Cyclin G1 overcomes radiation-induced G2 arrest and increases cell death through transcriptional activation of cyclin B1

Cell Death and Differentiation

Volumn 13, Issue 9, 2006, Pages 1475-1484

  Seo, H R ^a   Lee, D H ^a   Lee, H J ^a   Baek, M ^b   Bae, S ^a   Soh, J W ^c   Lee, S J ^a   Kim, J ^d   Lee, Y S ^a  

^a Korea Institute of Radiation and Medical Science   (South Korea)

^b Ministry of Science and Technology   (South Korea)

^c Inha University   (South Korea)

^d Korea University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; CYCLIN B1; CYCLIN DEPENDENT KINASE 1; CYCLIN G1; HISTONE H2AX; PROTEIN MPM2; PROTEIN P53; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE REGULATION; CELL DEATH; CONTROLLED STUDY; CORRELATION ANALYSIS; DNA DAMAGE; ENZYME ASSAY; GENE OVEREXPRESSION; GROWTH INHIBITION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; LUNG CARCINOMA; MITOSIS; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; RADIOSENSITIVITY; REAL TIME POLYMERASE CHAIN REACTION; RNA INTERFERENCE; UPREGULATION; WESTERN BLOTTING;

ADENOCARCINOMA, PAPILLARY; CARCINOMA, SQUAMOUS CELL; CDC2 PROTEIN KINASE; CELL DEATH; CELL LINE; CELL LINE, TUMOR; CYCLIN B; CYCLIN B1; CYCLIN G; CYCLIN G1; CYCLINS; DNA DAMAGE; FIBROBLASTS; G2 PHASE; HISTONES; HUMANS; LUNG; LUNG NEOPLASMS; TISSUE ARRAY ANALYSIS; TRANS-ACTIVATION (GENETICS); TRANSCRIPTIONAL ACTIVATION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 33747055614     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/sj.cdd.4401822     Document Type: Article

References (41)

