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Volumn 22, Issue 5, 2010, Pages 662-668

T regulatory cells and the control of alloimmunity: From characterisation to clinical application

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIBODY; CYCLOSPORIN A; GAMMA INTERFERON; INTERLEUKIN 17; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR ALPHA; RAPAMYCIN; TRANSCRIPTION FACTOR FOXP3;

EID: 78049267160     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coi.2010.08.011     Document Type: Review
Times cited : (41)

References (46)
  • 2
    • 0347785480 scopus 로고    scopus 로고
    • Control of regulatory T cell development by the transcription factor Foxp3
    • Hori S., Nomura T., Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003, 299:1057-1061.
    • (2003) Science , vol.299 , pp. 1057-1061
    • Hori, S.1    Nomura, T.2    Sakaguchi, S.3
  • 3
    • 1642454708 scopus 로고    scopus 로고
    • Alloantigen-induced CD25+CD4+ regulatory T cells can develop in vivo from CD25-CD4+ precursors in a thymus-independent process
    • Karim M., Kingsley C.I., Bushell A.R., Sawitzki B.S., Wood K.J. Alloantigen-induced CD25+CD4+ regulatory T cells can develop in vivo from CD25-CD4+ precursors in a thymus-independent process. J Immunol 2004, 172:923-928.
    • (2004) J Immunol , vol.172 , pp. 923-928
    • Karim, M.1    Kingsley, C.I.2    Bushell, A.R.3    Sawitzki, B.S.4    Wood, K.J.5
  • 4
    • 77951638740 scopus 로고    scopus 로고
    • Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells
    • Thornton A.M., Korty P.E., Tran D.Q., Wohlfert E.A., Murray P.E., Belkaid Y., Shevach E.M. Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells. J Immunol 2010, 184:3433-3441.
    • (2010) J Immunol , vol.184 , pp. 3433-3441
    • Thornton, A.M.1    Korty, P.E.2    Tran, D.Q.3    Wohlfert, E.A.4    Murray, P.E.5    Belkaid, Y.6    Shevach, E.M.7
  • 7
    • 0037385330 scopus 로고    scopus 로고
    • Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
    • Fontenot J.D., Gavin M.A., Rudensky A.Y. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol 2003, 4:330-336.
    • (2003) Nat Immunol , vol.4 , pp. 330-336
    • Fontenot, J.D.1    Gavin, M.A.2    Rudensky, A.Y.3
  • 8
    • 34247271308 scopus 로고    scopus 로고
    • Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3
    • Williams L.M., Rudensky A.Y. Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3. Nat Immunol 2007, 8:277-284.
    • (2007) Nat Immunol , vol.8 , pp. 277-284
    • Williams, L.M.1    Rudensky, A.Y.2
  • 9
    • 70449717294 scopus 로고    scopus 로고
    • Epigenetic mechanisms of regulation of Foxp3 expression
    • Lal G., Bromberg J.S. Epigenetic mechanisms of regulation of Foxp3 expression. Blood 2009, 114:3727-3735.
    • (2009) Blood , vol.114 , pp. 3727-3735
    • Lal, G.1    Bromberg, J.S.2
  • 15
    • 60549115770 scopus 로고    scopus 로고
    • Heterogeneity of natural Foxp3+ T cells: a committed regulatory T-cell lineage and an uncommitted minor population retaining plasticity
    • Komatsu N., Mariotti-Ferrandiz M.E., Wang Y., Malissen B., Waldmann H., Hori S. Heterogeneity of natural Foxp3+ T cells: a committed regulatory T-cell lineage and an uncommitted minor population retaining plasticity. Proc Natl Acad Sci USA 2009, 106:1903-1908.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 1903-1908
    • Komatsu, N.1    Mariotti-Ferrandiz, M.E.2    Wang, Y.3    Malissen, B.4    Waldmann, H.5    Hori, S.6
  • 16
    • 72949107091 scopus 로고    scopus 로고
    • Regulatory T cells in transplantation: transferring mouse studies to the clinic
    • Long E., Wood K.J. Regulatory T cells in transplantation: transferring mouse studies to the clinic. Transplantation 2009, 88:1050-1056.
