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Volumn 19, Issue 11, 2008, Pages 4968-4979

Cyclin G2 is degraded through the ubiquitin-proteasome pathway and mediates the antiproliferative effect of activin receptor-Like kinase 7

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVIN RECEPTOR LIKE KINASE 7; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; CYCLIN G2; CYCLINE; LACTACYSTIN; PROTEASOME; PROTEIN NODAL; PROTEIN SERINE THREONINE KINASE; S PHASE KINASE ASSOCIATED PROTEIN; S PHASE KINASE ASSOCIATED PROTEIN 1; S PHASE KINASE ASSOCIATED PROTEIN 2; SMALL INTERFERING RNA; UBIQUITIN; UNCLASSIFIED DRUG; ACTIVIN RECEPTOR 1; ACVR1C PROTEIN, HUMAN; CCNG2 PROTEIN, HUMAN; MESSENGER RNA;

EID: 58149286563     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.E08-03-0259     Document Type: Article
Times cited : (51)

References (61)
  • 1
    • 33750080428 scopus 로고    scopus 로고
    • Calpain activation is required for glutamate-induced p27 down-regulation in cultured cortical neurons
    • Akashiba, H., Matsuki, N., and Nishiyama, N. (2006). Calpain activation is required for glutamate-induced p27 down-regulation in cultured cortical neurons. J. Neurochem. 99, 733-744.
    • (2006) J. Neurochem , vol.99 , pp. 733-744
    • Akashiba, H.1    Matsuki, N.2    Nishiyama, N.3
  • 2
    • 36749055738 scopus 로고    scopus 로고
    • Cyclin G2 is a centrosome-associated nucleo-cytoplasmic shuttling protein that influences microtubule stability and in duces a p53-dependent cell cycle arrest
    • Arachchige Don, A. S., Dallapiazza, R. F., Bennin, D. A., Brake, T., Cowan,C. E., and Horne, M. C. (2006). Cyclin G2 is a centrosome-associated nucleo-cytoplasmic shuttling protein that influences microtubule stability and in duces a p53-dependent cell cycle arrest. Exp. Cell Res. 312, 4181-4204.
    • (2006) Exp. Cell Res , vol.312 , pp. 4181-4204
    • Arachchige Don, A.S.1    Dallapiazza, R.F.2    Bennin, D.A.3    Brake, T.4    Cowan, C.E.5    Horne, M.C.6
  • 3
    • 0029774760 scopus 로고    scopus 로고
    • Characterisation of human cyclin G1 and G2, DNA damage inducible genes
    • Bates, S., Rowan, S., and Vousden, K. H. (1996). Characterisation of human cyclin G1 and G2, DNA damage inducible genes. Oncogene 13, 1103-1109.
    • (1996) Oncogene , vol.13 , pp. 1103-1109
    • Bates, S.1    Rowan, S.2    Vousden, K.H.3
  • 4
    • 0037178863 scopus 로고    scopus 로고
    • Cyclin G2 associates with protein phosphatase 2A catalytic and regulatory B' subunits in active complexes and induces nuclear aberrations and a G1/S phase cell cycle arrest
    • Bennin, D. A., Don, A. S., Brake, T., McKenzie, J. L., Rosenbaum, H., Ortiz, L., DePaoli-Roach, A. A., and Horne, M. C. (2002). Cyclin G2 associates with protein phosphatase 2A catalytic and regulatory B' subunits in active complexes and induces nuclear aberrations and a G1/S phase cell cycle arrest. J. Biol. Chem. 277, 27449-27467.
    • (2002) J. Biol. Chem , vol.277 , pp. 27449-27467
    • Bennin, D.A.1    Don, A.S.2    Brake, T.3    McKenzie, J.L.4    Rosenbaum, H.5    Ortiz, L.6    DePaoli-Roach, A.A.7    Horne, M.C.8
  • 6
    • 0037325853 scopus 로고    scopus 로고
    • Deregulated degradation of the cdk inhibitor p27 and malignant transformation
    • Bloom, J., and Pagano, M. (2003). Deregulated degradation of the cdk inhibitor p27 and malignant transformation. Semin. Cancer Biol. 13, 41-47.
