Use of human skin equivalent Apligraf for in vitro assessment of cumulative skin irritation potential of topical products

Toxicology and Applied Pharmacology

Volumn 164, Issue 1, 2000, Pages 38-45

  Medina, Jesús ^a   De Brugerolle De Fraissinette, Anne ^a   Chibout, Salah Dine ^a   Kolopp, Maryelle ^a   Kammermann, Rahel ^a   Burtin, Pascale ^a   Ebelin, Marie Eve ^a   Cordier, A ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Cytokines; Gene expression; Human skin equivalent; In vitro model; Patch test; Predictivity; Skin irritation

Indexed keywords

DODECYL SULFATE SODIUM; INTERLEUKIN 1ALPHA; INTERLEUKIN 8; MESSENGER RNA; PETROLATUM; RETINOIC ACID;

ADULT; ARTICLE; ARTIFICIAL SKIN; CLINICAL FEATURE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG SAFETY; FEMALE; HISTOPATHOLOGY; HUMAN; MALE; NORMAL HUMAN; RANDOMIZED CONTROLLED TRIAL; SKIN BLOOD FLOW; SKIN IRRITATION; SKIN TOXICITY; SKIN WATER LOSS; TOXICITY TESTING;

EID: 0034177053     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1999.8875     Document Type: Article

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