Interaction of a lecithin microemulsion gel with human stratum corneum and its effect on transdermal transport

Journal of Controlled Release

Volumn 45, Issue 2, 1997, Pages 131-140

  Dreher, F ^a   Walde, P ^a   Walther, P ^a   Wehrli, E ^a  

^a ETH ZURICH   (Switzerland)

Author keywords

Lecithin; Microemulsion gel; Penetration enhancer; Skin interaction; Skin permeation

Indexed keywords

DICLOFENAC; EPIKURON 200; INDOMETACIN; PALMITIC ACID ISOPROPYL ESTER; PHOSPHATIDYLCHOLINE; UNCLASSIFIED DRUG;

ARTICLE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DOSAGE FORM; GEL; HUMAN; HUMAN TISSUE; INFRARED SPECTROSCOPY; MICROEMULSION; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; SKIN PENETRATION; SKIN PERMEABILITY; STRATUM CORNEUM;

EID: 0031050471     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(96)01559-3     Document Type: Article

References (38)

1. R. Scartazzini and P.L. Luisi, Organogels from lecithins, J. Phys. Chem. 92 (1988) 829-833.
2. P.L. Luisi, R. Scartazzini, G. Haering and P. Schurtenberger, Organogels from water-in-oil microemulsions, Colloid Polym. Sci. 268 (1990) 356-374.
3. P. Schurtenberger, R. Scartazzini, L.J. Magid, M.E. Leser and P.L. Luisi, Structural and dynamic properties of polymer-like reverse micelles, J. Phys. Chem. 94 (1990) 3695-3701.
4. H. Willimann, P. Walde, P.L. Luisi, A. Gazzaniga and F. Stroppolo, Lecithin organogel as matrix for transdermal transport of drugs, J. Pharm. Sci. 81 (1991) 871-874.
5. P. Walde and F. Dreher, Microemulsion-based phospholipid gels for percutaneous absorption of drugs. In: R. Gambari and C. Nastruzzi (Eds.), Tissue Cultures in Cosmetic Biotechnology, A. Nocenti, Ferrara, 1992, pp. 65-76.
6. F.P. Bonina, L. Montenegro, N. Scrofani, E. Esposito, R. Cortesi, E. Menegatti and C. Nastruzzi, Effects of phospholipid based formulations on in vitro and in vivo percutaneous absorption of methyl nicotinate, J. Control. Release 34 (1995) 53-63.
7. C. Nastruzzi and R. Gambari, Antitumor activity of (trans) dermally delivered aromatic tetra-amidines, J. Control. Release 29 (1994) 53-62.
8. F. Dreher, P. Walde, P.L. Luisi and P. Elsner, Human skin irritation studies of a lecithin microemulsion gel and of lecithin liposomes, Skin Pharmacol. 9 (1996) 124-129.
9. M.G. Ganesan, N.D. Weiner, G.L. Flynn and N.F.H. Ho, Influence of liposomal drug entrapment on percutaneous absorption, Int. J. Pharm. 20 (1984) 139-154.
10. N.F.H. Ho, M.G. Ganesan, N.D. Weiner and G.L. Flynn, Mechanisms of topical delivery of liposomally entrapped drugs, J. Control. Release 2 (1985) 61-65.
11. V.M. Knepp, F.C. Szoka, J. Guy and R.H. Guy, Controlled drug release from a novel liposomal delivery system. II. Transdermal delivery characteristics, J. Control. Release 12 (1990) 25-30.
12. M. Mahjour, B. Mauser, Z. Rashidbaigi and M.B. Fawzi, Effect of egg yolk lecithins and commercial soybean lecithins on in vitro skin permeation of drugs, J. Control. Release 14 (1990) 243-252.
13. C. Michel, T. Purmann, E. Mentrup, E. Seiller and J. Kreuter, Effect of liposomes on percutaneous penetration of lipophilic materials, Int. J. Pharm. 84 (1992) 93-105.
14. E. Touitou, F. Levi-Schaffer, N. Dayan, F. Alhaique and F. Riccieri, Modulation of caffeine skin delivery by carrier design: liposomes versus permeation enhancers, Int. J. Pharm. 103 (1994) 131-136.
15. E. Touitou, H.E. Junginger, N.D. Weiner, T. Nagai and M. Mezei, Liposomes as carriers for topical and transdermal delivery, J. Pharm. Sci. 83 (1994) 1189-1203.
16. G. Cevc, A. Schätzlein and G. Blume, Transdermal drug carriers: basic properties, optimization and transfer efficiency in the case of epicutaneously applied peptides, J. Control. Release 36 (1995) 3-16.
17. D.R. Sanvordeker, J.G. Cooney and R.C. Wester, Transdermal nitroglycerin pad, U.S. Patent No. 4,336,243, June 22, 1982.
18. K. Sato, K. Sugibayashi and Y. Morimoto, Effect and mode of action of aliphatic esters on the in vitro skin permeation of nicorandil, Int. J. Pharm. 43 (1988) 31-40.
