Differential cytostatic and apoptotic effects of ecteinascidin-743 in cancer cells: Transcription-dependent cell cycle arrest and transcription-independent JNK and mitochondrial mediated apoptosis

Journal of Biological Chemistry

Volumn 277, Issue 44, 2002, Pages 41580-41589

  Gajate, Consuelo ^a   An, Feiyun ^a   Mollinedo, Faustino ^a  

^a Centro de Investigacion del Cancer   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITION; SYNTHESIS (CHEMICAL); TUMORS;

CELL CYCLE;

CELLS;

CASPASE 3; CHEMOKINE RECEPTOR; CURCUMIN; CYCLIN DEPENDENT KINASE INHIBITOR; CYCLOHEXIMIDE; CYTOCHROME C; DACTINOMYCIN; DNA; FAS ANTIGEN; FAS LIGAND; GLUTATHIONE TRANSFERASE; HISTONE; NATURAL PRODUCT; PROTEIN; PROTEIN BCL 2; PROTEIN P21; STRESS ACTIVATED PROTEIN KINASE; TRABECTEDIN;

APOPTOSIS; ARTICLE; CANCER CELL; CANCER CELL CULTURE; CELL CYCLE; CELL DEATH; CELL STRAIN HL 60; CELL STRAIN MCF 7; CYTOTOXICITY; DNA CONTENT; DOSE TIME EFFECT RELATION; DRUG CYTOTOXICITY; ENZYME ASSAY; FLOW CYTOMETRY; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; HELA CELL; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MITOCHONDRION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; UNINDEXED SEQUENCE;

ANTIGENS, CD95; ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASE 3; CASPASES; CELL CYCLE; CYCLOHEXIMIDE; CYTOCHROME C GROUP; DIOXOLES; DNA; GENE EXPRESSION REGULATION; HUMANS; ISOQUINOLINES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MITOCHONDRIA; MITOGEN-ACTIVATED PROTEIN KINASES; NUCLEOSOMES; PROTO-ONCOGENE PROTEINS C-BCL-2; TETRAHYDROISOQUINOLINES; TRANSCRIPTION, GENETIC;

MINK CELL FOCUS-FORMING VIRUS;

EID: 0036830244     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M204644200     Document Type: Article

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