IL-10 Induces Regulatory T Cell Apoptosis by Up-Regulation of the Membrane Form of TNF-α

Journal of Immunology

Volumn 172, Issue 2, 2004, Pages 1028-1035

  Marra, Luciano E ^a   Zhang, Zhu X ^a   Joe, Betty ^a   Campbell, Jon ^a   Levy, Gary A ^a   Penninger, Josef ^b   Zhang, Li ^a,c  

^a UNIVERSITY HEALTH NETWORK   (Canada)

^b PRINCESS MARGARET HOSPITAL   (Canada)

^c TORONTO GENERAL HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 10; TUMOR NECROSIS FACTOR ALPHA;

ALLOGRAFT; ANIMAL CELL; ANTIGEN SPECIFICITY; APOPTOSIS; ARTICLE; AUTOIMMUNE DISEASE; CELL DEATH; CELL FUNCTION; CROSS LINKING; GRAFT REJECTION; GRAFT VERSUS HOST REACTION; MEMBRANE BINDING; MOUSE; NONHUMAN; PLEIOTROPY; PRIORITY JOURNAL; RECEPTOR UPREGULATION; T LYMPHOCYTE ACTIVATION;

EID: 1642495754     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.172.2.1028     Document Type: Article

References (56)

1. Bluestone, J. A., and A. K. Abbas. 2003. Natural versus adaptive regulatory T cells. Nat. Rev. Immunol. 3:253.
2. von Herrath, M. G., and L. C. Harrison. 2003. Antigen-induced regulatory T cells in autoimmunity. Nat. Rev. Immunol. 3:223.
3. Wood, K. J., and S. Sakaguchi. 2003. Regulatory T cells in transplantation tolerance. Nat. Rev. Immunol. 3:199.
4. + suppressor T cells: more questions than answers. Nat. Rev. Immunol. 2:389.
5. Lechler, R. I., O. A. Garden, and L. A. Turka. 2003. The complementary roles of deletion and regulation in transplantation tolerance. Nat. Rev. Immunol. 3:147.
6. + T cell as immune regulatory cell. J. Mol. Med. 79:419.
7. Roncarolo, M. G., and M. K. Levings. 2000. The role of different subsets of T regulatory cells in controlling autoimmunity. Curr. Opin. Immunol. 12:676.
8. Zhang, Z. X., L. Yang, K. J. Young, B. DuTemple, and L. Zhang. 2000. Identification of a previously unknown antigen-specific regulatory T cell and its mechanism of suppression. Nat. Med. 6:782.
9. Ford, M. S., K. J. Young, Z. X. Zhang, P. S. Ohashi, and L. Zhang. 2002. The immune regulatory function of lymphoproliferative double negative T cells in vitro and in vivo. J. Exp. Med. 196:261.
10. Zhang, Z. X., W. L. Stanford, and L. Zhang. 2002. Ly-6A is critical for the function of double negative regulatory T cells. Eur. J. Immunol. 32:1584.
11. Chen, W., M. S. Ford, K. J. Young, M. I. Cybulsky, and L. Zhang. 2003. Role of double-negative regulatory T cells in long-term cardiac xenograft survival. J. Immunol. 170:1846.
12. Young, K. J., B. DuTemple, M. J. Phillips, and L. Zhang. 2003. Inhibition of graft-versus-host disease by double-negative regulatory T cells. J. Immunol. 171:134.
13. +) T cells which promote tolerance induction and regulate autoimmunity. Immunol. Rev. 149:217.
14. Priatel, J. J., O. Utting, and H. S. Teh. 2001. TCR/self-antigen interactions drive double-negative T cell peripheral expansion and differentiation into suppressor cells. J. Immunol. 167:6188.
15. - T cells differentiate extrathymically in an lck-independent manner and participate in early response against Listeria monocytogenes infection through interferon-γ production. Immunology 91:511.
16. - T cells with regulatory functions dominates the mouse female genital tract. J. Immunol. 170:1659.
17. + T cells: a highly differentiated and apoptosis-prone population. Eur. J. Immunol. 31:1122.
18. - antigen-specific suppressor T cell clones. J. Immunol. 162:5860.