19. F. Stroppolo, D. Bonadeo, M. Chiodo, L. Soldati and A. Gazzaniga, In vitro percutaneous penetration of the β2-agonist, broxaterol: influence of several enhancers. In: R.C. Scott, R.H. Guy, J. Hadgraft and H.E. Boddé (Eds.), Prediction of Percutaneous Penetration: Methods; Measurements, Modelling, Vol. 2, IBC Technical Services Ltd., London, 1991, pp. 373-379.
20. P. Walther, E. Wehrli, R. Hermann and M. Müller, Double-layer coating for high-resolution low-temperature scanning electron microscopy, J. Microsc. 179 (1995) 229-237.
21. A.M. Kligman and E. Christophers, Preparation of isolated sheets of human stratum corneum, Arch. Dermatol. 88 (1963) 702-705.
22. M.D. Garrison, L.M. Doh, R.O. Potts and W. Abraham, Effect of oleic acid on human epidermis: fluorescence spectroscopic investigation, J. Control. Release 31 (1994) 263-269.
23. T. Nagatani, S. Saito, M. Sato and M. Yamada, Development of an ultra high resolution scanning electron microscope by means of a field emission source and in-lens system, Scanning Microsc. 1 (1987) 901-909.
24. R. Autrata, R. Hermann and M. Müller, An efficient single crystal BSE detector in SEM, Scanning 14 (1992) 127-135.
25. M.L. Francoeur, G.M. Golden and R.O. Potts, Oleic acid: Its effect on stratum corneum in relation to (trans)dermal drug delivery, Pharm. Res. 7 (1990) 621-627.
26. V.H.W. Mak, R.O. Potts and R.H. Guy, Oleic acid concentration and effect in human stratum corneum: Non-invasive determination by attenuated total reflectance infrared spectroscopy in vivo, J. Control. Release 12 (1990) 67-75.
27. B.F. van Duzee, Thermal analysis of human stratum corneum, J. Invest. Dermatol. 65 (1975) 404-408.
28. M. Goodman and B.W. Barry, Differential scanning calorimetry (DSC) of human stratum corneum: effect of azone, J. Pharm. Pharmacol. 37 (1985) suppl. 80.
29. M. Goodman and B.W. Barry, Differential scanning calorimetry of human stratum corneum: effects of penetration enhancers azone and dimethyl sulphoxide, Anal. Proc. 23 (1986) 397-398.
30. J.A. Bouwstra, L.J.C. Peschier, J. Brussee and H.E. Boddé, Effect of N-alkyl-azocycloheptan-2-ones including azone on the thermal behaviour of human stratum corneum, Int. J. Pharm. 52 (1989) 47-54.
31. C.S. Leopold and B.C. Lippold, An attempt to clarify the mechanism of the penetration enhancing effects of lipophilic vesicles with differential scanning calorimetry (DSC), J. Pharm. Pharmacol. 47 (1995) 276-281.
32. M. Goodman and B.W. Barry, Action of skin permeation enhancers azone, oleic acid and decylmethyl sulphoxide: permeation and DSC studies, J. Pharm. Pharmacol. 38 (1986) suppl. 71.
33. 2H NMR and freeze fracture electron microscopy reveal rapid isotropic motion and lipid perturbation by azone® in human stratum corneum. In: K.R. Brain, V.J. James and K.A. Walters (Eds.), Prediction of Percutaneous Penetration, Vol. 3b, STS Publishing, Cardiff, 1993, pp. 8-17.
34. H. Tanojo, A. Bos-van Geest, H.E. Junginger and H.E. Boddé, Mechanism of skin barrier perturbation by oleic acid: a new perspective, Proc. Int. Symp. Control. Release Bioact. Mater. 22 (1995) 692-693.
35. J.A. Bouwstra, H.E.J. Hofland, F. Spies, G.S. Gooris and H.E. Junginger, Changes in the structure of human stratum corneum induced by liposomes. In: O. Braun-Falco, H.C. Korting and H.I. Maibach (Eds.), Liposome Dermatics, Springer, Berlin, 1992, pp. 121-136.
36. D.A. van Hal, E. Jeremiasse, H.E. Junginger, F. Spies and J.A. Bouwstra, Structure of hydrated human stratum corneum and influence of application of nonionic surfactant vesicles: a freeze-fracture electron microscopical study, Proc. Int. Symp. Control. Release Bioact. Mater. 21 (1994) 168-169.
37. H.E.J. Hofland, J.A. Bouwstra, M. Ponec, H.E. Boddé, F. Spies, J. Coos Verhoef and H.E. Junginger, Interactions of non-ionic surfactant vesicles with cultured keratinocytes and human skin in vitro: a survey of toxicological aspects and ultrastructural changes in stratum corneum, J. Control. Release 16 (1991) 155-168.
38. H.E.J. Hofland, J.A. Bouwstra, H.E. Boddé, F. Spies and H.E. Junginger, Interactions between liposomes and human stratum corneum in vitro: freeze fracture electron microscopical visualization and small angle X-ray scattering studies, Br. J. Dermatol. 132 (1995) 853-866.