-
1
-
-
18244385718
-
ATRIP binding to replication protein A-single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylation
-
Ball, H. L., Myers, J. S. and Cortez, D. (2005). ATRIP binding to replication protein A-single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylation. Mol. Biol. Cell 16, 2372-2381.
-
(2005)
Mol. Biol. Cell
, vol.16
, pp. 2372-2381
-
-
Ball, H.L.1
Myers, J.S.2
Cortez, D.3
-
2
-
-
34247877694
-
Function of a conserved checkpoint recruitment domain in ATRIP proteins
-
Ball, H. L., Ehrhardt, M. R., Mordes, D. A., Glick, G. G., Chazin, W. J. and Cortez, D. (2007). Function of a conserved checkpoint recruitment domain in ATRIP proteins. Mol. Cell. Biol. 27, 3367-3377.
-
(2007)
Mol. Cell. Biol
, vol.27
, pp. 3367-3377
-
-
Ball, H.L.1
Ehrhardt, M.R.2
Mordes, D.A.3
Glick, G.G.4
Chazin, W.J.5
Cortez, D.6
-
3
-
-
0038418869
-
Chk1 and Chk2 kinases in checkpoint control and cancer
-
Bartek, J. and Lukas, J. (2003). Chk1 and Chk2 kinases in checkpoint control and cancer. Cancer Cell 3, 421-429.
-
(2003)
Cancer Cell
, vol.3
, pp. 421-429
-
-
Bartek, J.1
Lukas, J.2
-
4
-
-
47549098471
-
The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint
-
Bassermann, F., Frescas, D., Guardavaccaro, D., Busino, L., Peschiaroli, A. and Pagano, M. (2008). The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint. Cell 134, 256-267.
-
(2008)
Cell
, vol.134
, pp. 256-267
-
-
Bassermann, F.1
Frescas, D.2
Guardavaccaro, D.3
Busino, L.4
Peschiaroli, A.5
Pagano, M.6
-
5
-
-
34447551681
-
Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair
-
Berkovich, E., Monnat, R. J., Jr and Kastan, M. B. (2007). Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair. Nat. Cell Biol. 9, 683-690.
-
(2007)
Nat. Cell Biol
, vol.9
, pp. 683-690
-
-
Berkovich, E.1
Monnat Jr, R.J.2
Kastan, M.B.3
-
6
-
-
42949130159
-
Colocalization of sensors is sufficient to activate the DNA damage checkpoint in the absence of damage
-
Bonilla, C. Y., Melo, J. A. and Toczyski, D. P. (2008). Colocalization of sensors is sufficient to activate the DNA damage checkpoint in the absence of damage. Mol. Cell 30, 267-276.
-
(2008)
Mol. Cell
, vol.30
, pp. 267-276
-
-
Bonilla, C.Y.1
Melo, J.A.2
Toczyski, D.P.3
-
7
-
-
0037335861
-
Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance
-
Brown, E. J. and Baltimore, D. (2003). Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance. Genes Dev. 17, 615-628.
-
(2003)
Genes Dev
, vol.17
, pp. 615-628
-
-
Brown, E.J.1
Baltimore, D.2
-
8
-
-
52949109260
-
Mre11 nuclease activity has essential roles in DNA repair and genomic stability distinct from ATM activation
-
Buis, J., Wu, Y., Deng, Y., Leddon, J., Westfield, G., Eckersdorff, M., Sekiguchi, J. M., Chang, S. and Ferguson, D. O. (2008). Mre11 nuclease activity has essential roles in DNA repair and genomic stability distinct from ATM activation. Cell 135, 85-96.
-
(2008)
Cell
, vol.135
, pp. 85-96
-
-
Buis, J.1
Wu, Y.2
Deng, Y.3
Leddon, J.4
Westfield, G.5
Eckersdorff, M.6
Sekiguchi, J.M.7
Chang, S.8
Ferguson, D.O.9
-
9
-
-
18244371925
-
Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint
-
Byun, T. S., Pacek, M., Yee, M. C., Walter, J. C. and Cimprich, K. A. (2005). Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint. Genes Dev. 19, 1040-1052.
