Cell therapy with autologous tolerogenic dendritic cells induces allograft tolerance through interferon-gamma and Epstein-Barr virus-induced gene 3

American Journal of Transplantation

Volumn 11, Issue 10, 2011, Pages 2036-2045

  Hill, M ^a,b,c,d   Thebault, P ^a,b,c,e   Segovia, M ^a,b,c   Louvet, C ^a,b,c   Beriou G ^a,b,c   Tilly, G ^a,b,c   Merieau, E ^a,b,c   Anegon, I ^a,b,c   Chiffoleau, E ^a,b,c   Cuturi, M C ^a,b,c  

^a INSERM   (France)

^b NANTES UNIVERSITY HOSPITAL   (France)

^c UNIVERSITÉ DE NANTES   (France)

^d DEPARTAMENTO DE BIOQUÍMICA   (Uruguay)

^e UNIVERSITY OF MONTREAL   (Canada)

Author keywords

Cellular therapy; dendritic cells; immunology and tolerance; Interferon gamma (IFN gamma)

Indexed keywords

CD161 ANTIGEN; CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 12; SMALL INTERFERING RNA;

ALLOGRAFT; ANIMAL EXPERIMENT; ARTICLE; AUTOLOGOUS TOLEROGENIC DENDRITIC CELL; CARDIAC GRAFT REJECTION; CELL THERAPY; CYTOKINE PRODUCTION; DENDRITIC CELL; EPSTEIN BARR VIRUS INDUCED GENE 3; GRAFT RECIPIENT; GRAFT SURVIVAL; HEART TRANSPLANTATION; IMMUNOLOGICAL TOLERANCE; IMMUNOREGULATION; IMMUNOSUPPRESSIVE TREATMENT; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SPLEEN; T LYMPHOCYTE;

ANIMALS; CELL TRANSPLANTATION; DENDRITIC CELLS; HERPESVIRUS 4, HUMAN; INTERFERON-GAMMA; LYMPHOCYTE CULTURE TEST, MIXED; MICROSCOPY, CONFOCAL; RATS; REAL-TIME POLYMERASE CHAIN REACTION; TRANSPLANTATION, HOMOLOGOUS; VIRAL PROTEINS;

EID: 80053329222     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/j.1600-6143.2011.03651.x     Document Type: Article

References (36)