    • (2003) Semin. Cancer Biol , vol.13 , pp. 41-47
    • Bloom, J.1    Pagano, M.2
  • 7
  • 8
    • 0037106188 scopus 로고    scopus 로고
    • Nodal activity in the node governs left-right asymmetry
    • Brennan, J., Norris, D. P., and Robertson, E. J. (2002). Nodal activity in the node governs left-right asymmetry. Genes Dev. 16, 2339-2344.
    • (2002) Genes Dev , vol.16 , pp. 2339-2344
    • Brennan, J.1    Norris, D.P.2    Robertson, E.J.3
  • 9
    • 58449103836 scopus 로고    scopus 로고
    • Carrano, A. C., Eytan, E., Hershko, A., and Pagano, M. (1999). SKP2 is
    • Carrano, A. C., Eytan, E., Hershko, A., and Pagano, M. (1999). SKP2 is
  • 10
    • 0033176887 scopus 로고    scopus 로고
    • required for ubiquitin-mediated degradation of the CDK inhibitor p27
    • required for ubiquitin-mediated degradation of the CDK inhibitor p27. Nat. Cell Biol. 1, 193-199.
    • Nat. Cell Biol , vol.1 , pp. 193-199
  • 11
    • 0036904895 scopus 로고    scopus 로고
    • Genetic analysis of the mammalian transforming growth factor-beta superfamily
    • Chang, H., Brown, C. W., and Matzuk, M. M. (2002). Genetic analysis of the mammalian transforming growth factor-beta superfamily. Endocr. Rev. 23, 787-823.
    • (2002) Endocr. Rev , vol.23 , pp. 787-823
    • Chang, H.1    Brown, C.W.2    Matzuk, M.M.3
  • 12
    • 0028018268 scopus 로고
    • The ubiquitin-proteasome proteolytic pathway
    • Ciechanover, A. (1994). The ubiquitin-proteasome proteolytic pathway. Cell 79, 13-21.
    • (1994) Cell , vol.79 , pp. 13-21
    • Ciechanover, A.1
  • 13
    • 0036337994 scopus 로고    scopus 로고
    • Effects of heterodimerization and proteolytic processing on Derriere and Nodal activity: Implications for mesoderm induction in Xenopus
    • Eimon, P. M., and Harland, R. M. (2002). Effects of heterodimerization and proteolytic processing on Derriere and Nodal activity: implications for mesoderm induction in Xenopus. Development 129, 3089-3103.
    • (2002) Development , vol.129 , pp. 3089-3103
    • Eimon, P.M.1    Harland, R.M.2
  • 14
    • 0242344011 scopus 로고    scopus 로고
    • The role of ubiquitin-proteasome pathway in oncogenic signaling
    • Fuchs, S. Y. (2002). The role of ubiquitin-proteasome pathway in oncogenic signaling. Cancer Biol. Ther. 1, 337-341.
    • (2002) Cancer Biol. Ther , vol.1 , pp. 337-341
    • Fuchs, S.Y.1
  • 15
    • 0037144583 scopus 로고    scopus 로고
    • Cyclin F is degraded during G2-M by mechanisms fundamentally different from other cyclins
    • Fung, T. K., Siu, W. Y., Yam, C. H., Lau, A., and Poon, R. Y. (2002). Cyclin F is degraded during G2-M by mechanisms fundamentally different from other cyclins. J. Biol. Chem. 277, 35140-35149.