-
(2005)
Genes Dev
, vol.19
, pp. 1040-1052
-
-
Byun, T.S.1
Pacek, M.2
Yee, M.C.3
Walter, J.C.4
Cimprich, K.A.5
-
10
-
-
33746047485
-
Chk1 is required to maintain claspin stability
-
Chini, C. C., Wood, J. and Chen, J. (2006). Chk1 is required to maintain claspin stability. Oncogene 25, 4165-4171.
-
(2006)
Oncogene
, vol.25
, pp. 4165-4171
-
-
Chini, C.C.1
Wood, J.2
Chen, J.3
-
11
-
-
47749141560
-
ATR: An essential regulator of genome integrity
-
Cimprich, K. A. and Cortez, D. (2008). ATR: an essential regulator of genome integrity. Nat. Rev. Mol. Cell. Biol. 9, 616-627.
-
(2008)
Nat. Rev. Mol. Cell. Biol
, vol.9
, pp. 616-627
-
-
Cimprich, K.A.1
Cortez, D.2
-
12
-
-
48649086824
-
The Yku70-Yku80 complex contributes to regulate double-strand break processing and checkpoint activation during the cell cycle
-
Clerici, M., Mantiero, D., Guerini, I., Lucchini, G. and Longhese, M. P. (2008). The Yku70-Yku80 complex contributes to regulate double-strand break processing and checkpoint activation during the cell cycle. EMBO Rep. 9, 810-818.
-
(2008)
EMBO Rep
, vol.9
, pp. 810-818
-
-
Clerici, M.1
Mantiero, D.2
Guerini, I.3
Lucchini, G.4
Longhese, M.P.5
-
13
-
-
34250705797
-
The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1
-
Delacroix, S., Wagner, J. M., Kobayashi, M., Yamamoto, K. and Karnitz, L. M. (2007). The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1. Genes Dev. 21, 1472-1477.
-
(2007)
Genes Dev
, vol.21
, pp. 1472-1477
-
-
Delacroix, S.1
Wagner, J.M.2
Kobayashi, M.3
Yamamoto, K.4
Karnitz, L.M.5
-
14
-
-
4243156107
-
Biochemical characterization of DNA damage checkpoint complexes: Clamp loader and clamp complexes with specificity for 5′ recessed DNA
-
Ellison, V. and Stillman, B. (2003). Biochemical characterization of DNA damage checkpoint complexes: clamp loader and clamp complexes with specificity for 5′ recessed DNA. PLoS Biol. 1, E33.
-
(2003)
PLoS Biol
, vol.1
-
-
Ellison, V.1
Stillman, B.2
-
15
-
-
15844394846
-
Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage
-
Falck, J., Coates, J. and Jackson, S. P. (2005). Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage. Nature 434, 605-611.
-
(2005)
Nature
, vol.434
, pp. 605-611
-
-
Falck, J.1
Coates, J.2
Jackson, S.P.3
-
16
-
-
85015066476
-
DNA damage and repair
-
Friedberg, E. C. (2003). DNA damage and repair. Nature 421, 436-440.
-
(2003)
Nature
, vol.421
, pp. 436-440
-
-
Friedberg, E.C.1
-
17
-
-
53649090109
-
DNA helicases Sgs1 and BLM promote DNA double-strand break resection
-
Gravel, S., Chapman, J. R., Magill, C. and Jackson, S. P. (2008). DNA helicases Sgs1 and BLM promote DNA double-strand break resection. Genes Dev. 22, 2767-2772.
-
(2008)
Genes Dev
, vol.22
, pp. 2767-2772
-
-
Gravel, S.1
Chapman, J.R.2
Magill, C.3
Jackson, S.P.4
-
18
-
-
36749022214
-
The DNA damage response: Ten years after
-
Harper, J. W. and Elledge, S. J. (2007). The DNA damage response: ten years after. Mol. Cell 28, 739-745.
-
(2007)
Mol. Cell
, vol.28
, pp. 739-745
-
-
Harper, J.W.1
Elledge, S.J.2
-
19
-
-
33747493040
-
The phosphorylated C-terminal domain of Xenopus Cut5 directly mediates ATR-dependent activation of Chk1
-
Hashimoto, Y., Tsujimura, T., Sugino, A. and Takisawa, H. (2006). The phosphorylated C-terminal domain of Xenopus Cut5 directly mediates ATR-dependent activation of Chk1. Genes Cells 11, 993-1007.
