메뉴 건너뛰기




Volumn 4, Issue 1, 2012, Pages 48-58

Double negative regulatory T cells in transplantation and autoimmunity: Recent progress and future directions

Author keywords

autoimmunity; double negative T cells; graft versus host disease; regulatory T cells; transplantation; type 1 diabetes mellitus

Indexed keywords

TRANSCRIPTION FACTOR FOXP3;

EID: 84863078551     PISSN: 16742788     EISSN: 17594685     Source Type: Journal    
DOI: 10.1093/jmcb/mjr043     Document Type: Review
Times cited : (116)

References (98)
  • 1
    • 0035496231 scopus 로고    scopus 로고
    • Lymphostromal interactions in thymic development and function
    • Anderson, G., and Jenkinson, E.J. (2001). Lymphostromal interactions in thymic development and function. Nat. Rev. Immunol. 1, 31-40. (Pubitemid 33741973)
    • (2001) Nature Reviews Immunology , vol.1 , Issue.1 , pp. 31-40
    • Anderson, G.1    Jenkinson, E.J.2
  • 2
  • 4
    • 27144495833 scopus 로고    scopus 로고
    • + regulatory T cells control autoimmunity?
    • DOI 10.1016/j.coi.2005.09.002, PII S0952791505001548, Autoimmunity / Allergy and Hypersensitivity
    • + regulatory T cells control autoimmunity? Curr. Opin. Immunol. 17, 638-642. (Pubitemid 41506909)
    • (2005) Current Opinion in Immunology , vol.17 , Issue.6 , pp. 638-642
    • Bluestone, J.A.1    Tang, Q.2
  • 5
    • 0027333549 scopus 로고
    • Interferon-gamma prevents graft-versus-host disease after allogeneic bone marrow transplantation in mice
    • Brok, H.P., Heidt, P.J., van der Meide, P.H., et al. (1993). Interferon-gamma prevents graft-versus-host disease after allogeneic bone marrow transplantation in mice. J. Immunol. 151, 6451-6459.
    • (1993) J. Immunol. , vol.151 , pp. 6451-6459
    • Brok, H.P.1    Heidt, P.J.2    Van Der Meide, P.H.3
  • 7
    • 0037442004 scopus 로고    scopus 로고
    • Role of double-negative regulatory T cells in long-term cardiac xenograft survival
    • Chen, W., Ford, M.S., Young, K.J., et al. (2003a). Role of double-negative regulatory T cells in long-term cardiac xenograft survival. J. Immunol. 170, 1846-1853. (Pubitemid 36197401)
    • (2003) Journal of Immunology , vol.170 , Issue.4 , pp. 1846-1853
    • Chen, W.1    Ford, M.S.2    Young, K.J.3    Cybulsky, M.I.4    Zhang, L.5
  • 8
    • 0242721627 scopus 로고    scopus 로고
    • Infusion of in vitro-generated DN T regulatory cells induces permanent cardiac allograft survival in mice
    • DOI 10.1016/j.transproceed.2003.08.030
    • Chen, W., Ford, M.S., Young, K.J., et al. (2003b). Infusion of in vitro-generated DN T regulatory cells induces permanent cardiac allograft survival in mice. Transplant. Proc. 35, 2479-2480. (Pubitemid 37378037)
    • (2003) Transplantation Proceedings , vol.35 , Issue.7 , pp. 2479-2480
    • Chen, W.1    Ford, M.S.2    Young, K.J.3    Zhang, L.4
  • 9
    • 23844459503 scopus 로고    scopus 로고
    • Donor lymphocyte infusion induces long-term donor-specific cardiac xenograft survival through activation of recipient double-negative regulatory T cells
    • Chen, W., Zhou, D., Torrealba, J.R., et al. (2005). Donor lymphocyte infusion induces long-term donor-specific cardiac xenograft survival through activation of recipient double-negative regulatory T cells. J. Immunol. 175, 3409-3416. (Pubitemid 41170564)
    • (2005) Journal of Immunology , vol.175 , Issue.5 , pp. 3409-3416
    • Chen, W.1    Zhou, D.2    Torrealba, J.R.3    Waddell, T.K.4    Grant, D.5    Zhang, L.6
  • 10
    • 34548649776 scopus 로고    scopus 로고
    • Both infiltrating regulatory T cells and insufficient antigen presentation are involved in long-term cardiac xenograft survival
    • Chen, W., Diao, J., Stepkowski, S.M., et al. (2007). Both infiltrating regulatory T cells and insufficient antigen presentation are involved in long-term cardiac xenograft survival. J. Immunol. 179, 1542-1548.
