLYSING); DNA TOPOISOMERASE INHIBITOR; DOXORUBICIN; GYRASE INHIBITOR; HISTONE H3; PROTEIN KINASE; PROTEIN P21; PROTEIN P53; RETINOBLASTOMA PROTEIN;

CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA DAMAGE; DOWN REGULATION; DRUG MECHANISM; DRUG MEGADOSE; HUMAN; HUMAN CELL; IONIZING RADIATION; LOW DRUG DOSE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REVIEW;

ANTIBIOTICS, ANTINEOPLASTIC; CAFFEINE; CAMPTOTHECIN; CELL CYCLE; CELL CYCLE PROTEINS; CELL DEATH; CELL LINE, TUMOR; DNA DAMAGE; DNA TOPOISOMERASES, TYPE I; DNA TOPOISOMERASES, TYPE II; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOXORUBICIN; ENZYME INHIBITORS; G1 PHASE; G2 PHASE; GENES, CDC; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; NUCLEAR PROTEINS; PROTEIN-SERINE-THREONINE KINASES; S PHASE; TUMOR SUPPRESSOR PROTEINS;

EID: 3543112227     PISSN: 15357163     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

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