How do CD4+CD25+ regulatory T cells control autoimmunity?

Current Opinion in Immunology

Volumn 17, Issue 6, 2005, Pages 638-642

  Bluestone, Jeffrey A ^a   Tang, Qizhi ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; INTERLEUKIN 2 RECEPTOR ALPHA;

AUTOIMMUNITY; DENDRITIC CELL; GENE CONTROL; GENE LOCATION; GENETIC LINKAGE; IMMUNE RESPONSE; MEDICAL LITERATURE; MICROENVIRONMENT; NONHUMAN; REVIEW; T LYMPHOCYTE; VALIDATION PROCESS;

ANIMALS; AUTOIMMUNITY; DENDRITIC CELLS; INFLAMMATION; MICE; RECEPTORS, INTERLEUKIN-2; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, REGULATORY;

EID: 27144495833     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coi.2005.09.002     Document Type: Review

References (49)

1. L. Chatenoud, B. Salomon, and J.A. Bluestone Suppressor T cells-they're back and critical for regulation of autoimmunity! Immunol Rev 182 2001 149 163
2. M.R. Ehrenstein, J.G. Evans, A. Singh, S. Moore, G. Warnes, D.A. Isenberg, and C. Mauri Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFalpha therapy J Exp Med 200 2004 277 285
3. S. Lindley, C.M. Dayan, A. Bishop, B.O. Roep, M. Peakman, and T.I. Tree Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes Diabetes 54 2005 92 99
4. V. Viglietta, C. Baecher-Allan, H.L. Weiner, and D.A. Hafler Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis J Exp Med 199 2004 971 979
5. J.A. Bluestone, and A.K. Abbas Natural versus adaptive regulatory T cells Nat Rev Immunol 3 2003 253 257
6. M.A. Lerman, J. Larkin III, C. Cozzo, M.S. Jordan, and A.J. Caton CD4+ CD25+ regulatory T cell repertoire formation in response to varying expression of a neo-self-antigen J Immunol 173 2004 236 244
7. C.S. Hsieh, Y. Liang, A.J. Tyznik, S.G. Self, D. Liggitt, and A.Y. Rudensky Recognition of the peripheral self by naturally arising CD25+ CD4+ T cell receptors Immunity 21 2004 267 277 This is a clear demonstration that the T cell repertoire of natural Tregs is skewed towards autoreactivity.
8. C.T. Huang, C.J. Workman, D. Flies, X. Pan, A.L. Marson, G. Zhou, E.L. Hipkiss, S. Ravi, J. Kowalski, and H.I. Levitsky Role of LAG-3 in regulatory T cells Immunity 21 2004 503 513
9. S. Sakaguchi Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self Nat Immunol 6 2005 345 352
10. S. Fu, N. Zhang, A.C. Yopp, D. Chen, M. Mao, H. Zhang, Y. Ding, and J.S. Bromberg TGF-beta induces Foxp3 + T-regulatory cells from CD4 + CD25 - precursors Am J Transplant 4 2004 1614 1627
11. M.K. Levings, and M.G. Roncarolo Phenotypic and functional differences between human CD4+CD25+ and type 1 regulatory T cells Curr Top Microbiol Immunol 293 2005 303 326
12. E.M. Shevach, R.S. McHugh, C.A. Piccirillo, and A.M. Thornton Control of T-cell activation by CD4+ CD25+ suppressor T cells Immunol Rev 182 2001 58 67
13. C. Asseman, S. Mauze, M.W. Leach, R.L. Coffman, and F. Powrie An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation J Exp Med 190 1999 995 1004
14. M.G. Roncarolo, R. Bacchetta, C. Bordignon, S. Narula, and M.K. Levings Type 1 T regulatory cells Immunol Rev 182 2001 68 79
15. K. Nakamura, A. Kitani, and W. Strober Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta J Exp Med 194 2001 629 644
16. M. Belghith, J.A. Bluestone, S. Barriot, J. Megret, J.F. Bach, and L. Chatenoud TGF-beta-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes Nat Med 9 2003 1202 1208
17. H. Jonuleit, E. Schmitt, H. Kakirman, M. Stassen, J. Knop, and A.H. Enk Infectious tolerance: human CD25(+) regulatory T cells convey suppressor activity to conventional CD4(+) T helper cells J Exp Med 196 2002 255 260
