Self-specific MHC class II-restricted CD4-CD8- T cells that escape deletion and lack regulatory activity

Journal of Immunology

Volumn 170, Issue 1, 2003, Pages 201-209

  Viret, Christophe ^a,b   Janeway Jr , Charles A ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CEA GRENOBLE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; INTERLEUKIN 2; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR ALPHA,BETA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL INTERACTION; CLONAL ANERGY; COMPLEX FORMATION; CONTROLLED STUDY; GENE DELETION; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REGULATORY MECHANISM; STROMA CELL; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; THYMOCYTE; TRANSGENIC MOUSE;

EID: 0037222541     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.170.1.201     Document Type: Article

References (69)

1. Robey, E., and B. J. Fowlkes. 1994. Selective events in T cell development. Annu. Rev. Immunol. 12:675.
2. Janeway, C. A., Jr. 1994. Thymic selection: Two pathways to life and two to death. Immunity 1:3.
3. Von Boehmer, H. 1994. Positive selection of lymphocytes. Cell 76:219.
4. Nossal, G. J. 1994. Negative selection of lymphocytes. Cell 76:229.
5. Sprent, J., and S. R. Webb. 1995. Intrathymic and extrathymic clonal deletion of T cells. Curr. Opin. Immunol. 7:196.
6. Ramsdell, F., T. Lantz, and B. J. Fowlkes. 1989. A nondeletional mechanism of thymic self tolerance. Science 246:1038.
7. Roberts, J. L., S. O. Sharrow, and A. Singer. 1990. Clonal deletion and clonal anergy in the thymus induced by cellular elements with different radiation sensitivities. J. Exp. Med. 171:935.
8. Schonrich, G., F. Momburg, G. J. Hammerling, and B. Arnold. 1992. Anergy induced by thymic medullary epithelium. Eur. J. Immunol. 22:1687.
9. Schonrich, G., U. Kalinke, F. Momburg, M. Malissen, A. M. Schmitt-Verhulst, B. Malissen, G. J. Hammerling, and B. Arnold. 1991. Down-regulation of T cell receptors on self-reactive T cells as a novel mechanism for extrathymic tolerance induction. Cell 65:293.
10. Schonrich, G., F. Momburg, M. Malissen, A. M. Schmitt-Verhulst, B. Malissen, G. J. Hammerling, and B. Arnold. 1992. Distinct mechanisms of extrathymic T cell tolerance due to differential expression of self antigen. Int. Immunol. 4:581.
11. Wang, F., C. Y. Huang, and O. Kanagawa. 1998. Rapid deletion of rearranged T cell antigen receptor (TCR) Vα-Jα segment by secondary rearrangement in the thymus: Role of continuous rearrangement of TCR a chain gene and positive selection in the T cell repertoire formation. Proc. Natl. Acad. Sci. USA 95:1834.
12. McGargill, M. A., J. M. Derbinski, and K. A. Hogquist. 2000. Receptor editing in developing T cells. Nat. Immun. 1:336.
13. Miller, J. F., and R. A. Flavell. 1994. T-cell tolerance and autoimmunity in transgenic models of central and peripheral tolerance. Curr. Opin. Immunol. 6:892.
14. Klein, L., and B. Kyewski. 2000. "Promiscuous" expression of tissue antigens in the thymus: A key to T-cell tolerance and autoimmunity? J. Mol. Med. 78:483.
15. Janeway, C. A., P. Travers, M. Walport, and M. Shlomchik. 2001. Immunobiology: The Immune System in Health and Disease, 5th Ed. Current Biology Publications/Garland Publishers, New York.
16. Viret, C., and C. A. Janeway, Jr. 2000. Functional and phenotypic evidence for presentation of Eα 52-68 structurally related self-peptide(s) in 1-Eα-deficient mice. J. Immunol. 164:4627.
17. Widera, G., L. C. Burkly, C. A. Pinkert, E. C. Bottger, C. Cowing, R. D. Palmiter, R. L. Brinster, and R. A. Flavell. 1987. Transgenic mice selectively lacking MHC class II (I-E) antigen expression on B cells: An in vivo approach to investigate 1a gene function. Cell 51:175.
18. Surh, C. D., E. K. Gao, H. Kosaka, D. Lo, C. Ahn, D. B. Murphy, L. Karlsson, P. Peterson, and J. Sprent. 1992. Two subsets of epithelial cells in the thymic medulla. J. Exp. Med. 176:495.
19. + T cells by transgenic I-E restricted to thymic medullary epithelium. J. Immunol. 151:3954.