    • (2007) J. Immunol. , vol.179 , pp. 1542-1548
    • Chen, W.1    Diao, J.2    Stepkowski, S.M.3
  • 11
    • 0028928654 scopus 로고
    • Massive upregulation of the Fas ligand in lpr and gld mice: Implications for Fas regulation and the graft-versus-host disease-like wasting syndrome
    • Chu, J.L., Ramos, P., Rosendorff, A., et al. (1995). Massive upregulation of the Fas ligand in lpr and gld mice: Implications for Fas regulation and the graft-versus-host disease-like wasting syndrome. J. Exp. Med. 181, 393-398.
    • (1995) J. Exp. Med. , vol.181 , pp. 393-398
    • Chu, J.L.1    Ramos, P.2    Rosendorff, A.3
  • 13
    • 77954731553 scopus 로고    scopus 로고
    • - double-negative T cells are prominent producers of IL-17A and IFN-gamma during primary respiratory murine infection with Francisella tularensis live vaccine strain
    • - double-negative T cells are prominent producers of IL-17A and IFN-gamma during primary respiratory murine infection with Francisella tularensis live vaccine strain. J. Immunol. 184, 5791-5801.
    • (2010) J. Immunol. , vol.184 , pp. 5791-5801
    • Cowley, S.C.1    Meierovics, A.I.2    Frelinger, J.A.3
  • 14
    • 70449719356 scopus 로고    scopus 로고
    • + T cells and display an inflammatory effector phenotype
    • + T cells and display an inflammatory effector phenotype. J. Immunol. 183, 4675-4681.
    • (2009) J. Immunol. , vol.183 , pp. 4675-4681
    • Crispin, J.C.1    Tsokos, G.C.2
  • 15
    • 58849162766 scopus 로고    scopus 로고
    • Expanded double negative T cells in patients with systemic lupus erythematosus produce IL-17 and infiltrate the kidneys
    • Crispin, J.C., Oukka, M., Bayliss, G., et al. (2008). Expanded double negative T cells in patients with systemic lupus erythematosus produce IL-17 and infiltrate the kidneys. J. Immunol. 181, 8761-8766.
    • (2008) J. Immunol. , vol.181 , pp. 8761-8766
    • Crispin, J.C.1    Oukka, M.2    Bayliss, G.3
  • 16
    • 79960362531 scopus 로고    scopus 로고
    • - (double negative) T cells: Saviours or villains of the immune response?
    • - (double negative) T cells: Saviours or villains of the immune response? Biochem. Pharmacol. 82, 333-340.
    • (2011) Biochem. Pharmacol. , vol.82 , pp. 333-340
    • D'Acquisto, F.1    Crompton, T.2
  • 18
    • 77953289018 scopus 로고    scopus 로고
    • Implication of the CD47 pathway in autoimmune diabetes
    • Dugas, V., Beauchamp, C., Chabot-Roy, G., et al. (2010). Implication of the CD47 pathway in autoimmune diabetes. J. Autoimmun. 35, 23-32.
    • (2010) J. Autoimmun. , vol.35 , pp. 23-32
    • Dugas, V.1    Beauchamp, C.2    Chabot-Roy, G.3
  • 19
    • 77955354249 scopus 로고    scopus 로고
    • -4-8-) TCR alphabeta splenic cells from young NOD mice provide long-lasting protection against type 1 diabetes
    • -4-8-) TCR alphabeta splenic cells from young NOD mice provide long-lasting protection against type 1 diabetes. PLoS One 5, e11427.
    • (2010) PLoS One , vol.5
    • Duncan, B.1    Nazarov-Stoica, C.2    Surls, J.3
  • 21
    • 10844252294 scopus 로고    scopus 로고
    • + regulatory cell activation and function by dendritic cells
    • DOI 10.1093/intimm/dxh178
    • + regulatory cell activation and function by dendritic cells. Int. Immunol. 16, 1769-1780. (Pubitemid 40003865)
    • (2004) International Immunology , vol.16 , Issue.12 , pp. 1769-1780
    • Fehervari, Z.1    Sakaguchi, S.2
  • 24
    • 0037099691 scopus 로고    scopus 로고
    • The immune regulatory function of lymphoproliferative double negative T cells in vitro and in vivo
    • DOI 10.1084/jem.20020029
    • Ford, M.S., Young, K.J., Zhang, Z., et al. (2002). The immune regulatory function of lymphoproliferative double negative T cells in vitro and in vivo. J. Exp. Med. 196, 261-267. (Pubitemid 34787516)
    • (2002) Journal of Experimental Medicine , vol.196 , Issue.2 , pp. 261-267
    • Ford, M.S.1    Young, K.J.2    Zhang, Z.3    Ohashi, P.S.4    Zhang, L.5
  • 27
    • 53149152263 scopus 로고    scopus 로고
    • Cutting edge: In vivo trogocytosis as a mechanism of double negative regulatory T cell-mediated antigen-specific suppression
    • Ford McIntyre, M.S., Young, K.J., Gao, J., et al. (2008). Cutting edge: In vivo trogocytosis as a mechanism of double negative regulatory T cell-mediated antigen-specific suppression. J. Immunol. 181, 2271-2275.