19. Chiffoleau, E., P. T. Walsh, and L. Turka. 2003. Apoptosis and transplantation tolerance. Immunol. Rev. 193:124.
20. van Parijs, L., and A. K. Abbas. 1998. Homeostasis and self-tolerance in the immune system: turning lymphocytes off. Science 280:243.
21. Li, X. C., G. Demirci, S. Ferrari-Lacraz, C. Groves, A. Coyle, T. R. Malek, and T. B. Strom. 2001. IL-15 and IL-2: a matter of life and death for T cells in vivo. Nat. Med. 7:114.
22. Lenardo, M. J. 1991. Interleukin-2 programs mouse αβ T lymphocytes for apoptosis. Nature 353:858.
23. Zamorano, J., A. L. Mora, M. Boothby, and A. D. Keegan. 2001. NF-κB activation plays an important role in the IL-4-induced protection from apoptosis. Int. Immunol. 13:1479.
24. Wurster, A. L., V. L. Rodgers, M. F. White, T. L. Rothstein, and M. J. Grusby. 2002. Interleukin-4-mediated protection of primary B cells from apoptosis through Stat6-dependent up-regulation of Bcl-xL. J. Biol. Chem. 277:27169.
25. Hill, N. J., K. Van Gunst, and N. Sarvetnick. 2003. Th1 and Th2 pancreatic inflammation differentially affects homing of islet-reactive CD4 cells in nonobese diabetic mice. J. Immunol. 170:1649.
26. + T-cell responses. Nat. Med. 7:206.
27. + T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 389:737.
28. + T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells. J. Exp. Med. 192:1213.
29. + T cells regulate the expansion of peripheral CD4 T cells through the production of IL-10. J. Immunol. 166:3008.
30. Hara, M., C. I. Kingsley, M. Niimi, S. Read, S. E. Turvey, A. R. Bushell, P. J. Morris, F. Powrie, and K. J. Wood. 2001. IL-10 is required for regulatory T cells to mediate tolerance to alloantigens in vivo. J. Immunol. 166:3789.
31. Asseman, C., S. Mauze, M. W. Leach, R. L. Coffman, and F. Powrie. 1999. An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation. J. Exp. Med. 190:995.
32. Stohlman, S. A., L. Pei, D. J. Cua, Z. Li, and D. R. Hinton. 1999. Activation of regulatory cells suppresses experimental allergic encephalomyelitis via secretion of IL-10. J. Immunol. 163:6338.
33. Moore, K. W., M. R. de Waal, R. L. Coffman, and A. O'Garra. 2001. Interleukin-10 and the interleukin-10 receptor. Annu. Rev. Immunol. 19:683.
34. Fillatreau, S., C. H. Sweenie, M. J. McGeachy, D. Gray, and S. M. Anderton. 2002. B cells regulate autoimmunity by provision of IL-10. Nat. Immun. 3:944.
35. Saito, I. 2000. Structure of IL-10 and its role in autoimmune exocrinopathy. Crit. Rev. Immunol. 20:153.
36. Yang, Z., M. Chen, R. Wu, L. B. Fialkow, J. S. Bromberg, M. McDuffie, A. Naji, and J. L. Nadler. 2002. Suppression of autoimmune diabetes by viral IL-10 gene transfer. J. Immunol. 168:6479.
37. Qian, S., W. Li, Y. Li, F. Fu, L. Lu, J. J. Fung, and A. W. Thomson. 1996. Systemic administration of cellular interleukin-10 can exacerbate cardiac allograft rejection in mice. Transplantation 62:1709.
38. Li, W., F. Fu, L. Lu, S. K. Narula, J. J. Fung, A. W. Thomson, and S. Qian. 1998. Systemic administration of anti-interleukin-10 antibody prolongs organ allograft survival in normal and presensitized recipients. Transplantation 66:1587.
39. Furukawa, Y., G. Becker, J. L. Stinn, K. Shimizu, P. Libby, and R. N. Mitchell. 1999. Interleukin-10 (IL-10) augments allograft arterial disease: paradoxical effects of IL-10 in vivo. Am. J. Pathol. 155:1929.