    • (2002) J. Biol. Chem , vol.277 , pp. 35140-35149
    • Fung, T.K.1    Siu, W.Y.2    Yam, C.H.3    Lau, A.4    Poon, R.Y.5
  • 16
    • 33646035242 scopus 로고    scopus 로고
    • Graham, H., and Peng, C. (2006). Activin receptor-like kinases: structure, function and clinical implications. Endocr. Metab. Immune Disord. Drug Targets 6, 45-58.
    • Graham, H., and Peng, C. (2006). Activin receptor-like kinases: structure, function and clinical implications. Endocr. Metab. Immune Disord. Drug Targets 6, 45-58.
  • 17
    • 0036498527 scopus 로고    scopus 로고
    • A phosphorylation-driven ubiquitination switch for cell-cycle control
    • Harper, J. W. (2002). A phosphorylation-driven ubiquitination switch for cell-cycle control. Trends Cell Biol. 12, 104-107.
    • (2002) Trends Cell Biol , vol.12 , pp. 104-107
    • Harper, J.W.1
  • 18
    • 34547489950 scopus 로고    scopus 로고
    • Knockdown of polypyrimidine tract-binding protein suppresses ovarian tumor cell growth and invasiveness in vitro
    • He, X., Pool, M., Darcy, K. M., Lim, S. B., Auersperg, N., Coon, J. S., and Beck, W. T. (2007). Knockdown of polypyrimidine tract-binding protein suppresses ovarian tumor cell growth and invasiveness in vitro. Oncogene 26, 4961-4968.
    • (2007) Oncogene , vol.26 , pp. 4961-4968
    • He, X.1    Pool, M.2    Darcy, K.M.3    Lim, S.B.4    Auersperg, N.5    Coon, J.S.6    Beck, W.T.7
  • 19
    • 33748990147 scopus 로고    scopus 로고
    • Degradation of Tob1 mediated by SCFSkp2-dependent ubiquitination
    • Hiramatsu, Y. et al. (2006). Degradation of Tob1 mediated by SCFSkp2-dependent ubiquitination. Cancer Res. 66, 8477-8483.
    • (2006) Cancer Res , vol.66 , pp. 8477-8483
    • Hiramatsu, Y.1
  • 20
    • 0030987302 scopus 로고    scopus 로고
    • Cyclin G2 is up-regulated during growth inhibition and B cell antigen receptor-mediated cell cycle arrest
    • Horne, M. C., Donaldson, K. L., Goolsby, G. L., Tran, D., Mulheisen, M., Hell, J. W., and Wahl, A. F. (1997). Cyclin G2 is up-regulated during growth inhibition and B cell antigen receptor-mediated cell cycle arrest. J. Biol. Chem. 272, 12650-12661.
    • (1997) J. Biol. Chem , vol.272 , pp. 12650-12661
    • Horne, M.C.1    Donaldson, K.L.2    Goolsby, G.L.3    Tran, D.4    Mulheisen, M.5    Hell, J.W.6    Wahl, A.F.7
  • 21
    • 0029866746 scopus 로고    scopus 로고
    • Cyclin G1 and cyclin G2 comprise a new family of cyclins with contrasting tissue-specific and cell cycle-regulated expression
    • Horne, M. C., Goolsby, G. L., Donaldson, K. L., Tran, D., Neubauer, M., and Wahl, A. F. (1996). Cyclin G1 and cyclin G2 comprise a new family of cyclins with contrasting tissue-specific and cell cycle-regulated expression. J. Biol. Chem. 271, 6050-6061.
    • (1996) J. Biol. Chem , vol.271 , pp. 6050-6061
    • Horne, M.C.1    Goolsby, G.L.2    Donaldson, K.L.3    Tran, D.4    Neubauer, M.5    Wahl, A.F.6
  • 22
    • 0042807699 scopus 로고    scopus 로고
    • Decreased expression of cyclin G2 is significantly linked to the malignant transformation of papillary carcinoma of the thyroid
    • Ito, Y. et al. (2003). Decreased expression of cyclin G2 is significantly linked to the malignant transformation of papillary carcinoma of the thyroid. Antican-cer Res. 23, 2335-2338.