-
(2006)
Genes Cells
, vol.11
, pp. 993-1007
-
-
Hashimoto, Y.1
Tsujimura, T.2
Sugino, A.3
Takisawa, H.4
-
20
-
-
53349162987
-
CDK targets Sae2 to control DNA-end resection and homologous recombination
-
Huertas, P., Cortes-Ledesma, F., Sartori, A. A., Aguilera, A. and Jackson, S. P. (2008). CDK targets Sae2 to control DNA-end resection and homologous recombination. Nature 455, 689-692.
-
(2008)
Nature
, vol.455
, pp. 689-692
-
-
Huertas, P.1
Cortes-Ledesma, F.2
Sartori, A.A.3
Aguilera, A.4
Jackson, S.P.5
-
21
-
-
7244220162
-
DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1
-
Ira, G., Pellicioli, A., Balijja, A., Wang, X., Fiorani, S., Carotenuto, W., Liberi, G., Bressan, D., Wan, L., Hollingsworth, N. M. et al. (2004). DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1. Nature 431, 1011-1017.
-
(2004)
Nature
, vol.431
, pp. 1011-1017
-
-
Ira, G.1
Pellicioli, A.2
Balijja, A.3
Wang, X.4
Fiorani, S.5
Carotenuto, W.6
Liberi, G.7
Bressan, D.8
Wan, L.9
Hollingsworth, N.M.10
-
22
-
-
30344463835
-
ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks
-
Jazayeri, A., Falck, J., Lukas, C., Bartek, J., Smith, G. C., Lukas, J. and Jackson, S. P. (2006). ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks. Nat. Cell Biol. 8, 37-45.
-
(2006)
Nat. Cell Biol
, vol.8
, pp. 37-45
-
-
Jazayeri, A.1
Falck, J.2
Lukas, C.3
Bartek, J.4
Smith, G.C.5
Lukas, J.6
Jackson, S.P.7
-
23
-
-
2942687831
-
-
Kitagawa, R., Bakkenist, C. J., McKinnon, P. J. and Kastan, M. B. (2004). Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway Genes Dev. 18, 1423-1438.
-
Kitagawa, R., Bakkenist, C. J., McKinnon, P. J. and Kastan, M. B. (2004). Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway Genes Dev. 18, 1423-1438.
-
-
-
-
24
-
-
0035955398
-
Recruitment of Mec1 and Ddc1 checkpoint proteins to double-strand breaks through distinct mechanisms
-
Kondo, T., Wakayama, T., Naiki, T., Matsumoto, K. and Sugimoto, K. (2001). Recruitment of Mec1 and Ddc1 checkpoint proteins to double-strand breaks through distinct mechanisms. Science 294, 867-870.
-
(2001)
Science
, vol.294
, pp. 867-870
-
-
Kondo, T.1
Wakayama, T.2
Naiki, T.3
Matsumoto, K.4
Sugimoto, K.5
-
25
-
-
0037289840
-
Repeated phosphopeptide motifs in Claspin mediate the regulated binding of Chk1
-
Kumagai, A. and Dunphy, W. G. (2003). Repeated phosphopeptide motifs in Claspin mediate the regulated binding of Chk1. Nat. Cell Biol. 5, 161-165.
-
(2003)
Nat. Cell Biol
, vol.5
, pp. 161-165
-
-
Kumagai, A.1
Dunphy, W.G.2
-
26
-
-
9644275421
-
Claspin and the activated form of ATR-ATRIP collaborate in the activation of Chk1
-
Kumagai, A., Kim, S. M. and Dunphy, W. G. (2004). Claspin and the activated form of ATR-ATRIP collaborate in the activation of Chk1. J. Biol. Chem. 279, 49599-49608.
-
(2004)
J. Biol. Chem
, vol.279
, pp. 49599-49608
-
-
Kumagai, A.1
Kim, S.M.2
Dunphy, W.G.3
-
27
-
-
33644757806
-
TopBP1 activates the ATR-ATRIP complex
-
Kumagai, A., Lee, J., Yoo, H. Y. and Dunphy, W. G. (2006). TopBP1 activates the ATR-ATRIP complex. Cell 124, 943-955.
