Expression profiling of murine double-negative regulatory T cells suggest mechanisms for prolonged cardiac allograft survival

Journal of Immunology

Volumn 174, Issue 8, 2005, Pages 4535-4544

  Lee, Boris P L ^a,b   Mansfield, Elaine ^c   Hsieh, Szu Chuan ^c   Hernandez Boussard, Tina ^c   Chen, Wenhao ^a,b   Thomson, Christopher W ^a,b   Ford, Megan S ^a,b   Bosinger, Steven E ^a   Der, Sandy ^b   Zhang, Zhu Xu ^a,b   Zhang, Meixia ^c   Kelvin, David J ^a,c   Sarwal, Minnie M ^c   Zhang, Li ^a,b  

^a UNIVERSITY HEALTH NETWORK   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; CHEMOKINE RECEPTOR CXCR5; FC RECEPTOR; PHOSPHOPROTEIN PHOSPHATASE; RECEPTOR SUBUNIT;

ANIMAL CELL; ANTIGEN PRESENTATION; APOPTOSIS; ARTICLE; CARDIAC GRAFT REJECTION; CELL KILLING; CHEMOTAXIS; CONTROLLED STUDY; DOWN REGULATION; FLUORESCENCE ACTIVATED CELL SORTING; GENE EXPRESSION; GRAFT SURVIVAL; HEART TRANSPLANTATION; IMMUNE RESPONSE; IMMUNOREGULATION; LYMPHOCYTE FUNCTION; LYMPHOCYTE PROLIFERATION; MOLECULAR CLONING; MOUSE; MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SURVIVAL TIME; T LYMPHOCYTE;

EID: 20144389329     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.174.8.4535     Document Type: Article

References (68)