    • (2003) Antican-cer Res , vol.23 , pp. 2335-2338
    • Ito, Y.1
  • 23
    • 58449087012 scopus 로고    scopus 로고
    • Jackson, P. K., and Eldridge, A. G. (2002). The SCF ubiquitin ligase: an
    • Jackson, P. K., and Eldridge, A. G. (2002). The SCF ubiquitin ligase: an
  • 24
    • 58449109430 scopus 로고    scopus 로고
    • extended look. Mol. Cell 9, 923-925.
    • extended look. Mol. Cell 9, 923-925.
  • 28
    • 10844253962 scopus 로고    scopus 로고
    • Cyclin G2 dysregulation in human oral cancer
    • Kim, Y., Shintani, S., Kohno, Y., Zhang, R., and Wong, D. T. (2004). Cyclin G2 dysregulation in human oral cancer. Cancer Res. 64, 8980-8986.
    • (2004) Cancer Res , vol.64 , pp. 8980-8986
    • Kim, Y.1    Shintani, S.2    Kohno, Y.3    Zhang, R.4    Wong, D.T.5
  • 29
    • 36749080325 scopus 로고    scopus 로고
    • Roles of human epidermal growth factor receptor 2, c-jun NH2-terminal kinase, phosphoinositide 3-kinase, and p70 S6 kinase pathways in regulation of cyclin G2 expression in human breast cancer cells
    • Le, X. F., Arachchige-Don, A. S., Mao, W., Horne, M. C., and Bast, R. C., Jr. (2007). Roles of human epidermal growth factor receptor 2, c-jun NH2-terminal kinase, phosphoinositide 3-kinase, and p70 S6 kinase pathways in regulation of cyclin G2 expression in human breast cancer cells. Mol. Cancer Ther. 6, 2843-2857.
    • (2007) Mol. Cancer Ther , vol.6 , pp. 2843-2857
    • Le, X.F.1    Arachchige-Don, A.S.2    Mao, W.3    Horne, M.C.4    Bast Jr., R.C.5
  • 30
    • 38049103266 scopus 로고    scopus 로고
    • MicroRNA-378 promotes cell survival, tumor growth, and angiogenesis by targeting SuFu and Fus-1 expression
    • Lee, D. Y., Deng, Z., Wang, C. H., and Yang, B. B. (2007). MicroRNA-378 promotes cell survival, tumor growth, and angiogenesis by targeting SuFu and Fus-1 expression. Proc. Natl. Acad. Sci. USA 104, 20350-20355.
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 20350-20355
    • Lee, D.Y.1    Deng, Z.2    Wang, C.H.3    Yang, B.B.4
  • 34
    • 34147213257 scopus 로고    scopus 로고
    • Cdh1-anaphase-promoting complex targets Skp2 for destruction in transforming growth factor beta-induced growth inhibition
    • Liu, W., Wu, G., Li, W., Lobur, D., and Wan, Y. (2007). Cdh1-anaphase-promoting complex targets Skp2 for destruction in transforming growth factor beta-induced growth inhibition. Mol. Cell. Biol. 27, 2967-2979.
    • (2007) Mol. Cell. Biol , vol.27 , pp. 2967-2979
    • Liu, W.1    Wu, G.2    Li, W.3    Lobur, D.4    Wan, Y.5
  • 35
    • 0026808859 scopus 로고
    • Simian virus 40-transformed human ovarian surface epithelial cells escape normal growth controls but retain morphogenetic responses to extracellular matrix
    • Maines-Bandiera, S. L., Kruk, P. A., and Auersperg, N. (1992). Simian virus 40-transformed human ovarian surface epithelial cells escape normal growth controls but retain morphogenetic responses to extracellular matrix. Am. J.Obstet. Gynecol. 167, 729-735.