-
(2006)
Cell
, vol.124
, pp. 943-955
-
-
Kumagai, A.1
Lee, J.2
Yoo, H.Y.3
Dunphy, W.G.4
-
28
-
-
17644409069
-
ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex
-
Lee, J. H. and Paull, T. T. (2005). ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex. Science 308, 551-554.
-
(2005)
Science
, vol.308
, pp. 551-554
-
-
Lee, J.H.1
Paull, T.T.2
-
29
-
-
34948889415
-
The Rad9-Hus1-Rad1 checkpoint clamp regulates interaction of TopBP1 with ATR
-
Lee, J., Kumagai, A. and Dunphy, W. G. (2007). The Rad9-Hus1-Rad1 checkpoint clamp regulates interaction of TopBP1 with ATR. J. Biol. Chem. 282, 28036-28044.
-
(2007)
J. Biol. Chem
, vol.282
, pp. 28036-28044
-
-
Lee, J.1
Kumagai, A.2
Dunphy, W.G.3
-
30
-
-
0032493889
-
Saccharomyces Ku70, mre11/rad50 and RPA proteins regulate adaptation to G2/M arrest after DNA damage
-
Lee, S. E., Moore, J. K., Holmes, A., Umezu, K., Kolodner, R. D. and Haber, J. E. (1998). Saccharomyces Ku70, mre11/rad50 and RPA proteins regulate adaptation to G2/M arrest after DNA damage. Cell 94, 399-409.
-
(1998)
Cell
, vol.94
, pp. 399-409
-
-
Lee, S.E.1
Moore, J.K.2
Holmes, A.3
Umezu, K.4
Kolodner, R.D.5
Haber, J.E.6
-
31
-
-
29544437558
-
Multiple mechanisms control chromosome integrity after replication fork uncoupling and restart at irreparable UV lesions
-
Lopes, M., Foiani, M. and Sogo, J. M. (2006). Multiple mechanisms control chromosome integrity after replication fork uncoupling and restart at irreparable UV lesions. Mol. Cell 21, 15-27.
-
(2006)
Mol. Cell
, vol.21
, pp. 15-27
-
-
Lopes, M.1
Foiani, M.2
Sogo, J.M.3
-
32
-
-
33745331961
-
Phosphorylation of Xenopus Rad1 and Hus1 defines a readout for ATR activation that is independent of Claspin and the Rad9 carboxy terminus
-
Lupardus, P. J. and Cimprich, K. A. (2006). Phosphorylation of Xenopus Rad1 and Hus1 defines a readout for ATR activation that is independent of Claspin and the Rad9 carboxy terminus. Mol. Biol. Cell 17, 1559-1569.
-
(2006)
Mol. Biol. Cell
, vol.17
, pp. 1559-1569
-
-
Lupardus, P.J.1
Cimprich, K.A.2
-
33
-
-
34247257202
-
The structural determinants of checkpoint activation
-
MacDougall, C. A., Byun, T. S., Van, C., Yee, M. C. and Cimprich, K. A. (2007). The structural determinants of checkpoint activation. Genes Dev. 21, 898-903.
-
(2007)
Genes Dev
, vol.21
, pp. 898-903
-
-
MacDougall, C.A.1
Byun, T.S.2
Van, C.3
Yee, M.C.4
Cimprich, K.A.5
-
34
-
-
33746429958
-
Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress
-
Mailand, N., Bekker-Jensen, S., Bartek, J. and Lukas, J. (2006). Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress. Mol. Cell 23, 307-318.
-
(2006)
Mol. Cell
, vol.23
, pp. 307-318
-
-
Mailand, N.1
Bekker-Jensen, S.2
Bartek, J.3
Lukas, J.4
-
35
-
-
33748780358
-
Replication protein A directs loading of the DNA damage checkpoint clamp to 5b-DNA junctions
-
Majka, J., Binz, S. K., Wold, M. S. and Burgers, P. M. (2006a). Replication protein A directs loading of the DNA damage checkpoint clamp to 5b-DNA junctions. J. Biol. Chem. 281, 27855-27861.