    • (2008) J. Immunol. , vol.181 , pp. 2271-2275
    • Ford McIntyre, M.S.1    Young, K.J.2    Gao, J.3
  • 28
    • 79954630416 scopus 로고    scopus 로고
    • Consequences of double negative regulatory T cell and antigen presenting cell interaction on immune response suppression
    • Ford McIntyre, M.S., Gao, J.F., Li, X., et al. (2010). Consequences of double negative regulatory T cell and antigen presenting cell interaction on immune response suppression. Int. Immunopharmacol. 11, 597-603.
    • (2010) Int. Immunopharmacol. , vol.11 , pp. 597-603
    • Ford McIntyre, M.S.1    Gao, J.F.2    Li, X.3
  • 29
    • 80052151755 scopus 로고    scopus 로고
    • Regulation of antigen-expressing dendritic cells by double negative regulatory T cells
    • Gao, J.F., McIntyre, M.S., Juvet, S.C., et al. (2011). Regulation of antigen-expressing dendritic cells by double negative regulatory T cells. Eur. J. Immunol. 41, 2699-2708.
    • (2011) Eur. J. Immunol. , vol.41 , pp. 2699-2708
    • Gao, J.F.1    McIntyre, M.S.2    Juvet, S.C.3
  • 30
    • 0026730836 scopus 로고
    • Evidence for early onset, polyclonal activation of T cell subsets in mice homozygous for lpr
    • Giese, T., and Davidson, W.F. (1992). Evidence for early onset, polyclonal activation of T cell subsets in mice homozygous for lpr. J. Immunol. 149, 3097-3106.
    • (1992) J. Immunol. , vol.149 , pp. 3097-3106
    • Giese, T.1    Davidson, W.F.2
  • 31
    • 0028268517 scopus 로고
    • Chronic treatment of C3H-lpr/lpr and C3H-gld/gld mice with anti-CD8 monoclonal antibody prevents the accumulation of double negative T cells but not autoantibody production
    • Giese, T., and Davidson, W.F. (1994). Chronic treatment of C3H-lpr/lpr and C3H-gld/gld mice with anti-CD8 monoclonal antibody prevents the accumulation of double negative T cells but not autoantibody production. J. Immunol. 152, 2000-2010. (Pubitemid 24075734)
    • (1994) Journal of Immunology , vol.152 , Issue.4 , pp. 2000-2010
    • Giese, T.1    Davidson, W.F.2
  • 32
    • 0027209634 scopus 로고
    • + double-negative T cells express CD28 and respond to costimulation with phorbol myristate acetate and antibodies to CD28 and the TCR
    • + double-negative T cells express CD28 and respond to costimulation with phorbol myristate acetate and antibodies to CD28 and the TCR. J. Immunol. 151, 597-609. (Pubitemid 23215725)
    • (1993) Journal of Immunology , vol.151 , Issue.2 , pp. 597-609
    • Giese, T.1    Allison, J.P.2    Davidson, W.F.3
  • 33
    • 77954112755 scopus 로고    scopus 로고
    • + regulatory T cells utilize FasL as a mechanism to restrict DC priming functions in cutaneous immune responses
    • + regulatory T cells utilize FasL as a mechanism to restrict DC priming functions in cutaneous immune responses. Eur. J. Immunol. 40, 2006-2015.