    • (1992) Am. J.Obstet. Gynecol , vol.167 , pp. 729-735
    • Maines-Bandiera, S.L.1    Kruk, P.A.2    Auersperg, N.3
  • 36
    • 2342653278 scopus 로고    scopus 로고
    • Control of cyclin G2 mRNA expression by forkhead transcription factors: Novel mechanism for cell cycle control by phosphoinositide 3-kinase and forkhead
    • Martinez-Gac, L., Marques, M., Garcia, Z., Campanero, M. R., and Carrera, A. C. (2004). Control of cyclin G2 mRNA expression by forkhead transcription factors: novel mechanism for cell cycle control by phosphoinositide 3-kinase and forkhead. Mol. Cell. Biol. 24, 2181-2189.
    • (2004) Mol. Cell. Biol , vol.24 , pp. 2181-2189
    • Martinez-Gac, L.1    Marques, M.2    Garcia, Z.3    Campanero, M.R.4    Carrera, A.C.5
  • 37
    • 0034654497 scopus 로고    scopus 로고
    • Controlling TGF-beta signaling
    • Massague, J., and Chen, Y. G. (2000). Controlling TGF-beta signaling. Genes Dev. 14, 627-644.
    • (2000) Genes Dev , vol.14 , pp. 627-644
    • Massague, J.1    Chen, Y.G.2
  • 38
    • 0031466305 scopus 로고    scopus 로고
    • Cyclin-dependent kinases: Engines, clocks, and microprocessors
    • Morgan, D. O. (1997). Cyclin-dependent kinases: engines, clocks, and microprocessors. Annu. Rev. Cell Dev. Biol. 13, 261-291.
    • (1997) Annu. Rev. Cell Dev. Biol , vol.13 , pp. 261-291
    • Morgan, D.O.1
  • 39
    • 3843110160 scopus 로고    scopus 로고
    • Nodal and ALK7 inhibit proliferation and induce apoptosis in human trophoblast cells
    • Munir, S., Xu, G., Wu, Y., Yang, B., Lala, P. K., and Peng, C. (2004). Nodal and ALK7 inhibit proliferation and induce apoptosis in human trophoblast cells. J. Biol. Chem. 279, 31277-31286.
    • (2004) J. Biol. Chem , vol.279 , pp. 31277-31286
    • Munir, S.1    Xu, G.2    Wu, Y.3    Yang, B.4    Lala, P.K.5    Peng, C.6
  • 40
    • 0034595292 scopus 로고    scopus 로고
    • Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication
    • Nakayama, K. et al. (2000). Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication. EMBO J. 19, 2069-2081.
    • (2000) EMBO J , vol.19 , pp. 2069-2081
    • Nakayama, K.1
  • 41
    • 33646345376 scopus 로고    scopus 로고
    • Ubiquitin ligases: Cell-cycle control and cancer
    • Nakayama, K. I., and Nakayama, K. (2006). Ubiquitin ligases: cell-cycle control and cancer. Nat. Rev. Cancer 6, 369-381.
    • (2006) Nat. Rev. Cancer , vol.6 , pp. 369-381
    • Nakayama, K.I.1    Nakayama, K.2
  • 42
    • 0037019287 scopus 로고    scopus 로고
    • Determination of left-right patterning of the mouse embryo by artificial nodal flow
    • Nonaka, S., Shiratori, H., Saijoh, Y., and Hamada, H. (2002). Determination of left-right patterning of the mouse embryo by artificial nodal flow. Nature 418, 96-99.
    • (2002) Nature , vol.418 , pp. 96-99
    • Nonaka, S.1    Shiratori, H.2    Saijoh, Y.3    Hamada, H.4
  • 43
    • 0034625418 scopus 로고    scopus 로고
    • Mitotic clonal expansion during preadi-pocyte differentiation: Calpain-mediated turnover of p27
    • Patel, Y. M., and Lane, M. D. (2000). Mitotic clonal expansion during preadi-pocyte differentiation: calpain-mediated turnover of p27. J. Biol. Chem. 275, 17653-17660.