18. M.G. von Herrath, and L.C. Harrison Antigen-induced regulatory T cells in autoimmunity Nat Rev Immunol 3 2003 223 232
19. Q. Tang, K.J. Henriksen, M. Bi, E.B. Finger, G. Szot, J. Ye, E.L. Masteller, H. McDevitt, M. Bonyhadi, and J.A. Bluestone In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes J Exp Med 199 2004 1455 1465 This is the first demonstration that autoantigen-specific Tregs can be expanded and used to suppress Type 1 diabetes in an efficient manner.
20. P.A. Taylor, C.J. Lees, and B.R. Blazar The infusion of ex vivo activated and expanded CD4(+)CD25(+) immune regulatory cells inhibits graft-versus-host disease lethality Blood 99 2002 3493 3499
21. T. Barthlott, G. Kassiotis, and B. Stockinger T cell regulation as a side effect of homeostasis and competition J Exp Med 197 2003 451 460
22. R.K. Gershon, and K. Kondo Infectious immunological tolerance Immunology 21 1971 903 914
23. K.J. Wood, and S. Sakaguchi Regulatory T cells in transplantation tolerance Nat Rev Immunol 3 2003 199 210
24. E.A. Green, L. Gorelik, C.M. McGregor, E.H. Tran, and R.A. Flavell CD4+CD25+ T regulatory cells control anti-islet CD8+ T cells through TGF-beta-TGF-beta receptor interactions in type 1 diabetes Proc Natl Acad Sci USA 100 2003 10878 10883
25. Y. Belkaid, C.A. Piccirillo, S. Mendez, E.M. Shevach, and D.L. Sacks CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity Nature 420 2002 502 507
26. J.L. Coombes, N.J. Robinson, K.J. Maloy, H.H. Uhlig, and F. Powrie Regulatory T cells and intestinal homeostasis Immunol Rev 204 2005 184 194
27. S. Stoll, J. Delon, T.M. Brotz, and R.N. Germain Dynamic imaging of T cell-dendritic cell interactions in lymph nodes Science 296 2002 1873 1876
28. T.R. Mempel, S.E. Henrickson, and U.H. Von Andrian T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases Nature 427 2004 154 159 These authors demonstrate the usefulness of 2-photon microscopy in the study of dendritic cell biology in vivo.
29. M.J. Miller, S.H. Wei, I. Parker, and M.D. Cahalan Two-photon imaging of lymphocyte motility and antigen response in intact lymph node Science 296 2002 1869 1873
30. S. Yamazaki, T. Iyoda, K. Tarbell, K. Olson, K. Velinzon, K. Inaba, and R.M. Steinman Direct expansion of functional CD25+ CD4+ regulatory T cells by antigen-processing dendritic cells J Exp Med 198 2003 235 247
31. G. Oldenhove, M. de Heusch, G. Urbain-Vansanten, J. Urbain, C. Maliszewski, O. Leo, and M. Moser CD4+ CD25+ regulatory T cells control T helper cell type 1 responses to foreign antigens induced by mature dendritic cells in vivo J Exp Med 198 2003 259 266
32. Y. Cong, A. Konrad, N. Iqbal, R.D. Hatton, C.T. Weaver, and C.O. Elson Generation of antigen-specific, Foxp3-expressing CD4+ regulatory T cells by inhibition of APC proteosome function J Immunol 174 2005 2787 2795
33. H. Kared, A. Masson, H. Adle-Biassette, J.F. Bach, L. Chatenoud, and F. Zavala Treatment with granulocyte colony-stimulating factor prevents diabetes in NOD mice by recruiting plasmacytoid dendritic cells and functional CD4(+)CD25(+) regulatory T-cells Diabetes 54 2005 78 84
34. J. Bilsborough, T.C. George, A. Norment, and J.L. Viney Mucosal CD8alpha+ DC, with a plasmacytoid phenotype, induce differentiation and support function of T cells with regulatory properties Immunology 108 2003 481 492