    • (2009) Transplantation , vol.88 , pp. 1050-1056
    • Long, E.1    Wood, K.J.2
  • 17
    • 0036467522 scopus 로고    scopus 로고
    • CD25+CD4+ regulatory T cells prevent graft rejection: CTLA-4- and IL-10-dependent immunoregulation of alloresponses
    • Kingsley C.I., Karim M., Bushell A.R., Wood K.J. CD25+CD4+ regulatory T cells prevent graft rejection: CTLA-4- and IL-10-dependent immunoregulation of alloresponses. J Immunol 2002, 168:1080-1086.
    • (2002) J Immunol , vol.168 , pp. 1080-1086
    • Kingsley, C.I.1    Karim, M.2    Bushell, A.R.3    Wood, K.J.4
  • 18
    • 49649108520 scopus 로고    scopus 로고
    • Anti-CD4-mediated selection of Treg in vitro-in vitro suppression does not predict in vivo capacity to prevent graft rejection
    • Oliveira V., Sawitzki B., Chapman S., Appelt C., Gebuhr I., Wieckiewicz J., Long E., Wood K.J. Anti-CD4-mediated selection of Treg in vitro-in vitro suppression does not predict in vivo capacity to prevent graft rejection. Eur J Immunol 2008, 38:1677-1688.
    • (2008) Eur J Immunol , vol.38 , pp. 1677-1688
    • Oliveira, V.1    Sawitzki, B.2    Chapman, S.3    Appelt, C.4    Gebuhr, I.5    Wieckiewicz, J.6    Long, E.7    Wood, K.J.8
  • 19
    • 52449099834 scopus 로고    scopus 로고
    • Interferon-gamma conditioning ex vivo generates CD25+CD62L+Foxp3+ regulatory T cells that prevent allograft rejection: potential avenues for cellular therapy
    • Feng G., Wood K.J., Bushell A. Interferon-gamma conditioning ex vivo generates CD25+CD62L+Foxp3+ regulatory T cells that prevent allograft rejection: potential avenues for cellular therapy. Transplantation 2008, 86:578-589.
    • (2008) Transplantation , vol.86 , pp. 578-589
    • Feng, G.1    Wood, K.J.2    Bushell, A.3
  • 20
    • 55249099643 scopus 로고    scopus 로고
    • Exogenous IFN-gamma ex vivo shapes the alloreactive T-cell repertoire by inhibition of Th17 responses and generation of functional Foxp3+ regulatory T cells
    • Feng G., Gao W., Strom T.B., Oukka M., Francis R.S., Wood K.J., Bushell A. Exogenous IFN-gamma ex vivo shapes the alloreactive T-cell repertoire by inhibition of Th17 responses and generation of functional Foxp3+ regulatory T cells. Eur J Immunol 2008, 38:2512-2527.
    • (2008) Eur J Immunol , vol.38 , pp. 2512-2527
    • Feng, G.1    Gao, W.2    Strom, T.B.3    Oukka, M.4    Francis, R.S.5    Wood, K.J.6    Bushell, A.7
  • 21
    • 72549089070 scopus 로고    scopus 로고
    • IFN-gamma triggered STAT1-PKB/AKT signalling pathway influences the function of alloantigen reactive regulatory T cells
    • Wei B., Baker S., Wieckiewicz J., Wood K.J. IFN-gamma triggered STAT1-PKB/AKT signalling pathway influences the function of alloantigen reactive regulatory T cells. Am J Transplant 2009, 10:69-80.
    • (2009) Am J Transplant , vol.10 , pp. 69-80
    • Wei, B.1    Baker, S.2    Wieckiewicz, J.3    Wood, K.J.4
  • 22
    • 45549097247 scopus 로고    scopus 로고
    • Location and time-dependent control of rejection by regulatory T cells culminates in a failure to generate memory T cells
    • Carvalho-Gaspar M., Jones N.D., Luo S., Martin L., Brook M.O., Wood K.J. Location and time-dependent control of rejection by regulatory T cells culminates in a failure to generate memory T cells. J Immunol 2008, 180:6640-6648.
    • (2008) J Immunol , vol.180 , pp. 6640-6648
    • Carvalho-Gaspar, M.1    Jones, N.D.2    Luo, S.3    Martin, L.4    Brook, M.O.5    Wood, K.J.6
  • 23
    • 34250156673 scopus 로고    scopus 로고
    • Contrasting effects of cyclosporine and rapamycin in de novo generation of alloantigen-specific regulatory T cells
    • Gao W., Lu Y., El Essawy B., Oukka M., Kuchroo V.K., Strom T.B. Contrasting effects of cyclosporine and rapamycin in de novo generation of alloantigen-specific regulatory T cells. Am J Transplant 2007, 7:1722-1732.