40. Yanagi, K., N. Haneji, H. Hamano, M. Takahashi, H. Higashiyama, and Y. Hayashi. 1996. In vivo role of IL-10 and IL-12 during development of Sjogren's syndrome in MRL/lpr mice. Cell. Immunol. 168:243.
41. Balasa, B., K. Van Gunst, N. Jung, D. Balakrishna, P. Santamaria, T. Hanafusa, N. Itoh, and N. Sarvetnick. 2000. Islet-specific expression of IL-10 promotes diabetes in nonobese diabetic mice independent of Fas, perforin, TNF receptor-1, and TNF receptor-2 molecules. J. Immunol. 165:2841.
42. Watanabe, N., K. Ikuta, S. Nisitani, T. Chiba, and T. Honjo. 2002. Activation and differentiation of autoreactive B-1 cells by interleukin 10 induce autoimmune hemolytic anemia in Fas-deficient antierythrocyte immunoglobulin transgenic mice. J Exp. Med. 196:141.
43. Chan, K. F., M. R. Siegel, and J. M. Lenardo. 2000. Signaling by the TNF receptor superfamily and T cell homeostasis. Immunity 13:419.
44. Zheng, X. X., A. W. Steele, P. W. Nickerson, W. Steurer, J. Steiger, and T. B. Strom. 1995. Administration of noncytolytic IL-10/Fc in murine models of lipopolysaccharide-induced septic shock and allogeneic islet transplantation. J. Immunol. 154:5590.
45. de Waal, M. R., J. Abrams, B. Bennett, C. G. Figdor, and J. E. de Vries. 1991. Interleukin 10 (IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J. Exp. Med. 174:1209.
46. Clarke, C. J., A. Hales, A. Hunt, and B. M. Foxwell. 1998. IL-10-mediated suppression of TNF-α production is independent of its ability to inhibit NF κB activity. Eur. J. Immunol. 28:1719.
47. Kontoyiannis, D., A. Kotlyarov, E. Carballo, L. Alexopoulou, P. J. Blackshear, M. Gaestel, R. Davis, R. Flavell, and G. Kollias. 2001. Interleukin-10 targets p38 MAPK to modulate ARE-dependent TNF mRNA translation and limit intestinal pathology. EMBO J. 20:3760.
48. 2 production. J. Immunol. 170:158.
49. Locksley, R. M., N. Killeen, and M. J. Lenardo. 2001. The TNF and TNF receptor superfamilies: integrating mammalian biology. Cell 104:487.
50. Black, R. A., C. T. Rauch, C. J. Kozlosky, J. J. Peschon, J. L. Slack, M. F. Wolfson, B. J. Castner, K. L. Stocking, P. Reddy, S. Srinivasan, et al. 1997. A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells. Nature 385:729.
51. Moss, M. L., S. L. Jin, M. E. Milla, D. M. Bickett, W. Burkhart, H. L. Carter, W. J. Chen, W. C. Clay, J. R. Didsbury, D. Hassler, et al. 1997. Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-α. Nature 385:733.
52. Kriegler, M., C. Perez, K. DeFay, I. Albert, and S. D. Lu. 1988. A novel form of TNF/cachectin is a cell surface cytotoxic transmembrane protein: ramifications for the complex physiology of TNF. Cell 53:45.
53. Bazzoni, F., and B. Beutler. 1996. The tumor necrosis factor ligand and receptor families. N. Engl. J. Med. 334:1717.
54. Eissner, G., F. Kohlhuber, M. Grell, M. Ueffing, P. Scheurich, A. Hieke, G. Multholf, G. W. Bornkamm, and E. Holler. 1995. Critical involvement of transmembrane tumor necrosis factor-α in endothelial programmed cell death mediated by ionizing radiation and bacterial endotoxin. Blood 86:4184.
55. Monastra, G., A. Cabrelle, A. Zambon, A. Rosato, B. Macino, D. Collavo, and P. Zanovello. 1996. Membrane form of TNF α induces both cell lysis and apoptosis in susceptible target cells. Cell. Immunol. 171:102.
56. Grell, M., E. Douni, H. Wajant, M. Lohden, M. Clauss, B. Maxeiner, S. Georgopoulos, W. Lesslauer, G. Kollias, K. Pfizenmaier, et al. 1995. The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor. Cell 83:793.