The in vitro acute skin irritation of chemicals: Optimisation of the EPISKIN prediction model within the framework of the ECVAM validation process

Alternatives to Laboratory Animals

Volumn 33, Issue 4, 2005, Pages 329-349

  Cotovio, José ^a   Grandidier, Marie Hélène ^a   Portes, Pascal ^a   Roguet, Roland ^b   Rubinstenn, Gilles ^b  

^a L'Oréal Recherche Department of Analytical Chemistry   (France)

^b L ORÉAL RECHERCHE   (France)

Author keywords

Alternative methods; Cytokines; ECVAM; Epidermis; EPISKIN; In vitro; MTT; Prevalidation; Reconstructed skin; Skin irritation; Tiered strategy

Indexed keywords

3 [4,5 DIMETHYLTHIAZOL 2 YL] 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ADENYLATE KINASE; BROMINE DERIVATIVE; CHEMICAL AGENT; INTERLEUKIN 1ALPHA; INTERLEUKIN 8; IRRITANT AGENT; UNCLASSIFIED DRUG; INTERLEUKIN 1;

ACCURACY; ARTICLE; BIOLOGICAL MODEL; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; EPIDERMIS; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INCUBATION TIME; MEMBRANE DAMAGE; PRIORITY JOURNAL; SCORING SYSTEM; SENSITIVITY AND SPECIFICITY; SKIN IRRITATION; VISUAL SYSTEM; ANIMAL TESTING ALTERNATIVE; DRUG EFFECT; METABOLISM; PREDICTION AND FORECASTING; REPRODUCIBILITY; SKIN; TOXICITY TESTING; VALIDATION STUDY;

ANIMALIA;

ANIMAL TESTING ALTERNATIVES; HUMANS; INTERLEUKIN-1; INTERLEUKIN-8; IRRITANTS; MODELS, BIOLOGICAL; PREDICTIVE VALUE OF TESTS; REPRODUCIBILITY OF RESULTS; SKIN; SKIN IRRITANCY TESTS;

EID: 24944481113     PISSN: 02611929     EISSN: None     Source Type: Journal    
DOI: 10.1177/026119290503300403     Document Type: Article

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