1. + regulatory T cells for immunologic self-tolerance and negative control of immune responses. Annu. Rev. Immunol. 22:531.
2. O'Garra, A., and P. Vieira. 2004. Regulatory T cells and mechanisms of immune system control. Nat. Med. 10:801.
3. Lechler, R. I., O. A. Garden, and L. A. Turka. 2003. The complementary roles of deletion and regulation in transplantation tolerance. Nat. Rev. Immunol. 3:147.
4. Robinson, D. S., M. Larche, and S. R. Durham. 2004. Tregs and allergic disease. J. Clin. Invest. 114:1389.
5. Mills, K. H. 2004. Regulatory T cells: friend or foe in immunity to infection? Nat. Rev. Immunol. 4:841.
6. + regulatory T cells in antitumor therapy reveals alternative pathways for suppression of autoreactive cytotoxic T lymphocyte responses. J. Exp. Med. 194:823.
7. Sakaguchi, S., N. Sakaguchi, M. Asano, M. Itoh, and M. Toda. 1995. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25): breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 155:1151.
8. + T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 389:737.
9. + regulatory T cells. J. Exp. Med. 199:303.
10. - regulatory cells mediate dominant transplantation tolerance. J. Immunol. 168:5558.
11. + tolerogenic endothelial cells, inhibiting alloreactivity. Int. Immunol. 16:1055.
12. Skelsey, M. E., J. Mellon, and J. Y. Niederkorn. 2001. γ δ T cells are needed for ocular immune privilege and corneal graft survival. J. Immunol. 166:4327.
13. Godfrey, D. I., and M. Kronenberg. 2004. Going both ways: immune regulation via CD1d-dependent NKT cells. J. Clin. Invest. 114:1379.
14. Young, K. J., B. DuTemple, M. J. Phillips, and L. Zhang. 2003. Inhibition of graft-versus-host disease by double-negative regulatory T cells. J. Immunol. 171:134.
15. Zhang, Z. X., L. Yang, K. J. Young, B. DuTemple, and L. Zhang. 2000. Identification of a previously unknown antigen-specific regulatory T cell and its mechanism of suppression. Nat. Med. 6:782.
16. Chen, W., M. S. Ford, K. J. Young, M. I. Cybulsky, and L. Zhang. 2003. Role of double-negative regulatory T cells in long-term cardiac xenograft survival. J. Immunol. 170:1846.
17. Ford, M. S., K. J. Young, Z. Zhang, P. S. Ohashi, and L. Zhang. 2002. The immune regulatory function of lymphoproliferative double negative T cells in vitro and in vivo. J. Exp. Med. 196:261.
18. - double negative regulatory T cells. Blood. In press.
19. Sarwal, M. M., J. R. Vidhun, S. R. Alexander, T. Satterwhite, M. Millan, and O. Salvatierra, Jr. 2003. Continued superior outcomes with modification and lengthened follow-up of a steroid-avoidance pilot with extended daclizumab induction in pediatric renal transplantation. Transplantation 76:1331.
20. Damrauer, S. M., R. DeFina, H. He, K. J. Haley, and D. L. Perkins. 2002. Molecular profiles of allograft rejection following inhibition of CD40 ligand costimulation differentiated by cluster analysis. J. Leukocyte Biol. 71:348.
21. Scherer, A., A. Krause, J. R. Walker, A. Korn, D. Niese, and F. Raulf. 2003. Early prognosis of the development of renal chronic allograft rejection by gene expression profiling of human protocol biopsies. Transplantation 75:1323.
22. + immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor. Immunity 16:311.
23. +. Ann. NY Acad. Sci. 1005:279.
24. Hori, S., T. Nomura, and S. Sakaguchi. 2003. Control of regulatory T cell development by the transcription factor Foxp3. Science 299:1057.
25. + regulatory thymocytes. Blood 102:4107.
26. Bruder, D., M. Probst-Kepper, A. M. Westendorf, R. Geffers, S. Beissert, K. Loser, H. von Boehmer, J. Buer, and W. Hansen. 2004. Neuropilin-1: a surface marker of regulatory T cells. Eur. J. Immunol. 34:1498.
27. Priatel, J. J., O. Utting, and H. S. Teh. 2001. TCR/self-antigen interactions drive double-negative T cell peripheral expansion and differentiation into suppressor cells. J. Immunol. 167:6188.
28. Young, K. J., L. Yang, M. J. Phillips, and L. Zhang. 2002. Donor-lymphocyte infusion induces transplantation tolerance by activating systemic and graft-infiltrating double-negative regulatory T cells. Blood 100:3408.
29. Sha, W. C., C. A. Nelson, R. D. Newberry, D. M. Kranz, J. H. Russell, and D. Y. Loh. 1988. Positive and negative selection of an antigen receptor on T cells in transgenic mice. Nature 336:73.
30. Sherlock, G., T. Hernandez-Boussard, A. Kasarskis, G. Binkley, J. C. Matese, S. S. Dwight, M. Kaloper, S. Weng, H. Jin, C. A. Ball, et al. 2001. The Stanford microarray database. Nucleic Acids Res. 29:152.
31. Eisen, M. B., P. T. Spellman, P. O. Brown, and D. Botstein. 1998. Cluster analysis and display of genome-wide expression patterns. Proc. Natl. Acad. Sci. USA 95:14863.
32. Tusher, V. G., R. Tibshirani, and G. Chu. 2001. Significance analysis of microarrays applied to the ionizing radiation response. Proc. Natl. Acad. Sci. USA 98:5116.
33. Tibshirani, R., T. Hastie, B. Narasimhan, and G. Chu. 2002. Diagnosis of multiple cancer types by shrunken centroids of gene expression. Proc. Natl. Acad. Sci. USA 99:6567.
34. Dennis, G., Jr., B. T. Sherman, D. A. Hosack, J. Yang, W. Gao, H. C. Lane, and R. A. Lempicki. 2003. DAVID: database for annotation, visualization, and integrated discovery. Genome Biol. 4:3.
35. Takayama, H., G. Trenn, W. Humphrey, Jr., J. A. Bluestone, P. A. Henkart, and M. V. Sitkovsky. 1987. Antigen receptor-triggered secretion of a trypsin-type esterase from cytotoxic T lymphocytes. J. Immunol. 138:566.
36. Hahn, S., R. Gehri, and P. Erb. 1995. Mechanism and biological significance of CD4-mediated cytotoxicity. Immunol. Rev. 146:57.