-
(2006)
J. Biol. Chem
, vol.281
, pp. 27855-27861
-
-
Majka, J.1
Binz, S.K.2
Wold, M.S.3
Burgers, P.M.4
-
36
-
-
33845607102
-
The checkpoint clamp activates Mec1 kinase during initiation of the DNA damage checkpoint
-
Majka, J., Niedziela-Majka, A. and Burgers, P. M. (2006b). The checkpoint clamp activates Mec1 kinase during initiation of the DNA damage checkpoint. Mol. Cell 24, 891-901.
-
(2006)
Mol. Cell
, vol.24
, pp. 891-901
-
-
Majka, J.1
Niedziela-Majka, A.2
Burgers, P.M.3
-
37
-
-
0242456024
-
BRCT domain-containing protein TopBP1 functions in DNA replication and damage response
-
Makiniemi, M., Hillukkala, T., Tuusa, J., Reini, K., Vaara, M., Huang, D., Pospiech, H., Majuri, I., Westerling, T., Makela, T. P. et al. (2001). BRCT domain-containing protein TopBP1 functions in DNA replication and damage response. J. Biol. Chem. 276, 30399-30406.
-
(2001)
J. Biol. Chem
, vol.276
, pp. 30399-30406
-
-
Makiniemi, M.1
Hillukkala, T.2
Tuusa, J.3
Reini, K.4
Vaara, M.5
Huang, D.6
Pospiech, H.7
Majuri, I.8
Westerling, T.9
Makela, T.P.10
-
38
-
-
33749246225
-
Polo-like kinase-1 controls proteasome-dependent degradation of Claspin during checkpoint recovery
-
Mamely, I., van Vugt, M. A., Smits, V. A., Semple, J. I., Lemmens, B., Perrakis, A., Medema, R. H. and Freire, R. (2006). Polo-like kinase-1 controls proteasome-dependent degradation of Claspin during checkpoint recovery. Curr. Biol. 16, 1950-1955.
-
(2006)
Curr. Biol
, vol.16
, pp. 1950-1955
-
-
Mamely, I.1
van Vugt, M.A.2
Smits, V.A.3
Semple, J.I.4
Lemmens, B.5
Perrakis, A.6
Medema, R.H.7
Freire, R.8
-
39
-
-
34249947699
-
-
Matsuoka, S., Ballif, B. A., Smogorzewska, A., McDonald, E. R., 3rd, Hurov, K. E., Luo, J., Bakalarski, C. E., Zhao, Z., Solimini, N., Lerenthal, Y. et al. (2007). ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science 316, 1160-1166.
-
Matsuoka, S., Ballif, B. A., Smogorzewska, A., McDonald, E. R., 3rd, Hurov, K. E., Luo, J., Bakalarski, C. E., Zhao, Z., Solimini, N., Lerenthal, Y. et al. (2007). ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science 316, 1160-1166.
-
-
-
-
40
-
-
0035498938
-
Two checkpoint complexes are independently recruited to sites of DNA damage in vivo
-
Melo, J. A., Cohen, J. and Toczyski, D. P. (2001). Two checkpoint complexes are independently recruited to sites of DNA damage in vivo. Genes Dev. 15, 2809-2821.
-
(2001)
Genes Dev
, vol.15
, pp. 2809-2821
-
-
Melo, J.A.1
Cohen, J.2
Toczyski, D.P.3
-
41
-
-
53649104599
-
Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing
-
Mimitou, E. P. and Symington, L. S. (2008). Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing. Nature 455, 770-774.
-
(2008)
Nature
, vol.455
, pp. 770-774
-
-
Mimitou, E.P.1
Symington, L.S.2
-
42
-
-
44849093460
-
TopBP1 activates ATR through ATRIP and a PIKK regulatory domain
-
Mordes, D. A., Glick, G. G., Zhao, R. and Cortez, D. (2008a). TopBP1 activates ATR through ATRIP and a PIKK regulatory domain. Genes Dev. 22, 1478-1489.
-
(2008)
Genes Dev
, vol.22
, pp. 1478-1489
-
-
Mordes, D.A.1
Glick, G.G.2
Zhao, R.3
Cortez, D.4
-
43
-
-
57749099248
-
Dpb11 activates the Mec1-Ddc2 complex
-
Mordes, D. A., Nam, E. A. and Cortez, D. (2008b). Dpb11 activates the Mec1-Ddc2 complex. Proc. Natl. Acad. Sci. USA 105, 18730-18734.