    • (2007) Am J Transplant , vol.7 , pp. 1722-1732
    • Gao, W.1    Lu, Y.2    El Essawy, B.3    Oukka, M.4    Kuchroo, V.K.5    Strom, T.B.6
  • 24
    • 20444373376 scopus 로고    scopus 로고
    • Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells
    • Battaglia M., Stabilini A., Roncarolo M.G. Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells. Blood 2005, 105:4743-4748.
    • (2005) Blood , vol.105 , pp. 4743-4748
    • Battaglia, M.1    Stabilini, A.2    Roncarolo, M.G.3
  • 25
    • 76249084928 scopus 로고    scopus 로고
    • Mammalian target of rapamycin inhibition and alloantigen-specific regulatory T cells synergize to promote long-term graft survival in immunocompetent recipients
    • Raimondi G., Sumpter T.L., Matta B.M., Pillai M., Corbitt N., Vodovotz Y., Wang Z., Thomson A.W. Mammalian target of rapamycin inhibition and alloantigen-specific regulatory T cells synergize to promote long-term graft survival in immunocompetent recipients. J Immunol 2010, 184:624-636.
    • (2010) J Immunol , vol.184 , pp. 624-636
    • Raimondi, G.1    Sumpter, T.L.2    Matta, B.M.3    Pillai, M.4    Corbitt, N.5    Vodovotz, Y.6    Wang, Z.7    Thomson, A.W.8
  • 28
    • 65549091509 scopus 로고    scopus 로고
    • In vivo expansion of T reg cells with IL-2-mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression
    • Webster K.E., Walters S., Kohler R.E., Mrkvan T., Boyman O., Surh C.D., Grey S.T., Sprent J. In vivo expansion of T reg cells with IL-2-mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression. J Exp Med 2009, 206:751-760.
    • (2009) J Exp Med , vol.206 , pp. 751-760
    • Webster, K.E.1    Walters, S.2    Kohler, R.E.3    Mrkvan, T.4    Boyman, O.5    Surh, C.D.6    Grey, S.T.7    Sprent, J.8
  • 33
    • 66949171924 scopus 로고    scopus 로고
    • Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor
    • Miyara M., Yoshioka Y., Kitoh A., Shima T., Wing K., Niwa A., Parizot C., Taflin C., Heike T., Valeyre D., et al. Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor. Immunity 2009, 30:899-911.
    • (2009) Immunity , vol.30 , pp. 899-911
    • Miyara, M.1    Yoshioka, Y.2    Kitoh, A.3    Shima, T.4    Wing, K.5    Niwa, A.6    Parizot, C.7    Taflin, C.8    Heike, T.9    Valeyre, D.10
  • 34
    • 70249122695 scopus 로고    scopus 로고
    • First-in-man clinical results of the treatment of patients with graft versus host disease with human ex vivo expanded CD4+CD25+CD127-T regulatory cells
    • Trzonkowski P., Bieniaszewska M., Juscinska J., Dobyszuk A., Krzystyniak A., Marek N., Mysliwska J., Hellmann A. First-in-man clinical results of the treatment of patients with graft versus host disease with human ex vivo expanded CD4+CD25+CD127-T regulatory cells. Clin Immunol 2009, 133:22-26.
    • (2009) Clin Immunol , vol.133 , pp. 22-26
    • Trzonkowski, P.1    Bieniaszewska, M.2    Juscinska, J.3    Dobyszuk, A.4    Krzystyniak, A.5    Marek, N.6    Mysliwska, J.7    Hellmann, A.8
  • 35
    • 48249098901 scopus 로고    scopus 로고
    • Ex vivo generation of human alloantigen-specific regulatory T cells from CD4(pos)CD25(high) T cells for immunotherapy
    • Peters J.H., Hilbrands L.B., Koenen H.J., Joosten I. Ex vivo generation of human alloantigen-specific regulatory T cells from CD4(pos)CD25(high) T cells for immunotherapy. PLoS ONE 2008, 3:e2233.
    • (2008) PLoS ONE , vol.3
    • Peters, J.H.1    Hilbrands, L.B.2    Koenen, H.J.3    Joosten, I.4
  • 36
    • 65549127618 scopus 로고    scopus 로고
    • Human T regulatory cell therapy: take a billion or so and call me in the morning
    • Riley J.L., June C.H., Blazar B.R. Human T regulatory cell therapy: take a billion or so and call me in the morning. Immunity 2009, 30:656-665.