    • (2010) Eur. J. Immunol. , vol.40 , pp. 2006-2015
    • Gorbachev, A.V.1    Fairchild, R.L.2
  • 36
    • 0035052851 scopus 로고    scopus 로고
    • - extrathymic T cells in the liver by injection of bone marrow cells isolated from mice with a mutation of polymorphic major histocompatibility complex antigens
    • DOI 10.1046/j.1365-2567.2001.01210.x
    • Halder, R.C., Kawamura, T., Bannai, M., et al. (2001). Intensive generation of NK1.1-extrathymic T cells in the liver by injection of bone marrow cells isolated from mice with a mutation of polymorphic major histocompatibility complex antigens. Immunology 102, 450-459. (Pubitemid 32322957)
    • (2001) Immunology , vol.102 , Issue.4 , pp. 450-459
    • Halder, R.C.1    Kawamura, T.2    Bannai, M.3    Watanabe, H.4    Kawamura, H.5    Mannoor, M.K.6    Morshed, S.R.M.7    Abo, T.8
  • 37
    • 0042430410 scopus 로고    scopus 로고
    • + double-negative T cells suppress polyclonal T cell activation by a fas-independent mechanism that involves inhibition of IL-2 production
    • + double-negative T cells suppress polyclonal T cell activation by a Fas-independent mechanism that involves inhibition of IL-2 production. J. Immunol. 171, 2421-2426. (Pubitemid 37025549)
    • (2003) Journal of Immunology , vol.171 , Issue.5 , pp. 2421-2426
    • Hamad, A.R.A.1    Mohamood, A.S.2    Trujillo, C.J.3    Huang, C.-T.4    Yuan, E.5    Schneck, J.P.6
  • 38
    • 0027424263 scopus 로고
    • Double-negative T cells from MRL-lpr/lpr mice mediate cytolytic activity when triggered through adhesion molecules and constitutively express perforin gene
    • DOI 10.1084/jem.178.6.2225
    • Hammond, D.M., Nagarkatti, P.S., Gote, L.R., et al. (1993). Double-negative T cells from MRL-lpr/lpr mice mediate cytolytic activity when triggered through adhesion molecules and constitutively express perforin gene. J. Exp. Med. 178, 2225-2230. (Pubitemid 23344882)
    • (1993) Journal of Experimental Medicine , vol.178 , Issue.6 , pp. 2225-2230
    • Hammond, D.M.1    Nagarkatti, P.S.2    Gote, L.R.3    Seth, A.4    Hassuneh, M.R.5    Nagarkatti, M.6
  • 39
    • 37549007140 scopus 로고    scopus 로고
    • Donor double-negative Treg promote allogeneic mixed chimerism and tolerance
    • He, K.M., Ma, Y., Wang, S., et al. (2007). Donor double-negative Treg promote allogeneic mixed chimerism and tolerance. Eur. J. Immunol. 37, 3455-3466.
    • (2007) Eur. J. Immunol. , vol.37 , pp. 3455-3466
    • He, K.M.1    Ma, Y.2    Wang, S.3
  • 40
    • 80053329222 scopus 로고    scopus 로고
    • Cell therapy with autologous tolerogenic dendritic cells induces allograft tolerance through interferongamma and epstein-barr virus-induced gene 3
    • Hill, M., Thebault, P., Segovia, M., et al. (2011). Cell therapy with autologous tolerogenic dendritic cells induces allograft tolerance through interferongamma and epstein-barr virus-induced gene 3. Am. J. Transplant. 11, 2036-2045.
    • (2011) Am. J. Transplant. , vol.11 , pp. 2036-2045
    • Hill, M.1    Thebault, P.2    Segovia, M.3
  • 44
    • 77649244808 scopus 로고    scopus 로고
    • Ligand binding but undetected functional response of FcR after their capture by T cells via trogocytosis
    • Hudrisier, D., Clemenceau, B., Balor, S., et al. (2009). Ligand binding but undetected functional response of FcR after their capture by T cells via trogocytosis. J. Immunol. 183, 6102-6113.
    • (2009) J. Immunol. , vol.183 , pp. 6102-6113
    • Hudrisier, D.1    Clemenceau, B.2    Balor, S.3
  • 45
    • 0037441993 scopus 로고    scopus 로고
    • - T cells with regulatory functions dominates the mouse female genital tract
    • - T cells with regulatory functions dominates the mouse female genital tract. J. Immunol. 170, 1659-1666. (Pubitemid 36197379)
    • (2003) Journal of Immunology , vol.170 , Issue.4 , pp. 1659-1666
    • Johansson, M.1    Lycke, N.2
  • 46
    • 0041381374 scopus 로고    scopus 로고
    • What is trogocytosis and what is its purpose?
    • DOI 10.1038/ni0903-815
    • Joly, E., and Hudrisier, D. (2003). What is trogocytosis and what is its purpose? Nat. Immunol. 4, 815. (Pubitemid 37098646)
    • (2003) Nature Immunology , vol.4 , Issue.9 , pp. 815
    • Joly, E.1    Hudrisier, D.2
  • 48
    • 78650669332 scopus 로고    scopus 로고
    • Cutting edge: Lymphoproliferation caused by Fas deficiency is dependent on the transcription factor eomesodermin
    • Kinjyo, I., Gordon, S.M., Intlekofer, A.M., et al. (2010). Cutting edge: Lymphoproliferation caused by Fas deficiency is dependent on the transcription factor eomesodermin. J. Immunol. 185, 7151-7155.
    • (2010) J. Immunol. , vol.185 , pp. 7151-7155
    • Kinjyo, I.1    Gordon, S.M.2    Intlekofer, A.M.3
  • 49
    • 58149384550 scopus 로고    scopus 로고
    • Graft-versus-leukemia effects of transplantation and donor lymphocytes
    • Kolb, H.J. (2008). Graft-versus-leukemia effects of transplantation and donor lymphocytes. Blood 112, 4371-4383.
