A model for the origin of TCR-αβ+ CD4-CD8- B220+ cells based on high affinity TCR signals

Journal of Immunology

Volumn 162, Issue 10, 1999, Pages 5747-5756

  Mixter, Philip F ^a,b   Russell, Jennifer Q ^a   Morrissette, Gregory J ^a   Charland, Colette ^a   Aleman Hoey, Deborah ^a   Budd, Ralph C ^a  

^a UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

^b WASHINGTON STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD2 ANTIGEN; CD4 ANTIGEN; CD45 ANTIGEN; CD8 ANTIGEN; INTERLEUKIN 2 RECEPTOR; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOIMMUNITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; THYMOCYTE; TRANSGENIC MOUSE;

EID: 0033563166     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Budd, R. C., N. Van Houlen, J. Clements, and P. F. Mixter. 1994. Parallels in T lymphocyte development between lpr and normal mice. Semin. Immunol. 6:43.
2. Budd, R. C., M. Schreyer, G. C. Miescher, and H. R. MacDonald. 1987. T cell lineages in the thymus of lpr/lpr mice: evidence for parallel pathways of normal and abnormal T cell development. J. Immunol. 139:2210.
3. Cohen, P. L., and R. A. Eisenberg. 1991. Lpr and gld: single gene models of systemic autoimmunity and lymphoproliferative disease. Annu. Rev. Immunol. 9:243.
4. - T cells in mice and humans. J. Exp. Med. 180:1097.
5. + T lymphocytes. Science 268:863.
6. + cells: new clues to their origin, specificity, and function. J. Exp. Med. 182:633.
7. + T cells. Curr. Opin. Immunol. 7:367.
8. Budd, R. C., G. C. Miescher, R. C. Howe, R. K. Lees, C. Bron, and H. R. MacDonald. 1987. Developmentally regulated expression of T cell receptor β chain variable domains in immature thymocytes. J. Exp. Med. 166:577.
9. Herron, L. R., and R. A. Eisenberg, E. Roper, V. N. Kakkanaiah, P. L. Cohen, and B .L. Kotzin. 1993. Selection of the T cell receptor repertoire in lpr mice. J. Immunol. 151:3450.
10. - T lymphocytes from MRL lpr mice. J. Immunol. 145: 2862.
11. - thymocytes by class I molecules expressed by hematopoietic cells. J. Exp. Med. 178:901.
12. 2-microglobulin. J. Immunol. 154:2063.
13. Maldonado, M. A., R. A. Eisenberg, E. Roper, P. L. Cohen, P.L., and B. L. Kotzin. 1995. Greatly reduced lymphoproliferation in lpr mice lacking major histocompatibility complex class I. J. Exp. Med.181:641.
14. + T cells but normal autoantibody production in lpr/lpr mice lacking major histocompatibility class I molecules. Eur. J. Immunol. 25:37.
15. + thymic precursor. J. Immunol. 151: 1086.
16. - thymocytes that express the T cell receptor may have previously expressed CD8. Int. Immunol. 2:51.
17. Jameson, S. C., K. A. Hogquist, and M. J. Sevan. 1994. Specificity and flexibility in thymic selection. Nature 369:750.
18. Huang, L., G. Soldeville, M. Leeker, R. Flavell, and I. N. Crispe. 1994. The liver eliminates T cells undergoing antigen-triggered apoptosis in vivo. Immunity 1:741.
19. Kishimoto, H., C. D. Surh, and J. Sprent. 1995. Upregulation of surface markers on dying thymocytes. J. Exp. Med. 181:649.
20. von Boehmer, H., J. Kirberg, and B. Rocha. 1991. An unusual lineage of α/β T cells that contains autoreactive cells. J. Exp. Med. 174:1001.
21. Hanke, T., R. Mitnacht, R. Boyd, and T. Hunig. 1994. Induction of interleukin-2 receptor β chain expression by self-recognition in the thymus. J. Exp. Med. 180: 1629.
22. +, double positive stage. J. Exp. Med. 184:1619.
23. + thymocytes: a model based on T cell receptor avidity. Immunol. Today 16:428.
24. + T helper cells in humans augment the production of pathogenic anti-DNA autoantibodies associated with lupus nephritis. J. Immunol 143:103.
25. lo thymocytes in vivo. Science 250: 1720.
26. Hogquist, K. A., S. C. Jameson, W. R. Heath, J. L. Howard, M. J. Bevan, and F. R. Carbone. 1994. T cell receptor antagonist peptides induce positive selection. Cell 76:17.
27. Coding J. W. 1993. Monoclonal Antibodies: Principles and Practice. Academic Press, New York. pp. 232-233.
28. Sgorc, R., G. Boeck, H. Dietrich, J. Gruber, and G. Wick. 1994. Simultaneous determination of cell surface antigens and apoptosis. Trends Genet. 10:41.
29. + peptide recognition. J. Exp. Med. 185:1919.
30. Alam, S. M., P. J. Travers, J. L. Wung, W. Nasholds, S. Redpath, S. C. Jameson, and N. R. J. Gascoigne. 1996. T-cell receptor affinity and thymocyte positive selection. Nature 381:616.
31. - T cells in lpr mice. J. Immunol. 148:1055.
32. Van Houten, N., P. F. Mixter, J. Wolfe, and R. C. Budd. 1993. CD2 expression on murine intestinal intraepithelial lymphocytes is bimodal and defines proliferative capacity. InI. Immunol. 5:665.
33. Van Houten, N., and R. C. Budd. 1992. Accelerated programmed cell death on MRL-lpr/lpr T lymphocytes. J. Immunol. 149:2513.
34. Mosley, R. L., M. Whetsell, and J. R. Klein. 1991. Proliferative properties of murine intestinal intraepithelial lymphocytes (IEL): IEL expressing TCRαβ or TCRγδ are largely unresponsive to proliferative signals mediated via conventional stimulation of the CD3-TCR complex. Int. Immunol. 3:563.
35. Scherer, M. T., L. Ignatowicz, G. M. Winslow, J. W. Kappler, and P. Marrack. 1993. Superantigens. Annu. Rev. Cell Biol. 9:101.
36. Goldrath, A. W., K. A. Hogquist, and M. J. Bevan. 1997. CD8 lineage commitment in the absence of CD8. Immunity 6:633.
37. Urdahl, K. B., D. M. Pardoll, and M. K. Jenkins. 1994. Cyclosporin A inhibits positive selection and delays negative selection in αβ TCR transgenic mice. J. Immunol. 152:2853.
38. H2 cytokines and help B cells. Science 260:1802.