    • (2009) Immunity , vol.30 , pp. 656-665
    • Riley, J.L.1    June, C.H.2    Blazar, B.R.3
  • 37
    • 66649115650 scopus 로고    scopus 로고
    • Human memory FOXP3+ Tregs secrete IL-17 ex vivo and constitutively express the T(H)17 lineage-specific transcription factor RORgamma t
    • Ayyoub M., Deknuydt F., Raimbaud I., Dousset C., Leveque L., Bioley G., Valmori D. Human memory FOXP3+ Tregs secrete IL-17 ex vivo and constitutively express the T(H)17 lineage-specific transcription factor RORgamma t. Proc Natl Acad Sci USA 2009, 106:8635-8640.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 8635-8640
    • Ayyoub, M.1    Deknuydt, F.2    Raimbaud, I.3    Dousset, C.4    Leveque, L.5    Bioley, G.6    Valmori, D.7
  • 40
    • 69449086689 scopus 로고    scopus 로고
    • Expression of GARP selectively identifies activated human FOXP3+ regulatory T cells
    • Wang R., Kozhaya L., Mercer F., Khaitan A., Fujii H., Unutmaz D. Expression of GARP selectively identifies activated human FOXP3+ regulatory T cells. Proc Natl Acad Sci USA 2009, 106:13439-13444.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 13439-13444
    • Wang, R.1    Kozhaya, L.2    Mercer, F.3    Khaitan, A.4    Fujii, H.5    Unutmaz, D.6
  • 41
    • 65549168545 scopus 로고    scopus 로고
    • Selective expression of latency-associated peptide (LAP) and IL-1 receptor type I/II (CD121a/CD121b) on activated human FOXP3+ regulatory T cells allows for their purification from expansion cultures
    • Tran D.Q., Andersson J., Hardwick D., Bebris L., Illei G.G., Shevach E.M. Selective expression of latency-associated peptide (LAP) and IL-1 receptor type I/II (CD121a/CD121b) on activated human FOXP3+ regulatory T cells allows for their purification from expansion cultures. Blood 2009, 113:5125-5133.
    • (2009) Blood , vol.113 , pp. 5125-5133
    • Tran, D.Q.1    Andersson, J.2    Hardwick, D.3    Bebris, L.4    Illei, G.G.5    Shevach, E.M.6
  • 42
    • 38949164425 scopus 로고    scopus 로고
    • Retinoic acid inhibits Th17 polarization and enhances FoxP3 expression through a Stat-3/Stat-5 independent signaling pathway
    • Elias K.M., Laurence A., Davidson T.S., Stephens G., Kanno Y., Shevach E.M., O'Shea J.J. Retinoic acid inhibits Th17 polarization and enhances FoxP3 expression through a Stat-3/Stat-5 independent signaling pathway. Blood 2008, 111:1013-1020.
    • (2008) Blood , vol.111 , pp. 1013-1020
    • Elias, K.M.1    Laurence, A.2    Davidson, T.S.3    Stephens, G.4    Kanno, Y.5    Shevach, E.M.6    O'Shea, J.J.7
  • 43
    • 45849153869 scopus 로고    scopus 로고
    • Coordination of early protective immunity to viral infection by regulatory T cells
    • Lund J.M., Hsing L., Pham T.T., Rudensky A.Y. Coordination of early protective immunity to viral infection by regulatory T cells. Science 2008, 320:1220-1224.
    • (2008) Science , vol.320 , pp. 1220-1224
    • Lund, J.M.1    Hsing, L.2    Pham, T.T.3    Rudensky, A.Y.4
  • 44
    • 14844365222 scopus 로고    scopus 로고
    • The generation of CD25+CD4+ regulatory T cells that prevent allograft rejection does not compromise immunity to a viral pathogen
    • Bushell A., Jones E., Gallimore A., Wood K. The generation of CD25+CD4+ regulatory T cells that prevent allograft rejection does not compromise immunity to a viral pathogen. J Immunol 2005, 174:3290-3297.
    • (2005) J Immunol , vol.174 , pp. 3290-3297
    • Bushell, A.1    Jones, E.2    Gallimore, A.3    Wood, K.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.