A composite picture of TcRα/β+ CD4-CD8- T cells (α/β-DNTCs) in humans with autoimmune lymphoproliferative syndrome

Clinical Immunology

Volumn 104, Issue 1, 2002, Pages 21-30

  Bleesing, Jack J H ^a   Brown, Margaret R ^a   Novicio, Cynthia ^a   Guarraia, David ^a   Dale, Janet K ^b   Straus, Stephen E ^b   Fleisher, Thomas A ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

Apoptosis; Auto immunity; CD45; Cell surface molecules; Human; Lymphoproliferation; O glycans; T lymphocytes

Indexed keywords

CARBOHYDRATE; CD4 ANTIGEN; CD45 ANTIGEN; CD8 ANTIGEN; CELL SURFACE MARKER; FAS ANTIGEN; FAS LIGAND; INTERLEUKIN 10; LEUKOSIALIN; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; AUTOIMMUNE DISEASE; CELL SURFACE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; GLYCOSYLATION; HUMAN; HUMAN CELL; IMMUNOPHENOTYPING; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE PROLIFERATION; LYMPHOMA; LYMPHOPROLIFERATIVE DISEASE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPLENOMEGALY; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION;

EID: 0036334807     PISSN: 15216616     EISSN: None     Source Type: Journal    
DOI: 10.1006/clim.2002.5225     Document Type: Article

References (68)

1. Immunophenotyping
2. A novel lymphoproliferative/autoimmune syndrome resembling murine 1pr/gld disease
3. Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis
4. Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand
5. Dominant interfering Fas gene mutations impair apoptosis in a human lymphoproliferative syndrome
6. Mutations in Fas associated with human lymphoproliferative syndrome and autoimmunity
7. Autoimmune lymphoproliferative syndrome: A human disorder of abnormal lymphocyte apoptosis
8. Autoimmune lymphoproliferative syndrome, a disorder of apoptosis
9. Clinical, immunologic and genetic features of an autoimmune lymphoproliferative syndrome associated with abnormal lymphocyte apoptosis
10. Missense mutations in the Fas gene resulting in autoimmune lymphoproliferative syndrome: A molecular and immunological analysis
11. The development of lymphomas in families with autoimmune lymphoproliferative syndrome with germline Fas mutations and defective lymphocyte apoptosis
12. Characteristic T helper 2 T cell cytokine abnormalities in autoimmune lymphoproliferative syndrome marked by defective apoptosis and humoral autoimmunity
13. Pathological findings in human autoimmune lymphoproliferative syndrome
14. Immunophenotypic profiles in families with the autoimmune lymphoproliferative syndrome
15. - T cells in humans with the autoimmune lymphoproliferative syndrome express a novel CD45 isoform that is analogous to murine B220 and represents a marker of altered O-glycan biosynthesis
16. Abnormalities induced by the mutant gene lpr: Expansion of a unique lymphocyte subset
17. Phenotypic, functional, and molecular genetic comparisons of the abnormal lymphoid cells of C3H-lpr/lpr and C3H-gld/gld mice
18. Abnormal antigen receptor-initiated signal transduction in lpr T lymphocytes
19. - T cells in mice and humans
20. - cells: New clues to their origin and function
21. TCR Vα24 and Vβ11 coexpression defines a human NK1 T cell analog containing a unique Th0 subpopulation
22. + T cells, from normal subjects
23. Gene expression in NKT cells: Defining a functionally distinct CD1d-restricted T cell subset
24. + NK T cells associated with disease development in autoimmuneprone mice
25. Clinical, immunological, and pathological consequences of Fas-deficient conditions
26. Novel Fas (CD95/APO-1) mutations in infants with a lymphoproliferative disorder
27. The molecular basis for apoptotic defects in patients with CD95 (Fas/APO-1) mutations
28. Autoimmune lymphoproliferative syndrome (ALPS) in a child from consanguineous parents: A dominant or recessive disease?
29. Prevention of nephritis in major histocompatibility complex class II-deficient MRL-lpr mice
30. 2-microglobulin
31. + double negative T cells as the predominant populations in enlarged lymph nodes
32. Murine lupus in MRL/lpr mice lacking CD4 or CD8 T cells
33. + T cells but normal autoantibody production in lpr/lpr mice lacking major histocompatibility complex class I molecules
34. 2-microglobulin dependence of the lupus-like autoimmune syndrome of MRL-lpr mice
35. Familial CD8 deficiency due to a mutation in the CD8 alpha gene
36. Faces and phases of human CD8 T-cell development
37. + T cells
38. - cells are induced by antigen and evolve through extensive rounds of division
39. Distribution of human CMV-specific memory T cells among the CD8pos. subsets defined by CD57, CD27, and CD45 isoforms
40. Aberrant expression of CD27 and soluble CD27 (sCD27) in HIV infection and in AIDS-associated lymphoma
41. Regulation of CD27 expression on subsets of mature T-lymphocytes
42. Evidence for early onset, polyclonal activation of T cell subsets in mice homozygous for lpr
43. Lpr and gld: Single gene models of systemic autoimmunity and lymphoproliferative disease
44. Dynamic recruitment of human CD2 into lipid rafts
45. Potent apoptotic sigaling and subsequent unresponsiveness induced by a single CD2 mAb (BTI-322) in activated human peripheral T cells
46. Altered O-glycan synthesis in lymphocytes from patients with Wiskott-Aldrich syndrome
47. +T lymphocyte homeostasis by modulating O-glycan biosynthesis
48. Core 2 oligosaccharide biosynthesis distinguishes between selectin ligands essential for leukocyte homing and inflammation
49. Cutting edge: TCR signaling induces selective exclusion of CD43 from the T cell-antigen-presenting cell site
50. CD45: New jobs for an old acquaintance
51. Branched O-linked oligosaccharides ectopically expressed in transgenic mice reduce primary T-cell immune responses
52. Increases in circulating and lymphoid tissue IL-10 in autoimmune lymphoproliferative syndrome (ALPS) are associated with disease expression
53. Mechanisms of interleukin-10-mediated immune suppression
54. Control of lymphocyte circulation in man
55. CD8 naïve T cell counts decrease progressively in HIV-infected adults
56. High endothelial venules: Lymphocyte traffic control and controlled traffic
57. Prevention of lymphadenopathy in MRL-lpr/lpr mice by blocking peripheral lymph node homing with Mel-14 in vivo
58. T-cell function and migration: Two sides of the same coin
59. Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production
60. +T cells
61. In vivo-activated CD4 T cells upregulate CXC chemokine receptor 5 and reprogram their response to lymphoid chemokines
62. Circulating valpha24(+) vbeta11(+) nkt cell numbers are decreased in a wide variety of diseases that are characterized by autoreactive tissue damage
63. An invariant T cell receptor alpha chain defines a novel TAP-independent major histocompatibility complex class Ib-restricted alpha/beta T cell subpopulation in mammals
64. Identification of a previously unknown antigen-specific regulatory T cell and its mechanism of suppression
65. Generation and maintenance of memory T cells
66. Linear differentiation of cytotoxic effectors into memory T lymphocytes
67. Modelling T-cell memory by genetic marking of memory T cells in vivo
68. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions