-
1
-
-
0037449737
-
Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17
-
S. Aggarwal, N. Ghilardi, M.H. Xie, F.J. de Sauvage, and A.L. Gurney Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17 J. Biol. Chem. 278 2003 1910 1914
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 1910-1914
-
-
Aggarwal, S.1
Ghilardi, N.2
Xie, M.H.3
De Sauvage, F.J.4
Gurney, A.L.5
-
2
-
-
0036677420
-
Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12
-
B. Becher, B.G. Durell, and R.J. Noelle Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12 J. Clin. Invest. 110 2002 493 497
-
(2002)
J. Clin. Invest.
, vol.110
, pp. 493-497
-
-
Becher, B.1
Durell, B.G.2
Noelle, R.J.3
-
3
-
-
0347357773
-
IL-23 produced by CNS-resident cells controls T cell encephalitogenicity during the effector phase of experimental autoimmune encephalomyelitis
-
B. Becher, B.G. Durell, and R.J. Noelle IL-23 produced by CNS-resident cells controls T cell encephalitogenicity during the effector phase of experimental autoimmune encephalomyelitis J. Clin. Invest. 112 2003 1186 1191
-
(2003)
J. Clin. Invest.
, vol.112
, pp. 1186-1191
-
-
Becher, B.1
Durell, B.G.2
Noelle, R.J.3
-
4
-
-
0033583431
-
Lineage-specific requirement for signal transducer and activator of transcription (Stat)4 in interferon gamma production from CD4(+) versus CD8(+) T cells
-
L.L. Carter, and K.M. Murphy Lineage-specific requirement for signal transducer and activator of transcription (Stat)4 in interferon gamma production from CD4(+) versus CD8(+) T cells J. Exp. Med. 189 1999 1355 1360
-
(1999)
J. Exp. Med.
, vol.189
, pp. 1355-1360
-
-
Carter, L.L.1
Murphy, K.M.2
-
5
-
-
0025819340
-
Induction of interferon gamma production by natural killer cell stimulatory factor: Characterization of the responder cells and synergy with other inducers
-
S.H. Chan, B. Perussia, J.W. Gupta, M. Kobayashi, M. Pospisil, H.A. Young, S.F. Wolf, D. Young, S.C. Clark, and G. Trinchieri Induction of interferon gamma production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers J. Exp. Med. 173 1991 869 879
-
(1991)
J. Exp. Med.
, vol.173
, pp. 869-879
-
-
Chan, S.H.1
Perussia, B.2
Gupta, J.W.3
Kobayashi, M.4
Pospisil, M.5
Young, H.A.6
Wolf, S.F.7
Young, D.8
Clark, S.C.9
Trinchieri, G.10
-
6
-
-
0034601012
-
Failure to suppress the expansion of the activated CD4 T cell population in interferon gamma-deficient mice leads to exacerbation of experimental autoimmune encephalomyelitis
-
C.Q. Chu, S. Wittmer, and D.K. Dalton Failure to suppress the expansion of the activated CD4 T cell population in interferon gamma-deficient mice leads to exacerbation of experimental autoimmune encephalomyelitis J. Exp. Med. 192 2000 123 128
-
(2000)
J. Exp. Med.
, vol.192
, pp. 123-128
-
-
Chu, C.Q.1
Wittmer, S.2
Dalton, D.K.3
-
7
-
-
0032211092
-
Antibodies against IL-12 prevent superantigen-induced and spontaneous relapses of experimental autoimmune encephalomyelitis
-
C.S. Constantinescu, M. Wysocka, B. Hilliard, E.S. Ventura, E. Lavi, G. Trinchieri, and A. Rostami Antibodies against IL-12 prevent superantigen-induced and spontaneous relapses of experimental autoimmune encephalomyelitis J. Immunol. 161 1998 5097 5104
-
(1998)
J. Immunol.
, vol.161
, pp. 5097-5104
-
-
Constantinescu, C.S.1
Wysocka, M.2
Hilliard, B.3
Ventura, E.S.4
Lavi, E.5
Trinchieri, G.6
Rostami, A.7
-
8
-
-
0037434789
-
Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
-
D.J. Cua, J. Sherlock, Y. Chen, C.A. Murphy, B. Joyce, B. Seymour, L. Lucian, W. To, S. Kwan, T. Churakova, S. Zurawski, M. Wiekowski, S.A. Lira, D. Gorman, R.A. Kastelein, and J.D. Sedgwick Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain Nature 421 2003 744 748
-
(2003)
Nature
, vol.421
, pp. 744-748
-
-
Cua, D.J.1
Sherlock, J.2
Chen, Y.3
Murphy, C.A.4
Joyce, B.5
Seymour, B.6
Lucian, L.7
To, W.8
Kwan, S.9
Churakova, T.10
Zurawski, S.11
Wiekowski, M.12
Lira, S.A.13
Gorman, D.14
Kastelein, R.A.15
Sedgwick, J.D.16
-
9
-
-
0035472079
-
IFN-gamma production by antigen-presenting cells: Mechanisms emerge
-
D.M. Frucht, T. Fukao, C. Bogdan, H. Schindler, J.J. O'Shea, and S. Koyasu IFN-gamma production by antigen-presenting cells: mechanisms emerge Trends Immunol. 22 2001 556 560
-
(2001)
Trends Immunol.
, vol.22
, pp. 556-560
-
-
Frucht, D.M.1
Fukao, T.2
Bogdan, C.3
Schindler, H.4
O'Shea, J.J.5
Koyasu, S.6
-
10
-
-
0037114150
-
IL-12p35-deficient mice are susceptible to experimental autoimmune encephalomyelitis: Evidence for redundancy in the IL-12 system in the induction of central nervous system autoimmune demyelination
-
B. Gran, G.X. Zhang, S. Yu, J. Li, X.H. Chen, E.S. Ventura, M. Kamoun, and A. Rostami IL-12p35-deficient mice are susceptible to experimental autoimmune encephalomyelitis: evidence for redundancy in the IL-12 system in the induction of central nervous system autoimmune demyelination J. Immunol. 169 2002 7104 7110
-
(2002)
J. Immunol.
, vol.169
, pp. 7104-7110
-
-
Gran, B.1
Zhang, G.X.2
Yu, S.3
Li, J.4
Chen, X.H.5
Ventura, E.S.6
Kamoun, M.7
Rostami, A.8
-
11
-
-
0035801332
-
A pathogenic role for myelin-specific CD8(+) T cells in a model for multiple sclerosis
-
E.S. Huseby, D. Liggitt, T. Brabb, B. Schnabel, C. Ohlen, and J. Goverman A pathogenic role for myelin-specific CD8(+) T cells in a model for multiple sclerosis J. Exp. Med. 194 2001 669 676
-
(2001)
J. Exp. Med.
, vol.194
, pp. 669-676
-
-
Huseby, E.S.1
Liggitt, D.2
Brabb, T.3
Schnabel, B.4
Ohlen, C.5
Goverman, J.6
-
12
-
-
0036838565
-
Effect of IL-12 on TNF-alpha-mediated osteoclast formation in bone marrow cells: Apoptosis mediated by Fas/Fas ligand interaction
-
H. Kitaura, N. Nagata, Y. Fujimura, H. Hotokezaka, N. Yoshida, and K. Nakayama Effect of IL-12 on TNF-alpha-mediated osteoclast formation in bone marrow cells: apoptosis mediated by Fas/Fas ligand interaction J. Immunol. 169 2002 4732 4738
-
(2002)
J. Immunol.
, vol.169
, pp. 4732-4738
-
-
Kitaura, H.1
Nagata, N.2
Fujimura, Y.3
Hotokezaka, H.4
Yoshida, N.5
Nakayama, K.6
-
13
-
-
0032476615
-
Immune suppression by recombinant interleukin (rIL)-12 involves interferon gamma induction of nitric oxide synthase 2 (iNOS) activity: Inhibitors of NO generation reveal the extent of rIL-12 vaccine adjuvant effect
-
H.K. Koblish, C.A. Hunter, M. Wysocka, G. Trinchieri, and W.M. Lee Immune suppression by recombinant interleukin (rIL)-12 involves interferon gamma induction of nitric oxide synthase 2 (iNOS) activity: inhibitors of NO generation reveal the extent of rIL-12 vaccine adjuvant effect J. Exp. Med. 188 1998 1603 1610
-
(1998)
J. Exp. Med.
, vol.188
, pp. 1603-1610
-
-
Koblish, H.K.1
Hunter, C.A.2
Wysocka, M.3
Trinchieri, G.4
Lee, W.M.5
-
14
-
-
0028966091
-
Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin
-
J.P. Leonard, K.E. Waldburger, and S.J. Goldman Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin J. Exp. Med. 181 1995 381 386
-
(1995)
J. Exp. Med.
, vol.181
, pp. 381-386
-
-
Leonard, J.P.1
Waldburger, K.E.2
Goldman, S.J.3
-
15
-
-
0036105484
-
Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis
-
C. Lock, G. Hermans, R. Pedotti, A. Brendolan, E. Schadt, H. Garren, A. Langer-Gould, S. Strober, B. Cannella, J. Allard, P. Klonowski, A. Austin, N. Lad, N. Kaminski, S.J. Galli, J.R. Oksenberg, C.S. Raine, R. Heller, and L. Steinman Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis Nat. Med. 8 2002 500 508
-
(2002)
Nat. Med.
, vol.8
, pp. 500-508
-
-
Lock, C.1
Hermans, G.2
Pedotti, R.3
Brendolan, A.4
Schadt, E.5
Garren, H.6
Langer-Gould, A.7
Strober, S.8
Cannella, B.9
Allard, J.10
Klonowski, P.11
Austin, A.12
Lad, N.13
Kaminski, N.14
Galli, S.J.15
Oksenberg, J.R.16
Raine, C.S.17
Heller, R.18
Steinman, L.19
-
16
-
-
0037105485
-
Peripheral immature CD2-/low T cell development from type 2 to type 1 cytokine production
-
M.J. Loza, and B. Perussia Peripheral immature CD2-/low T cell development from type 2 to type 1 cytokine production J. Immunol. 169 2002 3061 3068
-
(2002)
J. Immunol.
, vol.169
, pp. 3061-3068
-
-
Loza, M.J.1
Perussia, B.2
-
17
-
-
0034763143
-
Regulation of interleukin-12 production in antigen-presenting cells
-
X. Ma, and G. Trinchieri Regulation of interleukin-12 production in antigen-presenting cells Adv. Immunol. 79 2001 55 92
-
(2001)
Adv. Immunol.
, vol.79
, pp. 55-92
-
-
Ma, X.1
Trinchieri, G.2
-
18
-
-
0346962972
-
Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation
-
C.A. Murphy, C.L. Langrish, Y. Chen, W. Blumenschein, T. McClanahan, R.A. Kastelein, J.D. Sedgwick, and D.J. Cua Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation J. Exp. Med. 198 2003 1951 1957
-
(2003)
J. Exp. Med.
, vol.198
, pp. 1951-1957
-
-
Murphy, C.A.1
Langrish, C.L.2
Chen, Y.3
Blumenschein, W.4
McClanahan, T.5
Kastelein, R.A.6
Sedgwick, J.D.7
Cua, D.J.8
-
19
-
-
0037725220
-
Linear "2-0-1" lymphocyte development: Hypotheses on cellular bases for immunity
-
B. Perussia, and M.J. Loza Linear "2-0-1" lymphocyte development: hypotheses on cellular bases for immunity Trends Immunol. 24 2003 235 241
-
(2003)
Trends Immunol.
, vol.24
, pp. 235-241
-
-
Perussia, B.1
Loza, M.J.2
-
20
-
-
0036065808
-
Further checkpoints in Th1 development
-
D.S. Robinson, and A. O'Garra Further checkpoints in Th1 development Immunity 16 2002 755 758
-
(2002)
Immunity
, vol.16
, pp. 755-758
-
-
Robinson, D.S.1
O'Garra, A.2
-
21
-
-
0032536447
-
An interleukin (IL)-10/IL-12 immunoregulatory circuit controls susceptibility to autoimmune disease
-
B.M. Segal, B.K. Dwyer, and E.V. Shevach An interleukin (IL)-10/IL-12 immunoregulatory circuit controls susceptibility to autoimmune disease J. Exp. Med. 187 1998 537 546
-
(1998)
J. Exp. Med.
, vol.187
, pp. 537-546
-
-
Segal, B.M.1
Dwyer, B.K.2
Shevach, E.V.3
-
22
-
-
0030944709
-
Interleukin-12 induces relapse in experimental allergic encephalomyelitis in the Lewis rat
-
T. Smith, A.K. Hewson, C.I. Kingsley, J.P. Leonard, and M.L. Cuzner Interleukin-12 induces relapse in experimental allergic encephalomyelitis in the Lewis rat Am. J. Pathol. 150 1997 1909 1917
-
(1997)
Am. J. Pathol.
, vol.150
, pp. 1909-1917
-
-
Smith, T.1
Hewson, A.K.2
Kingsley, C.I.3
Leonard, J.P.4
Cuzner, M.L.5
-
23
-
-
0033231305
-
Assessment of animal models for MS and demyelinating disease in the design of rational therapy
-
L. Steinman Assessment of animal models for MS and demyelinating disease in the design of rational therapy Neuron 24 1999 511 514
-
(1999)
Neuron
, vol.24
, pp. 511-514
-
-
Steinman, L.1
-
24
-
-
0033579881
-
Interleukin 12 protects from a T helper type 1-mediated autoimmune disease, experimental autoimmune uveitis, through a mechanism involving interferon gamma, nitric oxide, and apoptosis
-
T.K. Tarrant, P.B. Silver, J.L. Wahlsten, L.V. Rizzo, C.C. Chan, B. Wiggert, and R.R. Caspi Interleukin 12 protects from a T helper type 1-mediated autoimmune disease, experimental autoimmune uveitis, through a mechanism involving interferon gamma, nitric oxide, and apoptosis J. Exp. Med. 189 1999 219 230
-
(1999)
J. Exp. Med.
, vol.189
, pp. 219-230
-
-
Tarrant, T.K.1
Silver, P.B.2
Wahlsten, J.L.3
Rizzo, L.V.4
Chan, C.C.5
Wiggert, B.6
Caspi, R.R.7
-
25
-
-
0345358584
-
The IL-12 family of heterodimeric cytokines: New players in the regulation of T cell responses
-
G. Trinchieri, S. Pflanz, and R.A. Kastelein The IL-12 family of heterodimeric cytokines: new players in the regulation of T cell responses Immunity 19 2003 641 644
-
(2003)
Immunity
, vol.19
, pp. 641-644
-
-
Trinchieri, G.1
Pflanz, S.2
Kastelein, R.A.3
-
26
-
-
0034946808
-
IFN-gamma and Fas/FasL are required for the antitumor and antiangiogenic effects of IL-12/pulse IL-2 therapy
-
J.M. Wigginton, E. Gruys, L. Geiselhart, J. Subleski, K.L. Komschlies, J.W. Park, T.A. Wiltrout, K. Nagashima, T.C. Back, and R.H. Wiltrout IFN-gamma and Fas/FasL are required for the antitumor and antiangiogenic effects of IL-12/pulse IL-2 therapy J. Clin. Invest. 108 2001 51 62
-
(2001)
J. Clin. Invest.
, vol.108
, pp. 51-62
-
-
Wigginton, J.M.1
Gruys, E.2
Geiselhart, L.3
Subleski, J.4
Komschlies, K.L.5
Park, J.W.6
Wiltrout, T.A.7
Nagashima, K.8
Back, T.C.9
Wiltrout, R.H.10
-
27
-
-
0030587910
-
IFN-gamma plays a critical down-regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis
-
D.O. Willenborg, S. Fordham, C.C. Bernard, W.B. Cowden, and I.A. Ramshaw IFN-gamma plays a critical down-regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis J. Immunol. 157 1996 3223 3227
-
(1996)