1. Morelli AE, Thomson AW,. Tolerogenic dendritic cells and the quest for transplant tolerance. Nat Rev Immunol 2007; 7: 610-621. (Pubitemid 47123548)
2. Bluestone JA, Thomson AW, Shevach EM, Weiner HL,. What does the future hold for cell-based tolerogenic therapy? Nat Rev Immunol 2007; 7: 650-654. (Pubitemid 47123553)
3. Lechler RI, Sykes M, Thomson AW, Turka LA,. Organ transplantation-how much of the promise has been realized? Nat Med 2005; 11: 605-613. (Pubitemid 40868300)
4. Beriou G, Peche H, Guillonneau C, Merieau E, Cuturi MC,. Donor-specific allograft tolerance by administration of recipient-derived immature dendritic cells and suboptimal immunosuppression. Transplantation 2005; 79: 969-972. (Pubitemid 40586872)
5. Wood KJ, Sawitzki B,. Interferon gamma: A crucial role in the function of induced regulatory T cells in vivo. Trends Immunol 2006; 27: 183-187.
6. Wood KJ, Feng G, Wei B, Sawitzki B, Bushell AR,. Interferon gamma: Friend or foe? Transplantation 2007; 84 (1 Suppl): S4-S5. (Pubitemid 47067533)
7. Zhang J,. Yin and yang interplay of IFN-gamma in inflammation and autoimmune disease. J Clin Invest 2007; 117: 871-873. (Pubitemid 46556742)
8. Thebault P, Condamine T, Heslan M, et al,. Role of IFN-gamma in allograft tolerance mediated by CD4+CD25 +regulatory T cells by induction of IDO in endothelial cells. Am J Transplant 2007; 7: 2472-2482. (Pubitemid 47561604)
9. Sawitzki B, Kingsley CI, Oliveira V, Karim M, Herber M, Wood KJ,. IFN-gamma production by alloantigen-reactive regulatory T cells is important for their regulatory function in vivo. J Exp Med 2005; 201: 1925-1935. (Pubitemid 41002929)
10. Guillonneau C, Hill M, Hubert FX, et al,. CD40Ig treatment results in allograft acceptance mediated by CD8+CD45RClow T cells, IFN-gamma and indoleamine 2,3-dioxygenase. J Clin Invest 2007; 117: 1096-1106. (Pubitemid 46556766)
11. Yoshida H, Miyazaki Y,. Regulation of immune responses by interleukin-27. Immunol Rev 2008; 226: 234-247.
12. Collison LW, Workman CJ, Kuo TT, et al,. The inhibitory cytokine IL-35 contributes to regulatory T-cell function. Nature 2007; 450: 566-569. (Pubitemid 350190247)
13. Collison LW, Vignali DA,. Interleukin-35: Odd one out or part of the family? Immunol Rev 2008; 226: 248-262.
14. Niedbala W, Wei XQ, Cai B, et al,. IL-35 is a novel cytokine with therapeutic effects against collagen-induced arthritis through the expansion of regulatory T cells and suppression of Th17 cells. Eur J Immunol 2007; 37: 3021-3029. (Pubitemid 350131282)
15. Ilarregui JM, Croci DO, Bianco GA, et al,. Rabinovich. Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10. Nat Immunol 2009; 10: 981-991.
16. Fitzgerald DC, Ciric B, Touil T, et al,. Suppressive effect of IL-27 on encephalitogenic Th17 cells and the effector phase of experimental autoimmune encephalomyelitis. J immunol 2007; 179: 3268-3275.
17. Awasthi A, Carrier Y, Peron JP, et al,. A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells. Nat Immunol 2007; 8: 1380-1389. (Pubitemid 350131175)
18. Stumhofer JS, Silver JS, Laurence A, et al,. Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10. Nat Immunol 2007; 8: 1363-1371. (Pubitemid 350131173)
19. Zhang ZX, Yang L, Young KJ, DuTemple B, Zhang L,. Identification of a previously unknown antigen-specific regulatory T cell and its mechanism of suppression. Nat Med 2000; 6: 782-789. (Pubitemid 30469427)
20. Thomson CW, Lee BP, Zhang L,. Double-negative regulatory T cells: Non-conventional regulators. Immunol Res 2006; 35: 163-178. (Pubitemid 44547511)
21. Ono K, Lindsey ES,. Improved technique of heart transplantation in rats. J Thorac Cardiovasc Surg 1969; 57: 225-229.
22. Peche H, Trinite B, Martinet B, Cuturi MC,. Prolongation of heart allograft survival by immature dendritic cells generated from recipient type bone marrow progenitors. Am J Transplant 2005; 5: 255-267. (Pubitemid 40179512)
23. Josien R, Douillard P, Guillot C, et al,. A critical role for transforming growth factor-beta in donor transfusion-induced allograft tolerance. J Clin Invest 1998; 102: 1920-1926. (Pubitemid 29001837)
24. Louvet C, Heslan JM, Merieau E, Soulillou JP, Cuturi MC, Chiffoleau E,. Induction of Fractalkine and CX3CR1 mediated by host CD8+ T cells in allograft tolerance induced by donor specific blood transfusion. Transplantation 2004; 78: 1259-166.
25. Pflanz S, Timans JC, Cheung J, et al,. IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells. Immunity 2002; 16: 779-790. (Pubitemid 34786477)
26. Hill M, Tanguy-Royer S, Royer PJ, et al,. IDO expands human CD4+CD25high regulatory T cells by promoting maturation of LPS-treated dendritic cells. Eur J Immunol 2007; 37: 3054-3062. (Pubitemid 350131285)
27. De Wilde V, Van Rompaey N, Hill M, et al,. Endotoxin challange induces myeloid-derived suppressor cells controlling allograft rejection through heme oxygenase-1. Am J Transplant 2009; 9: 2034-2047.
28. Fitzgerald DC, Zhang GX, El-Behi M, et al,. Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cells. Nat Immunol 2007; 8: 1372-1379. (Pubitemid 350131174)
29. Batten M, Kljavin NM, Li J, Walter MJ, de Sauvage FJ, Ghilardi N,. Cutting edge: IL-27 is a potent inducer of IL-10 but not FoxP3 in murine T cells. J Immunol 2008; 180: 2752-2756.
30. Trinchieri G,. Interleukin-10 production by effector T cells: Th1 cells show self control. J Exp Med 2007; 204: 239-243. (Pubitemid 46294539)
31. Anderson CF, Oukka M, Kuchroo VJ, Sacks D,. CD4(+)CD25(-)Foxp3(-) Th1 cells are the source of IL-10-mediated immune suppression in chronic cutaneous leishmaniasis. J Exp Med 2007; 204: 285-297. (Pubitemid 46294545)
32. Onodera K, Chandraker A, Volk HD, et al,. Role of regulatory T cells in the "infectious" tolerance pathway in transplant recipients. Transplant Proc 1998; 30: 13-15. (Pubitemid 28090300)
33. Onodera K, Lehmann M, Akalin E, Volk HD, Sayegh MH, Kupiec-Weglinski JW,. Induction of "infectious" tolerance to MHC-incompatible cardiac allografts in CD4 monoclonal antibody-treated sensitized rat recipients. J Immunol 1996; 157: 1944-1950. (Pubitemid 126449667)
34. Kishimoto K, Sandner S, Imitola J, et al,. Th1 cytokines, programmed cell death, and alloreactive T cell clone size in transplant tolerance. J Clin Invest 2002; 109: 1471-1479. (Pubitemid 34596173)
35. Ford McIntyre M, Young K, Gao J, Joe B, Zhang L,. Cutting edge: In vivo trogocytosis as a mechanism of double negative regulatory T cell-mediated antigen-specific suppression. J immunol 2008; 181: 2271-2275.
36. Carl JW, Bai XF,. IL27: Its roles in the induction and inhibition of inflammation. Int J Clin Exp Pathol 2008; 1: 117-123.