35. N. Misra, J. Bayry, S. Lacroix-Desmazes, M.D. Kazatchkine, and S.V. Kaveri Cutting edge: human CD4+CD25+ T cells restrain the maturation and antigen-presenting function of dendritic cells J Immunol 172 2004 4676 4680
36. L. Cederbom, H. Hall, and F. Ivars CD4+CD25+ regulatory T cells down-regulate co-stimulatory molecules on antigen-presenting cells Eur J Immunol 30 2000 1538 1543
37. P. Serra, A. Amrani, J. Yamanouchi, B. Han, S. Thiessen, T. Utsugi, J. Verdaguer, and P. Santamaria CD40 ligation releases immature dendritic cells from the control of regulatory CD4+CD25+ T cells Immunity 19 2003 877 889
38. K. Sato, S. Tateishi, K. Kubo, T. Mimura, K. Yamamoto, and H. Kanda Downregulation of IL-12 and a novel negative feedback system mediated by CD25+CD4+ T cells Biochem Biophys Res Commun 330 2005 226 232
39. C. Pasare, and R. Medzhitov Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells Science 299 2003 1033 1036
40. J.C. Ochado, A.C. Yopp, Y. Yang, A. Garin, Y. Li, P. Boros, J. Llodra, Y. Ding, S.A. Lira, and N.R. Krieger Lymph node occupancy is required for the peripheral development of alloantigen-specific Foxp3+ regulatory T cells J Immunol 174 2005 6993 7005
41. B. Salomon, D.J. Lenschow, L. Rhee, N. Ashourian, B. Singh, A. Sharpe, and J.A. Bluestone B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes Immunity 12 2000 431 440
42. E.A. Green, Y. Choi, and R.A. Flavell Pancreatic lymph node-derived CD4(+)CD25(+) Treg cells: highly potent regulators of diabetes that require TRANCE-RANK signals Immunity 16 2002 183 191
43. H. Bour-Jordan, B.L. Salomon, H.L. Thompson, G.L. Szot, M.R. Bernhard, and J.A. Bluestone Costimulation controls diabetes by altering the balance of pathogenic and regulatory T cells J Clin Invest 114 2004 979 987
44. S. You, M. Belghith, S. Cobbold, M.A. Alyanakian, C. Gouarin, S. Barriot, C. Garcia, H. Waldmann, J.F. Bach, and L. Chatenoud Autoimmune diabetes onset results from qualitative rather than quantitative age-dependent changes in pathogenic T-cells Diabetes 54 2005 1415 1422 This study emphasizes both the changes in Treg function and loss of responsiveness of effector T cells to Treg activity in older NOD mice.
45. L. Graca, S.P. Cobbold, and H. Waldmann Identification of regulatory T cells in tolerated allografts J Exp Med 195 2002 1641 1646
46. B. Ludewig, B. Odermatt, S. Landmann, H. Hengartner, and R.M. Zinkernagel Dendritic cells induce autoimmune diabetes and maintain disease via de novo formation of local lymphoid tissue J Exp Med 188 1998 1493 1501
47. M.C. Gagnerault, J.J. Luan, C. Lotton, and F. Lepault Pancreatic lymph nodes are required for priming of beta cell reactive T cells in NOD mice J Exp Med 196 2002 369 377
48. J. Huehn, K. Siegmund, J.C. Lehmann, C. Siewert, U. Haubold, M. Feuerer, G.F. Debes, J. Lauber, O. Frey, and G.K. Przybylski Developmental stage, phenotype, and migration distinguish naive- and effector/memory-like CD4+ regulatory T cells J Exp Med 199 2004 303 313
49. Siegmund K, Feuerer M, Siewert C, Ghani S, Haubold U, Dankof A, Krenn V, Schon MP, Scheffold A, Lowe JB et al.: Migration matters: regulatory T cell compartmentalization determines suppressive activity in vivo. Blood 2005, DOI 10.1182/blood-2005-05-1864 (prepublished online July 12, 2005). This study emphasizes the clear relationship between the migratory properties of Tregs and their function activity in vivo. The authors describe experiments using migration antagonists to demonstrate the importance of location in Treg function.