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 18730-18734
-
-
Mordes, D.A.1
Nam, E.A.2
Cortez, D.3
-
44
-
-
34547107878
-
A proteomic analysis of ataxia telangiectasia-mutated (ATM)/ATM-Rad3-related (ATR) substrates identifies the ubiquitin-proteasome system as a regulator for DNA damage checkpoints
-
Mu, J. J., Wang, Y., Luo, H., Leng, M., Zhang, J., Yang, T., Besusso, D., Jung, S. Y. and Qin, J. (2007). A proteomic analysis of ataxia telangiectasia-mutated (ATM)/ATM-Rad3-related (ATR) substrates identifies the ubiquitin-proteasome system as a regulator for DNA damage checkpoints. J. Biol. Chem. 282, 17330-17334.
-
(2007)
J. Biol. Chem
, vol.282
, pp. 17330-17334
-
-
Mu, J.J.1
Wang, Y.2
Luo, H.3
Leng, M.4
Zhang, J.5
Yang, T.6
Besusso, D.7
Jung, S.Y.8
Qin, J.9
-
45
-
-
33646777679
-
Rapid activation of ATR by ionizing radiation requires ATM and Mre11
-
Myers, J. S. and Cortez, D. (2006). Rapid activation of ATR by ionizing radiation requires ATM and Mre11. J. Biol. Chem. 281, 9346-9350.
-
(2006)
J. Biol. Chem
, vol.281
, pp. 9346-9350
-
-
Myers, J.S.1
Cortez, D.2
-
46
-
-
31444452984
-
ATRIP associates with replication protein A-coated ssDNA through multiple interactions
-
Namiki, Y. and Zou, L. (2006). ATRIP associates with replication protein A-coated ssDNA through multiple interactions. Proc. Natl. Acad. Sci. USA 103, 580-585.
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 580-585
-
-
Namiki, Y.1
Zou, L.2
-
47
-
-
58149102035
-
Yeast DNA replication protein Dpb11 activates the Mec1/ATR checkpoint kinase
-
Navadgi-Patil, V. M. and Burgers, P. M. (2008). Yeast DNA replication protein Dpb11 activates the Mec1/ATR checkpoint kinase. J. Biol. Chem. 283, 35853-35859.
-
(2008)
J. Biol. Chem
, vol.283
, pp. 35853-35859
-
-
Navadgi-Patil, V.M.1
Burgers, P.M.2
-
48
-
-
0038506000
-
Mrc1 is a replication fork component whose phosphorylation in response to DNA replication stress activates Rad53
-
Osborn, A. J. and Elledge, S. J. (2003). Mrc1 is a replication fork component whose phosphorylation in response to DNA replication stress activates Rad53. Genes Dev. 17, 1755-1767.
-
(2003)
Genes Dev
, vol.17
, pp. 1755-1767
-
-
Osborn, A.J.1
Elledge, S.J.2
-
49
-
-
33746413746
-
SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response
-
Peschiaroli, A., Dorrello, N. V., Guardavaccaro, D., Venere, M., Halazonetis, T., Sherman, N. E. and Pagano, M. (2006). SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response. Mol. Cell 23, 319-329.
-
(2006)
Mol. Cell
, vol.23
, pp. 319-329
-
-
Peschiaroli, A.1
Dorrello, N.V.2
Guardavaccaro, D.3
Venere, M.4
Halazonetis, T.5
Sherman, N.E.6
Pagano, M.7
-
50
-
-
34249885603
-
Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss
-
Ruzankina, Y., Pinzon-Guzman, C., Asare, A., Ong, T., Pontano, L., Cotsarelis, G., Zediak, V. P., Velez, M., Bhandoola, A. and Brown, E. J. (2007). Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss. Cell Stem Cell 1, 113-126.
