Cutting edge: In vivo trogocytosis as a mechanism of double negative regulatory T cell-mediated antigen-specific suppression

Journal of Immunology

Volumn 181, Issue 4, 2008, Pages 2271-2275

  Ford McIntyre, Megan S ^a,b   Young, Kevin J ^a,b   Gao, Julia ^a,b   Joe, Betty ^a   Zhang, Li ^a,b  

^a UNIVERSITY HEALTH NETWORK   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOANTIGEN; CD8 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN; CD4 ANTIGEN; EPITOPE; KILLER CELL LECTIN LIKE RECEPTOR SUBFAMILY B; KILLER CELL LECTIN-LIKE RECEPTOR SUBFAMILY B; LECTIN; MEMBRANE ANTIGEN; PEPTIDE FRAGMENT;

ANIMAL CELL; ANTIBODY LABELING; ANTIGEN EXPRESSION; ANTIGEN PRESENTING CELL; ANTIGEN RECOGNITION; ANTIGEN SPECIFICITY; ARTICLE; AUTOIMMUNE DISEASE; CD8+ T LYMPHOCYTE; CELL INTERACTION; CELL KILLING; CELL SURFACE; CELL TRANSFER; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOTOXICITY; GRAFT REJECTION; IMMUNE DEFICIENCY; IMMUNE RESPONSE; IMMUNOTHERAPY; IN VIVO STUDY; LYMPHOCYTE TRANSFER; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE; TROGOCYTOSIS; ANIMAL; BAGG ALBINO MOUSE; C57BL MOUSE; CELL CULTURE; CYTOLOGY; CYTOTOXIC T LYMPHOCYTE; CYTOTOXICITY TEST; GENETICS; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; METABOLISM; MOUSE MUTANT; TRANSGENIC MOUSE;

ANIMALS; ANTIGENS, CD4; ANTIGENS, CD8; ANTIGENS, SURFACE; CELLS, CULTURED; CYTOTOXICITY TESTS, IMMUNOLOGIC; EPITOPES; IMMUNE TOLERANCE; ISOANTIGENS; LECTINS, C-TYPE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MICE, SCID; MICE, TRANSGENIC; PEPTIDE FRAGMENTS; T-LYMPHOCYTES, CYTOTOXIC; T-LYMPHOCYTES, REGULATORY;

EID: 53149152263     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.181.4.2271     Document Type: Article

References (27)