37. Dzialo-Hatton, R., J. Milbrandt, R. D. Hockett, Jr., and C. T. Weaver. 2001. Differential expression of Fas ligand in Th1 and Th2 cells is regulated by early growth response gene and NF-AT family members. J. Immunol. 166:4534.
38. Droin, N. M., M. J. Pinkoski, E. Dejardin, and D. R. Green. 2003. Egr family members regulate nonlymphoid expression of Fas ligand, TRAIL, and tumor necrosis factor during immune responses. Mol. Cell. Biol. 23:7638.
39. Griffith, T. S., T. Brunner, S. M. Fletcher, D. R. Green, and T. A. Ferguson. 1995. Fas ligand-induced apoptosis as a mechanism of immune privilege. Science 270:1189.
40. + regulatory T cells. J. Immunol. 173:4433.
41. Daeron, M. 1997. Fc receptor biology. Annu. Rev. Immunol. 15:203.
42. Petersson, K., and F. Ivars. 2001. Early TCR α β expression promotes maturation of T cells expressing FcεRIγ containing TCR/CD3 complexes. J. Immunol. 166:6616.
43. Krishnan, S., V. G. Warke, M. P. Nambiar, G. C. Tsokos, and D. L. Farber. 2003. The FcRγ subunit and Syk kinase replace the CD3 ζ-chain and ZAP-70 kinase in the TCR signaling complex of human effector CD4 T cells. J. Immunol. 170:4189.
44. Graca, L., S. P. Cobbold, and H. Waldmann. 2002. Identification of regulatory T cells in tolerated allografts. J. Exp. Med. 195:1641.
45. Dobner, T., I. Wolf, T. Emrich, and M. Lipp. 1992. Differentiation- specific expression of a novel G protein-coupled receptor from Burkitt's lymphoma. Eur. J. Immunol. 22:2795.
46. Forster, R., T. Emrich, E. Kremmer, and M. Lipp. 1994. Expression of the G-protein-coupled receptor BLR1 defines mature, recirculating B cells and a subset of T-helper memory cells. Blood 84:830.
47. Ansel, K. M., L. J. McHeyzer-Williams, V. N. Ngo, M. G. McHeyzer-Williams, and J. G. Cyster. 1999. In vivo-activated CD4 T cells up-regulate CXC chemokine receptor 5 and reprogram their response to lymphoid chemokines. J. Exp. Med. 190:1123.
48. Legler, D. F., M. Loetscher, R. S. Roos, I. Clark-Lewis, M. Baggiolini, and B. Moser. 1998. B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5. J. Exp. Med. 187:655.
49. Schaerli, P., K. Willimann, A. B. Lang, M. Lipp, P. Loetscher, and B. Moser. 2000. CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function. J. Exp. Med. 192:1553.
50. Fahmy, N. M., M. H. Yamani, R. C. Starling, N. B. Ratliff, J. B. Young, P. M. McCarthy, J. Feng, A. C. Novick, and R. L. Fairchild. 2003. Chemokine and receptor-gene expression during early and late acute rejection episodes in human cardiac allografts. Transplantation 75:2044.
51. Schroppel, B., N. Zhang, P. Chen, W. Zang, D. Chen, K. L. Hudkins, W. A. Kuziel, R. Sung, J. S. Bromberg, and B. Murphy. 2004. Differential expression of chemokines and chemokine receptors in murine islet allografts: the role of CCR2 and CCR5 signaling pathways. J. Am. Soc. Nephrol. 15:1853.
52. Abdi, R., T. K. Means, T. Ito, R. N. Smith, N. Najafian, M. Jurewicz, V. Tchipachvili, I. Charo, H. Auchincloss, Jr., M. H. Sayegh, and A. D. Luster. 2004. Differential role of CCR2 in islet and heart allograft rejection: tissue specificity of chemokine/chemokine receptor function in vivo. J. Immunol. 172:767.
53. Midha, R., C. A. Munro, V. Ramakrishna, T. Matsuyama, and R. M. Gorczynski. 2004. Chemokine expression in nerve allografts. Neurosurgery 54:1472.
54. Solomon, M. F., W. A. Kuziel, D. A. Mann, and C. J. Simeonovic. 2003. The role of chemokines and their receptors in the rejection of pig islet tissue xenografts. Xenotransplantation 10:164.
55. - antigen-specific suppressor T cell clones. J. Immunol. 162:5860.
56. Marra, L. E., Z. X. Zhang, B. Joe, J. Campbell, G. A. Levy, J. Penninger, and L. Zhang. 2004. IL-10 induces regulatory T cell apoptosis by up-regulation of the membrane form of TNF-α. J. Immunol. 172:1028.
57. Miyagawa, S., T., Kubo, K. Matsunami, T. Kusama, K. Beppu, H. Nozaki, T. Moritan, C. Ahn, J. Y., Kim, D. Fukuta, and R. Shirakura. 2004. Delta-short consensus repeat 4-decay accelerating factor (DAF: CD55) inhibits complement-mediated cytolysis but not NK cell-mediated cytolysis. J. Immunol. 173:3945.
58. Kusama, T., S. Miyagawa, T. Moritan, T. Kubo, M. Yamada, H. Sata, D. Fukuta, K. Matsunami, and R. Shirakura. 2003. Down-regulation of NK cell-mediated swine endothelial cell lysis by DAF (CD55). Transplant. Proc. 35:529.
59. Jia, H., A. Bagherzadeh, R. Bicknell, M. R. Duchen, D. Liu, and I. Zachary. 2004. Vascular endothelial growth factor (VEGF)-D and VEGF-A differentially regulate KDR-mediated signaling and biological function in vascular endothelial cells. J. Biol. Chem. 279:36148.
60. Nor, J. E., J. Christensen, D. J. Mooney, and P. J. Polverini. 1999. Vascular endothelial growth factor (VEGF)-mediated angiogenesis is associated with enhanced endothelial cell survival and induction of Bcl-2 expression. Am. J. Pathol. 154:375.
61. Young, K. J., and L. Zhang. 2002. The nature and mechanisms of DN regulatory T-cell mediated suppression. Hum. Immunol. 63:926.
62. Chow, L. M., M. Fournel, D. Davidson, and A. Veillette. 1993. Negative regulation of T-cell receptor signalling by tyrosine protein kinase p50csk. Nature 365:156.
63. Mustelin, T., and K. Tasken. 2003. Positive and negative regulation of T-cell activation through kinases and phosphatases. Biochem. J. 371:15.
64. Palacios, E. H., and A. Weiss. 2004. Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation. Oncogene 23:7990.
65. + regulatory T cells. Nat. Immunol. 4:330.
66. + T regulatory cells. Nat. Immunol. 4:337.
67. +. J. Clin. Invest. 112:1437.
68. + suppressor T cells in vivo. Nat. Immunol. 3:33.