-
(2007)
Cell Stem Cell
, vol.1
, pp. 113-126
-
-
Ruzankina, Y.1
Pinzon-Guzman, C.2
Asare, A.3
Ong, T.4
Pontano, L.5
Cotsarelis, G.6
Zediak, V.P.7
Velez, M.8
Bhandoola, A.9
Brown, E.J.10
-
51
-
-
36549060102
-
Human CtIP promotes DNA end resection
-
Sartori, A. A., Lukas, C., Coates, J., Mistrik, M., Fu, S., Bartek, J., Baer, R., Lukas, J. and Jackson, S. P. (2007). Human CtIP promotes DNA end resection. Nature 450, 509-514.
-
(2007)
Nature
, vol.450
, pp. 509-514
-
-
Sartori, A.A.1
Lukas, C.2
Coates, J.3
Mistrik, M.4
Fu, S.5
Bartek, J.6
Baer, R.7
Lukas, J.8
Jackson, S.P.9
-
52
-
-
34548259806
-
Exonuclease-1 deletion impairs DNA damage signaling and prolongs lifespan of telomere-dysfunctional mice
-
Schaetzlein, S., Kodandaramireddy, N. R., Ju, Z., Lechel, A., Stepczynska, A., Lilli, D. R., Clark, A. B., Rudolph, C., Kuhnel, F., Wei, K. et al. (2007). Exonuclease-1 deletion impairs DNA damage signaling and prolongs lifespan of telomere-dysfunctional mice. Cell 130, 863-877.
-
(2007)
Cell
, vol.130
, pp. 863-877
-
-
Schaetzlein, S.1
Kodandaramireddy, N.R.2
Ju, Z.3
Lechel, A.4
Stepczynska, A.5
Lilli, D.R.6
Clark, A.B.7
Rudolph, C.8
Kuhnel, F.9
Wei, K.10
-
53
-
-
34547499407
-
Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases
-
Smolka, M. B., Albuquerque, C. P., Chen, S. H. and Zhou, H. (2007). Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases. Proc. Natl. Acad. Sci. USA 104, 10364-10369.
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 10364-10369
-
-
Smolka, M.B.1
Albuquerque, C.P.2
Chen, S.H.3
Zhou, H.4
-
54
-
-
38049184488
-
Profiling of UV-induced ATM/ATR signaling pathways
-
Stokes, M. P., Rush, J., Macneill, J., Ren, J. M., Sprott, K., Nardone, J., Yang, V., Beausoleil, S. A., Gygi, S. P., Livingstone, M. et al. (2007). Profiling of UV-induced ATM/ATR signaling pathways. Proc. Natl. Acad. Sci. USA 104, 19855-19860.
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 19855-19860
-
-
Stokes, M.P.1
Rush, J.2
Macneill, J.3
Ren, J.M.4
Sprott, K.5
Nardone, J.6
Yang, V.7
Beausoleil, S.A.8
Gygi, S.P.9
Livingstone, M.10
-
55
-
-
0033637837
-
Initiation of eukaryotic DNA replication: Origin unwinding and sequential chromatin association of Cdc45, RPA, and DNA polymerase alpha
-
Walter, J. and Newport, J. (2000). Initiation of eukaryotic DNA replication: origin unwinding and sequential chromatin association of Cdc45, RPA, and DNA polymerase alpha. Mol. Cell 5, 617-627.
-
(2000)
Mol. Cell
, vol.5
, pp. 617-627
-
-
Walter, J.1
Newport, J.2
-
56
-
-
0036237806
-
Genetic and physical interactions between DPB11 and DDC1 in the yeast DNA damage response pathway
-
Wang, H. and Elledge, S. J. (2002). Genetic and physical interactions between DPB11 and DDC1 in the yeast DNA damage response pathway. Genetics 160, 1295-1304.
-
(2002)
Genetics
, vol.160
, pp. 1295-1304
-
-
Wang, H.1
Elledge, S.J.2
-
57
-
-
43249094413
-
Chk1 and Claspin potentiate PCNA ubiquitination
-
Yang, X. H., Shiotani, B., Classon, M. and Zou, L. (2008). Chk1 and Claspin potentiate PCNA ubiquitination. Genes Dev. 22, 1147-1152.