    • (2008) Blood , vol.112 , pp. 4371-4383
    • Kolb, H.J.1
  • 51
    • 20144389329 scopus 로고    scopus 로고
    • Expression profiling of murine double-negative regulatory T cells suggest mechanisms for prolonged cardiac allograft survival
    • Lee, B.P., Mansfield, E., Hsieh, S.C., et al. (2005). Expression profiling of murine double-negative regulatory T cells suggest mechanisms for prolonged cardiac allograft survival. J. Immunol. 174, 4535-4544.
    • (2005) J. Immunol. , vol.174 , pp. 4535-4544
    • Lee, B.P.1    Mansfield, E.2    Hsieh, S.C.3
  • 52
    • 40549117001 scopus 로고    scopus 로고
    • Adoptive transfer of double negative T regulatory cells induces B-cell death in vivo and alters rejection pattern of rat-to-mouse heart transplantation
    • DOI 10.1111/j.1399-3089.2008.00444.x
    • Ma, Y., He, K.M., Garcia, B., et al. (2008). Adoptive transfer of double negative T regulatory cells induces B-cell death in vivo and alters rejection pattern of rat-to-mouse heart transplantation. Xenotransplantation 15, 56-63. (Pubitemid 351360242)
    • (2008) Xenotransplantation , vol.15 , Issue.1 , pp. 56-63
    • Ma, Y.1    He, K.M.2    Garcia, B.3    Min, W.4    Jevnikar, A.5    Zhang, Z.-X.6
  • 53
    • 0028898599 scopus 로고
    • Greatly reduced lymphoproliferation in lpr mice lacking major histocompatibility complex class I
    • Maldonado, M.A., Eisenberg, R.A., Roper, E., et al. (1995). Greatly reduced lymphoproliferation in lpr mice lacking major histocompatibility complex class I. J. Exp. Med. 181, 641-648.
    • (1995) J. Exp. Med. , vol.181 , pp. 641-648
    • Maldonado, M.A.1    Eisenberg, R.A.2    Roper, E.3
  • 56
    • 0032529216 scopus 로고    scopus 로고
    • + T cells creates double-negative cells in vivo
    • + T cells creates double-negative cells in vivo. J Immunol. 161, 1686-1693. (Pubitemid 28387585)
    • (1998) Journal of Immunology , vol.161 , Issue.4 , pp. 1686-1693
    • Mehal, W.Z.1    Crispe, I.N.2
  • 57
    • 0028983345 scopus 로고
    • - double negative T cells and of the autoimmune syndrome in MRL-lpr/lpr mice
    • - double negative T cells and of the autoimmune syndrome in MRL-lpr/lpr mice. J. Autoimmun. 8, 33-45.
    • (1995) J. Autoimmun. , vol.8 , pp. 33-45
    • Merino, R.1    Fossati, L.2    Iwamoto, M.3
  • 59
    • 48249103057 scopus 로고    scopus 로고
    • + natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation
    • + natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation. Proc. Natl Acad. Sci. USA 105, 10113-10118.
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 10113-10118
    • Onishi, Y.1    Fehervari, Z.2    Yamaguchi, T.3
  • 60
    • 0035575989 scopus 로고    scopus 로고
    • TCR/self-antigen interactions drive double-negative T cell peripheral expansion and differentiation into suppressor cells
    • Priatel, J.J., Utting, O., and Teh, H.S. (2001). TCR/self-antigen interactions drive double-negative T cell peripheral expansion and differentiation into suppressor cells. J. Immunol. 167, 6188-6194. (Pubitemid 33081546)
    • (2001) Journal of Immunology , vol.167 , Issue.11 , pp. 6188-6194
    • Priatel, J.J.1    Utting, O.2    Teh, H.-S.3
  • 61
    • 77949895907 scopus 로고    scopus 로고
    • IL-23 receptor regulates unconventional IL-17-producing T cells that control bacterial infections
    • Riol-Blanco, L., Lazarevic, V., Awasthi, A., et al. (2010). IL-23 receptor regulates unconventional IL-17-producing T cells that control bacterial infections. J. Immunol. 184, 1710-1720.
    • (2010) J. Immunol. , vol.184 , pp. 1710-1720
    • Riol-Blanco, L.1    Lazarevic, V.2    Awasthi, A.3
  • 62
    • 77955228203 scopus 로고    scopus 로고
    • Adoptive regulatory T cell therapy: Challenges in clinical transplantation
    • Safinia, N., Sagoo, P., Lechler, R., et al. (2010). Adoptive regulatory T cell therapy: Challenges in clinical transplantation. Curr. Opin. Organ. Transplant. 15, 427-434.