    • (2000) J. Biol. Chem , vol.275 , pp. 17653-17660
    • Patel, Y.M.1    Lane, M.D.2
  • 44
    • 0028828204 scopus 로고
    • Cyclins and cyclin-dependent kinases: Theme and variations
    • Pines, J. (1995). Cyclins and cyclin-dependent kinases: theme and variations. Adv. Cancer Res. 66, 181-212.
    • (1995) Adv. Cancer Res , vol.66 , pp. 181-212
    • Pines, J.1
  • 45
    • 23144439184 scopus 로고    scopus 로고
    • Proteolysis: Anytime, any place, anywhere?
    • Pines, J., and Lindon, C. (2005). Proteolysis: anytime, any place, anywhere? Nat. Cell Biol. 7, 731-735.
    • (2005) Nat. Cell Biol , vol.7 , pp. 731-735
    • Pines, J.1    Lindon, C.2
  • 46
    • 0030200110 scopus 로고    scopus 로고
    • PEST sequences and regulation by proteolysis
    • Rechsteiner, M., and Rogers, S. W. (1996). PEST sequences and regulation by proteolysis. Trends Biochem. Sci. 21, 267-271.
    • (1996) Trends Biochem. Sci , vol.21 , pp. 267-271
    • Rechsteiner, M.1    Rogers, S.W.2
  • 48
    • 0037407439 scopus 로고    scopus 로고
    • Identification of novel isoforms of activin receptor-like kinase 7 (ALK7) generated by alternative splicing and expression of ALK7 and its ligand, Nodal, in human placenta
    • Roberts, H. J., Hu, S., Qiu, Q., Leung, P. C., Caniggia, I., Gruslin, A., Tsang, B., and Peng, C. (2003). Identification of novel isoforms of activin receptor-like kinase 7 (ALK7) generated by alternative splicing and expression of ALK7 and its ligand, Nodal, in human placenta. Biol. Reprod. 68, 1719-1726.
    • (2003) Biol. Reprod , vol.68 , pp. 1719-1726
    • Roberts, H.J.1    Hu, S.2    Qiu, Q.3    Leung, P.C.4    Caniggia, I.5    Gruslin, A.6    Tsang, B.7    Peng, C.8
  • 49
    • 0022971952 scopus 로고
    • Amino acid sequences common to rapidly degraded proteins: The PEST hypothesis
    • Rogers, S., Wells, R., and Rechsteiner, M. (1986). Amino acid sequences common to rapidly degraded proteins: the PEST hypothesis. Science 234, 364-368.
    • (1986) Science , vol.234 , pp. 364-368
    • Rogers, S.1    Wells, R.2    Rechsteiner, M.3
  • 51
    • 0033595636 scopus 로고    scopus 로고
    • The PEST domain of IkappaBalpha is necessary and sufficient for in vitro degradation by mu-calpain
    • Shumway, S. D., Maki, M., and Miyamoto, S. (1999). The PEST domain of IkappaBalpha is necessary and sufficient for in vitro degradation by mu-calpain. J. Biol. Chem. 274, 30874-30881.
    • (1999) J. Biol. Chem , vol.274 , pp. 30874-30881
    • Shumway, S.D.1    Maki, M.2    Miyamoto, S.3
  • 53
    • 0037112174 scopus 로고    scopus 로고
    • The pRb-related protein p130 is regulated by phosphorylation-dependent proteolysis via the protein-ubiq-uitin ligase SCF(Skp2)
    • Tedesco, D., Lukas, J., and Reed, S. I. (2002). The pRb-related protein p130 is regulated by phosphorylation-dependent proteolysis via the protein-ubiq-uitin ligase SCF(Skp2). Genes Dev. 16, 2946-2957.