20. Viret, C., D. B. Sant'Angelo, X. He, H. Ramaswamy, and C. A. Janeway, Jr. 2001. A role for accessibility to self-peptide-self-MHC complexes in intrathymic negative selection. J. Immunol. 166:4429.
21. Rudensky, A. Y., S. Rath, P. Preston-Hurlburt, D. B. Murphy, and C. A. Janeway, Jr. 1991. On the complexity of self. Nature 353:660.
22. Rudensky, A. Y., P. Preston-Hurlburt, S. C. Hong, A. Barlow, and C. A. Janeway, Jr. 1991. Sequence analysis of peptides bound to MHC class II molecules. Nature 353:622.
23. Murphy, D. B., S. Rath, E. Pizzo, A. Y. Rudensky, A. George, J. K. Larson, and C. A. Janeway, Jr. 1992. Monoclonal antibody detection of a major self peptide: MHC class II complex. J. Immunol. 148:3483.
24. Chervonsky, A. V., R. Medzhitov, L. K. Denzin, A. K. Barlow, A. Y. Rudensky, and C. A. Janeway, Jr. 1998. Subtle conformational changes induced in major histocompatibility complex class II molecules by binding peptides. Proc. Natl. Acad. Sci. USA 95:10094.
25. Dutton, R. W., L. M. Bradley, and S. L. Swain. 1998. T cell memory. Annu. Rev. Immunol. 16:201.
26. Viret, C., X. He, and C. A. Janeway, Jr. 2000. On the self-referential nature of naive MHC class II-restricted T cells. J. Immunol. 165:6183.
27. + T cells. J. Exp. Med. 185:405.
28. Boyd, R. L., C. L. Tucek, D. I. Godfrey, D. J. Izon, T. J. Wilson, N. J. Davidson, A. G. Bean, H. M. Ladyman, M. A. Ritter, and P. Hugo. 1993. The thymic microenvironment. Immunol. Today 14:445.
29. Yamada, H., T. Ninomiya, A. Hashimoto, K. Tamada, H. Takimoto, and K. Nomoto. 1998. Positive selection of extrathymically developed T cells by self-antigens. J. Exp. Med. 188:779.
30. Wang, R., Y. Wang-Zhu, and H. Grey. 2002. Interactions between double positive thymocytes and high affinity ligands presented by cortical epithelial cells generate double negative thymocytes with T cell regulatory activity. Proc. Natl. Acad. Sci. USA 99:2181.
31. + T cells selected by specific class I MHC antigen. Immunity 3:427.
32. + T lymphocytes: Thymic selection by self antigen. J. Immunol. 157:4379.
33. d. Proc. Natl. Acad. Sci. USA 95:8199.
34. Capone, M., M. Troesch, G. Eberl, B. Hausmann, E. Palmer, and H. R. MacDonald. 2001. A critical role for the T cell receptor a-chain connecting peptide domain in positive selection of CD1-independent NKT cells. Eur. J. Immunol. 31:1867.
35. + T cells are positively selected in the thymus by agonist self-peptides. Immunity 16:355.
36. + regulatory T cells induced by an agonist self-peptide. Nat. Immun. 2:301.
37. Viret, C., F. S. Wong, and C. A. Janeway, Jr. 1999. Designing and maintaining the mature TCR repertoire: The continuum of self-peptide:self-MHC complex recognition. Immunity 10:559.
38. Azzam, H. S., A. Grinberg, K. Lui, H. Shen, E. W. Shores, and P. E. Love. 1998. CD5 expression is developmentally regulated by T cell receptor (TCR) signals and TCR avidity. J. Exp. Med. 188:2301.
39. The, H. S., H. Kishi, B. Scott, and H. Von Boehmer. 1989. Deletion of autospecific T cells in T cell receptor (TCR) transgenic mice spares cells with normal TCR levels and low levels of CD8 molecules. J. Exp. Med. 169:795.
40. Rocha, B., and H. von Boehmer. 1991. Peripheral selection of the T cell repertoire. Science 251:1225.
41. Mamalaki, C., M. Murdjeva, M. Tolaini, T. Norton, P. Chandler, A. Townsend, E. Simpson, and D. Kioussis. 1996. Tolerance in TCR/cognate antigen double-transgenic mice mediated by incomplete thymic deletion and peripheral receptor down-regulation. Dev. Immunol. 4:299.
42. Dyson, P. J., and J. I. Elliott. 1999. Chronic deletion, escape from deletion and activation of mouse mammary tumor virus superantigen-reactive T cells in C57BL/10 mice. Eur. J. Immunol. 29:1456.
43. - αβ T cells in antigen-expressing mice. J. Immunol. 163:1222.
44. +, double-positive stage. J. Exp. Med. 184:1619.
45. Maier, C. C., A. Bhandoola, W. Borden, K. Yui, K. Hayakawa, and M. I. Greene. 1998. Unique molecular surface features of in vivo tolerized T cells. Proc. Natl. Acad. Sci. USA 95:4499.
46. + T cell responses to a self peptide. Eur. J. Immunol. 30:136.