-
(2008)
Genes Dev
, vol.22
, pp. 1147-1152
-
-
Yang, X.H.1
Shiotani, B.2
Classon, M.3
Zou, L.4
-
58
-
-
33645516584
-
Site-specific phosphorylation of a checkpoint mediator protein controls its responses to different DNA structures
-
Yoo, H. Y., Jeong, S. Y. and Dunphy, W. G. (2006). Site-specific phosphorylation of a checkpoint mediator protein controls its responses to different DNA structures. Genes Dev. 20, 772-783.
-
(2006)
Genes Dev
, vol.20
, pp. 772-783
-
-
Yoo, H.Y.1
Jeong, S.Y.2
Dunphy, W.G.3
-
59
-
-
34547115962
-
Ataxia-telangiectasia mutated (ATM)-dependent activation of ATR occurs through phosphorylation of TopBP1 by ATM
-
Yoo, H. Y., Kumagai, A., Shevchenko, A. and Dunphy, W. G. (2007). Ataxia-telangiectasia mutated (ATM)-dependent activation of ATR occurs through phosphorylation of TopBP1 by ATM. J. Biol. Chem. 282, 17501-17506.
-
(2007)
J. Biol. Chem
, vol.282
, pp. 17501-17506
-
-
Yoo, H.Y.1
Kumagai, A.2
Shevchenko, A.3
Dunphy, W.G.4
-
60
-
-
33646503204
-
ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts
-
Yoshioka, K., Yoshioka, Y. and Hsieh, P. (2006). ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts. Mol. Cell 22, 501-510.
-
(2006)
Mol. Cell
, vol.22
, pp. 501-510
-
-
Yoshioka, K.1
Yoshioka, Y.2
Hsieh, P.3
-
61
-
-
20744436198
-
ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1
-
You, Z., Chahwan, C., Bailis, J., Hunter, T. and Russell, P. (2005). ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1. Mol. Cell. Biol. 25, 5363-5379.
-
(2005)
Mol. Cell. Biol
, vol.25
, pp. 5363-5379
-
-
You, Z.1
Chahwan, C.2
Bailis, J.3
Hunter, T.4
Russell, P.5
-
62
-
-
51549095956
-
Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break ends
-
Zhu, Z., Chung, W. H., Shim, E. Y., Lee, S. E. and Ira, G. (2008). Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break ends. Cell 134, 981-994.
-
(2008)
Cell
, vol.134
, pp. 981-994
-
-
Zhu, Z.1
Chung, W.H.2
Shim, E.Y.3
Lee, S.E.4
Ira, G.5
-
63
-
-
46949098616
-
Break dosage, cell cycle stage and DNA replication influence DNA double strand break response
-
Zierhut, C. and Diffley, J. F. (2008). Break dosage, cell cycle stage and DNA replication influence DNA double strand break response. EMBO J. 27, 1875-1885.
-
(2008)
EMBO J
, vol.27
, pp. 1875-1885
-
-
Zierhut, C.1
Diffley, J.F.2
-
64
-
-
34247251276
-
Single- and double-stranded DNA: Building a trigger of ATR-mediated DNA damage response
-
Zou, L. (2007). Single- and double-stranded DNA: building a trigger of ATR-mediated DNA damage response. Genes Dev. 21, 879-885.
-
(2007)
Genes Dev
, vol.21
, pp. 879-885
-
-
Zou, L.1
-
65
-
-
0037567268
-
Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes
-
Zou, L. and Elledge, S. J. (2003). Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science 300, 1542-1548.
-
(2003)
Science
, vol.300
, pp. 1542-1548
-
-
Zou, L.1
Elledge, S.J.2
-
66
-
-
0037080675
-
Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin
-
Zou, L., Cortez, D. and Elledge, S. J. (2002). Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin. Genes Dev. 16, 198-208.
-
(2002)
Genes Dev
, vol.16
, pp. 198-208
-
-
Zou, L.1
Cortez, D.2
Elledge, S.J.3
-
67
-
-
0345564858
-
Replication protein A-mediated recruitment and activation of Rad17 complexes
-
Zou, L., Liu, D. and Elledge, S. J. (2003). Replication protein A-mediated recruitment and activation of Rad17 complexes. Proc. Natl. Acad. Sci. USA 100, 13827-13832.
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 13827-13832
-
-
Zou, L.1
Liu, D.2
Elledge, S.J.3
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