    • (2010) Curr. Opin. Organ. Transplant. , vol.15 , pp. 427-434
    • Safinia, N.1    Sagoo, P.2    Lechler, R.3
  • 63
    • 43949105866 scopus 로고    scopus 로고
    • Regulatory T Cells and Immune Tolerance
    • DOI 10.1016/j.cell.2008.05.009, PII S0092867408006247
    • Sakaguchi, S., Yamaguchi, T., Nomura, T., et al. (2008). Regulatory T cells and immune tolerance. Cell 133, 775-787. (Pubitemid 351707693)
    • (2008) Cell , vol.133 , Issue.5 , pp. 775-787
    • Sakaguchi, S.1    Yamaguchi, T.2    Nomura, T.3    Ono, M.4
  • 65
    • 22344434572 scopus 로고    scopus 로고
    • IFN-γ production by alloantigen-reactive regulatory T cells is important for their regulatory function in vivo
    • DOI 10.1084/jem.20050419
    • Sawitzki, B., Kingsley, C.I., Oliveira, V., et al. (2005). IFN-gamma production by alloantigen-reactive regulatory T cells is important for their regulatory function in vivo. J. Exp. Med. 201, 1925-1935. (Pubitemid 41002929)
    • (2005) Journal of Experimental Medicine , vol.201 , Issue.12 , pp. 1925-1935
    • Sawitzki, B.1    Kingsley, C.I.2    Oliveira, V.3    Karim, M.4    Herber, M.5    Wood, K.J.6
  • 67
    • 33747143361 scopus 로고    scopus 로고
    • From Vanilla to 28 Flavors: Multiple Varieties of T Regulatory Cells
    • DOI 10.1016/j.immuni.2006.08.003, PII S1074761306003578
    • Shevach, E.M. (2006). From vanilla to 28 flavors: Multiple varieties of T regulatory cells. Immunity 25, 195-201. (Pubitemid 44224153)
    • (2006) Immunity , vol.25 , Issue.2 , pp. 195-201
    • Shevach, E.M.1
  • 68
    • 65549136983 scopus 로고    scopus 로고
    • + T regulatory cell-mediated suppression
    • + T regulatory cell-mediated suppression. Immunity 30, 636-645.
    • (2009) Immunity , vol.30 , pp. 636-645
    • Shevach, E.M.1
  • 69
    • 34247573902 scopus 로고    scopus 로고
    • Graft-versus-host disease
    • DOI 10.1038/nri2000, PII NRI2000
    • Shlomchik, W.D. (2007). Graft-versus-host disease. Nat. Rev. Immunol. 7, 340-352. (Pubitemid 46674485)
    • (2007) Nature Reviews Immunology , vol.7 , Issue.5 , pp. 340-352
    • Shlomchik, W.D.1
  • 70
    • 0018935423 scopus 로고
    • Effects of thymectomy or androgen administration upon the autoimmune disease of MRL/Mp-lpr mice
    • Steinberg, A.D., Roths, J.B., Murphy, E.D., et al. (1980). Effects of thymectomy or androgen administration upon the autoimmune disease of MRL/Mp-lpr/ lpr mice. J. Immunol. 125, 871-873. (Pubitemid 10045673)
    • (1980) Journal of Immunology , vol.125 , Issue.2 , pp. 871-873
    • Steinberg, A.D.1    Roths, J.B.2    Murphy, E.D.3
  • 72
    • 0026062580 scopus 로고
    • + thymocytes. Variable influence of self-antigens on T cell receptor V beta usage
    • + thymocytes. Variable influence of self-antigens on T cell receptor V beta usage. J. Immunol. 146, 1134-1141.
    • (1991) J. Immunol. , vol.146 , pp. 1134-1141
    • Takahama, Y.1    Kosugi, A.2    Singer, A.3
  • 73
    • 0028223847 scopus 로고
    • Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand
    • DOI 10.1016/0092-8674(94)90375-1
    • Takahashi, T., Tanaka, M., Brannan, C.I., et al. (1994). Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell 76, 969-976. (Pubitemid 24106378)
    • (1994) Cell , vol.76 , Issue.6 , pp. 969-976
    • Takahashi, T.1    Tanaka, M.2    Brannan, C.I.3    Jenkins, N.A.4    Copeland, N.G.5    Suda, T.6    Nagata, S.7
  • 74
    • 33749607355 scopus 로고    scopus 로고
    • Double-negative regulatory T cells: Non-conventional regulators
    • DOI 10.1385/IR:35:1:163, PII IR351163
    • Thomson, C.W., Lee, B.P., and Zhang, L. (2006). Double-negative regulatory T cells: Non-conventional regulators. Immunol. Res. 35, 163-178. (Pubitemid 44547511)
    • (2006) Immunologic Research , vol.35 , Issue.1-2 , pp. 163-178
    • Thomson, C.W.1    Lee, B.P.-L.2    Zhang, L.3
  • 75
    • 33748163913 scopus 로고    scopus 로고
    • CD1d- and MR1-restricted invariant T cells: of mice and men
    • DOI 10.1016/j.coi.2006.07.001, PII S0952791506001373, Innate Lymphocytes/Transplantation/Immunogenetics
    • Treiner, E., and Lantz, O. (2006). CD1d- and MR1-restricted invariant T cells: Of mice and men. Curr. Opin. Immunol. 18, 519-526. (Pubitemid 44311447)
    • (2006) Current Opinion in Immunology , vol.18 , Issue.5 , pp. 519-526
    • Treiner, E.1    Lantz, O.2
  • 77
    • 0037222541 scopus 로고    scopus 로고
    • - T cells that escape deletion and lack regulatory activity
    • - T cells that escape deletion and lack regulatory activity. J. Immunol. 170, 201-209. (Pubitemid 36026141)
    • (2003) Journal of Immunology , vol.170 , Issue.1 , pp. 201-209
    • Viret, C.1    Janeway Jr., C.A.2
  • 80
    • 0028835952 scopus 로고
    • Constitutive activation of the Fas ligand gene in mouse lymphoproliferative disorders
    • Watanabe, D., Suda, T., Hashimoto, H., et al. (1995). Constitutive activation of the Fas ligand gene in mouse lymphoproliferative disorders. EMBO J. 14, 12-18.