47. Bruno, L., H. J. Fehling, and H. von Boehmer. 1996. The αβ T cell receptor can replace the γδ receptor in the development of γδ lineage cells. Immunity 5:343.
48. Von Boehmer, H. 1990. Developmental biology of T cells in T cell-receptor transgenic mice. Annu. Rev. Immunol. 8:531.
49. Von Boehmer, H., J. Kirberg, and B. Rocha. 1991. An unusual lineage of α/β T cells that contains autoreactive cells. J. Exp. Med. 174:1001.
50. Ignatowicz, L., J. Kappler, and P. Marrack. 1996. The repertoire of T cells shaped by a single MHC/peptide ligand. Cell 84:521.
51. Viret, C., X. He, and C. A. Janeway, Jr. 2001. Paradoxical intrathymic positive selection in mice with only a covalently presented agonist peptide. Proc. Natl. Acad. Sci. USA 98:9243.
52. Zal, T., S. Weiss, A. Mellor, and B. Stockinger. 1996. Expression of a second receptor rescues self-specific T cells from thymic deletion and allows activation of autoreactive effector function. Proc. Natl. Acad. Sci. USA 93:9102.
53. Stockinger, B. 1999. T lymphocyte tolerance: From thymic deletion to peripheral control mechanisms. Adv. Immunol. 71:229.
54. Girgis, L., M. M. Davis, and B. F. de St Groth. 1999. The avidity spectrum of T cell receptor interactions accounts for T cell anergy in a double transgenic model. J. Exp. Med. 189:265.
55. Kanagawa, O., J. Shimizu, and B. A. Vaupel. 2000. Thymic and postthymic regulation of diabetogenic CD8 T cell development in TCR transgenic nonobese diabetic (NOD) mice. J. Immunol. 164:5466.
56. + T cells that evade deletion by a self peptide display Th1-biased differentiation. Eur. J. Immunol. 31:311.
57. Yagi, J., and C. A. Janeway, Jr. 1990. Ligand thresholds at different stages of T cell development. Int. Immunol. 2:83.
58. Pircher, H., U. H. Rohrer, D. Moskophidis, R. M. Zirkernagel, and H. Hengartner. 1991. Lower receptor avidity required for thymic clonal deletion than for effector T-cell function. Nature 351:482.
59. Vasquez, N. J., J. Kaye, and S. M. Hedrick. 1992. In vivo and in vitro clonal deletion of double-positive thymocytes. J. Exp. Med. 175:1307.
60. Davey, G. M., S. L. Schober, B. T. Endrizzi, A. K. Dutcher, S. C. Jameson, and K. A. Hogquist. 1998. Preselection thymocytes are more sensitive to T cell receptor stimulation than mature T cells. J. Eyp. Med. 188:1867.
61. Peterson, D. A., R. J. DiPaolo, O. Kanagawa, and E. R. Unanue. 1999. Cutting edge: Negative selection of immature thymocytes by a few peptide-MHC complexes: Differential sensitivity of immature and mature T cells. J. Immunol. 162:3117.
62. Pircher, H., D. Moskophidis, U. Rohrer, K. Burki, H. Hengartner, and R. M. Zinkernagel. 1990. Viral escape by selection of cytotoxic T cell-resistant virus variants in vivo. Nature 346:629.
63. Goldrath, A. W., and M. J. Bevan. 1999. Selecting and maintaining a diverse T-cell repertoire. Nature 402:255.
64. Freitas, A. A., and B. Rocha. 2000. Population biology of lymphocytes: The flight for survival. Annu. Rev. Immunol. 18:83.
65. Kassiotis, G., S. Garcia, E. Simpson, and B. Stockinger. 2002. Impairment of immunological memory in the absence of MHC despite survival of memory T cells. Nat. Immun. 3:244.
66. Barthlott, T., R. J. Wright, and B. Stockinger. 1998. Normal thymic selection of TCR transgenic CD4 T cells but impaired survival in the periphery despite the presence of selecting MHC molecules. J. Immunol. 161:3992.
67. Wyss, M., V. von Fliedner, E. Jacot-Des-Combes, M. Jeannet, J. P. Despont, Y. Kapanci, and J. N. Cox. 1982. A lymphoproliferative syndrome, "cutaneous dystrophy" and combined immune deficiency with lack of helper T-cell factor. Clin. Immunol. Immunopathol. 23:34.
68. + T helper cells in humans augment the production of pathogenic anti-DNA autoantibodies associated with lupus nephritis. J. Immunol. 143:103.
69. Oishi, Y., T. Sumida, A. Sakamoto, Y. Kita, K. Kurasawa, Y. Nawata, K. Takabayashi, H. Takahashi, S. Yoshida, M. Taniguchi, et al. 2001. Selective reduction and recovery of invariant Vα24JαQ T cell receptor T cells in correlation with disease activity in patients with systemic lupus erythematosus. J. Rheummatol. 28:275.