1. Okamoto K and Beach D (1995) Cyclin G is a transcriptional target of the p53 tumor suppressor protein. EMBO J. 13: 4816-4822
2. Zauberman A, Lupo A and Oren M (1995) Identification of p53 target genes through immune selection of genomic DNA: The cyclin G gene contains two distinct p53 binding sites. Oncogene 10: 2361-2366
3. Kanaoka Y, Kimura SH, Okazaki I, Ikeda M and Nojima H (1997) GAK: A cyclin G associated kinase contains a tensin/auxilin-like domain. FEBS Lett. 402: 73-80
4. Kimura SH, Tsuruga H, Yabuta N, Endo Y and Nojima H (1997) Structure, expression, and chromosomal localization of human GAK. Genomics 44: 179-187
5. Reimer CL, Borras AM, Kurdistani SK, Garreau JR, Chung M, Aaronson SA and Lee SW (1999) Altered regulation of cyclin G in human breast cancer and its specific localization at replication foci in response to DNA damage in p53+/+ cells. J. Biol. Chem. 274: 11022-11029
6. Baek WK, Kim D, Jung N, Yi YW, Kim JM, Cha SK, Bae I and Cho CH (2003) Increased expression of cyclin G1 in leiomyoma compared with normal myometrium. Am. J. Obstet. Gynecol. 188: 634-649
7. Kimura SH and Nojima H (2002) Cyclin G1 associates with MDM2 and regulates accumulation and degradation of p53 protein. Genes Cell 7: 869-880
8. Okamoto K and Prives C (1999) A role of cyclin G in the process of apoptosis. Oncogene 18: 4606-4615
9. Teyssier F, Bay JO, Dionet C and Verrelle P (1999) Cell cycle regulation after exposure to ionizing radiation. Bull. Cancer 86: 345-357
10. Hartwell LH and Kastan MB (1994) Cell cycle control and cancer. Science 266: 1821-1828
11. Morgan DO (1997) Cyclin dependent kinases, clocks, and microprocessors. Annu. Rev. Cell Dev. Biol. 13: 261-291
12. Gould KL and Murse P (1989) Tyrosine phosphorylation of the fission yeast cdc2+ protein kinase regulates entry into mitosis. Nature 342: 39-45
13. Krek W and Nigg EA (1991) Mutations of p34cdc2 phosphorylation sites induce premature mitotic events in HeLa cells: Evidence for a double block to p34cdc2 kinase activation in vertebrates. EMBO J. 10: 3331-3341
14. Gautier J, Solomon MJ, Booher RN, Bazan JF and Kirschner MW (1991) Cdc25 is a specific tyrosine phosphatase that directly activates p34cdc2. Cell 67: 197-211
15. Dunphy WG and Kumagai A (1991) The cdc25 protein contains an intrinsic phosphatase activity. Cell 67: 189-196
16. Borgne A and Meijer L (1996) Sequential dephosphorylation of p34cdc2 on Thr-14 and Try-15 at the prophase/metaphase transition. J. Biol. Chem. 271: 27847-27854
17. Kang CM, Park KP, Song JE, Jeoung DI, Cho CK, Kim TH, Bae S, Lee SJ and Lee YS (2003) Possible biomarkers for ionizing radiation exposure in human peripheral blood lymphocytes. Radiat. Res. 159: 312-319
18. Rimokh R, Berger F, Bastard C, Klein B, French M, Archimbaud E, Rouault JP, Santa Lucia B, Duret L, Vuillaume M, Coiffer B, Bryon P and Magoud JP (1994) Rearrangement of CCND1 (BCL1/PRAD1) 3′ untranslated region in mantle-cell lymphomas and t(11q13)-associated leukemias. Blood 83: 3689-3696
19. Banath JP, Macphail SH and Olive PL (2004) Radiation sensitivity, H2AX phosphorylation, and kinetic of repair of DNA strand breaks in irradiated cervical cancer cell lines. Cancer Res. 64: 7144-7149
20. Cho HN, Lee SJ, Park SH, Lee YJ, Cho CK and Lee YS (2001) Overexpression of heat-shock protein 25 augments radiation-induced cell-cycle arrest in murine L929 cells. Int. J. Radiat. Biol. 77: 225-233
21. Zhao L, Samuels T, Winckler S, Korgaonkar C, Tompkins V, Horne MC and Quelle DE (2004) Cyclin G1 has growth inhibitory activity linked to the ARF-Mdm2-p53 and pRb tumor suppressor pathways. Mol. Cancer Res. 1: 195-206
22. Xu B, Kim ST, Lim DS and Kastan MB (2002) Two molecularly distinct G(2)/ M checkpoints are induced by ionizing irradiation. Mol. Cell. Biol. 22: 1049-1059
23. Smith ML, Bortnick RA, Sheikh MS and Fornace Jr AJ (1998) Chromatin relaxation by overexpression of 1. mutant p53, HPV16-E6, or cyclin G1 transgens. Exp. Cell Res. 242: 235-243
24. Shimizu A, Nishida J, Ueoka Y, Kato K, Hachiya T, Kuriaki Y and Wake N (1998) Cyclin G contributes to G2/M arrest of cells in response to DNA damage. Biochem. Biophys. Res. Commun. 242: 529-533
25. King RW, Jackson P and Kirschner MW (1994) Mitosis in transition. Cell 79: 563-571
26. Dong Y, Sui L, Watanabe Y, Sugimoto K and Tokuda M (2002) Clinical relevance of cyclin B1 overexpression in laryngeal squamous cell carcinoma. Cancer Lett. 177: 13-19
27. Jin P, Hardy S and David OM (2002) Nuclear localization of cyclin B1 controls mitotic entry after DNA damage. J. Cell Biol. 141: 875-885
28. Takeno S, Noguchi T, Kikuchi R, Uchida Y, Yokoyama S and Müller W (2002) Prognostic value of cyclin B1 in patients with esophageal squamous cell carcinoma. Cancer 94: 2874-2881
29. Li JQ, Kubo A, Wu F, Usuki H, Fujita J, Bandoh S, Masaki T, Saoo K, Takeuchi H, Kobayashi S, Imaida K, Maeta H, Ishida T and Kuriyama S (2003) Cyclin B1, unlike cyclin G1, increases significantly during colorectal carcinogenesis and during later metastasis to lymph nodes. Int. J. Oncol. 22: 1101-1110
30. Jackman MR and Pines J (1997) Cyclins and the G2/M transition. Cancer Surv. 29: 47-73
31. Cogswell JP, Godlevski MM, Bonham M, Bisi J and Babiss L (1995) Upstream stimulatory factor regulates expression of the cell cycle dependent cyclin B1 gene promoter. Mol. Cell. Biol. 15: 2782-2790
32. Hwang A, Maity A, McKenna WG and Muschel RJ (1995) Cell cycle dependent regulation of the cyclin B1 promoter. J. Biol. Chem. 270: 28419-28424
33. Piaggio G, Farina A, Perrotti D, Manni I, Fuschi P, Sacchi A and Gaetano C (1995) Structure and growth-dependent regulation of the human cyclin B1 promoter. Exp. Cell Res. 216: 396-402
34. Katula KS, Wright KL, Paul H, Surman DR, Nuckolls FJ, Smith JW, Ting JP, Yates J and Cogswell JP (1997) Cyclin dependent kinase activation and S-phase induction of the cyclin B1 gene are linked through the CCAAT elements. Cell Growth Differ. 8: 811-820
35. Park M, Chae HD, Yun J, Jung M, Kim YJ, Kim SH, Han MH and Shin DY (2000) Constitutive activation of cyclin B1-associated cdc2 kinase overrides p53-mediated G2-M arrest. Cancer Res. 60: 542-545
36. Ruth AC and Roninson IB (2000) Effects of the multidrug transporter P-glycoprotein on cellular responses to ionizing radiation. Cancer Res. 60: 2576-2578
37. Yoshikawa R, Kusunoki M, Yanagi H, Noda M, Furuyama JI, Yamamura T and Hashimoto-Tamaoki T (2002) Dual antitumor effects of 5-fluorouracil on the cell cycle in colorectal carcinoma cells: A novel target mechanism concept for pharmacokinetic modulating chemotherapy. Cancer Res. 61: 1029-1037
38. Ling YH, Leibes L, Jiang JD, Holland JF, Elliott PJ, Adams J, Muggia FM and Perez-Soler R (2003) Mechanisms of proteasome inhibitor PS-341-induced G2-M Phase arrest and apoptosis in human non-small cell lung cancer cell lines. Clin. Cancer Res. 9: 1145-1154
39. Wasner M, Tschop K, Spiesbach K, Haugwitz U, Johne C, Mossner J, Mantovani R and Engeland K (2004) Cyclin B1 transcription is enhanced by the p300 coactivator and regulated during the cell cycle by a CHR-dependent repression mechanism. FEBS Lett. 536: 66-70
40. Cho HN, Lee YJ, Cho CK, Lee SJ and Lee YS (2002) Downregulation of ERK2 is essential for the inhibition of radiation-induced cell death in HSP25 overexpressed L929 cells. Cell Death Differ. 9: 448-456
41. Lee YJ, Soh JW, Dean NM, Cho CK, Kim TH, Lee SJ and Lee YS (2003) Protein kinase C delta overexpression enhances radiation sensitivity via extracellular regulated protein kinase 1/2 activation, abolishing the radiation-induced G(2)-M arrest. Cell Growth Differ. 13: 237-246