    • (1995) EMBO J. , vol.14 , pp. 12-18
    • Watanabe, D.1    Suda, T.2    Hashimoto, H.3
  • 81
    • 0026568919 scopus 로고
    • Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis
    • Watanabe-Fukunaga, R., Brannan, C.I., Copeland, N.G., et al. (1992). Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature 356, 314-317.
    • (1992) Nature , vol.356 , pp. 314-317
    • Watanabe-Fukunaga, R.1    Brannan, C.I.2    Copeland, N.G.3
  • 82
    • 72549089070 scopus 로고    scopus 로고
    • IFN-gamma triggered STAT1-PKB/AKT signalling pathway influences the function of alloantigen reactive regulatory T cells
    • Wei, B., Baker, S., Wieckiewicz, J., et al. (2010). IFN-gamma triggered STAT1-PKB/AKT signalling pathway influences the function of alloantigen reactive regulatory T cells. Am. J. Transplant. 10, 69-80.
    • (2010) Am. J. Transplant. , vol.10 , pp. 69-80
    • Wei, B.1    Baker, S.2    Wieckiewicz, J.3
  • 83
    • 78049267160 scopus 로고    scopus 로고
    • T regulatory cells and the control of alloimmunity: From characterisation to clinical application
    • Wieckiewicz, J., Goto, R., and Wood, K.J. (2010). T regulatory cells and the control of alloimmunity: From characterisation to clinical application. Curr. Opin. Immunol. 22, 662-668.
    • (2010) Curr. Opin. Immunol. , vol.22 , pp. 662-668
    • Wieckiewicz, J.1    Goto, R.2    Wood, K.J.3
  • 85
    • 0019943417 scopus 로고
    • Thymic influences on autoimmunity in MRL-1pr mice
    • DOI 10.1111/j.1365-3083.1982.tb00698.x
    • Wofsy, D., Ledbetter, J.A., Roubinian, J.R., et al. (1982). Thymic influences on autoimmunity in MRL-lpr mice. Scand J. Immunol. 16, 51-58. (Pubitemid 12089553)
    • (1982) Scandinavian Journal of Immunology , vol.16 , Issue.1 , pp. 51-58
    • Wofsy, D.1    Ledbetter, J.A.2    Roubinian, J.R.3
  • 86
    • 34447535593 scopus 로고    scopus 로고
    • Interferon gamma: Friend or foe?
    • DOI 10.1097/01.tp.0000269115.60728.b1, PII 0000789020070715100003
    • Wood, K.J., Feng, G., Wei, B., et al. (2007). Interferon gamma: Friend or foe? Transplantation 84, S4-S5. (Pubitemid 47067533)
    • (2007) Transplantation , vol.84 , Issue.1 SUPPL.
