Predictivity of an in vitro model for acute and chronic skin irritation (SkinEthic) applied to the testing of topical vehicles

Cell Biology and Toxicology

Volumn 15, Issue 2, 1999, Pages 121-135

  De Brugerolle De Fraissinette, A ^a,d   Picarles, V ^a   Chibout, S ^a   Kolopp, M ^a   Medina, J ^a   Burtin, P ^a   Ebelin, M E ^a   Osborne, S ^a   Mayer, F K ^a   Spake, A ^b   Rosdy, M ^c   De Wever, B ^c   Ettlin, R A ^a   Cordier, A ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

^b Aster Cephac   (France)

^c SkinEthic   (France)

^d Preclin Safety/Toxicology Pathology   (Switzerland)

Author keywords

Acute and chronic skin irritation; Cytokines; Gene expression; In vitro human epidermis; Predictivity

Indexed keywords

CALCIPOTRIOL; CYTOKINE; DODECYL SULFATE SODIUM; DRUG VEHICLE; INTERLEUKIN 1ALPHA; INTERLEUKIN 8; RETINOIC ACID;

ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXICITY; DRUG FORMULATION; DRUG SCREENING; DRUG SYNTHESIS; EPIDERMIS; ERYTHEMA; HUMAN; HUMAN TISSUE; PRIORITY JOURNAL; SKIN INFLAMMATION; SKIN IRRITATION;

ADULT; CALCITRIOL; HUMANS; KERATINOCYTES; MODELS, BIOLOGICAL; SKIN; SODIUM DODECYL SULFATE; TRETINOIN;

EID: 0033067625     PISSN: 07422091     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1007577515215     Document Type: Article

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