1. Sakaguchi, S., and F. Powrie. 2007. Emerging challenges in regulatory T cell function and biology. Science 317: 627-629.
2. + regulatory T cells in transplantation: progress, challenges and prospects. Am. J. Transplant. 7: 1457-1463.
3. Thomson, C. W., B. P. Lee, and L. Zhang. 2006. Double-negative regulatory T cells: non-conventional regulators. Immunol. Res. 35: 163-178.
4. Hayday, A., and R. Tigelaar. 2003. Immunoregulation in the tissues by αβ T cells. Nat. Rev. Immunol. 3: 233-242.
5. Zhang, C., J. Zhang, and Z. Tian. 2006. The regulatory effect of natural killer cells: do "NK-reg cells" exist? Cell. Mol. Immunol. 3: 241-254.
6. Zhang, Z. X., L. Yang, K. J. Young, B. DuTemple, and L. Zhang. 2000. Identification of a previously unknown antigen-specific regulatory T cell and its mechanism of suppression. Nat. Med. 6: 782-789.
7. - double-negative regulatory T cells. Blood 105: 2828-2835.
8. Zhang, D., W. Yang, N. Degauque, Y. Tian, A. Mikita, and X. X. Zheng. 2007. New differentiation pathway for double-negative regulatory T cells that regulates the magnitude of immune responses. Blood 109: 4071-4079.
9. Ford, M. S., K. J. Young, Z. X. Zhang, P. S. Ohashi, and L. Zhang. 2002. The immune regulatory function of lymphoproliferative double negative T cells in vitro and in vivo. J. Exp. Med. 196: 261-267.
10. McIver, Z., B. Serio, A. Dunbar, C. L. O'Keefe, J. Powers, M. Wlodarski, T. Jin, R. Sobecks, B. Bolwell, and J. P. Maciejewski. 2008. Double-negative regulatory T cells induce allotolerance when expanded after allogeneic haematopoietic stem cell transplantation. Br. J. Haematol. 141: 170-178.
11. Young, K. J., B. Du Temple, M. J. Phillips, and L. Zhang. 2003. Inhibition of graft versus host disease by double negative regulatory T cells. J. Immunol. 171: 134-141.
12. Hudson, L., J. Sprent, J. F. Miller, and J. H. Playfair. 1974. B cell-derived immunoglobulin on activated mouse T lymphocytes. Nature 251: 60-62.
13. Joly, E., and D. Hudrisier. 2003. What is trogocytosis and what is its purpose? Nat. Immunol. 4: 815.
14. + T helper-antigen-presenting cells. J. Immunol. 174: 7497-7505.
15. Huang, J. F., Y. Yang, H. Sepulveda, W. Shi, I. Hwang, P. A. Peterson, M. R. Jackson, J. Sprent, and Z. Cai. 1999. TCR-Mediated internalization of peptide-MHC complexes acquired by T cells. Science 286: 952-954.
16. Hwang, I., J. F. Huang, H. Kishimoto, A. Brunmark, P. A. Peterson, M. R. Jackson, C. D. Surh, Z. Cai, and J. Sprent. 2000. T cells can use either T cell receptor or CD28 receptors to absorb and internalize cell surface molecules derived from antigen-presenting cells. J. Exp. Med. 191: 1137-1148.
17. Hudrisier, D., J. Riond, H. Mazarguil, J. E. Gairin, and E. Joly. 2001. Cutting edge: CTLs rapidly capture membrane fragments from target cells in a TCR signaling-dependent manner. J. Immunol. 166: 3645-3649.
18. Batista, F. D., D. Iber, and M. S. Neuberger. 2001. B cells acquire antigen from target cells after synapse formation. Nature 411: 489-494.
19. Aucher, A., E. Magdeleine, E. Joly, and D. Hudrisier. 2008. Capture of plasma membrane fragments from target cells by trogocytosis requires signaling in T cells but not in B cells. Blood 111: 5621-5638.
20. Hwang, I., and J. Sprent. 2001. Role of the actin cytoskeleton in T cell absorption and internalization of ligands from APC. J. Immunol. 166: 5099-5107.
21. LeMaoult, J., J. Caumartin, M. Daouya, B. Favier, S. Le Rond, A. Gonzalez, and E. D. Carosella. 2007. Immune regulation by pretenders: cell-to-cell transfers of HLA-G make effector T cells act as regulatory cells. Blood 109: 2040-2048.
22. Hwang, I., X. Shen, and J. Sprent. 2003. Direct stimulation of naive T cells by membrane vesicles from antigen-presenting cells: distinct roles for CD54 and B7 molecules. Proc. Natl. Acad. Sci. USA 100: 6670-6675.
23. + T cells. J. Exp. Med. 185: 641-651.
24. Young, K. J., L. M. Yang, M. J. Phillips, and L. Zhang. 2002. Donor-lymphocyte infusion induces tolerance by activating systemic and graft-infiltrating double negative T regulatory cells. Blood 100: 3408-3414.
25. Chen, W., J. Diao, S. M. Stepkowski, and L. Zhang. 2007. Both infiltrating regulatory T cells and insufficient antigen presentation are involved in long-term cardiac xenograft survival. J. Immunol. 179: 1542-1548.
26. Tsang, J. Y., J. G. Chai, and R. Lechler. 2003. Antigen presentation by mouse CD4+ T cells involving acquired MHC class II:peptide complexes: another mechanism to limit clonal expansion? Blood 101: 2704-2710.
27. Ford, M. S., W. Chen, S. Wong, C. Li, R. Vanama, A. R. Elford, S. L. Asa, P. S. Ohashi, and L. Zhang. 2007. Peptide-activated double-negative T cells can prevent autoimmune type-1 diabetes development. Eur. J. Immunol. 37: 2234-2241.