J. Immunol.
, vol.157
, pp. 3223-3227
-
-
Willenborg, D.O.1
Fordham, S.2
Bernard, C.C.3
Cowden, W.B.4
Ramshaw, I.A.5
-
28
-
-
0033571331
-
IFN-gamma is critical to the control of murine autoimmune encephalomyelitis and regulates both in the periphery and in the target tissue: A possible role for nitric oxide
-
D.O. Willenborg, S.A. Fordham, M.A. Staykova, I.A. Ramshaw, and W.B. Cowden IFN-gamma is critical to the control of murine autoimmune encephalomyelitis and regulates both in the periphery and in the target tissue: a possible role for nitric oxide J. Immunol. 163 1999 5278 5286
-
(1999)
J. Immunol.
, vol.163
, pp. 5278-5286
-
-
Willenborg, D.O.1
Fordham, S.A.2
Staykova, M.A.3
Ramshaw, I.A.4
Cowden, W.B.5
-
29
-
-
0036736028
-
Distinct lineages of T(H)1 cells have differential capacities for memory cell generation in vivo
-
C.Y. Wu, J.R. Kirman, M.J. Rotte, D.F. Davey, S.P. Perfetto, E.G. Rhee, B.L. Freidag, B.J. Hill, D.C. Douek, and R.A. Seder Distinct lineages of T(H)1 cells have differential capacities for memory cell generation in vivo Nat. Immunol. 3 2002 852 858
-
(2002)
Nat. Immunol.
, vol.3
, pp. 852-858
-
-
Wu, C.Y.1
Kirman, J.R.2
Rotte, M.J.3
Davey, D.F.4
Perfetto, S.P.5
Rhee, E.G.6
Freidag, B.L.7
Hill, B.J.8
Douek, D.C.9
Seder, R.A.10
-
30
-
-
0033065120
-
The involvement of IL-12 in murine experimentally induced autoimmune thyroid disease
-
P. Zaccone, P. Hutchings, F. Nicoletti, G. Penna, L. Adorini, and A. Cooke The involvement of IL-12 in murine experimentally induced autoimmune thyroid disease Eur. J. Immunol. 29 1999 1933 1942
-
(1999)
Eur. J. Immunol.
, vol.29
, pp. 1933-1942
-
-
Zaccone, P.1
Hutchings, P.2
Nicoletti, F.3
Penna, G.4
Adorini, L.5
Cooke, A.6
-
31
-
-
0037442020
-
Induction of experimental autoimmune encephalomyelitis in IL-12 receptor-beta 2-deficient mice: IL-12 responsiveness is not required in the pathogenesis of inflammatory demyelination in the central nervous system
-
G.X. Zhang, B. Gran, S. Yu, J. Li, I. Siglienti, X. Chen, M. Kamoun, and A. Rostami Induction of experimental autoimmune encephalomyelitis in IL-12 receptor-beta 2-deficient mice: IL-12 responsiveness is not required in the pathogenesis of inflammatory demyelination in the central nervous system J. Immunol. 170 2003 2153 2160
-
(2003)
J. Immunol.
, vol.170
, pp. 2153-2160
-
-
Zhang, G.X.1
Gran, B.2
Yu, S.3
Li, J.4
Siglienti, I.5
Chen, X.6
Kamoun, M.7
Rostami, A.8
-
32
-
-
10744230574
-
Role of IL-12 receptor beta 1 in regulation of T cell response by APC in experimental autoimmune encephalomyelitis
-
G.X. Zhang, S. Yu, B. Gran, J. Li, I. Siglienti, X. Chen, D. Calida, E. Ventura, M. Kamoun, and A. Rostami Role of IL-12 receptor beta 1 in regulation of T cell response by APC in experimental autoimmune encephalomyelitis J. Immunol. 171 2003 4485 4492
-
(2003)
J. Immunol.
, vol.171
, pp. 4485-4492
-
-
Zhang, G.X.1
Yu, S.2
Gran, B.3
Li, J.4
Siglienti, I.5
Chen, X.6
Calida, D.7
Ventura, E.8
Kamoun, M.9
Rostami, A.10
|