    • (2002) Genes Dev , vol.16 , pp. 2946-2957
    • Tedesco, D.1    Lukas, J.2    Reed, S.I.3
  • 54
    • 0033578073 scopus 로고    scopus 로고
    • p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27
    • Tsvetkov, L. M., Yeh, K. H., Lee, S. J., Sun, H., and Zhang, H. (1999). p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27. Curr. Biol. 9, 661-664.
    • (1999) Curr. Biol , vol.9 , pp. 661-664
    • Tsvetkov, L.M.1    Yeh, K.H.2    Lee, S.J.3    Sun, H.4    Zhang, H.5
  • 55
    • 0036467496 scopus 로고    scopus 로고
    • TGF-beta signaling: Positive and negative effects on tumorigenesis
    • Wakefield, L. M., and Roberts, A. B. (2002). TGF-beta signaling: positive and negative effects on tumorigenesis. Curr. Opin. Genet. Dev. 12, 22-29.
    • (2002) Curr. Opin. Genet. Dev , vol.12 , pp. 22-29
    • Wakefield, L.M.1    Roberts, A.B.2
  • 56
    • 1442284076 scopus 로고    scopus 로고
    • Negative regulation of SCFSkp2 ubiquitin ligase by TGF-beta signaling
    • Wang, W., Ungermannova, D., Jin, J., Harper, J. W., and Liu, X. (2004). Negative regulation of SCFSkp2 ubiquitin ligase by TGF-beta signaling. On-cogene 23, 1064-1075.
    • (2004) On-cogene , vol.23 , pp. 1064-1075
    • Wang, W.1    Ungermannova, D.2    Jin, J.3    Harper, J.W.4    Liu, X.5
  • 58
    • 8744286786 scopus 로고    scopus 로고
    • Xu, G., Zhong, Y., Munir, S., Yang, B. B., Tsang, B. K., and Peng, C. (2004).Nodal induces apoptosis and inhibits proliferation in human epithelial ovarian cancer cells via activin receptor-like kinase 7. J. Clin. Endocrinol. Metab.5523-5534.
    • Xu, G., Zhong, Y., Munir, S., Yang, B. B., Tsang, B. K., and Peng, C. (2004).Nodal induces apoptosis and inhibits proliferation in human epithelial ovarian cancer cells via activin receptor-like kinase 7. J. Clin. Endocrinol. Metab.5523-5534.
  • 59
    • 33646128737 scopus 로고    scopus 로고
    • Activin receptor-like kinase 7 induces apoptosis through up-regulation of Bax and down-regulation of Xiap in normal and malignant ovarian epithelial cell lines
    • Xu, G., Zhou, H., Wang, Q., Auersperg, N., and Peng, C. (2006). Activin receptor-like kinase 7 induces apoptosis through up-regulation of Bax and down-regulation of Xiap in normal and malignant ovarian epithelial cell lines. Mol. Cancer Res. 4, 235-246.
    • (2006) Mol. Cancer Res , vol.4 , pp. 235-246
    • Xu, G.1    Zhou, H.2    Wang, Q.3    Auersperg, N.4    Peng, C.5
  • 60
    • 0028980273 scopus 로고
    • p19Skp1 and p45Skp2 are essential elements of the cyclin A-CDK2 S phase kinase
    • Zhang, H., Kobayashi, R., Galaktionov, K., and Beach, D. (1995). p19Skp1 and p45Skp2 are essential elements of the cyclin A-CDK2 S phase kinase. Cell 82, 915-925.
    • (1995) Cell , vol.82 , pp. 915-925
    • Zhang, H.1    Kobayashi, R.2    Galaktionov, K.3    Beach, D.4
  • 61
    • 0034673972 scopus 로고    scopus 로고
    • Transforming growth factor beta signaling mediators and modulators
    • Zimmerman, C. M., and Padgett, R. W. (2000). Transforming growth factor beta signaling mediators and modulators. Gene 249, 17-30.
    • (2000) Gene , vol.249 , pp. 17-30
    • Zimmerman, C.M.1    Padgett, R.W.2


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