    • Wood, K.J.1    Feng, G.2    Wei, B.3    Sawitzki, B.4    Bushell, A.R.5
  • 88
    • 0032535087 scopus 로고    scopus 로고
    • Donor-derived interferon γ is required for inhibition of acute graft- versus-host disease by interleukin 12
    • Yang, Y.G., Dey, B.R., Sergio, J.J., et al. (1998). Donor-derived interferon gamma is required for inhibition of acute graft-versus-host disease by interleukin 12. J. Clin. Invest. 102, 2126-2135. (Pubitemid 29018819)
    • (1998) Journal of Clinical Investigation , vol.102 , Issue.12 , pp. 2126-2135
    • Yang, Y.-G.1    Dey, B.R.2    Sergio, J.J.3    Pearson, D.A.4    Sykes, M.5
  • 89
    • 0036775008 scopus 로고    scopus 로고
    • The nature and mechanisms of DN regulatory T-cell mediated suppression
    • DOI 10.1016/S0198-8859(02)00446-9, PII S0198885902004469
    • Young, K.J., and Zhang, L. (2002). The nature and mechanisms of DN regulatory T-cell mediated suppression. Hum. Immunol. 63, 926-934. (Pubitemid 35246773)
    • (2002) Human Immunology , vol.63 , Issue.10 , pp. 926-934
    • Young, K.J.1    Zhang, L.2
  • 90
    • 0036839481 scopus 로고    scopus 로고
    • Donor-lymphocyte infusion induces transplantation tolerance by activating systemic and graft-infiltrating double-negative regulatory T cells
    • DOI 10.1182/blood-2002-01-0235
    • Young, K.J., Yang, L., Phillips, M.J., et al. (2002). Donor-lymphocyte infusion induces transplantation tolerance by activating systemic and graft-infiltrating double-negative regulatory T cells. Blood 100, 3408-3414. (Pubitemid 35217094)
    • (2002) Blood , vol.100 , Issue.9 , pp. 3408-3414
    • Young, K.J.1    Yang, L.2    James Phillips, M.3    Zhang, L.4
  • 91
    • 0038545422 scopus 로고    scopus 로고
    • Inhibition of graft-versus-host disease by double-negative regulatory T cells
    • Young, K.J., DuTemple, B., Phillips, M.J., et al. (2003a). Inhibition of graft-versus-host disease by double-negative regulatory T cells. J. Immunol. 171, 134-141. (Pubitemid 36745281)
    • (2003) Journal of Immunology , vol.171 , Issue.1 , pp. 134-141
    • Young, K.J.1    DuTemple, B.2    Phillips, M.J.3    Zhang, L.4
  • 92
    • 0345707569 scopus 로고    scopus 로고
    • Antitumor Activity Mediated by Double-Negative T Cells
    • Young, K.J., Kay, L.S., Phillips, M.J., et al. (2003b). Antitumor activity mediated by double-negative T cells. Cancer Res. 63, 8014-8021. (Pubitemid 37466740)
    • (2003) Cancer Research , vol.63 , Issue.22 , pp. 8014-8021
    • Young, K.J.1    Kay, L.S.2    Phillips, M.J.3    Zhang, L.4
  • 93
    • 80053309996 scopus 로고    scopus 로고
    • New partners for tolerogenic dendritic cells
    • Zhang, L., and Thomson, A.W. (2011). New partners for tolerogenic dendritic cells. Am. J. Transplant. 11, 2003-2004.
    • (2011) Am. J. Transplant. , vol.11 , pp. 2003-2004
    • Zhang, L.1    Thomson, A.W.2
  • 94
    • 33750814875 scopus 로고    scopus 로고
    • Double-negative T cells, activated by xenoantigen, lyse autologous B and T cells using a perforin/granzyme-dependent, fas-fas ligand-independent pathway
    • Zhang, Z.X., Ma, Y., Wang, H., et al. (2006). Double-negative T cells, activated by xenoantigen, lyse autologous B and T cells using a perforin/granzymedependent, Fas-Fas ligand-independent pathway. J. Immunol. 177, 6920-6929. (Pubitemid 44715058)
    • (2006) Journal of Immunology , vol.177 , Issue.10 , pp. 6920-6929
    • Zhang, Z.-X.1    Ma, Y.2    Wang, H.3    Arp, J.4    Jiang, J.5    Huang, X.6    He, K.M.7    Garcia, B.8    Madrenas, J.9    Zhong, R.10
  • 95
    • 34247359509 scopus 로고    scopus 로고
    • New differentiation pathway for double-negative regulatory T cells that regulates the magnitude of immune responses
    • DOI 10.1182/blood-2006-10-050625
    • Zhang, D., Yang, W., Degauque, N., et al. (2007). New differentiation pathway for double-negative regulatory T cells that regulates the magnitude of immune responses. Blood 109, 4071-4079. (Pubitemid 46641763)
    • (2007) Blood , vol.109 , Issue.9 , pp. 4071-4079
    • Zhang, D.1    Yang, W.2    Degauque, N.3    Tian, Y.4    Mikita, A.5    Xin, X.Z.6
  • 96
    • 0033929005 scopus 로고    scopus 로고
    • Identification of a previously unknown antigen-specific regulatory T cell and its mechanism of suppression
    • DOI 10.1038/77513
    • Zhang, Z.X., Yang, L., Young, K.J., et al. (2000). Identification of a previously unknown antigen-specific regulatory T cell and its mechanism of suppression. Nat. Med. 6, 782-789. (Pubitemid 30469427)
    • (2000) Nature Medicine , vol.6 , Issue.7 , pp. 782-789
    • Zhang, Z.-X.1    Yang, L.2    Young, K.J.3    DuTemple, B.4    Zhang, L.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.